Health-Related Quality of Life After Thyroid Cancer Surgery: A Single-Center, Cross-Sectional Study in Southern Vietnam.

CUREUS JOURNAL OF MEDICAL SCIENCE - Tập 15 Số 6 - Trang e40496 - 2023
Tran Thanh Vy1,2, Tran Le Thi Thanh Nam3, Lam Thao Cuong1,2, Ho Tat Bang1,4
1Thoracic and Vascular Department, University Medical Center Ho Chi Minh City, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh, VNM.
2Department of Cardiovascular and Thoracic Surgery, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh, VNM.
3Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh, VNM.
4Department of Health Organization and Management, Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh, VNM.

Tóm tắt

Background Thyroid cancer is the most common malignant disease in the endocrine glands. Symptoms of the disease affect the functions of organs in the body. Although thyroid cancer is often considered a "good cancer" because it progresses slowly, the likelihood of successful treatment is quite high; what is special is that the effect on the quality of life (QoL) is on par with more severe types of cancer. Currently, studies on QoL assessment in thyroid cancer patients are quite limited in southern Vietnam. The present study investigated the potential risk factors of deterioration in QoL scores in thyroid cancer patients after thyroidectomy. Methodology A descriptive, cross-sectional study was performed on a total of 162 patients who were diagnosed with thyroid cancer and underwent thyroidectomy at the University Medical Center Ho Chi Minh City, Vietnam, from February to May 2023. Data were collected through face-to-face interviews with patients and from medical records. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 was used to assess the QoL one month after thyroidectomy. Multivariable logistic regression was used to identify factors related to QoL with statistical significance set at p-value <0.05. Results The mean overall QoL in thyroid cancer survivors was 84.4 ± 10.00 (on a scale of 0-100, where 100 was the best). The results of multivariate logistic regression analysis showed that the factors related to QoL after thyroidectomy were surgery type (p < 0.001), having a comorbidity (p = 0.029), economic status (p = 0.026), and hormone disorder (p = 0.009). Conclusions Our study indicated that surgery type, having a comorbidity, economic status, and hormone disorders were independent risk factors for decreased QoL one month after thyroidectomy. It is necessary to thoroughly assess the QoL before and after surgery in thyroid cancer patients. Longer follow-up QoL studies should be performed with larger sample sizes for more accurate results.

Từ khóa

#eortc qlq-c30 #patient #quality of life #surgery #thyroid cancer

Tài liệu tham khảo

Mulita F, Anjum F. Treasure Island, FL: StatPearls Publishing; 2023. Thyroid Adenoma.

Health-related quality of life of community thyroid cancer survivors in Hangzhou, China. Wang T, Jiang M, Ren Y, Liu Q, Zhao G, Cao C, Wang H. Thyroid. 2018;28:1013–1023.

Quality of life in thyroid cancer is similar to that of other cancers with worse survival. Applewhite MK, James BC, Kaplan SP, Angelos P, Kaplan EL, Grogan RH, Aschebrook-Kilfoy B. World J Surg. 2016;40:551–561.

GLOCOBAN 2020: estimated cancer incidence, mortality and prevalence in vietnam in 2020. GLOCOBAN. [ Mar; 2022 ]. 2020. https://gco.iarc.fr/today/data/factsheets/populations/704-viet-nam-fact-sheets.pdf https://gco.iarc.fr/today/data/factsheets/populations/704-viet-nam-fact-sheets.pdf

Projecting cancer incidence for 2025 in the 2 largest populated cities in Vietnam. Nguyen SM, Deppen S, Nguyen GH, Pham DX, Bui TD, Tran TV. Cancer Control. 2019;26:1073274819865274.

2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Haugen BR, Alexander EK, Bible KC, et al. Thyroid. 2016;26:1–133.

Risk factors of deterioration in quality of life scores in thyroid cancer patients after thyroidectomy. Li J, Xue LB, Gong XY, et al. Cancer Manag Res. 2019;11:10593–10598.

Thyroid cancer-specific quality of life and health-related quality of life in young adult thyroid cancer survivors. Goldfarb M, Casillas J. Thyroid. 2016;26:923–932.

Risk factors for decreased quality of life in thyroid cancer survivors: initial findings from the North American Thyroid Cancer Survivorship Study. Aschebrook-Kilfoy B, James B, Nagar S, et al. Thyroid. 2015;25:1313–1321.

Long-term quality of life (5-15 years post-thyroidectomy) of thyroid carcinoma patients in two tertiary care hospitals. Alyousef MY, Ghandour MK, Al-Mohawes M, Alnwaisir M, Islam T, Al Qahtani K. Cureus. 2022;14:0.

[Quality of life of patients with papillary and follicular thyroid carcinoma after thyroidectomy. Nhung DT, Thanh HT. J Med Res Ha Noi Med Univ. 2022;151:63–72.

The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. Aaronson NK, Ahmedzai S, Bergman B, et al. J Natl Cancer Inst. 1993;85:365–376.

Oestrogen mediates the growth of human thyroid carcinoma cells via an oestrogen receptor-ERK pathway. Zeng Q, Chen GG, Vlantis AC, van Hasselt CA. Cell Prolif. 2007;40:921–935.

Making sense of Cronbach's alpha. Tavakol M, Dennick R. Int J Med Educ. 2011;2:53–55.

Fatigue among short- and long-term thyroid cancer survivors: results from the population-based PROFILES registry. Husson O, Nieuwlaat WA, Oranje WA, Haak HR, van de Poll-Franse LV, Mols F. Thyroid. 2013;23:1247–1255.

Signal pathway of estrogen and estrogen receptor in the development of thyroid cancer. Liu J, Xu T, Ma L, Chang W. Front Oncol. 2021;11:593479.

Health-related quality of life after diagnosis and treatment of differentiated thyroid cancer and association with type of surgical treatment. Nickel B, Tan T, Cvejic E, et al. JAMA Otolaryngol Head Neck Surg. 2019;145:231–238.

Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Garber JR, Cobin RH, Gharib H, et al. Endocr Pract. 2012;18:988–1028.