Haemostatically active proteins in snake venoms
Tóm tắt
Từ khóa
Tài liệu tham khảo
de Albuquerque Modesto, 2005, Insularinase A, a prothrombin activator from Bothrops insularis venom, is a metalloprotease derived from a gene encoding protease and disintegrin domains, Biol. Chem., 386, 589, 10.1515/BC.2005.069
Arocas, 1996, Bothrojaracin: a potent two-site-directed thrombin inhibitor, Biochemistry, 35, 9083, 10.1021/bi960043l
Atanasov, 2009, Hemolytic and anticoagulant study of the neurotoxin vipoxin and its components-basic phospholipase A2 and an acidic inhibitor, Biochemistry (Moscow), 74, 276, 10.1134/S0006297909030055
Atoda, 1994, Binding properties of the coagulation factor IX/factor X-binding protein isolated from the venom of Trimeresurus flavoviridis, Eur. J. Biochem., 224, 703, 10.1111/j.1432-1033.1994.t01-1-00703.x
Atoda, 1995, Blood coagulation factor IX-binding protein from the venom of Trimeresurus flavoviridis: purification and characterization, J. Biochem., 118, 965, 10.1093/jb/118.5.965
Atoda, 1998, Coagulation factor X-binding protein from Deinagkistrodon acutus venom is a Gla domain-binding protein, Biochemistry, 37, 17361, 10.1021/bi981177x
Banerjee, 2005, Hemextin AB complex, a unique anticoagulant protein complex from Hemachatus haemachatus (African Ringhals cobra) venom that inhibits clot initiation and factor VIIa activity, J. Biol. Chem., 280, 42601, 10.1074/jbc.M508987200
Banerjee, 2007, Biophysical characterization of anticoagulant hemextin AB complex from the venom of snake Hemachatus haemachatus, Biophys. J., 93, 3963, 10.1529/biophysj.106.100164
Baramova, 1989, Degradation of extracellular matrix proteins by hemorrhagic metalloproteinases, Arch. Biochem. Biophys., 275, 63, 10.1016/0003-9861(89)90350-0
Belisario, 2000, H2O2 activity on platelet adhesion to fibrinogen and protein tyrosine phosphorylation, Biochim. Biophys. Acta, 1495, 183, 10.1016/S0167-4889(99)00160-3
Bello, 2006, Isolation and biochemical characterization of a fibrinolytic proteinase from Bothrops leucurus (white-tailed jararaca) snake venom, Biochimie, 88, 189, 10.1016/j.biochi.2005.07.008
Berger, 2008, Purification and functional characterization of bothrojaractivase, a prothrombin-activating metalloproteinase isolated from Bothrops jararaca snake venom, Toxicon, 51, 488, 10.1016/j.toxicon.2007.09.005
Bergmeier, 2001, Rhodocytin (aggretin) activates platelets lacking α2β1 integrin, glycoprotein VI, and the ligand-binding domain of glycoprotein Ibα, J. Biol. Chem., 276, 25121, 10.1074/jbc.M103892200
Bernardes, 2008, Isolation and structural characterization of a new fibrin(ogen)olytic metalloproteinase from Bothrops moojeni snake venom, Toxicon, 51, 574, 10.1016/j.toxicon.2007.11.017
Birrell, 2006, Molecular diversity in venom from the Australian Brown snake, Pseudonaja textilis, Mol. Cell. Proteomics, 5, 379, 10.1074/mcp.M500270-MCP200
Bjarnason, 1994, Hemorrhagic metalloproteinases from snake venoms, Pharmacol. Ther., 62, 325, 10.1016/0163-7258(94)90049-3
Bode, 1993, Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and Met-turn) and topologies and should be grouped into a common family, the ‘metzincins’, FEBS Lett., 331, 134, 10.1016/0014-5793(93)80312-I
Bos, 2009, Venom factor V from the common brown snake escapes haemostatic regulation through procoagulant adaptations, Blood, 114, 686, 10.1182/blood-2009-02-202663
Calvete, 2002, The presence of the WGD motif in CC8 heterodimeric disintegrin increases its inhibitory effect on αIIbβ3, αvβ3, and α5β1 integrins, Biochemistry, 41, 2014, 10.1021/bi015627o
Calvete, 2005, Snake venom disintegrins: evolution of structure and function, Toxicon, 45, 1063, 10.1016/j.toxicon.2005.02.024
Castro, 2004, Snake venom thrombin-like enzymes: from reptilase to now, Cell. Mol. Life Sci., 61, 843, 10.1007/s00018-003-3325-z
Castro, 2006, Current status of snake venom thrombin-like enzymes, Toxin. Rev., 25, 291, 10.1080/15569540600567321
Chattopadhyay, 1989, Molecular recognition in the activation of human blood coagulation factor X, J. Biol. Chem., 264, 11035, 10.1016/S0021-9258(18)60423-5
Chen, 2008, P-III hemorrhagic metalloproteinases from Russell’s viper venom: cloning, characterization, phylogenetic and functional site analyses, Biochimie, 90, 1486, 10.1016/j.biochi.2008.05.012
Clemetson, 2007, Snake venom proteins affecting platelets and their applications to anti-thrombotic research, Curr. Pharm. Des., 13, 2887, 10.2174/138161207782023702
Costa, 2009, Biochemical and functional properties of a thrombin-like enzyme isolated from Bothrops pauloensis snake venom, Toxicon, 54, 725, 10.1016/j.toxicon.2009.05.040
Costa, 2010, Bhalternin: functional and structural characterization of a new thrombin-like enzyme from Bothrops alternatus snake venom, Toxicon, 55, 1365, 10.1016/j.toxicon.2010.02.014
Covic, 2000, Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets, Biochemistry, 39, 5458, 10.1021/bi9927078
De Luca, 1995, Jararhagin and jaracetin: novel snake venom inhibitors of the integrin collagen receptor, α2β1, Biochem. Biophys. Res. Commun., 206, 570, 10.1006/bbrc.1995.1081
Deitcher, 2006, Non-clinical and clinical characterization of a novel acting thrombolytic: alfimeprase, Pathophysiol. Haemost. Thromb., 34, 215, 10.1159/000092427
Dhananjaya, 2010, The pharmacological role of nucleotidases in snake venoms, Cell. Biochem. Funct., 28, 171, 10.1002/cbf.1637
Dhananjaya, 2010, An overview on nucleases (DNase, RNase, and phosphodiesterase) in snake venoms, Biochemistry (Moscow), 75, 1, 10.1134/S0006297910010013
Dhananjaya, 2006, Anticoagulant effect of Naja naja venom 5’nucleotidase: demonstration through the use of novel specific inhibitor, vanillic acid, Toxicon, 48, 411, 10.1016/j.toxicon.2006.06.017
Doley, 2008, Accelerated exchange of exon segments in Viperid three-finger toxin genes (Sistrurus catenatus edwardsii; Desert Massasauga), BMC Evol. Biol., 8, 196, 10.1186/1471-2148-8-196
Drickamer, 1999, C-type lectin-like domains, Curr. Opin. Struct. Biol., 9, 585, 10.1016/S0959-440X(99)00009-3
Ducancel, 2008, Atractaspis venoms. [Les venins des Atractaspis], Med. Trop., 68, 340
Duncan, 2008, Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA), J. Biol. Chem., 283, 25428, 10.1074/jbc.M804146200
Escalante, 2004, Bothrops asper metalloproteinase BaP1 is inhibited by α2-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy, Toxicon, 43, 213, 10.1016/j.toxicon.2003.11.012
Filippovich, 2005, Cloning and functional expression of venom prothrombin activator protease from Pseudonaja textilis with whole blood procoagulant activity, Br. J. Haematol., 131, 237, 10.1111/j.1365-2141.2005.05744.x
Flight, 2009, Textilinin-1, an alternative anti-bleeding agent to aprotinin: importance of plasmin inhibition in controlling blood loss, Br. J. Haematol., 145, 207, 10.1111/j.1365-2141.2009.07605.x
Forsgren, 1987, Molecular cloning and characterization of a full-length cDNA clone for human plasminogen, FEBS Lett., 213, 254, 10.1016/0014-5793(87)81501-6
Fox, 2005, Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases, Toxicon, 45, 969, 10.1016/j.toxicon.2005.02.012
Fox, 2007, Approaching the golden age of natural product pharmaceuticals from venom libraries: an overview of toxin-derivatives currently involved in therapeutic or diagnostic applications, Curr. Pharm. Des., 13, 2927, 10.2174/138161207782023739
Fox, 2008, Insights into and speculations about snake venom metalloproteinase (SVMP) synthesis, folding and disulfide bond formation and their contribution to venom complexity, FEBS J., 275, 3016, 10.1111/j.1742-4658.2008.06466.x
Fukuda, 2002, Structural basis of von Willebrand factor activation by the snake toxin botrocetin, Structure, 10, 943, 10.1016/S0969-2126(02)00787-6
Fukuda, 2005, The snake venom protein botrocetin acts as a biological brace to promote dysfunctional platelet aggregation, Nat. Struct. Mol. Biol., 12, 152, 10.1038/nsmb892
Fuly, 2004, Signal transduction pathways involved in the platelet aggregation induced by a D-49 phospholipase A2 isolated from Bothrops jararacussu snake venom, Biochimie, 86, 731, 10.1016/j.biochi.2004.07.001
Funk, 1971, Reptilase-R, a new reagent in blood coagulation, Br. J. Haematol., 21, 43, 10.1111/j.1365-2141.1971.tb03415.x
Gay, 2005, Proteolytic, edematogenic and myotoxic activities of a hemorrhagic metalloproteinase isolated from Bothrops alternatus venom, Toxicon, 46, 546, 10.1016/j.toxicon.2005.06.019
Gay, 2009, Systemic alterations induced by a Bothrops alternatus hemorrhagic metalloproteinase (baltergin) in mice, Toxicon, 53, 53, 10.1016/j.toxicon.2008.10.010
Gempeler-Messina, 2006, Diagnostic use of the protein C activator from Agkistrodon contortrix, Tox. Rev., 25, 335, 10.1080/15569540600567362
Gomes, 2009, BthMP: a new weakly hemorrhagic metalloproteinase from Bothrops moojeni snake venom, Toxicon, 53, 24, 10.1016/j.toxicon.2008.10.007
Griffith, 1985, Enzymatic inactivation of heparin cofactor II by a proteinase (proteinase-1) isolated from Echis carinatus venom, Thromb. Res., 39, 659, 10.1016/0049-3848(85)90250-6
Guo, 2007, Isolation and cloning of a metalloproteinase from king cobra snake venom, Toxicon, 49, 954, 10.1016/j.toxicon.2007.01.003
Gutiérrez, 2000, Snake venom metalloproteinases: their role in the pathogenesis of local tissue damage, Biochimie, 82, 841, 10.1016/S0300-9084(00)01163-9
Gutiérrez, 2005, Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage, Toxicon, 45, 997, 10.1016/j.toxicon.2005.02.029
Gutiérrez, 2006, Blood flow is required for rapid endothelial cell damage induced by a snake venom hemorrhagic metalloproteinase, Microvasc. Res., 71, 55, 10.1016/j.mvr.2005.10.007
Gutiérrez, 2009, Experimental pathophysiology of systemic alterations induced by Bothrops asper snake venom, Toxicon, 54, 976, 10.1016/j.toxicon.2009.01.039
Hamako, 1996, Purification and characterization of bitiscetin, a novel von Willebrand factor modulator protein from Bitis arietans snake venom, Biochem. Biophys. Res. Commun., 226, 273, 10.1006/bbrc.1996.1345
Hamako, 1998, Purification and characterization of kauthiagin, a von Willebrand factor-binding and -cleaving metalloproteinase from Naja Kaouthia cobra venom, Thromb. Haemost., 80, 499, 10.1055/s-0037-1615236
Hart, 2008, Direct treatment of mouse or human blood with soluble 5′-nucleotidase inhibits platelet aggregation, Arterioscler. Thromb. Vasc. Biol., 28, 1477, 10.1161/ATVBAHA.108.169219
He, 2007, Identification and characterization of harobin, a novel fibrino(geno)lytic serine protease from a sea snake (Lapemis hardwickii), FEBS Lett., 581, 2965, 10.1016/j.febslet.2007.05.047
Hermogenes, 2006, Interaction of a plasminogen activator proteinase, LV-PA with human α2-macroglobulin, Toxicon, 47, 490, 10.1016/j.toxicon.2005.12.009
Ho, 2006, Ximelagatran: direct thrombin inhibitor, Vasc. Health. Risk Manage., 2, 49, 10.2147/vhrm.2006.2.1.49
Hong, 2003, The snake venom disintegrin salmosin induces apoptosis by disassembly of focal adhesions in bovine capillary endothelial cells, Biochem. Biophys. Res. Commun., 302, 502, 10.1016/S0006-291X(03)00213-4
Hooley, 2008, The crystal structure of the platelet activator aggretin reveals a novel (αβ)2 dimeric structure, Biochemistry, 47, 7831, 10.1021/bi800528t
Horii, 2009, Convulxin forms a dimer in solution and can bind eight copies of glycoprotein VI: implications for platelet activation, Biochemistry, 48, 2907, 10.1021/bi801820q
Hsu, 2007, Antithrombotic effect of a protein-type I class snake venom metalloproteinase, kistomin, is mediated by affecting glycoprotein Ib-von Willebrand factor interaction, Mol. Pharmacol., 72, 984, 10.1124/mol.107.038018
Hsu, 2008, A snake venom metalloproteinase, kistomin, cleaves platelet glycoprotein VI and impairs platelet functions, J. Thromb. Haemost., 6, 1578, 10.1111/j.1538-7836.2008.03071.x
Huang, 1997, Inhibition of human platelet aggregation by a phospholipase A2 platelet inhibitor from Ophiophagus hannah (king cobra) venom, Toxicon, 35, 492, 10.1016/S0041-0101(97)84755-1
Huang, 2004, Crystal structure of a platelet-agglutinating factor isolated from the venom of Taiwan habu (Trimeresurus mucrosquamatus), Biochem. J., 378, 399, 10.1042/bj20031507
Izidoro, 2006, Biochemical and functional characterization of an l-amino acid oxidase isolated from Bothrops pirajai snake venom, Bioorg. Med. Chem., 14, 7034, 10.1016/j.bmc.2006.06.025
Janssen, 1992, Purification and characterization of an antithrombin III inactivating enzyme from the venom of the African night adder (Causus rhombeatus), Toxicon, 30, 985, 10.1016/0041-0101(92)90043-5
Jia, 1996, Snake venom metalloproteinases: structure, function and relationship to the ADAMs family of proteins, Toxicon, 34, 1269, 10.1016/S0041-0101(96)00108-0
Jia, 2009, cDNA cloning, expression and fibrin(ogen)olytic activity of two low-molecular weight snake venom metalloproteinases, Toxicon, 54, 233, 10.1016/j.toxicon.2009.04.008
Jin, 2007, Molecular characterization of l-amino acid oxidase from king cobra venom, Toxicon, 50, 479, 10.1016/j.toxicon.2007.04.013
Joseph, 1999, Amino acid sequence of trocarin, a prothrombin activator from Tropidechis carinatus venom: its structural similarity to coagulation factor Xa, Blood, 94, 621, 10.1182/blood.V94.2.621
Kamiguti, 2005, Platelets as targets of snake venom metalloproteinases, Toxicon, 45, 1041, 10.1016/j.toxicon.2005.02.026
Kamiguti, 1994, Ineffectiveness of the inhibition of the main haemorrhagic metalloproteinase from Bothrops jararaca venom by its only plasma inhibtor, α2-macroglobulin, Biochim. Biophys. Acta, 1200, 307, 10.1016/0304-4165(94)90172-4
Kamiguti, 1996, Inhibition of collagen-induced platelet aggregation as the result of cleavage of α2β1-integrin by the snake venom metalloproteinase jarararhagin, Biochem. J., 320, 635, 10.1042/bj3200635
Kanaji, 2003, Convulxin binds to native, human glycoprotein Ibα, J. Biol. Chem., 278, 39452, 10.1074/jbc.M300199200
Kane, 1988, Blood coagulation factors V and VIII: structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders, Blood, 71, 539, 10.1182/blood.V71.3.539.539
Kauskot, 2008, Hemostatic effects of recombinant DisBa-01, a disintegrin from Bothrops alternatus, Front. Biosci., 13, 6604, 10.2741/3176
Keller, 1995, Thrombin-catalyzed activation of recombinant human factor V, Biochemistry, 34, 4118, 10.1021/bi00012a030
Kerns, 1999, Targeting of venom phospholipases: the strongly anticoagulant phospholipase A2 from Naja nigricollis venom binds to coagulation factor Xa to inhibit the prothrombinase complex, Arch. Biochem. Biophys., 369, 107, 10.1006/abbi.1999.1345
Kini, 2002, Molecular moulds with multiple missions: functional sites in three-finger toxins, Clin. Exp. Pharmacol. Physiol., 29, 815, 10.1046/j.1440-1681.2002.03725.x
Kini, 2003, Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes, Toxicon, 42, 827, 10.1016/j.toxicon.2003.11.002
Kini, 2005, Serine proteases affecting blood coagulation and fibrinolysis from snake venoms, Pathophysiol. Haemost. Thromb., 34, 200, 10.1159/000092424
Kini, 2005, The intriguing world of prothrombin activators from snake venom, Toxicon, 45, 1133, 10.1016/j.toxicon.2005.02.019
Kini, 2005, Structure–function relationships and mechanism of anticoagulant phospholipase A2 enzymes from snake venoms, Toxicon, 45, 1147, 10.1016/j.toxicon.2005.02.018
Kini, 1987, Structure–function relationships of phospholipases: the anticoagulant region of phospholipases A2, J. Biol. Chem., 262, 14402, 10.1016/S0021-9258(18)47808-8
Kini, 1990, Effects of snake venom proteins on blood platelets, Toxicon, 28, 1387, 10.1016/0041-0101(90)90155-Z
Kini, 1992, Structural domains in venom proteins: evidence that metalloproteinases and nonenzymatic platelet aggregation inhibitors (disintegrins) from snake venoms are derived by proteolysis from a common precursor, Toxicon, 30, 265, 10.1016/0041-0101(92)90869-7
Kini, 1995, The role of enzymatic activity in inhibition of the extrinsic tenase complex by phospholipase A2 isoenzymes from Naja nigricollis venom, Toxicon, 33, 1585, 10.1016/0041-0101(95)00103-4
Kini, 2010, Structure, function and evolution of three-finger toxins: mini proteins with multiple targets, Toxicon, 56, 855, 10.1016/j.toxicon.2010.07.010
Kini, 2001, Classification and nomenclature of prothrombin activators isolated from snake venoms, Thromb. Haemost., 86, 710, 10.1055/s-0037-1616108
Kisiel, 1987, Characterization of a protein C activator from Agkistrodon contortrix contortrix venom, J. Biol. Chem., 262, 12607, 10.1016/S0021-9258(18)45249-0
Kornalik, 1988, Ecarin test in diagnosis of dicoumarol therapy, liver diseases and DIC, Folia Haematol. (Leipzig), 115, 483
Kornalik, 1969, Isolation, biochemical and pharmacological characterization of a prothrombin activating principle from Echis carinatus venom, Naunyn. Schmiedebergs Arch. Pharmakol., 264, 259, 10.1007/BF02431455
Lambert, 2008, Competitive interactions of collagen and a jararhagin-derived disintegrin peptide with the integrin α2-I domain, J. Biol. Chem., 283, 16665, 10.1074/jbc.M710483200
Larréché, 2008, Haemostasis disorders caused by snake venoms, [Troubles de l’hećmostase induits par les venins de serpents], Ann. Fr. Anesth. Reanim., 27, 302, 10.1016/j.annfar.2008.02.009
Latallo, 1971, Evaluation of reptilase-R and thrombin clotting time in the presence of fibrinogen degradation products and heparin, Scand. J. Haematol., 13, 261, 10.1111/j.1600-0609.1971.tb02020.x
Lee, 1995, Isolation and properties of a blood coagulation factor X activator from the venom of king cobra (Ophiophagus hannah), Toxicon, 33, 1263, 10.1016/0041-0101(95)00077-Y
Leonardi, 2007, Ammodytase, a metalloprotease from Vipera ammodytes ammodytes venom, possesses strong fibrinolytic activity, Toxicon, 49, 833, 10.1016/j.toxicon.2006.12.003
Leonardi, 2008, Two coagulation factor X activators from Vipera a. ammodytes venom with potential to treat patients with dysfunctional factors IXa or VIIa, Toxicon, 52, 628, 10.1016/j.toxicon.2008.07.015
Levy, 2006, Ancrod: a potential treatment for acute, ischemic stroke from snake venom, Tox. Rev., 25, 323, 10.1080/15569540600567354
Li, 1994, Purification and characterization of l-amino acid oxidase from king cobra (Ophiophagus hannah) venom and its effects on human platelet aggregation, Toxicon, 32, 1349, 10.1016/0041-0101(94)90407-3
Li, 2008, l-amino acid oxidase from Naja atra venom activates and binds to human platelets, Acta Biochim. Biophys. Sin., 40, 19, 10.1111/j.1745-7270.2008.00372.x
Loría, 2003, Characterization of ‘basparin A,’ a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis, Arch. Biochem. Biophys., 418, 13, 10.1016/S0003-9861(03)00385-0
Lu, 2004, GPIb is involved in platelet aggregation induced by mucetin, a snake C-type lectin protein from Chinese habu (Trimeresurus mucrosquamatus) venom, Thromb. Haemost., 91, 1168, 10.1160/TH03-12-0747
Lu, 2005, Snake venom C-type lectins interacting with platelet receptors. Structure–function relationships and effects on haemostasis, Toxicon, 45, 1089, 10.1016/j.toxicon.2005.02.022
Lu, 2007, Snake venom C-type lectins interacting with platelet receptors, Tox. Rev., 26, 77, 10.1080/15569540600567438
Magalhães, 2007, Purification and properties of a coagulant thrombin-like enzyme from the venom of Bothrops leucurus, Comp. Biochem. Physiol. A Mol. Integr. Physiol., 146, 565, 10.1016/j.cbpa.2005.12.033
Maita, 2003, Crystal structure of von Willebrand factor A1 domain complexed with snake venom, bitiscetin: insight into glycoprotein Ib α binding mechanism induced by snake venom proteins, J. Biol. Chem., 278, 37777, 10.1074/jbc.M305566200
Marcinkiewicz, 2005, Functional characteristic of snake venom disintegrins: potential therapeutic implication, Curr. Pharm. Des., 11, 815, 10.2174/1381612053381765
Marcinkiewicz, 1997, Significance of RGD loop and C-terminal domain of echistatin for recognition of αIIbβ3 and αvβ3 integrins and expression of ligand-induced binding site, Blood, 90, 1565, 10.1182/blood.V90.4.1565
Marcinkiewicz, 2000, Isolation and characterization of EMS16, a C-lectin type protein from Echis multisquamatus venom, a potent and selective inhibitor of the α2β1 integrin, Biochemistry, 39, 9859, 10.1021/bi000428a
Marder, 2010, Direct fibrinolytic agents: biochemical attributes, preclinical foundation and clinical potential, J. Thromb. Haemost., 8, 433, 10.1111/j.1538-7836.2009.03701.x
Markland, 1998, Snake venoms and the hemostatic system, Toxicon, 36, 1749, 10.1016/S0041-0101(98)00126-3
Marsh, 2005, Practical applications of snake venom toxins in haemostasis, Toxicon, 45, 1171, 10.1016/j.toxicon.2005.02.016
May, 2009, CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis, Blood, 114, 3464, 10.1182/blood-2009-05-222273
Mazzucato, 1998, Characterization of the initial α-thrombin interaction with glycoprotein Ibα in relation to platelet activation, J. Biol. Chem., 273, 1880, 10.1074/jbc.273.4.1880
McDowell, 1992, Mambin, a potent glycoprotein IIb–IIIa antagonist and platelet aggregation inhibitor structurally related to the short neurotoxins, Biochemistry, 31, 4766, 10.1021/bi00135a004
Mizuno, 2001, Crystal structure of an anticoagulant protein in complex with Gla domain of factor X, Proc. Natl. Acad. Sci. USA, 98, 7230, 10.1073/pnas.131179698
More, 2010, Purification of an l-amino acid oxidase from Bungarus caeruleus (Indian krait) venom, J. Venom. Anim. Toxins. Incl. Trop. Dis., 16, 60, 10.1590/S1678-91992010005000002
Morita, 1998, Proteases which activate factor X, 179
Morita, 2005, Structures and functions of snake venom CLPs (C-type lectin-like proteins) with anticoagulant-, procoagulant-, and platelet-modulating activities, Toxicon, 45, 1099, 10.1016/j.toxicon.2005.02.021
Mounier, 2001, Anticoagulant venom and mammalian secreted phospholipases A2: protein-versus phospholipid-dependent mechanism of action, Haemostasis, 31, 279
Moura-da-Silva, 2001, Selective recognition of α2β1 integrin, by jararhagin, a metalloproteinase/disintegrin from Bothrops jararaca venom, Thromb. Res., 102, 153, 10.1016/S0049-3848(01)00216-X
Moura-da-Silva, 2007, Importance of snake venom metalloproteinases in cell biology: effects on platelets, inflammatory and endothelial cells, Curr. Pharm. Des., 13, 2893, 10.2174/138161207782023711
Moura-da-Silva, 2008, Collagen binding is a key factor for the hemorrhagic activity of snake venom metalloproteinases, Biochimie, 90, 484, 10.1016/j.biochi.2007.11.009
Muanpasitporn, 2007, Expression and characterization of a recombinant fibrinogenolytic serine protease from green pit viper (Trimeresurus albolabris) venom, Toxicon, 49, 1083, 10.1016/j.toxicon.2007.01.015
Mukherjee, 2008, Characterization of a novel pro-coagulant metalloprotease (RVBCMP) possessing α-fibrinogenase and tissue haemorrhagic activity from venom of Daboia russelli russelli (Russell’s viper): evidence of distinct coagulant and haemorrhagic sites in RVBCMP, Toxicon, 51, 923, 10.1016/j.toxicon.2007.12.008
Murakami, 2005, Thrombomodulin-independent activation of protein C and specificity of hemostatically active snake venom serine proteinases: crystal structures of native and inhibited Agkistrodon contortrix contortrix protein C activator, J. Biol. Chem., 280, 39309, 10.1074/jbc.M508502200
Murakami, 2003, Crystal structure of the platelet activator convulxin, a disulfide-linked α4β4 cyclic tetramer from the venom of Crotalus durissus terrificus, Biochem. Biophys. Res. Commun., 310, 478, 10.1016/j.bbrc.2003.09.032
Nakagaki, 1992, Activation of human factor VII by the prothrombin activator from the venom of Oxyuranus scutellatus (Taipan snake), Thromb. Res., 65, 105, 10.1016/0049-3848(92)90230-8
Nicolaes, 2006, Activation of factor V by venom proteases, Tox. Rev., 25, 217, 10.1080/15569540600567289
Nishida, 1994, Purification and characterization of bothrombin, a fibrinogen-clotting serine protease from the venom of Bothrops jararaca, Biochemistry, 33, 1843, 10.1021/bi00173a030
Nowak, 2003, The ecarin clotting time, a universal method to quantify direct thrombin inhibitors, Pathophysiol. Haemost. Thromb., 33, 173, 10.1159/000081505
Ogilvie, 1989, Platelet-aggregation is stimulated by lactose-inhibitable snake venom lectins, Thromb. Haemost., 62, 704, 10.1055/s-0038-1646887
Okuda, 2001, Purification and characterization of a new RGD/KGD-containing dimeric disintegrin, piscivostatin, from the venom of Agkistrodon piscivorus piscivorus: the unique effect of piscivostatin on platelet aggregation, J. Biochem., 130, 407, 10.1093/oxfordjournals.jbchem.a003000
Okuda, 2002, A new gene structure of the disintegrin family: a subunit of dimeric disintegrin has a short coding region, Biochemistry, 41, 14248, 10.1021/bi025876s
Osipov, 2010, A new type of thrombin inhibitor, noncytotoxic phospholipase A2, from the Naja haje cobra venom, Toxicon, 55, 186, 10.1016/j.toxicon.2009.07.011
Ouyang, 1983, Inhibition of platelet aggregation by 5’-nucleotidase purified from Trimeresurus gramineus snake venom, Toxicon, 21, 491, 10.1016/0041-0101(83)90127-7
Ozeki, 1994, C-type galactoside-binding lectin from Bothrops jararaca venom: comparison of its structure and function with those of botrocetin, Arch. Biochem. Biophys., 308, 306, 10.1006/abbi.1994.1043
Page, 2008, Serine peptidases: classification, structure and function, Cell. Mol. Life Sci., 65, 1220, 10.1007/s00018-008-7565-9
Park, 1998, Expression and characterization of a novel plasminogen activator from Agkistrodon halys venom, Toxicon, 36, 1807, 10.1016/S0041-0101(98)00090-7
Pawelek, 2000, The structure of l-amino acid oxidase reveals the substrate trajectory into an enantiomerically conserved active site, EMBO J., 19, 4204, 10.1093/emboj/19.16.4204
Peichoto, 2007, Purification and characterization of patagonfibrase, a metalloproteinase showing α-fibrinogenolytic and hemorrhagic activities, from Philodryas patagoniensis snake venom, Biochim. Biophys. Acta, 1770, 810, 10.1016/j.bbagen.2006.12.014
Peng, 1991, Alboaggregin-B: a new platelet agonist that binds to platelet membrane glycoprotein Ib, Biochemistry, 30, 11529, 10.1021/bi00113a007
Peng, 1993, Echicetin: a snake venom protein that inhibits binding of von Willebrand factor and alboaggregins to platelet glycoprotein Ib, Blood, 81, 2321, 10.1182/blood.V81.9.2321.2321
Petersen, 1995, Regulation of the exstrinsic pathway system in health and disease: the role of factor VIIa and tissue factor pathway inhibitor, Thromb. Res., 79, 1, 10.1016/0049-3848(95)00069-4
Pinto, 2007, Mapping von willebrand factor A domain binding sites on a snake venom metalloproteinase cysteine-rich domain, Arch. Biochem. Biophys., 457, 41, 10.1016/j.abb.2006.10.010
Pirkle, 1998, Thrombin-like enzymes from snake venoms: an update inventory, Thromb. Haemost., 79, 675, 10.1055/s-0037-1614965
Polgar, 1997, Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor, J. Biol. Chem., 272, 13576, 10.1074/jbc.272.21.13576
Prijatelj, 2006, The C-terminal and β-wing regions of ammodytoxin A, a neurotoxic phospholipase A2 from Vipera ammodytes ammodytes, are critical for binding to factor Xa and for anticoagulant effect, Biochimie, 88, 69, 10.1016/j.biochi.2005.06.015
Quick, 1971, Thromboplastin generation: effect of the Bell-Alton reagent and Russell’s viper venom on prothrombin consumption, Am. J. Clin. Pathol., 55, 555, 10.1093/ajcp/55.5.555
Ranby, 1982, A sensitive assay for tissue plasminogen activator, Thromb. Res., 27, 743, 10.1016/0049-3848(82)90012-3
Rao, 2002, Pseutarin C, a prothrombin activator from Pseudonaja textilis venom: its structural and functional similarity to mammalian coagulation factor Xa-Va complex, Thromb. Haemost., 88, 611, 10.1055/s-0037-1613264
Rao, 2003, The nonenzymatic subunit of pseutarin C, a prothrombin activator from eastern brown snake (Pseudonaja textilis) venom, shows structural similarity to mammalian coagulation factor V, Blood, 102, 1347, 10.1182/blood-2002-12-3839
Rao, 2004, The catalytic subunit of pseutarin C, a group C prothrombin activator from the venom of Pseudonaja textilis, is structurally similar to mammalian blood coagulation factor Xa, Thromb. Haemost., 92, 509, 10.1160/TH04-03-0144
Read, 1983, Venom coaggutinin for detection of von Willebrand factor activity in animal plasmas, J. Lab. Clin. Med., 101, 74
Rodrigues, 2007, Isolation and functional characterization of a new myotoxic acidic phospholipase A2 from Bothrops pauloensis snake venom, Toxicon, 50, 153, 10.1016/j.toxicon.2007.03.005
Rodrigues, 2009, Structural and functional properties of Bp-LAAO, a new l-amino acid oxidase isolated from Bothrops pauloensis snake venom, Biochimie, 91, 490, 10.1016/j.biochi.2008.12.004
Samel, 2006, Isolation and characterization of an apoptotic and platelet aggregation inhibiting l-amino acid oxidase from Vipera berus berus (common viper) venom, Biochim. Biophys. Acta, 1764, 707, 10.1016/j.bbapap.2006.01.021
Sanchez, 2006, Biochemical characterization and molecular cloning of a plasminogen activator proteinase (LV-PA) from bushmaster snake venom, Biochim. Biophys. Acta, 1760, 1762, 10.1016/j.bbagen.2006.08.023
Sanchez, 2000, Isolation of a proteinase with plasminogen-activating activity from Lachesis muta muta (bushmaster) snake venom, Arch. Biochem. Biophys., 378, 131, 10.1006/abbi.2000.1781
Sanchez, 2010, The novel metalloproteinase atroxlysin-I from peruvian Bothrops atrox (Jergón) snake venom acts both on blood vessel ECM and platelets, Arch. Biochem. Biophys., 496, 9, 10.1016/j.abb.2010.01.010
Sant’Ana, 2008, BjussuSP-I: a new thrombin-like enzyme isolated from Bothrops jararacussu snake venom, Comp. Biochem. Physiol. A Mol. Integr. Physiol., 151, 443, 10.1016/j.cbpa.2007.02.036
Santoro, 2009, NPP-BJ, a nucleotide pyrophosphatase/phosphodiesterase from Bothrops jararaca snake venom, inhibits platelet aggregation, Toxicon, 54, 499, 10.1016/j.toxicon.2009.05.016
Santos, 2000, Interaction of viper venom serine peptidases with thrombin receptors on human platelets, FEBS Lett., 477, 199, 10.1016/S0014-5793(00)01803-2
Santos-Filho, 2008, A new acidic myotoxic, anti-platelet and prostaglandin I2 inductor phospholipase A2 isolated from Bothrops moojeni snake venom, Toxicon, 52, 908, 10.1016/j.toxicon.2008.08.020
Scarborough, 1991, Barbourin. A GPIIb-IIIa-specific integrin antagonist from the venom of Sistrurus m. barbouri, J. Biol. Chem., 266, 9359, 10.1016/S0021-9258(18)92826-7
Scarborough, 1991, Design of potent and specific integrin antagonists. Peptide antagonists with high specificity for glycoprotein IIb–IIIa, J. Biol. Chem., 268, 1066, 10.1016/S0021-9258(18)54042-4
Schaloske, 2006, The phospholipase A2 superfamily and its group numbering system, Biochim. Biophys. Acta, 1761, 1246, 10.1016/j.bbalip.2006.07.011
Segers, 2006, Structural models of the snake venom factor V activators from Daboia russelli and Daboia lebetina, Proteins, 64, 968, 10.1002/prot.21051
Serrano, 2005, Snake venom serine proteinases: sequence homology vs. substrate specificity, a paradox to be solved, Toxicon, 45, 1115, 10.1016/j.toxicon.2005.02.020
Serrano, 2005, Function of the cysteine-rich domain of the haemorrhagic metalloproteinase atrolysin A: targeting adhesion proteins collagen I and von Willebrand factor, Biochem. J., 391, 69, 10.1042/BJ20050483
Serrano, 2006, The cysteine-rich domain of snake venom metalloproteinases is a ligand for von Willebrand factor A domains: role in substrate targeting, J. Biol. Chem., 281, 39746, 10.1074/jbc.M604855200
Serrano, 2007, Interaction of the cysteine-rich domain of snake venom metalloproteinases with the A1 domain of von Willebrand factor promotes site-specific proteolysis of von Willebrand factor and inhibition of von Willebrand factor-mediated platelet aggregation, FEBS J., 274, 3611, 10.1111/j.1742-4658.2007.05895.x
Shikamoto, 2003, Crystal structure of Mg2+ and Ca2+-bound Gla domain of factor IX complexed with binding protein, J. Biol. Chem., 278, 24090, 10.1074/jbc.M300650200
Shimokawa, 1998, Isolation, sequence analysis and biological activity of atrolysin E/D, the non-RGD disintegrin domain from Crotalus atrox venom, Arch. Biochem. Biophys., 354, 239, 10.1006/abbi.1998.0698
Shiu, 2004, Solution structure of γ-bungarotoxin: the functional significance of amino acid residues flanking the RGD motif in integrin binding, Proteins, 57, 839, 10.1002/prot.20269
Siigur, 2006, Factor X activating proteases from snake venoms, Tox. Rev., 25, 235, 10.1080/15569540600567305
Siigur, 1998, Isolation, properties and N-terminal amino acid sequence of a factor V activator from Vipera lebetina (Levantine viper) snake venom, Biochim. Biophys. Acta, 1429, 239, 10.1016/S0167-4838(98)00232-5
Siigur, 2001, Factor X activator from Vipera lebetina snake venom, molecular characterization and substrate specificity, Biochim. Biophys. Acta, 1568, 90, 10.1016/S0304-4165(01)00206-9
Silva, 2003, A prothrombin activator from Bothrops erythromelas (jararaca-da-seca) snake venom: characterization and molecular cloning, Biochem J., 369, 129, 10.1042/bj20020449
Silva-Junior, 2007, BJ-48, a novel thrombin-like enzyme from the Bothrops jararacussu venom with high selectivity for Arg over Lys in P1: role of N-glycosylation in thermostability and active site accessibility, Toxicon, 50, 18, 10.1016/j.toxicon.2007.02.018
Söderbäck, 1987, The disappearance of adenosine from blood and platelet suspension in relation to the platelet cyclic AMP content, Acta Physiol. Scand., 129, 189, 10.1111/j.1748-1716.1987.tb08058.x
Stábeli, 2004, Platelet aggregation and antibacterial effects of an l-amino acid oxidase purified from Bothrops alternatus snake venom, Bioorg. Med. Chem., 12, 2881, 10.1016/j.bmc.2004.03.049
Stábeli, 2007, Cytotoxic l-amino acid oxidase from Bothrops moojeni: Biochemical and functional characterization, Int. J. Biol. Macromol., 41, 132, 10.1016/j.ijbiomac.2007.01.006
Stefansson, 1990, The basic phospholipase A2 from Naja nigricollis venom inhibits the prothrombinase complex by a novel nonenzymatic mechanism, Biochemistry, 29, 7742, 10.1021/bi00485a024
Stocker, 1994, Isolation and characterization of Textarin, a prothrombin activator from eastern brown snake (Pseudonaja textilis) venom, Toxicon, 32, 1227, 10.1016/0041-0101(94)90352-2
Stroka, 2005, Purification and characterization of a hemorrhagic metalloproteinase from Bothrops lanceolatus (Fer-de-lance) snake venom, Toxicon, 45, 411, 10.1016/j.toxicon.2004.11.010
Sugiki, 1995, Enhancement of plasma fibrinolysis in vitro by jararhagin, the main haemorrhagic metalloproteinase in Bothrops jararaca venom, Toxicon, 33, 1605, 10.1016/0041-0101(95)00102-6
Sun, 2010, Biochemical, functional and structural characterization of Akbu-LAAO: a novel snake venom l-amino acid oxidase from Agkistrodon blomhoffii ussurensis, Biochimie, 92, 343, 10.1016/j.biochi.2010.01.013
Suzuki-Inoue, 2006, A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2, Blood, 107, 542, 10.1182/blood-2005-05-1994
Swenson, 2005, Snake venom fibrin(ogen)olytic enzymes, Toxicon, 45, 1021, 10.1016/j.toxicon.2005.02.027
Swenson, 2007, Anti-angiogenesis and RGD-containing snake venom disintegrins, Curr. Pharm. Des., 13, 2860, 10.2174/138161207782023793
Takeda, 2007, Crystal structure of RVV-X: an example of evolutionary gain of specificity by ADAM proteinases, FEBS Lett., 581, 5859, 10.1016/j.febslet.2007.11.062
Takeya, 1992, Coagulation factor X activating enzyme from Russell’s viper venom (RVV-X). A novel metalloproteinase with disintegrin (platelet aggregation inhibitor)-like and C-type lectin-like domains, J. Biol. Chem., 267, 14109, 10.1016/S0021-9258(19)49685-3
Tan, 2010, Isolation and characterization of the thrombin-like enzyme from Cryptelytrops purpureomaculatus venom, Comp. Biochem. Physiol. C Toxicol. Pharmacol., 151, 131, 10.1016/j.cbpc.2009.09.002
Tang, 2009, Biochemical and hemostatic mechanism of a novel thrombin-like enzyme, Thromb. Res., 124, 631, 10.1016/j.thromres.2009.06.022
Tanjoni, 2010, Different regions of the class P-III snake venom metalloproteinase jararhagin are involved in binding to α2β1 integrin and collagen, Toxicon, 55, 1093, 10.1016/j.toxicon.2009.12.010
Tans, 2001, Snake venom activators of factor X: an overview, Haemostasis, 31, 225
Teng, 1984, Biphasic effect on platelet aggregation by phospholipase a purified from Vipera russellii snake venom, Biochim. Biophys. Acta, 772, 393, 10.1016/0005-2736(84)90156-1
Thiagarajan, 1986, The use of dilute Russell viper venom time for the diagnosis of lupus coagulants, Blood, 68, 869, 10.1182/blood.V68.4.869.869
Tokunaga, 1988, The factor V-activating enzyme (RVV-V) from Russell’s viper venom. Identification of isoproteins RVV-Vα, -Vβ, and -Vγ and their complete amino acid sequences, J. Biol. Chem., 263, 17471, 10.1016/S0021-9258(19)77860-0
Tõnismägi, 2006, L-amino acid oxidase from Vipera lebetina venom: isolation, characterization, effects on platelets and bacteria, Toxicon, 48, 227, 10.1016/j.toxicon.2006.05.004
Torii, 1997, Apoxin I, a novel apoptosis-inducing factor with l-amino acid oxidase activity purified from Western diamondback rattlesnake venom, J. Biol. Chem., 272, 9539, 10.1074/jbc.272.14.9539
Toyama, 2006, Isolation of a new l-amino acid oxidase from Crotalus durissus cascavella venom, Toxicon, 47, 47, 10.1016/j.toxicon.2005.09.008
Triplett, 1993, The Textarin/Ecarin ratio: a confirmatory test for lupus anticoagulants, Thromb. Haemost., 70, 925, 10.1055/s-0038-1649701
Urano, 2000, The cleavage and inactivation of plasminogen activator inhibitor type 1 and α2-antiplasmin by reptilase, a thrombin-like venom enzyme, Blood Coagul. Fibrinol., 11, 145, 10.1097/00001721-200011020-00005
Usami, 1993, Primary structure of two-chain botrocetin, a von Willebrand factor modulator purified from the venom of Bothrops jararaca, Proc. Natl. Acad. Sci. USA, 90, 928, 10.1073/pnas.90.3.928
Valentin, 2000, Increasing molecular diversity of secreted phospholipases A2 and their receptors and binding proteins, Biochim. Biophys. Acta, 1488, 59, 10.1016/S1388-1981(00)00110-4
Vanhoorelbeke, 2003, Inhibition of platelet adhesion to collagen as a new target for antithrombotic drugs, Curr. Drug. Targets, Cardiovasc. Haematol. Disord., 3, 125, 10.2174/1568006033481500
Vanhoorelbeke, 2007, Inhibition of platelet glycoprotein Ib and its antithrombotic potential, Curr. Pharm. Des., 13, 2684, 10.2174/138161207781662867
Vija, 2009, VGD and MLD-motifs containing heterodimeric disintegrin viplebedin-2 from Vipera lebetina snake venom. Purification and cDNA cloning, Comp. Biochem. Physiol. B, Biochem. Mol. Biol., 153, 253, 10.1016/j.cbpb.2009.03.002
Vija, 2009, Purification, characterization, and cDNA cloning of acidic platelet aggregation inhibiting phospholipases A2 from the snake venom of Vipera lebetina (Levantine viper), Toxicon, 54, 429, 10.1016/j.toxicon.2009.05.010
Vilca-Quispe, 2010, Isolation and characterization of a new serine protease with thrombin-like activity (TLBm) from the venom of the snake Bothrops marajoensis, Toxicon, 55, 745, 10.1016/j.toxicon.2009.11.006
Wang, 2009, Novel recombinant fibrinogenase of Agkistrodon acutus venom protects against LPS-induced DIC, Thromb. Res., 123, 919, 10.1016/j.thromres.2008.10.017
Wang, 2007, Purification and functional characterization of AAV1, a novel P-III metalloproteinase, from formosan Agkistrodon acutus venom, Biochimie, 89, 105, 10.1016/j.biochi.2006.08.009
Wang, 2002, Purification and characterization of a novel metalloproteinase, acurhagin, from Agkistrodon acutus venom, Thromb. Haemost., 87, 641, 10.1055/s-0037-1613061
Wang, 2005, Primary structure and antiplatelet mechanism of a snake venom metalloproteinase, acurhagin, from Agkistrodon acutus venom, Biochimie, 87, 1065, 10.1016/j.biochi.2005.06.002
Wei, 2002, Purification and cloning of a novel C-type lectin-like protein with platelet aggregation activity from Trimeresurus mucrosquamatus venom, Toxicon, 40, 1331, 10.1016/S0041-0101(02)00144-7
Wei, 2009, Purification, characterization and biological activities of the l-amino acid oxidase from Bungarus fasciatus snake venom, Toxicon, 54, 262, 10.1016/j.toxicon.2009.04.017
Wijeyewickrema, 2005, Snake venom probes of platelet adhesion receptors and their ligands, Toxicon, 45, 1051, 10.1016/j.toxicon.2005.02.025
Willmott, 1995, A novel serine protease inhibitor from the Australian brown snake, Pseudonaja textilis textilis: inhibition kinetics, Fibrinolysis, 9, 1, 10.1016/S0268-9499(08)80040-9
Wilmer, 2004, Improved distinction of factor V wild-type and factor V Leiden using a novel prothrombin-based activated protein C resistance assay, Am. J. Clin. Pathol., 122, 836, 10.1309/T8AVVH7QWGL0QTF5
Wu, 2003, Activation of MMP-2, cleavage of matrix proteins, and adherens junctions during a snake venom metalloproteinase-induced endothelial cell apoptosis, Exp. Cell Res., 288, 143, 10.1016/S0014-4827(03)00183-6
Yamada, 1996, Isolation and characterization of carinactivase, a novel prothrombin activator in Echis carinatus venom with a unique catalytic mechanism, J. Biol. Chem., 271, 5200, 10.1074/jbc.271.9.5200
Yoshida, 1995, Impaired high-shear-stress-induced platelet aggregation in patients with chronic renal failure undergoing dialysis, Br. J. Haematol., 89, 861, 10.1111/j.1365-2141.1995.tb08425.x
You, 2004, Functional characterization of recombinant batroxobin, a snake venom thrombin-like enzyme, expressed from Pichia pastoris, FEBS Lett., 571, 67, 10.1016/j.febslet.2004.06.060
Zelensky, 2005, The C-type lectin-like domain superfamily, FEBS J., 272, 6179, 10.1111/j.1742-4658.2005.05031.x
Zhang, 2010, Cloning and identification of a novel P-II class snake venom metalloproteinase from Gloydius halys, Appl. Biochem. Biotechnol., 162, 1391, 10.1007/s12010-010-8911-6
Zhang, 1995, A novel plasminogen activator from snake venom. Purification, characterization, and molecular cloning, J. Biol. Chem., 270, 10246, 10.1074/jbc.270.17.10246
Zhang, 1995, An activator of blood coagulation factor X from the venom of Bungarus fasciatus, Toxicon, 33, 1277, 10.1016/0041-0101(95)00070-3
Zhong, 2009, Purification and characterization of a new l-amino acid oxidase from Daboia russellii siamensis venom, Toxicon, 54, 763, 10.1016/j.toxicon.2009.06.004
Zhou, 1996, The hemorrhagin catrocollastatin inhibits collagen-induced platelet aggregation by binding to collagen via its disintegrin-like domain, Biochem. Biophys. Res. Commun., 219, 720, 10.1006/bbrc.1996.0301
Zhu, 2010, Expression, purification and characterization of recombinant jerdonitin, a P-II class snake venom metalloproteinase comprising metalloproteinase and disintegrin domains, Toxicon, 55, 375, 10.1016/j.toxicon.2009.08.016
Zingali, 2007, Interaction of snake-venom proteins with blood coagulation factors: mechanisms of anticoagulant activity, Tox. Rev., 26, 25, 10.1080/15569540600567412
Zingali, 2005, Bothrojaracin, a Bothrops jararaca snake venom-derived (pro)thrombin inhibitor, as an anti-thrombotic molecule, Pathophysiol. Haemost. Thromb., 34, 160, 10.1159/000092416
Zouari-Kessentini, 2009, Two purified and characterized phospholipases A2 from Cerastes cerastes venom, that inhibit cancerous cell adhesion and migration, Toxicon, 53, 444, 10.1016/j.toxicon.2009.01.003