Hair cortisol-a stress marker in children and adolescents with chronic tic disorders? A large European cross-sectional study
Tóm tắt
There is clear evidence that tic disorders (TDs) are associated with psychosocial stress as well as emotional and behavioral problems. Studies have shown that individuals with TDs have higher acute physiological stress responses to external, single stressors (as reflected by saliva cortisol). The aim of the present study was to examine a physiological marker of longer-term stress (as reflected by hair cortisol concentration) in children and adolescents with TDs and unaffected siblings of individuals with TDs. Two samples of a European cohort were included in this study. In the COURSE sample, 412 children and adolescents aged 3–16 years with a chronic TD including Tourette syndrome according to DSM IV-TR criteria were included. The ONSET sample included 131 3–10 years old siblings of individuals with TDs, who themselves had no tics. Differences in hair cortisol concentration (HCC) between the two samples were examined. Within the COURSE sample, relations of HCC with tic severity and perceived psychosocial stress as well as potential effects and interaction effects of comorbid emotional and behavioral problems and psychotropic medication on HCC were investigated. There were no differences in HCC between the two samples. In participants with TDs, there were no associations between HCC and tic severity or perceived psychosocial stress. No main effects of sex, psychotropic medication status and comorbid emotional and behavioral problems on HCC were found in participants with TDs. A link between HCC and TDs is not supported by the present results.
Tài liệu tham khảo
American Psychiatric-Association (2000) Diagnostic and statistical manual of mental disorders DSM-IV-TR (Text revision) (4). Washington
Knight T, Steeves T, Day L, Lowerison M, Jette N, Pringsheim T (2012) Prevalence of tic disorders: a systematic review and meta-analysis. PediatrNeurol 47(2):77–90. https://doi.org/10.1016/j.pediatrneurol.2012.05.002
Robertson MM (2008) The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 2: tentative explanations for differing prevalence figures in GTS, including the possible effects of psychopathology, aetiology, cultural differences, and differing phenotypes. J Psychosom Res 65(5):473–486. https://doi.org/10.1016/j.jpsychores.2008.03.007
Dietrich A, Fernandez TV, King RA, State MW, Tischfield JA, Hoekstra PJ, Heiman GA, TIC Genetics Collaborative Group (2015) The Tourette International Collaborative Genetics (TIC Genetics) study, finding the genes causing Tourette syndrome: objectives and methods. Eur Child Adolesc Psychiatry 24(2):141–151. https://doi.org/10.1007/s00787-014-0543-x
Grados MA (2010) The genetics of obsessive-compulsive disorder and Tourette syndrome: an epidemiological and pathway-based approach for gene discovery. J Am Acad Child Adolesc Psychiatry 49(8):810-819.e2. https://doi.org/10.1016/j.jaac.2010.04.009
Pagliaroli L, Vető B, Arányi T, Barta C (2016) From genetics to epigenetics: new perspectives in Tourette syndrome research. Front Neurosci 10:277. https://doi.org/10.3389/fnins.2016.00277
Buse J, Kirschbaum C, Leckman JF, Münchau A, Roessner V (2014) The modulating role of stress in the onset and course of Tourette’s syndrome: a review. BehavModif 38(2):184–216. https://doi.org/10.1177/0145445514522056
Hoekstra PJ, Anderson GM, Limburg PC, Korf J, Kallenberg CGM, Minderaa RB (2004) Neurobiology and neuroimmunology of Tourette’s syndrome: an update. Cell Mol Life Sci 61(7–8):886–898. https://doi.org/10.1007/s00018-003-3320-4
Hoekstra PJ, Dietrich A, Edwards MJ, Elamin I, Martino D (2012) Environmental factors in Tourette syndrome. NeurosciBiobehav Rev 37(6):1040–1049. https://doi.org/10.1016/j.neubiorev.2012.10.010
Robertson MM, Eapen V (2017) The psychosocial aspects of the Gilles de la Tourette syndrome: empirical evidence from the literature. CurrBehavNeurosci Rep 4(1):59–69
Corbett BA, Mendoza SP, Baym CL, Bunge SA, Levine S (2008) Examining cortisol rhythmicity and responsivity to stress in children with Tourette syndrome. Psychoneuroendocrinology 33(6):810–820. https://doi.org/10.1016/j.psyneuen.2008.03.014
Chappell P, Riddle M, Anderson G, Scahill L, Hardin M, Walker D, Leckman J (1994) Enhanced stress responsivity of Tourette syndrome patients undergoing lumbar puncture. BiolPsychiat 36(1):35–43
Chappell P, Leckman J, Goodman W, Bissette G, Pauls D, Anderson G, Cohen D (1996) Elevated cerebrospinal fluid corticotropin-releasing factor in Tourette’s syndrome: comparison to obsessive compulsive disorder and normal controls. BiolPsychiat 39(9):776–783
Stalder T, Kirschbaum C (2012) Analysis of cortisol in hair—state of the art and future directions. Brain BehavImmun 26(7):1019–1029. https://doi.org/10.1016/j.bbi.2012.02.002
Stalder T, Steudte-Schmiedgen S, Alexander N, Klucken T, Vater A, Wichmann S, Miller R (2017) Stress-related and basic determinants of hair cortisol in humans: a meta-analysis. Psychoneuroendocrinology 77:261–274. https://doi.org/10.1016/j.psyneuen.2016.12.017
Dettenborn L, Tietze A, Bruckner F, Kirschbaum C (2010) Higher cortisol content in hair among long-term unemployed individuals compared to controls. Psychoneuroendocrinology 35(9):1404–1409. https://doi.org/10.1016/j.psyneuen.2010.04.006
Dettenborn L, Muhtz C, Skoluda N, Stalder T, Steudte S, Hinkelmann K, Otte C (2012) Introducing a novel method to assess cumulative steroid concentrations: increased hair cortisol concentrations over 6 months in medicated patients with depression. Stress (Amsterdam, Netherlands) 15(3):348–353. https://doi.org/10.3109/10253890.2011.619239
Kirschbaum C, Tietze A, Skoluda N, Dettenborn L (2009) Hair as a retrospective calendar of cortisol production-increased cortisol incorporation into hair in the third trimester of pregnancy. Psychoneuroendocrinology 34(1):32–37. https://doi.org/10.1016/j.psyneuen.2008.08.024
Steudte S, Kirschbaum C, Gao W, Alexander N, Schönfeld S, Hoyer J, Stalder T (2013) Hair cortisol as a biomarker of traumatization in healthy individuals and posttraumatic stress disorder patients. BiolPsychiat 74(9):639–646. https://doi.org/10.1016/j.biopsych.2013.03.011
Steudte S, Stalder T, Dettenborn L, Klumbies E, Foley P, Beesdo-Baum K, Kirschbaum C (2011) Decreased hair cortisol concentrations in generalised anxiety disorder. Psychiatry Res 186(2–3):310–314. https://doi.org/10.1016/j.psychres.2010.09.002
Van Uum SHM, Sauvé B, Fraser LA, Morley-Forster P, Paul TL, Koren G (2008) Elevated content of cortisol in hair of patients with severe chronic pain: a novel biomarker for stress. Stress (Amsterdam, Netherlands) 11(6):483–488. https://doi.org/10.1080/10253890801887388
Golub Y, Kuitunen-Paul S, Panaseth K, Stonawski V, Frey S, Steigleder R, Eichler A (2019) Salivary and hair cortisol as biomarkers of emotional and behavioral symptoms in 6–9 year old children. PhysiolBehav 209:112584. https://doi.org/10.1016/j.physbeh.2019.112584
Schloß S, Ruhl I, Müller V, Becker K, Skoluda N, Nater UM, Pauli-Pott U (2018) Low hair cortisol concentration and emerging attention-deficit/hyperactivity symptoms in preschool age. Dev Psychobiol 60(6):722–729. https://doi.org/10.1002/dev.21627
Kurlan R, Como PG, Miller B, Palumbo D, Deeley C, Andresen EM, McDermott MP (2002) The behavioral spectrum of tic disorders: a community-based study. Neurology 59(3):414–420
Bornstein RA, Stefl ME, Hammond L (1990) A survey of Tourette syndrome patients and their families: the 1987 Ohio Tourette survey. J Neuropsychiatry ClinNeurosci 2(3):275–281
Buse J, Enghardt S, Kirschbaum C, Ehrlich S, Roessner V (2016) Tic frequency decreases during short-term psychosocial stress—an experimental study on children with tic disorders. Front Psychiatry 7:84. https://doi.org/10.3389/fpsyt.2016.00084
Kraft JT, Dalsgaard S, Obel C, Thomsen PH, Henriksen TB, Scahill L (2012) Prevalence and clinical correlates of tic disorders in a community sample of school-age children. Eur Child Adolesc Psychiatry 21(1):5–13
Freeman RD, Fast DK, Burd L, Kerbeshian J, Robertson MM, Sandor P (2000) An international perspective on Tourette syndrome: selected findings from 3,500 individuals in 22 countries. Dev Med Child Neurol 42(7):436–447
Alink LR, Van Ijzendoorn MH, Bakermans-Kranenburg MJ, Mesman J, Juffer F, Koot HM (2008) Cortisol and externalizing behavior in children and adolescents: mixed meta-analytic evidence for the inverse relation of basal cortisol and cortisol reactivity with externalizing behavior. Dev Psychobiol 50:427–450
Lopez-Duran NL, Kovacs M, George CJ (2009) Hypothalamic— pituitary—adrenal axis dysregulation in depressed children and adolescents: a meta-analysis. Psychoneuroendocrinology 34:1272–1283
Ruttle PL, Shirtcliff EA, Serbin LA, Fisher DB, Stack DM, Schwartzman AE (2011) Disentangling psychobiological mechanisms underlying internalizing and externalizing behaviors in youth: longitudinal and concurrent associations with cortisol. HormBehav 59:123–132
Schrag A, Martino D, Apter A, Ball J, Bartolini E, Benaroya-Milshtein N, EMTICS Collaborative Group (2019) European Multicentre Tics in Children Studies (EMTICS): protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescents. Eur Child Adolesc Psychiatry 28(1):91–109. https://doi.org/10.1007/s00787-018-1190-4
Dettenborn L, Tietze A, Kirschbaum C, Stalder T (2012) The assessment of cortisol in human hair: associations with sociodemographic variables and potential confounders. Stress 15(6):578–588. https://doi.org/10.3109/10253890.2012.654479
Cohen S, Kamarck T, Mermelstein R (1983) A global measure of perceived stress. J Health SocBehav 24(4):385–396
Leckman JF, Riddle MA, Hardin MT, Ort SI, Swartz KL, Stevenson J, Cohen DJ (1989) The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of tic severity. J Am Acad Child Adolesc Psychiatry 28(4):566–573. https://doi.org/10.1097/00004583-198907000-00015
Goodman R (1997) The strengths and difficulties questionnaire: a research note. J Child Psychol Psychiatry 38(5):581–586. https://doi.org/10.1111/j.1469-7610.1997.tb01545.x
Goodman R (2001) Psychometric properties of the strengths and difficulties questionnaire. J Am Acad Child Adolesc Psychiatry 40(11):1337–1345. https://doi.org/10.1097/00004583-200111000-00015
Osborne JW (2010) Improving your data transformations: applying the box-cox transformation. Pract Assess Res Eval. https://doi.org/10.7275/qbpc-gk17
Straub J, Klaubert LM, Schmiedgen S, Kirschbaum C, Goldbeck L (2017) Hair cortisol in relation to acute and post-traumatic stress symptoms in children and adolescents. Anxiety Stress Coping 30(6):661–670. https://doi.org/10.1080/10615806.2017.1355458
Luo H, Hu X, Liu X, Ma X, Guo W, Qiu C, Li T (2012) Hair cortisol level as a biomarker for altered hypothalamic-pituitary-adrenal activity in female adolescents with posttraumatic stress disorder after the 2008 Wenchuan earthquake. BiolPsychiat 72(1):65–69. https://doi.org/10.1016/j.biopsych.2011.12.020
Manenschijn L, Spijker AT, Koper JW, Jetten AM, Giltay EJ, Haffmans J, van Rossum EFC (2012) Long-term cortisol in bipolar disorder: associations with age of onset and psychiatric co-morbidity. Psychoneuroendocrinology 37(12):1960–1968. https://doi.org/10.1016/j.psyneuen.2012.04.010
Staufenbiel SM, Penninx BWJH, Spijker AT, Elzinga BM, van Rossum EFC (2013) Hair cortisol, stress exposure, and mental health in humans: a systematic review. Psychoneuroendocrinology 38(8):1220–1235. https://doi.org/10.1016/j.psyneuen.2012.11.015
Miller GE, Chen E, Zhou ES (2007) If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychol Bull 133(1):25–45. https://doi.org/10.1037/0033-2909.133.1.25
Weckesser LJ, Dietz F, Schmidt K, Grass J, Kirschbaum C, Miller R (2019) The psychometric properties and temporal dynamics of subjective stress, retrospectively assessed by different informants and questionnaires, and hair cortisol concentrations. Sci Rep 9(1):1098. https://doi.org/10.1038/s41598-018-37526-2