HPV ctDNA detection of high-risk HPV types during chemoradiotherapy for locally advanced cervical cancer

Marth, 2017, Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up, Ann Oncol, 28, iv72, 10.1093/annonc/mdx220 Kim, 2017, Disease courses in patients with residual tumor following concurrent chemoradiotherapy for locally advanced cervical cancer, Gynecol Oncol, 144, 34, 10.1016/j.ygyno.2016.10.032 Kawaguchi, 2013, Posttreatment cut-off levels of squamous cell carcinoma antigen as a prognostic factor in patients with locally advanced cervical cancer treated with radiotherapy, J Gynecol Oncol, 24, 313, 10.3802/jgo.2013.24.4.313 Fu, 2019, The role of squamous cell carcinoma antigen (SCC Ag) in outcome prediction after concurrent chemoradiotherapy and treatment decisions for patients with cervical cancer, Radiat Oncol, 14, 146, 10.1186/s13014-019-1355-4 Alix-Panabières, 2016, Clinical applications of circulating tumor cells and circulating tumor DNA as liquid biopsy, Cancer Discov, 6, 479, 10.1158/2159-8290.CD-15-1483 Cabel, 2017, Circulating tumor cells and circulating tumor DNA: what surgical oncologists need to know?, Eur J Surg Oncol, 43, 949, 10.1016/j.ejso.2017.01.010 Bidard, 2013, Going with the flow: from circulating tumor cells to DNA, Sci Transl Med, 5, 207ps14, 10.1126/scitranslmed.3006305 Kilgour, 2020, Liquid biopsy-based biomarkers of treatment response and resistance, Cancer Cell, 37, 485, 10.1016/j.ccell.2020.03.012 Boonstra, 2020, Clinical utility of circulating tumor DNA as a response and follow-up marker in cancer therapy, Cancer Metastasis Rev, 39, 999, 10.1007/s10555-020-09876-9 Diehl, 2008, Circulating mutant DNA to assess tumor dynamics, Nat Med, 14, 985, 10.1038/nm.1789 Tie, 2016, Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer, Sci Transl Med, 8, 346ra92, 10.1126/scitranslmed.aaf6219 Garcia-Murillas, 2015, Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer, Sci Transl Med, 7, 302ra133, 10.1126/scitranslmed.aab0021 Olsson, 2015, Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease, EMBO Mol Med, 7, 1034, 10.15252/emmm.201404913 Riva, 2017, Patient-specific circulating tumor DNA detection during neoadjuvant chemotherapy in triple-negative breast cancer, Clin Chem, 63, 691, 10.1373/clinchem.2016.262337 de Martel, 2017, Worldwide burden of cancer attributable to HPV by site, country and HPV type, Int J Cancer, 141, 664, 10.1002/ijc.30716 2012, Human papillomavirus-associated cancers – United States, 2004-2008, MMWR Morb Mortal Wkly Rep, 61, 258 Muñoz, 2003, Epidemiologic classification of human papillomavirus types associated with cervical cancer, N Engl J Med, 348, 518, 10.1056/NEJMoa021641 de Villiers, 2004, Classification of papillomaviruses, Virology, 324, 17, 10.1016/j.virol.2004.03.033 de Sanjose, 2010, Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study, Lancet Oncol, 11, 1048, 10.1016/S1470-2045(10)70230-8 Valmary-Degano, 2013, Signature patterns of human papillomavirus type 16 in invasive anal carcinoma, Hum Pathol, 44, 992, 10.1016/j.humpath.2012.08.019 Cocuzza, 2017, Human papillomavirus DNA detection in plasma and cervical samples of women with a recent history of low grade or precancerous cervical dysplasia, PLoS One, 12, e0188592, 10.1371/journal.pone.0188592 Gu, 2020, Circulating HPV cDNA in the blood as a reliable biomarker for cervical cancer: a meta-analysis, PLoS One, 15, e0224001, 10.1371/journal.pone.0224001 Shimada, 2010, Human papillomavirus DNA in plasma of patients with HPV16 DNA-positive uterine cervical cancer, Jpn J Clin Oncol, 40, 420, 10.1093/jjco/hyp193 Cabel, 2018, Clinical potential of circulating tumour DNA in patients receiving anticancer immunotherapy, Nat Rev Clin Oncol, 15, 639, 10.1038/s41571-018-0074-3 Cabel, 2017, HPV circulating tumor DNA to monitor the efficacy of anti-PD-1 therapy in metastatic squamous cell carcinoma of the anal canal: a case report, Int J Cancer, 141, 1667, 10.1002/ijc.30863 Jeannot, 2016, Circulating human papillomavirus DNA detected using droplet digital PCR in the serum of patients diagnosed with early stage human papillomavirus-associated invasive carcinoma, J Pathol Clin Res, 2, 201, 10.1002/cjp2.47 Lee, 2017, Predicting response to radical (chemo)radiotherapy with circulating HPV DNA in locally advanced head and neck squamous carcinoma, Br J Cancer, 117, 876, 10.1038/bjc.2017.258 Campitelli, 2012, Human papillomavirus mutational insertion: specific marker of circulating tumor DNA in cervical cancer patients, PLoS One, 7, e43393, 10.1371/journal.pone.0043393 Bernard-Tessier, 2019, Clinical validity of HPV circulating tumor DNA in advanced anal carcinoma: an ancillary study to the epitopes-HPV02 trial, Clin Cancer Res, 25, 2109, 10.1158/1078-0432.CCR-18-2984 Kang, 2017, Circulating cell-free DNA for metastatic cervical cancer detection, genotyping, and monitoring, Clin Cancer Res, 23, 6856, 10.1158/1078-0432.CCR-17-1553 Damerla, 2019, Detection of early human papillomavirus-associated cancers by liquid biopsy, JCO Precis Oncol, 3 Veyer, 2020, HPV circulating tumoral DNA quantification by droplet-based digital PCR: a promising predictive and prognostic biomarker for HPV-associated oropharyngeal cancers, Int J Cancer, 147, 1222, 10.1002/ijc.32804 Cabel, 2018, Prognostic impact of residual HPV ctDNA detection after chemoradiotherapy for anal squamous cell carcinoma, Clin Cancer Res, 24, 5767, 10.1158/1078-0432.CCR-18-0922 Chera, 2020, Plasma circulating tumor HPV DNA for the surveillance of cancer recurrence in HPV-associated oropharyngeal cancer, J Clin Oncol, 38, 1050, 10.1200/JCO.19.02444 McShane, 2005, REporting recommendations for tumour MARKer prognostic studies (REMARK), Br J Cancer, 93, 387, 10.1038/sj.bjc.6602678 Cohen, 2018, Detection and localization of surgically resectable cancers with a multi-analyte blood test, Science, 359, 926, 10.1126/science.aar3247 Cabel, 2019, Limited sensitivity of circulating tumor DNA detection by droplet digital PCR in non-metastatic operable gastric cancer patients, Cancers, 11, 396, 10.3390/cancers11030396 Cheung, 2019, Liquid biopsy of HPV DNA in cervical cancer, J Clin Virol, 114, 32, 10.1016/j.jcv.2019.03.005 Han, 2018, Circulating human papillomavirus DNA as a biomarker of response in patients with locally advanced cervical cancer treated with definitive chemoradiation, JCO Precis Oncol, 2, 1