Haemoglobin, oxygen carriers and perioperative organ perfusion

Roman Kocian1, Donat R. Spahn1
1Institute of Anaesthesiology, University Hospital, Raemistrasse 100, 8091 Zürich, Switzerland

Tài liệu tham khảo

Morisaki, 2004, Tissue oxygen delivery and the microcirculation, Critical Care Clinics, 20, 213, 10.1016/j.ccc.2003.12.003 Jamnicki, 2003, Acute normovolemic hemodilution: physiology, limitations, and clinical use, Journal of Cardiothoracic and Vascular Anesthesia, 17, 747, 10.1053/j.jvca.2003.09.018 Spahn, 1994, Cardiovascular and coronary physiology of acute isovolemic hemodilution: a review of nonoxygen-carrying and oxygen-carrying solutions, Anesthesia and Analgesia, 78, 1000, 10.1213/00000539-199405000-00029 Weiskopf, 2003, Heart rate increases linearly in response to acute isovolemic anemia, Transfusion, 43, 235, 10.1046/j.1537-2995.2003.00302.x Nozaki, 2002, The effects of acute normovolemic hemodilution on left ventricular systolic and diastolic function in the absence or presence of beta-adrenergic blockade in dogs, Anesthesia and Analgesia, 94, 1120, 10.1097/00000539-200205000-00011 Hemmer, 1996, Regional blood flow and hemorrhage. How far do the protective mechanisms go?, Intensive Care Medicine, 22, 1006, 10.1007/BF01699219 Hébert, 2004, Physiologic aspects of anemia, Critical Care Clinics, 20, 187, 10.1016/j.ccc.2004.01.001 Borst, 1999, Repetitive hemodilution in chronic obstructive pulmonary disease and pulmonary hypertension: effects on pulmonary hemodynamics, gas exchange, and exercise capacity, Respiration, 66, 225, 10.1159/000029382 Deem, 1999, Mechanisms of improvement in pulmonary gas exchange during isovolemic hemodilution, Journal of Applied Physiology, 87, 132, 10.1152/jappl.1999.87.1.132 Spahn, 1996, Hemodilution tolerance in patients with coronary artery disease who are receiving chronic beta-adrenergic blocker therapy, Anesthesia and Analgesia, 82, 687 Spahn, 1996, Hemodilution tolerance in elderly patients without known cardiac disease, Anesthesia and Analgesia, 82, 681 Viele, 1994, What can we learn about the need for transfusion from patients who refuse blood? The experience with Jehovah's Witnesses, Transfusion, 34, 396, 10.1046/j.1537-2995.1994.34594249050.x Weiskopf, 1998, Human cardiovascular and metabolic response to acute, severe isovolemic anemia, Journal of the American Medical Association, 279, 217, 10.1001/jama.279.3.217 Zollinger, 1997, Extreme hemodilution due to massive blood loss in tumor surgery, Anesthesiology, 87, 985, 10.1097/00000542-199710000-00036 DeFoe, 2001, Lowest hematocrit on bypass and adverse outcomes associated with coronary artery bypass grafting. Northern New England Cardiovascular Disease Study Group, Annals of Thoracic Surgery, 71, 769, 10.1016/S0003-4975(00)02393-6 Fang, 1997, Impact of minimum hematocrit during cardiopulmonary bypass on mortality in patients undergoing coronary artery surgery, Circulation, 96, II-194 Licker, 2005, Cardiovascular response to acute normovolemic hemodilution in patients with coronary artery diseases: assessment with transesophageal echocardiography, Critical Care Medicine, 33, 591, 10.1097/01.CCM.0000156446.03285.E0 Licker, 2005, Cardioprotective effects of acute normovolemic hemodilution in patients undergoing coronary artery bypass surgery, Chest, 128, 838, 10.1378/chest.128.2.838 Rao, 2004, Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes, The Journal of the American Medical Association, 292, 1555, 10.1001/jama.292.13.1555 Hébert, 1999, A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group, New England Journal of Medicine, 340, 409, 10.1056/NEJM199902113400601 Hébert, 2001, Is a low transfusion threshold safe in critically ill patients with cardiovascular diseases?, Critical Care Medicine, 29, 227, 10.1097/00003246-200102000-00001 Spahn, 2004, Transfusion in the cardiac patient, Critical Care Clinics, 20, 269, 10.1016/S0749-0704(03)00112-X Spahn, 1998, Haemodilution tolerance in patients with mitral regurgitation, Anaesthesia, 53, 20, 10.1111/j.1365-2044.1998.00272.x Licker, 2004, Cardiovascular response to acute normovolaemic haemodilution in patients with severe aortic stenosis: assessment with transoesophageal echocardiography, Anaesthesia, 59, 1170, 10.1111/j.1365-2044.2004.03899.x Licker, 2007, Cardioprotective effects of acute normovolemic hemodilution in patients with severe aortic stenosis undergoing valve replacement, Transfusion, 47, 341, 10.1111/j.1537-2995.2007.01111.x Weiskopf, 2002, Oxygen reverses deficits of cognitive function and memory and increased heart rate induced by acute severe isovolemic anemia, Anesthesiology, 96, 871, 10.1097/00000542-200204000-00014 Weiskopf, 2000, Acute severe isovolemic anemia impairs cognitive function and memory in humans, Anesthesiology, 92, 1646, 10.1097/00000542-200006000-00023 Llewelyn, 2004, Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion, Lancet, 363, 417, 10.1016/S0140-6736(04)15486-X Houston, 2000, Transmission of BSE by blood transfusion in sheep, Lancet, 356, 999, 10.1016/S0140-6736(00)02719-7 Hunter, 2002, Transmission of prion diseases by blood transfusion, Journal of General Virology, 83, 2897, 10.1099/0022-1317-83-11-2897 Aguzzi, 2004, vCJD tissue distribution and transmission by transfusion – a worst-case scenario coming true?, Lancet, 363, 411, 10.1016/S0140-6736(04)15520-7 Kopko, 1999, Transfusion-related acute lung injury, British Journal of Haematology, 105, 322, 10.1111/j.1365-2141.1999.01357.x Wallis, 2003, Transfusion-related acute lung injury (TRALI) – under-diagnosed and under-reported, British Journal of Anaesthesia, 90, 573, 10.1093/bja/aeg101 Rana, 2006, Transfusion-related acute lung injury and pulmonary edema in critically ill patients: a retrospective study, Transfusion, 46, 1478, 10.1111/j.1537-2995.2006.00930.x Toy, 2005, Transfusion-related acute lung injury: definition and review, Critical Care Medicine, 33, 721, 10.1097/01.CCM.0000159849.94750.51 Silliman, 2005, Transfusion-related acute lung injury, Blood, 105, 2266, 10.1182/blood-2004-07-2929 Blumberg, 1998, Blood transfusion immunomodulation: the silent epidemic, Archives of Pathology and Laboratory Medicine, 122, 117 Vamvakas, 1996, Transfusion-associated cancer recurrence and postoperative infection: meta-analysis of randomized, controlled clinical trials, Transfusion, 36, 175, 10.1046/j.1537-2995.1996.36296181932.x Klein, 1999, Immunomodulatory aspects of transfusion: a once and future risk?, Anesthesiology, 91, 861, 10.1097/00000542-199909000-00040 Amato, 1998, Effect of perioperative blood transfusions on recurrence of colorectal cancer: meta-analysis stratified on risk factors, Diseases of the Colon and Rectum, 41, 570, 10.1007/BF02235262 Taylor, 2006, Red blood cell transfusions and nosocomial infections in critically ill patients, Critical Care Medicine, 34, 2302, 10.1097/01.CCM.0000234034.51040.7F Spahn, 2006, Physiologic transfusion triggers: do we have to use (our) brain?, Anesthesiology, 104, 905, 10.1097/00000542-200605000-00002 Spahn, 1993, Acute isovolemic hemodilution and blood transfusion. Effects on regional function and metabolism in myocardium with compromised coronary blood flow, Journal of Thoracic and Cardiovascular Surgery, 105, 694, 10.1016/S0022-5223(19)34196-0 Leung, 2000, Electrocardiographic ST-segment changes during acute, severe isovolemic hemodilution in humans, Anesthesiology, 93, 1004, 10.1097/00000542-200010000-00023 Carson, 2002, Mortality and morbidity in patients with very low postoperative Hb levels who decline blood transfusion, Transfusion, 42, 812, 10.1046/j.1537-2995.2002.00123.x American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies, 2006, Practice guidelines for perioperative blood transfusion and adjuvant therapies: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies, Anesthesiology, 105, 198, 10.1097/00000542-200607000-00030 Simon, 1998, Practice parameter for the use of red blood cell transfusions: developed by the Red Blood Cell Administration Practice Guideline Development Task Force of the College of American Pathologists, Archives of Pathology and Laboratory Medicine, 122, 130 Arifin, 2005, Polymersome encapsulated hemoglobin: a novel type of oxygen carrier, Biomacromolecules, 6, 2172, 10.1021/bm0501454 Spahn, 2003, The place of artificial oxygen carriers in reducing allogeneic blood transfusions and augmenting tissue oxygenation, Canadian Journal of Anaesthesia, 50, S41 Spahn, 2005, Artificial O2 carriers: status in 2005, Current Pharmaceutical Design, 11, 4099, 10.2174/138161205774913354 Winslow, 2006, Current status of oxygen carriers (‘blood substitutes’): 2006, Vox Sanguinis, 91, 102, 10.1111/j.1423-0410.2006.00789.x Spahn, 2001, Physiological properties of blood substitutes, News in Physiological Sciences, 16, 38 Winslow, 2000, Blood substitutes, Advanced Drug Delivery Reviews, 40, 131, 10.1016/S0169-409X(99)00045-9 Stowell, 2001, Progress in the development of RBC substitutes, Transfusion, 41, 287, 10.1046/j.1537-2995.2001.41020287.x Kasper, 1996, Effects of a hemoglobin-based oxygen carrier (HBOC-201) on hemodynamics and oxygen transport in patients undergoing preoperative hemodilution for elective abdominal aortic surgery, Anesthesia and Analgesia, 83, 921, 10.1213/00000539-199611000-00006 Dietz, 1997, The effects of cross-linked hemoglobin on regional vascular conductance in dogs, Anesthesia and Analgesia, 85, 265 Schechter, 2003, Hemoglobin and the paracrine and endocrine functions of nitric oxide, New England Journal of Medicine, 348, 1483, 10.1056/NEJMcibr023045 Gulati, 1996, Role of endothelin in the cardiovascular effects of diaspirin crosslinked and stroma reduced hemoglobin, Critical Care Medicine, 24, 137, 10.1097/00003246-199601000-00023 Gulati, 1994, Role of adrenergic mechanisms in the pressor effect of diaspirin cross-linked hemoglobin, Journal of Laboratory and Clinical Medicine, 124, 125 Cabrales, 2005, Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure, American Journal of Physiology. Heart and Circulatory Physiology, 288, H2146, 10.1152/ajpheart.00749.2004 Rohlfs, 1998, Arterial blood pressure responses to cell-free hemoglobin solutions and the reaction with nitric oxide, Journal of Biological Chemistry, 273, 12128, 10.1074/jbc.273.20.12128 Migita, 1997, Blood volume and cardiac index in rats after exchange transfusion with hemoglobin-based oxygen carriers, Journal of Applied Physiology, 82, 1995, 10.1152/jappl.1997.82.6.1995 Habler, 1998, Effects of hyperoxic ventilation on hemodilution-induced changes in anesthetized dogs, Transfusion, 38, 135, 10.1046/j.1537-2995.1998.38298193095.x Kemming, 2003, Hyperoxic ventilation at the critical haematocrit, Resuscitation, 56, 289, 10.1016/S0300-9572(02)00408-2 van Bommel, 2002, Intestinal and cerebral oxygenation during severe isovolemic hemodilution and subsequent hyperoxic ventilation in a pig model, Anesthesiology, 97, 660, 10.1097/00000542-200209000-00021 Kleen, 1998, Normovolaemic haemodilution and hyperoxia have no effect on fractal dimension of regional myocardial perfusion in dogs, Acta Physiologica Scandinavica, 162, 439, 10.1046/j.1365-201X.1998.0289f.x Tsai, 2003, Microvascular oxygen distribution in awake hamster window chamber model during hyperoxia, American Journal of Physiology. Heart and Circulatory Physiology, 285, H1537, 10.1152/ajpheart.00176.2003 Meier, 2004, Hyperoxic ventilation reduces 6-hour mortality at the critical hemoglobin concentration, Anesthesiology, 100, 70, 10.1097/00000542-200401000-00014 Zimmerman, 1999, Deciphering the dark side of free hemoglobin in sepsis, Critical Care Medicine, 27, 685, 10.1097/00003246-199904000-00010 Doherty, 2002, Micronutrient supplementation and infection: a double-edged sword?, Journal of Pediatric Gastroenterology and Nutrition, 34, 346, 10.1097/00005176-200204000-00004 Javadi, 2004, High-dose exogenous iron following cecal ligation and puncture increases mortality rate in mice and is associated with an increase in gut epithelial and splenic apoptosis, Critical Care Medicine, 32, 1178, 10.1097/01.CCM.0000124878.02614.4C Ma, 1997, Effect of hemoglobin- and Perflubron-based oxygen carriers on common clinical laboratory tests, Clinical Chemistry, 43, 1732, 10.1093/clinchem/43.9.1732 Reppucci, 1997, The effects of diaspirin-crosslinked hemoglobin on the assessment of immunohematology profiles, Transfusion, 37, 1143, 10.1046/j.1537-2995.1997.37111298088043.x Winslow, 2007, Red cell substitutes, Seminars in Hematology, 44, 51, 10.1053/j.seminhematol.2006.09.013 Brandt, 1951, The effects of hemoglobin solutions on renal functions in man, Blood, 6, 1152, 10.1182/blood.V6.11.1152.1152 Miller, 1951, The effect of hemoglobin on renal function in the human, Journal of Clinical Investigation, 30, 1033, 10.1172/JCI102522 Savitsky, 1978, A clinical safety trial of stroma-free hemoglobin, Clinical Pharmacology and Therapeutics, 23, 73, 10.1002/cpt197823173 Rosen, 1990, Effect of hemoglobin solution on compensation to anemia in the erythrocyte-free primate, Journal of Applied Physiology, 68, 938, 10.1152/jappl.1990.68.3.938 Jahr, 2004, PolyHeme. Northfield Laboratories, IDrugs, 7, 478 Gould, 1997, Clinical utility of human polymerized hemoglobin as a blood substitute after acute trauma and urgent surgery, Journal of Trauma, 43, 325, 10.1097/00005373-199708000-00019 Gould, 1998, The first randomized trial of human polymerized hemoglobin as a blood substitute in acute trauma and emergent surgery, Journal of the American College of Surgeons, 187, 113, 10.1016/S1072-7515(98)00095-7 Gould, 2002, The life-sustaining capacity of human polymerized hemoglobin when red cells might be unavailable, Journal of the American College of Surgeons, 195, 452, 10.1016/S1072-7515(02)01335-2 Kasper, 1998, The effects of increased doses of bovine hemoglobin on hemodynamics and oxygen transport in patients undergoing preoperative hemodilution for elective abdominal aortic surgery, Anesthesia and Analgesia, 87, 284, 10.1213/00000539-199808000-00009 Levy, 2002, Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: results of a randomized, double-blind trial, Journal of Thoracic and Cardiovascular Surgery, 124, 35, 10.1067/mtc.2002.121505 LaMuraglia, 2000, The reduction of the allogenic transfusion requirement in aortic surgery with a hemoglobin-based solution, Journal of Vascular Surgery, 31, 299, 10.1016/S0741-5214(00)90161-7 Sprung, 2002, The use of bovine hemoglobin glutamer-250 (Hemopure) in surgical patients: results of a multicenter, randomized, single-blinded trial, Anesthesia and Analgesia, 94, 799, 10.1097/00000539-200204000-00006 Kerger, 1997, Fluid resuscitation with O2 vs. non-O2 carriers after 2h of hemorrhagic shock in conscious hamsters, American Journal of Physiology, 272, H525 Cheng, 2004, A phase II dose-response study of hemoglobin raffimer (Hemolink) in elective coronary artery bypass surgery, Journal of Thoracic and Cardiovascular Surgery, 127, 79, 10.1016/j.jtcvs.2003.08.024 Hill, 2002, Safety and preliminary efficacy of hemoglobin raffimer for patients undergoing coronary artery bypass surgery, Journal of Cardiothoracic and Vascular Anesthesia, 16, 695, 10.1053/jcan.2002.128416 Greenburg, 2004, Use of an oxygen therapeutic as an adjunct to intraoperative autologous donation to reduce transfusion requirements in patients undergoing coronary artery bypass graft surgery, Journal of the American College of Surgeons, 198, 373, 10.1016/j.jamcollsurg.2003.11.020 Chatterjee, 1986, Isolation and characterization of a new hemoglobin derivative cross-linked between the alpha chains (lysine 99 alpha 1–--lysine 99 alpha 2), Journal of Biological Chemistry, 261, 9929, 10.1016/S0021-9258(18)67605-7 Vandegriff, 1989, Equilibrium oxygen binding to human hemoglobin cross-linked between the alpha chains by bis (3,5-dibromosalicyl) fumarate, Journal of Biological Chemistry, 264, 17824, 10.1016/S0021-9258(19)84647-1 Xu, 1997, Cellular responses to surgical trauma, hemorrhage, and resuscitation with diaspirin cross-linked hemoglobin in rats, Journal of Trauma, 42, 32, 10.1097/00005373-199701000-00007 Meisner, 2001, Diaspirin crosslinked hemoglobin enables extreme hemodilution beyond the critical hematocrit, Critical Care Medicine, 29, 829, 10.1097/00003246-200104000-00030 Lamy, 2000, Randomized trial of diaspirin cross-linked hemoglobin solution as an alternative to blood transfusion after cardiac surgery. The DCLHb Cardiac Surgery Trial Collaborative Group, Anesthesiology, 92, 646, 10.1097/00000542-200003000-00007 Schubert, 2003, Diaspirin-crosslinked hemoglobin reduces blood transfusion in noncardiac surgery: a multicenter, randomized, controlled, double-blinded trial, Anesthesia and Analgesia, 97, 323, 10.1213/01.ANE.0000068888.02977.DA Sloan, 1999, Diaspirin cross-linked hemoglobin (DCLHb) in the treatment of severe traumatic hemorrhagic shock: a randomized controlled efficacy trial, The Journal of the American Medical Association, 282, 1857, 10.1001/jama.282.19.1857 Kerner, 2003, DCL-Hb for trauma patients with severe hemorrhagic shock: the European “On-Scene” multicenter study, Intensive Care Medicine, 29, 378, 10.1007/s00134-002-1622-x Hoffman, 1990, Expression of fully functional tetrameric human hemoglobin in Escherichia coli, Procedings of the National Academy of Sciences of the United States of America, 87, 8521, 10.1073/pnas.87.21.8521 Looker, 1992, A human recombinant haemoglobin designed for use as a blood substitute, Nature, 356, 258, 10.1038/356258a0 Siegel, 1997, Use of recombinant hemoglobin solution in reversing lethal hemorrhagic hypovolemic oxygen debt shock, Journal of Trauma, 42, 199, 10.1097/00005373-199702000-00005 Olson, 2004, No scavenging and the hypertensive effect of hemoglobin-based blood substitutes, Free Radical Biology and Medicine, 36, 685, 10.1016/j.freeradbiomed.2003.11.030 Doherty, 1998, Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin, Nature Biotechnology, 16, 672, 10.1038/nbt0798-672 Loeb, 1998, Resuscitation after hemorrhage using recombinant human hemoglobin (rHb1.1) in rats: effects on nitric oxide and prostanoid systems, Critical Care Medicine, 26, 1071, 10.1097/00003246-199806000-00030 Sillerud, 1999, Efficacy of recombinant human Hb by 31P-NMR during isovolemic total exchange transfusion, Journal of Applied Physiology, 86, 887, 10.1152/jappl.1999.86.3.887 Razack, 1997, Crosslinked hemoglobin-superoxide dismutase-catalase scavenges free radicals in a rat model of intestinal ischemia-reperfusion injury, Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, 25, 181, 10.3109/10731199709118909 Powanda, 2002, Cross-linked polyhemoglobin-superoxide dismutase-catalase supplies oxygen without causing blood-brain barrier disruption or brain edema in a rat model of transient global brain ischemia-reperfusion, Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, 30, 23, 10.1081/BIO-120002725 McCarthy, 2001, The role of facilitated diffusion in oxygen transport by cell-free hemoglobins: implications for the design of hemoglobin-based oxygen carriers, Biophysical Chemistry, 92, 103, 10.1016/S0301-4622(01)00194-6 Vandegriff, 2003, MP4, a new nonvasoactive PEG-Hb conjugate, Transfusion, 43, 509, 10.1046/j.1537-2995.2003.00341.x Sakai, 2000, Molecular dimensions of Hb-based O(2) carriers determine constriction of resistance arteries and hypertension, American Journal of Physiology. Heart and Circulatory Physiology, 279, H908, 10.1152/ajpheart.2000.279.3.H908 Intaglietta, 1996, Microvascular and tissue oxygen distribution, Cardiovascular Research, 32, 632, 10.1016/0008-6363(96)00110-1 Winslow, 2002, Autoregulation and vasoconstriction: foundation for a new generation of blood substitutes, Blood, 100, 210 Tsai, 2006, Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers, Blood, 108, 3603, 10.1182/blood-2006-02-005272 Tsai, 2003, Targeted O2 delivery by low-P50 hemoglobin: a new basis for O2 therapeutics, American Journal of Physiology. Heart and Circulatory Physiology, 285, H1411, 10.1152/ajpheart.00307.2003 Wettstein, 2003, Resuscitation with polyethylene glycol-modified human hemoglobin improves microcirculatory blood flow and tissue oxygenation after hemorrhagic shock in awake hamsters, Critical Care Medicine, 31, 1824, 10.1097/01.CCM.0000069340.16319.F2 Drobin, 2004, Hemodynamic response and oxygen transport in pigs resuscitated with maleimide-polyethylene glycol-modified hemoglobin (MP4), Journal of Applied Physiology, 96, 1843, 10.1152/japplphysiol.00530.2003 Winslow, 2004, Comparison of PEG-modified albumin and hemoglobin in extreme hemodilution in the rat, Journal of Applied Physiology, 97, 1527, 10.1152/japplphysiol.00404.2004 Bjorkholm, 2005, A phase I single blind clinical trial of a new oxygen transport agent (MP4), human hemoglobin modified with maleimide-activated polyethylene glycol, Haematologica, 90, 505 Olofsson, 2006, A multicenter clinical study of the safety and activity of maleimide-polyethylene glycol-modified Hemoglobin (Hemospan) in patients undergoing major orthopedic surgery, Anesthesiology, 105, 1153, 10.1097/00000542-200612000-00015 Matheson, 2000, Appearance of dissociable and cross-linked hemoglobins in the renal hilar lymph, Journal of Laboratory and Clinical Medicine, 135, 459, 10.1067/mlc.2000.106458 Nemoto, 2006, Salvage of focal cerebral ischemic damage by transfusion of high O2-affinity recombinant hemoglobin polymers in mouse, Journal of Applied Physiology, 100, 1688, 10.1152/japplphysiol.01374.2005 Riess, 1992, Overview of progress in the fluorocarbon approach to in vivo oxygen delivery, Biomaterials, Artificial Cells, and Immobilization Biotechnology, 20, 183, 10.3109/10731199209119635 Riess, 2001, Oxygen carriers (“blood substitutes”) – raison d'etre, chemistry, and some physiology, Chemical Reviews, 101, 2797, 10.1021/cr970143c Cleman, 1986, Prevention of ischemia during percutaneous transluminal coronary angioplasty by transcatheter infusion of oxygenated Fluosol DA 20%, Circulation, 74, 555, 10.1161/01.CIR.74.3.555 Young, 1990, Metabolic and functional effects of perfluorocarbon distal perfusion during coronary angioplasty, American Journal of Cardiology, 65, 986, 10.1016/0002-9149(90)91001-M Kent, 1990, Reduction of myocardial ischemia during percutaneous transluminal coronary angioplasty with oxygenated Fluosol, American Journal of Cardiology, 66, 279, 10.1016/0002-9149(90)90836-P Bajaj, 1989, Limitation of myocardial reperfusion injury by intravenous perfluorochemicals. Role of neutrophil activation, Circulation, 79, 645, 10.1161/01.CIR.79.3.645 Forman, 1991, Demonstration of myocardial reperfusion injury in humans: results of a pilot study utilizing acute coronary angioplasty with perfluorochemical in anterior myocardial infarction, Journal of the American College of Cardiology, 18, 911, 10.1016/0735-1097(91)90746-V Spence, 1990, Fluosol DA-20 in the treatment of severe anemia: randomized, controlled study of 46 patients, Critical Care Medicine, 18, 1227, 10.1097/00003246-199011000-00008 Gould, 1986, Fluosol-DA as a red-cell substitute in acute anemia, New England Journal of Medicine, 314, 1653, 10.1056/NEJM198606263142601 Wahr, 1996, A pilot study of the effects of a perflubron emulsion, AF 0104, on mixed venous oxygen tension in anesthetized surgical patients, Anesthesia and Analgesia, 82, 103 Leese, 2000, Randomized safety studies of intravenous perflubron emulsion. I. Effects on coagulation function in healthy volunteers, Anesthesia and Analgesia, 91, 804, 10.1097/00000539-200010000-00008 Keipert, 1994, Oxygen delivery augmentation by low-dose perfluorochemical emulsion during profound normovolemic hemodilution, Advances in Experimental Medicine and Biology, 345, 197, 10.1007/978-1-4615-2468-7_26 Holman, 1995, Tissue oxygenation with graded dissolved oxygen delivery during cardiopulmonary bypass, Journal of Thoracic and Cardiovascular Surgery, 110, 774, 10.1016/S0022-5223(95)70111-7 Spahn, 1999, Perflubron emulsion delays blood transfusions in orthopedic surgery. European Perflubron Emulsion Study Group, Anesthesiology, 91, 1195, 10.1097/00000542-199911000-00009 Noveck, 2000, Randomized safety studies of intravenous perflubron emulsion. II. Effects on immune function in healthy volunteers, Anesthesia and Analgesia, 91, 812, 10.1097/00000539-200010000-00009 Spahn, 2002, Use of perflubron emulsion to decrease allogeneic blood transfusion in high-blood-loss non-cardiac surgery: results of a European phase 3 study, Anesthesiology, 97, 1338, 10.1097/00000542-200212000-00004 Sakai, 1996, Physical properties of hemoglobin vesicles as red cell substitutes, Biotechnology Progress, 12, 119, 10.1021/bp950068w Phillips, 1999, Polyethylene glycol-modified liposome-encapsulated hemoglobin: a long circulating red cell substitute, Journal of Pharmacology and Experimental Theraputics, 288, 665 Chang, 2003, Future generations of red blood cell substitutes, Journal of Internal Medicine, 253, 527, 10.1046/j.1365-2796.2003.01151.x Pagel, 1998, RSR13, a synthetic modifier of hemoglobin-oxygen affinity, enhances the recovery of stunned myocardium in anesthetized dogs, Journal of Pharmacology and Experimental Theraputics, 285, 1 Wahr, 2001, Allosteric modification of oxygen delivery by hemoglobin, Anesthesia and Analgesia, 92, 615, 10.1213/00000539-200103000-00011 Eichelbrönner, 2002, Increasing P(50) does not improve DO(2CRIT) or systemic VO(2) in severe anemia, American Journal of Physiology. Heart and Circulatory Physiology, 283, H92, 10.1152/ajpheart.01066.2001 Vamvakas, 2007, Transfusion-related immunomodulation (TRIM): an update. Blood Reviews, Blood Reviews, 21, 327, 10.1016/j.blre.2007.07.003 Pape, 2007, Alternatives to allogeneic blood transfusions, Best Practice & Research Clinical Anaesthesiology., 21, 221, 10.1016/j.bpa.2007.02.004 Murphy, 2006, Indications for blood transfusion in cardiac surgery, The Annals of Thoracic Surgery, 82, 2323, 10.1016/j.athoracsur.2006.06.020 Stumper-Groves, 2006, Perioperative blood transfusion and outcome, Current Opinion in Anaesthesiology, 19, 198, 10.1097/01.aco.0000192798.10420.45 Madjdpour, 2005, Allogeneic red blood cell transfusions: efficacy, risks, alternatives and indications, British Journal of Anaesthesia, 95, 33, 10.1093/bja/aeh290