Halogenated indoles eradicate bacterial persister cells and biofilms

AMB Express - Tập 6 Số 1 - 2016
Jin-Hyung Lee1, Yong‐Guy Kim1, Giyeon Gwon1, Thomas K. Wood2, Jintae Lee1
1School of Chemical Engineering, Yeungnam University, Gyeongsan, 38541, Republic of Korea
2Department of Chemical Engineering, Pennsylvania State University, University Park, PA, USA

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Bansal T, Alaniz RC, Wood TK, Jayaraman A (2010) The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation. Proc Natl Acad Sci USA 107:228–233. doi: 10.1073/pnas.0906112107

Brown ML, Gauthier JJ (1993) Cell density and growth phase as factors in the resistance of a biofilm of Pseudomonas aeruginosa (ATCC 27853) to iodine. Appl Environ Microbiol 59:2320–2322

Bunders CA, Minvielle MJ, Worthington RJ, Ortiz M, Cavanagh J, Melander C (2011) Intercepting bacterial indole signaling with flustramine derivatives. J Am Chem Soc 133:20160–20163. doi: 10.1021/ja209836z

Calvori C, Frontali L, Leoni L, Tecce G (1965) Effect of rifamycin on protein synthesis. Nature 207:417–418. doi: 10.1038/207417a0

Cegelski L, Marshall GR, Eldridge GR, Hultgren SJ (2008) The biology and future prospects of antivirulence therapies. Nat Rev Microbiol 6:17–27. doi: 10.1038/nrmicro1818

Conlon BP, Nakayasu ES, Fleck LE, LaFleur MD, Isabella VM, Coleman K, Leonard SN, Smith RD, Adkins JN, Lewis K (2013) Activated ClpP kills persisters and eradicates a chronic biofilm infection. Nature 503:365–370. doi: 10.1038/nature12790

Costerton JW, Stewart PS, Greenberg EP (1999) Bacterial biofilms: a common cause of persistent infections. Science 284:1318–1322. doi: 10.1126/science.284.5418.1318

Erb M, Veyrat N, Robert CA, Xu H, Frey M, Ton J, Turlings TC (2015) Indole is an essential herbivore-induced volatile priming signal in maize. Nat Commun 6:6273. doi: 10.1038/ncomms7273

Heydorn A, Nielsen AT, Hentzer M, Sternberg C, Givskov M, Ersboll BK, Molin S (2000) Quantification of biofilm structures by the novel computer program COMSTAT. Microbiology 146:2395–2407. doi: 10.1099/00221287-146-10-2395

Hoffman LR, D’Argenio DA, MacCoss MJ, Zhang Z, Jones RA, Miller SI (2005) Aminoglycoside antibiotics induce bacterial biofilm formation. Nature 436:1171–1175. doi: 10.1038/nature03912

Hu Y, Kwan BW, Osbourne DO, Benedik MJ, Wood TK (2015) Toxin YafQ increases persister cell formation by reducing indole signalling. Environ Microbiol 17:1275–1285. doi: 10.1111/1462-2920.12567

Keren I, Kaldalu N, Spoering A, Wang Y, Lewis K (2004) Persister cells and tolerance to antimicrobials. FEMS Microbiol Lett 230:13–18. doi: 10.1016/S0378-1097(03)00856-5

Kim Y-G, Lee J-H, Cho MH, Lee J (2011) Indole and 3-indolylacetonitrile inhibit spore maturation in Paenibacillus alvei. BMC Microbiol 11:119. doi: 10.1186/1471-2180-11-119

Kim Y-G, Lee J-H, Kim CJ, Lee J-C, Ju YJ, Cho MH, Lee J (2012) Antibiofilm activity of Streptomyces sp. BFI 230 and Kribbella sp. BFI 1562 against Pseudomonas aeruginosa. Appl Microbiol Biotechnol 96:1607–1617. doi: 10.1007/s00253-012-4225-7

Kwan BW, Valenta JA, Benedik MJ, Wood TK (2013) Arrested protein synthesis increases persister-like cell formation. Antimicrob Agents Chemother 57:1468–1473. doi: 10.1128/AAC.02135-12

Kwan BW, Osbourne DO, Hu Y, Benedik MJ, Wood TK (2015) Phosphodiesterase DosP increases persistence by reducing cAMP which reduces the signal indole. Biotechnol Bioeng 112:588–600. doi: 10.1002/bit.25456

Lee J-H, Lee J (2010) Indole as an intercellular signal in microbial community. FEMS Microbiol Rev 34:426–444. doi: 10.1111/j.1574-6976.2009.00204.x

Lee J, Jayaraman A, Wood TK (2007) Indole is an inter-species biofilm signal mediated by SdiA. BMC Microbiol 7:42. doi: 10.1186/1471-2180-7-42

Lee J, Attila C, Cirillo SLG, Cirillo JD, Wood TK (2009) Indole and 7-hydroxyindole diminish Pseudomonas aeruginosa virulence. Microbial Biotech 2:75–90. doi: 10.1111/j.1751-7915.2008.00061.x

Lee HH, Molla MN, Cantor CR, Collins JJ (2010) Bacterial charity work leads to population-wide resistance. Nature 467:82–85. doi: 10.1038/nature09354

Lee J-H, Cho MH, Lee J (2011) 3-Indolylacetonitrile decreases Escherichia coli O157:H7 biofilm formation and Pseudomonas aeruginosa virulence. Environ Microbiol 13:62–73. doi: 10.1111/j.1462-2920.2010.02308.x

Lee J-H, Kim Y-G, Cho MH, Kim J-A, Lee J (2012) 7-Fluoroindole as an antivirulence compound against Pseudomonas aeruginosa. FEMS Microbiol Lett 329:36–44. doi: 10.1111/j.1574-6968.2012.02500.x

Lee J-H, Cho HS, Kim Y-G, Kim J-A, Banskota S, Cho MH, Lee J (2013) Indole and 7-benzyloxyindole attenuate the virulence of Staphylococcus aureus. Appl Microbiol Biotechnol 97:4543–4552. doi: 10.1007/s00253-012-4674-z

Lee J-H, Kim Y-G, Baek KH, Cho MH, Lee J (2015) The multifaceted roles of the interspecies signalling molecule indole in Agrobacterium tumefaciens. Environ Microbiol 17:1234–1244. doi: 10.1111/1462-2920.12560

Levy SB, Marshall B (2004) Antibacterial resistance worldwide: causes, challenges and responses. Nat Med 10:S122–S129. doi: 10.1038/nm1145

Lewis K (2007) Persister cells, dormancy and infectious disease. Nat Rev Microbiol 5:48–56. doi: 10.1038/nrmicro1557

Lewis K (2008) Multidrug tolerance of biofilms and persister cells. Curr Top Microbiol Immunol 322:107–131. doi: 10.1007/978-3-540-75418-3_6

Lewis K (2010) Persister cells. Annu Rev Microbiol 64:357–372. doi: 10.1146/annurev.micro.112408.134306

Linares JF, Gustafsson I, Baquero F, Martinez JL (2006) Antibiotics as intermicrobial signaling agents instead of weapons. Proc Natl Acad Sci USA 103:19484–19489. doi: 10.1073/pnas.0608949103

Maeda T, Garcia-Contreras R, Pu M, Sheng L, Garcia LR, Tomas M, Wood TK (2012) Quorum quenching quandary: resistance to antivirulence compounds. ISME J 6:493–501. doi: 10.1038/ismej.2011.122

Marques CN, Morozov A, Planzos P, Zelaya HM (2014) The fatty acid signaling molecule cis-2-decenoic acid increases metabolic activity and reverts persister cells to an antimicrobial-susceptible state. Appl Environ Microbiol 80:6976–6991. doi: 10.1128/AEM.01576-14

Oh S, Go GW, Mylonakis E, Kim Y (2012) The bacterial signalling molecule indole attenuates the virulence of the fungal pathogen Candida albicans. J Appl Microbiol 113:622–628. doi: 10.1111/j.1365-2672.2012.05372.x

Rachid S, Ohlsen K, Witte W, Hacker J, Ziebuhr W (2000) Effect of subinhibitory antibiotic concentrations on polysaccharide intercellular adhesin expression in biofilm-forming Staphylococcus epidermidis. Antimicrob Agents Chemother 44:3357–3363. doi: 10.1128/AAC.44.12.3357-3363.2000

Seyfried PL, Fraser DJ (1980) Persistence of Pseudomonas aeruginosa in chlorinated swimming pools. Can J Microbiol 26:350–355. doi: 10.1139/m80-057

Vega NM, Allison KR, Khalil AS, Collins JJ (2012) Signaling-mediated bacterial persister formation. Nat Chem Biol 8:431–433. doi: 10.1038/nchembio.915

Vega NM, Allison KR, Samuels AN, Klempner MS, Collins JJ (2013) Salmonella typhimurium intercepts Escherichia coli signaling to enhance antibiotic tolerance. Proc Natl Acad Sci USA 110:14420–14425. doi: 10.1073/pnas.1308085110

Wang X, Wood TK (2011) Toxin-antitoxin systems influence biofilm and persister cell formation and the general stress response. Appl Environ Microbiol 77:5577–5583. doi: 10.1128/AEM.05068-11

Weston SA, Parish CR (1990) New fluorescent dyes for lymphocyte migration studies. Analysis by flow cytometry and fluorescence microscopy. J Immunol Methods 133:87–97. doi: 10.1016/0022-1759(90)90322-M

Wood TK (2016) Combatting bacterial persister cells. Biotechnol Bioeng 113:476–483. doi: 10.1002/bit.25721

Wood TK, Knabel SJ, Kwan BW (2013) Bacterial persister cell formation and dormancy. Appl Environ Microbiol 79:7116–7121. doi: 10.1128/AEM.02636-13