Health‐related quality of life in pediatric liver transplant recipients compared with other chronic disease groups

Pediatric Transplantation - Tập 15 Số 3 - Trang 245-253 - 2011
Christine A. Limbers1, Katie Neighbors2, Karen Martz3, John C. Bucuvalas4, Thomas Webb5, James W. Varni6, Estella M. Alonso2
1Department of Psychology and Neuroscience, Baylor University, Waco, TX
2Department of Pediatrics, Children's Memorial Hospital, Chicago, IL
3The Emmes Corporation, Rockville, MD
4Pediatrics, Cincinnati Children's Hospital Medical Center
5General Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH
6Departments of Pediatrics and Landscape Architecture and Urban Planning, Colleges of Architecture and Medicine, Texas A&M University, College Station, TX, USA

Tóm tắt

Limbers CA, Neighbors K, Martz K, Bucuvalas JC, Webb T, Varni JW, Alonso EM, on behalf of the Studies of Pediatric Liver Transplantation (SPLIT) Functional Outcomes Group (FOG). Health‐related quality of life in pediatric liver transplant recipients compared with other chronic disease groups.
Pediatr Transplantation 2011: 15: 245–253. © 2010 John Wiley & Sons A/S.Abstract:  This cross‐sectional, multicenter cohort study compares the level of HRQOL of pediatric LT recipients to children with other chronic health conditions. LT sample included 873 children who survived at least 12 months following LT. Six chronic disease samples were compiled from numerous studies, including over 800 patients with JRA, type 1 diabetes, cancer in remission, cardiac disease, end‐stage renal disease, and inflammatory bowel disease. Generic HRQOL was measured from both the parental and patient perspective using the PedsQL™ 4.0 Generic Core Scales. Pediatric LT patients reported better physical health than children with JRA. According to parents, pediatric LT recipients had better HRQOL than children on renal dialysis on all domains except school functioning. Across all domains but emotional functioning, pediatric LT recipients reported significantly lower HRQOL than children with type 1 diabetes. Overall, pediatric LT patients reported HRQOL comparable to that of children who had undergone renal transplantation and patients with cancer in remission. Pediatric LT patients manifested impaired HRQOL similar to that of children with chronic diseases and these data suggest that they face ongoing challenges that warrant monitoring and indicate a need for interventions to improve their HRQOL.

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Tài liệu tham khảo

FDA, 2009, Guidance for Industry: Patient‐reported Outcome Measures: Use in Medical Product Development To Support Labeling Claims

10.1016/S0899-9007(00)00404-4

10.1002/pbc.21026

World Health Organization, 1948, Constitution of the World Health Organization: Basic Document

10.1097/00005650-198903001-00018

10.1097/00005650-199902000-00003

10.1111/j.1600-6143.2010.03149.x

10.1016/j.jpeds.2009.08.048

10.1002/lt.21352

10.1097/00005176-200308000-00014

Apajasalo M, 1997, Health‐related quality of life after organ transplantation in childhood, Pediatr Transplant, 1, 130

Asonuma K, 1998, Growth and quality of life after living‐related liver transplantation in children, Pediatr Transplant, 2, 64

10.1053/jlts.2003.50012

10.1111/j.1399-3046.2004.00126.x

10.1111/j.1600-6143.2007.01878.x

10.1053/lv.2000.6139

10.1111/j.1600-6143.2009.02604.x

10.1542/peds.58.2.259

10.1002/cncr.10428

Varni JW, 2004, The PedsQL™ Multidimensional Fatigue Scale in pediatric rheumatology: Reliability and validity, J Rheumatol, 31, 2494

10.1016/S1058-9813(03)00087-0

10.1111/j.1524-4733.2007.00289.x

10.1542/peds.2006-3778

10.1007/s00467-006-0081-y

10.1016/j.cgh.2009.01.022

10.1097/00005650-200108000-00006

10.1002/sim.4780090710

Cohen J, 1988, Statistical Power Analysis for the Behavioral Sciences

2001, SAS System for Windows v 8.02

SPSS, 2008, SPSS 16.0 for Windows

10.1002/lt.22120

10.1037/0033-2909.101.2.213

10.1016/0895-4356(92)90052-O

10.1016/S0022-3476(94)70190-3

10.1016/S0022-3476(97)70352-4

10.1067/mpd.2000.106568

10.1093/jpepsy/26.8.485

10.2337/diacare.22.5.713

10.1093/jpepsy/25.1.23

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Pediatric Transplantation

Tập 15 Số 3

245-253

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