Head and neck cancer in the elderly: An overview on the treatment modalities

Vercelli, 1998, Overall cancer incidence and mortality trends among elderly and adult Europeans, Crit Rev Oncol Hematol, 27, 87, 10.1016/S1040-8428(97)10010-5

Parker, 1997, Cancer statistics, 1997, CA Cancer J Clin, 47, 5, 10.3322/canjclin.47.1.5

Yancik, 1994, Cancer in older persons magnitude of the problem − how do we apply what we know?, Cancer, 74, 1995, 10.1002/1097-0142(19941001)74:7+<1995::AID-CNCR2820741702>3.0.CO;2-Y

Socinski, 2003, Chemotherapeutic management of stage IV non-small cell lung cancer, Chest, 123, 226S, 10.1378/chest.123.1_suppl.226S

Parkin, 2005, Global cancer statistics, 2002, CA Cancer J Clin, 55, 74, 10.3322/canjclin.55.2.74

Balducci, 2006, Management of cancer in the elderly, Oncology (Williston Park), 20, 135

Muir, 1994, The interpretation of time trends, Cancer Surv, 19-20, 5

Pignon, 1996, No age limit for radical radiotherapy in head and neck tumours, Eur J Cancer, 32A, 2075, 10.1016/S0959-8049(96)00265-1

Koch, 1995, Squamous cell carcinoma of the head and neck in the elderly, Arch Otolaryngol Head Neck Surg, 121, 262, 10.1001/archotol.1995.01890030006001

Argiris, 2003, Epidemiology, staging, and screening of head and neck cancer, Cancer Treat Res, 114, 15, 10.1007/0-306-48060-3_2

Leon, 1998, Influence of age on laryngeal carcinoma, Ann Otol Rhinol Laryngol, 107, 164, 10.1177/000348949810700213

Sarini, 2001, Head and neck squamous cell carcinoma in elderly patients: a long-term retrospective review of 273 cases, Arch Otolaryngol Head Neck Surg, 127, 1089, 10.1001/archotol.127.9.1089

Lusinchi, 1990, Radiation therapy for head and neck cancers in the elderly, Int J Radiat Oncol Biol Phys, 18, 819, 10.1016/0360-3016(90)90403-7

Jones, 1998, Radical radiotherapy for squamous cell carcinoma of the larynx, oropharynx and hypopharynx: patterns of recurrence, treatment and survival, Clin Otolaryngol Allied Sci, 23, 496, 10.1046/j.1365-2273.1998.2360496.x

Hirano, 1998, Management of cancer in the elderly: therapeutic dilemmas, Otolaryngol Head Neck Surg, 118, 110, 10.1016/S0194-5998(98)70386-9

Argiris, 2008, Head and neck cancer, Lancet, 371, 1695, 10.1016/S0140-6736(08)60728-X

Balducci, 2001, Cancer and age in the USA, Crit Rev Oncol Hematol, 37, 137, 10.1016/S1040-8428(00)00109-8

Syrigos, 2007, Biweekly administration of docetaxel and gemcitabine for elderly patients with advanced non-small cell lung cancer: a phase II study, J Chemotherapy, 19, 438, 10.1179/joc.2007.19.4.438

Reid, 2001, Comorbidity and survival of elderly head and neck carcinoma patients, Cancer, 92, 2109, 10.1002/1097-0142(20011015)92:8<2109::AID-CNCR1552>3.0.CO;2-M

Extermann, 1998, Comorbidity and functional status are independent in older cancer patients, J Clin Oncol, 16, 1582, 10.1200/JCO.1998.16.4.1582

Read, 2004, Differential prognostic impact of comorbidity, J Clin Oncol, 22, 3099, 10.1200/JCO.2004.08.040

Balducci, 2005, Cancer and ageing: a nexus at several levels, Nat Rev Cancer, 5, 655, 10.1038/nrc1675

Lee, 2006, Development and validation of a prognostic index for 4-year mortality in older adults, JAMA, 295, 801, 10.1001/jama.295.7.801

Balducci, 2005, Senior adult oncology clinical practice guidelines in oncology, J Natl Compr Cancer Netw, 3, 572, 10.6004/jnccn.2005.0032

Ingram, 2002, Comprehensive assessment of the elderly cancer patient: the feasibility of self-report methodology, J Clin Oncol, 20, 770, 10.1200/JCO.20.3.770

Balducci, L. Cancer in the older person. American society on aging; 2006. p. 45–50. Ref type: conference proceeding.

Bernardi, 2005, Treatment of head and neck cancer in elderly patients: state of the art and guidelines, Crit Rev Oncol Hematol, 53, 71, 10.1016/j.critrevonc.2004.08.001

NCCN Practice guidelines in oncology-senior adult oncology v.; 2007 MS4-8. Ref type: electronic citation.

Audiosio, 2008, Shall we operate? Preoperative assessment in elderly cancer patients (PACE) can help. A SIOG surgical task force prospective study, Crit Rev Hematol, 65, 156, 10.1016/j.critrevonc.2007.11.001

Teymoortash, 2002, Head and neck cancer surgery in the elderly, Laryngorhinootologie, 81, 293, 10.1055/s-2002-25319

Scotish intercollegiate guidelines network. Diagnosis and management of head and neck cancer. Scottish intercollegiate guidelines network; 2006. Ref. type: electronic citation.

McGuirt, 1977, The risks of major head and neck surgery in the aged population, Laryngoscope, 87, 1378, 10.1288/00005537-197708000-00017

Morgan, 1982, Head and neck surgery in the aged, Am J Surg, 144, 449, 10.1016/0002-9610(82)90420-2

Zabrodsky, 2004, Major surgery in elderly head and neck cancer patients: immediate and long-term surgical results and complication rates, Surg Oncol, 13, 249, 10.1016/j.suronc.2004.09.003

Laccourreye, 1998, Supracricoid partial laryngectomies in the elderly: mortality, complications, and functional outcome, Laryngoscope, 108, 237, 10.1097/00005537-199802000-00015

Shestak, 1992, Effect of advanced age and medical disease on the outcome of microvascular reconstruction for head and neck defects, Head Neck, 14, 14, 10.1002/hed.2880140104

Bridger, 1994, Advanced patient age should not preclude the use of free-flap reconstruction for head and neck cancer, Am J Surg, 168, 425, 10.1016/S0002-9610(05)80091-1

Malata, 1996, Microvascular free-tissue transfers in elderly patients: the leeds experience, Plast Reconstr Surg, 98, 1234, 10.1097/00006534-199612000-00018

Shaari, 1998, Complications of microvascular head and neck surgery in the elderly, Arch Otolaryngol Head Neck Surg, 124, 407, 10.1001/archotol.124.4.407

Pompei, 1999, Age as a risk factor in cervicofacial reconstruction, J Exp Clin Cancer Res, 18, 209

Blackwell, 2002, Octogenarian free flap reconstruction: complications and cost of therapy, Otolaryngol Head Neck Surg, 126, 301, 10.1067/mhn.2002.122704

Moorthy, 1999, Management of anesthesia in geriatric patients undergoing head and neck surgery, Ear Nose Throat J, 78, 496, 10.1177/014556139907800711

Reppeto, 2002, Comprehensive geriatric assessment adds information to Eastern cooperative oncology group performance status in elderly cancer patients: an Italian group for geriatric oncology study, J Clin Oncol, 15, 494, 10.1200/JCO.20.2.494

Boruk, 2005, Age as a prognostic factor for complications of major head and neck surgery, Arch Otolaryngol Head Neck Surg, 131, 605, 10.1001/archotol.131.7.605

Sanabria, 2007, Comorbidity is a prognostic factor in elderly patients with head and neck cancer, Ann Surg Oncol, 14, 1449, 10.1245/s10434-006-9296-1

Derks, 2003, Elderly patients with head and neck cancer: short-term effects of surgical treatment on quality of life, Clin Otolaryngol Allied Sci, 28, 399, 10.1046/j.1365-2273.2003.00718.x

Sanabria, 2008, Predictive factors for complications in elderly patients who underwent head and neck oncologic surgery, Head Neck, 30, 170, 10.1002/hed.20671

Dhiwakar, 2007, Surgery for head and neck skin tumors in the elderly, Head Neck, 29, 851, 10.1002/hed.20605

Khafif, 2007, Quality of life in patients older than 75 years following major head and neck surgery, Head Neck, 29, 932, 10.1002/hed.20635

Donato, 2003, Short course radiation therapy for elderly cancer patients. Evidences from the literature review, Crit Rev Oncol Hematol, 45, 305, 10.1016/S1040-8428(02)00082-3

Nguyen, 2002, Radiotherapy for cancer of the head and neck: altered fractionation regimens, Lancet Oncol, 3, 693, 10.1016/S1470-2045(02)00906-3

Fu, 2000, A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003, Int J Radiat Oncol Biol Phys, 48, 7, 10.1016/S0360-3016(00)00663-5

Bourhis, 2006, Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis, Lancet, 368, 843, 10.1016/S0140-6736(06)69121-6

Guerrero Urbano, 2007, Target volume definition for head and neck intensity modulated radiotherapy: pre-clinical evaluation of PARSPORT trial guidelines, Clin Oncol (R Coll Radiol), 19, 604, 10.1016/j.clon.2007.07.001

Fielding, 2004, Verification of patient position and delivery of IMRT by electronic portal imaging, Radiother Oncol, 73, 339, 10.1016/j.radonc.2004.09.003

Eisbruch, 2004, Recurrences near base of skull after IMRT for head-and-neck cancer: implications for target delineation in high neck and for parotid gland sparing, Int J Radiat Oncol Biol Phys, 59, 28, 10.1016/j.ijrobp.2003.10.032

Urbano, 2007, Intensity Modulated Radiotherapy (IMRT) in locally advanced thyroid cancer: acute toxicity results of a phase I study, Radiother Oncol, 85, 58, 10.1016/j.radonc.2007.07.020

Mitsuhashi, 1999, Cancer in patients aged 90 years or older: radiation therapy, Radiology, 211, 829, 10.1148/radiology.211.3.r99jn21829

Yamakawa, 1994, Radiation therapy for esophageal cancer in patients over 80 years old, Int J Radiat Oncol Biol Phys, 30, 1225, 10.1016/0360-3016(94)90333-6

Zachariah, 1997, Radiotherapy for cancer patients aged 80 and older: a study of effectiveness and side effects, Int J Radiat Oncol Biol Phys, 39, 1125, 10.1016/S0360-3016(97)00552-X

Hishikawa, 1991, Radiotherapy for carcinoma of the esophagus in patients aged eighty or older, Int J Radiat Oncol Biol Phys, 20, 685, 10.1016/0360-3016(91)90009-S

Schilcher, 1995, Clinical results of radiotherapy in 140 elderly patients treated at Basel University Hospital between 1980 and 1985, Int J Radiat Oncol Biol Phys, 33, 774, 10.1016/0360-3016(95)96873-R

Huguenin, 1996, Radiotherapy for carcinomas of the head and neck in elderly patients, Strahlenther Onkol, 172, 485

Zachariah, 1997, Radiotherapy for cancer patients aged 80 and older: a study of effectiveness and side effects, Int J Radiat Oncol Biol Phys, 39, 1125, 10.1016/S0360-3016(97)00552-X

Schofield, 2003, Radiotherapy for head and neck cancer in elderly patients, Radiother Oncol, 69, 34, 10.1016/S0167-8140(03)00249-4

Oguchi, 1998, Experiences of 23 patients > or=90 years of age treated with radiation therapy, Int J Radiat Oncol Biol Phys, 41, 407, 10.1016/S0360-3016(98)00052-2

Allal, 2000, Feasibility and early results of accelerated radiotherapy for head and neck carcinoma in the elderly, Cancer, 88, 648, 10.1002/(SICI)1097-0142(20000201)88:3<648::AID-CNCR23>3.0.CO;2-R

Olmi, 1997, Radiation therapy in the elderly with head and neck cancer, Rays, 22, 77

Kouvaris, 2007, Amifostine: the first selective-target and broad-spectrum radioprotector, Oncologist, 12, 738, 10.1634/theoncologist.12-6-738

Wasil, 2000, Radiation therapy in cancer patients 80 years of age and older, Am J Clin Oncol, 23, 526, 10.1097/00000421-200010000-00019

Geinitz, 1999, Radiotherapy of the elderly patient. Radiotherapy tolerance and results in older patients, Strahlenther Onkol, 175, 119, 10.1007/BF02742345

Bhide, 2008, Sequential induction chemotherapy followed by radical chemo-radiation in the treatment of locoregionally advanced head-and-neck cancer, Br J Cancer, 99, 57, 10.1038/sj.bjc.6604444

Pignon, 2000, Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC collaborative group. meta-analysis of chemotherapy on head and neck cancer, Lancet, 355, 949, 10.1016/S0140-6736(00)90011-0

Bernier, 2005, Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501), Head Neck, 27, 843, 10.1002/hed.20279

Posner, 2007, Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer, N Engl J Med, 357, 1705, 10.1056/NEJMoa070956

Vermorken, 2007, Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer, N Engl J Med, 357, 1695, 10.1056/NEJMoa071028

Cohen, 2004, The expanding role of systemic therapy in head and neck cancer, J Clin Oncol, 22, 1743, 10.1200/JCO.2004.06.147

Argiris, 2004, Outcome of elderly patients with recurrent or metastatic head and neck cancer treated with cisplatin-based chemotherapy, J Clin Oncol, 22, 262, 10.1200/JCO.2004.08.039

Syrigos, 2005, Prostate cancer in the elderly, Anticancer Res, 25, 4527

Repetto, 2003, Greater risks of chemotherapy toxicity in elderly patients with cancer, J Support Oncol, 1, 18

Bonner, 2006, Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck, N Engl J Med, 354, 567, 10.1056/NEJMoa053422

Harari, 2001, Head and neck cancer as a clinical model for molecular targeting of therapy: combining EGFR blockade with radiation, Int J Radiat Oncol Biol Phys, 49, 427, 10.1016/S0360-3016(00)01488-7

Huang, 1999, Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck, Cancer Res, 59, 1935

Huang, 2000, Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis, Clin Cancer Res, 6, 2166

van der Schroeff, 2007, The effect of age on survival and quality of life in elderly head and neck cancer patients: a long- term prospective study, Eur Arch Otorhinolaryngol, 264, 415, 10.1007/s00405-006-0203-y