HbA1c – ein Alleskönner?

American Diabetes Association (2010) Diagnosis and classification of diabetes mellitus. Diabetes Care 33:S11–S61

Balion CM, Raina PS, Gerstein HC et al (2007) Reproducibility of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) classification: a systematic review. Clin Chem Lab Med 45:1180–1185

Christensen DL, Witte DR, Kaduka L et al (2010) Moving to an A1C-based diagnosis of diabetes has a different impact on prevalence in different ethnic groups. Diabetes Care 33:580–582

Cohen RM, Haggerty S, Herman WH (2010) HbA1c for the diagnosis of diabetes and prediabetes: is it time for a mid-course correction? J Clin Endocrinol Metab 95:5203–5206

Colagiuri S, Lee CM, Wong TY et al; DETECT-2 Collaboration Writing Group (2011) Glycemic thresholds for diabetes-specific retinopathy: implications for diagnostic criteria for diabetes. Diabetes Care 34:145–150

Consensus Committee (2007) Consensus statement on the worldwide standardization of the hemoglobin A1C measurement: the American Diabetes Association, European Association for the Study of Diabetes, International Federation of Clinical Chemistry and Laboratory Medicine, and the International Diabetes Federation. Diabetes Care 30:2399–2400

Dagogo-Jack S (2010) Pitfalls in the use of HbA1c as a diagnostic test: the ethnic conundrum. Nat Rev Endocrinol 6:589–593

Davidson MB, Schriger DL (2010) Effect of age and race/ethnicity on HbA1c levels in people without known diabetes mellitus: implications for the diagnosis of diabetes. Diabetes Res Clin Pract 87:415–421

Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group, Nathan DM, Zinman B, Cleary PA et al (2009) Modern-day clinical course of type 1 diabetes mellitus after 30 years‘ duration: the diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience (1983-2005). Arch Intern Med 169:1307–1316

Diabetes Prevention Program Research Group (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393–403

Fajans SS, Herman WH, Oral EA (2011) Insufficient sensitivity of hemoglobin A(1C) determination in diagnosis or screening of early diabetic states. Metabolism 60:86–91

Florez JC (2010) A genome-wide association study of treated A1C: a genetic needle in an environmental haystack? Diabetes 59:332–334

Gaede P, Lund-Andersen H, Parving HH, Pedersen O (2008) Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med 358:580–591

Herman WH, Dungan KM, Wolffenbuttel BH et al (2009) Racial and ethnic differences in mean plasma glucose, hemoglobin A1c, and 1,5-anhydroglucitol in over 2000 patients with type 2 diabetes. J Clin Endocrinol Metab 94:1689–94

Holman RR, Paul SK, Bethel MA et al (2008) 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 359:1577–1589

Home PD, Pocock SJ, Beck-Nielsen H et al; RECORD Study Team (2009) Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial. Lancet 373:2125–2135

Mosca A, Goodall I, Hoshino T et al; International Federation of Clinical Chemistry and Laboratory Medicine, IFCC Scientific Division (2007) Global standardization of glycated hemoglobin measurement: the position of the IFCC Working Group. Clin Chem Lab Med 45:1077–1080

International Expert Committee (2009) International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care 32:1327–1334

Jeppsson JO, Kobold U, Barr J et al; International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) (2002) Approved IFCC reference method for the measurement of HbA1c in human blood. Clin Chem Lab Med 40:78–89

Kamps JL, Hempe JM, Chalew SA (2010) Racial disparity in A1C independent of mean blood glucose in children with type 1 diabetes. Diabetes Care 33:1025–1027

Kerner W, Brückel J (2010) Definition, Klassifikation und Diagnostik des Diabetes mellitus. Diabetol Stoffwechs 5:S109–S112

Kirk JK, D’Agostino RB Jr, Bell RA et al (2006) Disparities in HbA1c levels between African-American and non-Hispanic white adults with diabetes: a meta-analysis. Diabetes Care 29:2130–2136

Kosaka K, Noda M, Kuzuya T (2005) Prevention of type 2 diabetes by lifestyle intervention: a Japanese trial in IGT males. Diabetes Res Clin Pract 67:152–162

Kowall B, Rathmann W (2011) Konsequenzen eines Wechsels von Glukose- zu HbA1c-basierten Kriterien für die Diabetesdiagnose: ein narratives Review aus epidemiologischer Sicht. Diabetol Stoffwechs 6:32–42

Lenters-Westra E, Slingerland RJ (2010) Six of eight hemoglobin A1c point-of-care instruments do not meet the general accepted analytical performance criteria. Clin Chem 56:44–52

Levitan EB, Song Y, Ford ES, Liu S (2004) is nondiabetic hyperglycemia a risk factor for cardiovascular disease? A meta-analysis of prospective studies. Arch Intern Med 164:2147–2155

Likhari T, Gama R (2009) Glycemia-independent ethnic differences in HbA(1c) in subjects with impaired glucose tolerance. Diabet Med 26:1068–1069

Lindström J, Louheranta A, Mannelin M et al (2003) The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity. Diabetes Care 26:3230–3236

Lindström J, Ilanne-Parikka P, Peltonen M et al (2006) Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: the follow-up results of the Finnish Diabetes Prevention Study. Lancet 368:1673–1679

Martin S, Buchholz G, Fach E et al (2009) Rolle der Selbstmessung der Blutglukose (SMBG) bei Diabetes mellitus. Empfehlungen für eine individualisierte Messfrequenz. Diabetologe 5:460–470

Meisinger C, Strassburger K, Heier M et al (2010) Prevalence of undiagnosed diabetes and impaired glucose regulation in 35–59-year-old individuals in Southern Germany: the KORA F4 Study. Diabet Med 27:360–362

Nathan DM, Kuenen J, Borg R et al; A1c-Derived Average Glucose Study Group (2008) Translating the A1C assay into estimated average glucose values (eAG). Diabetes Care 31:1473–1478

Pajunen P, Peltonen M, Eriksson JG et al for the Finnish Diabetes Prevention Study (DPS) (2011) HbA1c in diagnosing and predicting type 2 diabetes in impaired glucose tolerance: the Finnish Diabetes Prevention Study. Diabet Med 28:36–42

Pan XR, Li GW, Hu YH et al (1997) Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care 20:537–544

Pani LN, Korenda L, Meigs JB et al (2008) Effect of aging on A1C in individuals without diabetes. Evidence from the Framingham Offspring Study and the National Health and Nutrition Examination Survey 2001–2004. Diabetes Care 31:1991–1996

Peter A, Fritsche A, Stefan N et al (2011) Diagnostic value of hemoglobin A1c for type 2 diabetes mellitus in a population at risk. Exp Clin Endocrinol Diabetes 119:234–237

Ramachandran A, Snehalatha C, Mary S et al (2006) The Indian Diabetes Prevention Programme shows that lifestylemodification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP‑1). Diabetologia 49:289–297

Rathmann W, Kowall B, Tamayo T et al (2010) Hemoglobin A1c and glucose criteria identify different subjects as having type 2 diabetes in middle-aged and older populations: The KORA S4/F4 Study. Ann Med, doi 10.3109/07853890.2010.531759

Reinauer H, Scherbaum W(2009) Diabetes mellitus: neuer Referenzstandard für HbA1c. Dtsch Arztebl 106:A805–A806

Rohlfing CL, Wiedmeyer HM, Little RR et al (2002) Defining the relationship between plasma glucose and HbA(1c): analysis of glucose profiles and HbA(1c) in the Diabetes Control and Complications Trial. Diabetes Care 25:275–278

Schernthaner G (2010) Diabetes and Cardiovascular Disease: is intensive glucose control beneficial or deadly? Lessons from ACCORD, ADVANCE, VADT, UKPDS, PROactive, and NICE-SUGAR. Wien Med Wochenschr 160:8–19

Schleicher E, Landgraf R (2011) Diagnose und Differentialdiagnose. In: Häring HU, Gallwitz G, Müller-Wieland D, Usadel KH, Mehnert H (Hrsg) Diabetologie in Klinik und Praxis. Thieme, Stuttgart

Selvin E, Marinopoulos S, Berkenblit G et al (2004) Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus. Ann Intern Med 14:421–431

Selvin E, Crainiceanu CM, Brancati FL, Coresh J (2007) Short-term variability in measures of glycemia and implications for the classification of diabetes. Arch Intern Med 167:1545–1551

Selvin E, Steffes MW, Zhu H et al (2010) Glycated hemoglobin, diabetes, and cardiovascular risk in non-diabetic adults. N Engl J Med 362:800–811

Shichiri M, Kishikawa H, Ohkubo Y, Wake N (2000) Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients. Diabetes Care 23(Suppl 2):B21–29

Skriver et al (2010) HbA1c as predictor of all-cause mortality in individuals at high risk with NGT identified by screening. A follow-up of the ADDITION study of intensive treatment in people with screen-detected diabetes in primary care. Diabetologia 53:2328–2333

Snieder H, Sawtell PA, Ross L et al (2001) HbA1c levels are genetically determined even in type 1 diabetes. Evidence from healthy and diabetic twins. Diabetes 50:2858–2863

Szymezak J, Lavalard E, Martin M et al (2009) Carbamylated hemoglobin remains a critical issue in HbA1c measurements. Clin Chem Lab Med 47:612–613

DECODE Study Group (2003) Age- and sex-specific prevalences of diabetes and impaired glucose regulation in 13 European cohorts. Diabetes Care 26:61–69

van’t Riet E, Alssema M, Rijkelijkhuizen JM et al (2010) Relationship between A1C and glucose levels in the general Dutch population: the new Hoorn study. Diabetes Care 33:61–66

Weykamp C, John WG, Mosca A et al (2008) The IFCC reference measurement system for HbA1c: a 6-year progress report. Clin Chem 54:240–248

WHO (2011) Use of glycated haemoglobin (HbA1c) in the Diagnosis of diabetes mellitus. Abbreviated report of a WHO consultation WHO/NMH/CHP/CPM/11.1