HOTAIR is a REST-regulated lncRNA that promotes neuroendocrine differentiation in castration resistant prostate cancer

Cancer Letters - Tập 433 - Trang 43-52 - 2018
Yi-Ting Chang1, Tzu-Ping Lin2,3,4, Jui-Ting Tang1, Mel Campbell5, Yun-Li Luo1, Shih-Yen Lu4, Chia-Pei Yang1, Ting-Yu Cheng1, Ching-Hsin Chang6, Tze-Tze Liu7, Chi-Hung Lin1,2, Hsing-Jein Kung5,8,9,10, Chin-Chen Pan11, Pei-Ching Chang1,7,12,13
1Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan
2Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
3Department of Urology, School of Medicine, Shu-Tien Urological Research Center, National Yang-Ming University, Taipei, Taiwan
4Department of Urology, Taipei Veterans General Hospital, Taipei, Taiwan
5UC Davis Comprehensive Cancer Center, University of California, Davis, CA, 95616, USA
6Department of Urology, Taipei Medical University Hospital, Taipei, Taiwan
7Genome Research Center, National Yang-Ming University, Taipei, Taiwan
8Department of Biochemistry and Molecular Medicine, University of California, Davis, CA 95616, USA
9Institute for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, 250 Wu-Xin Street, Taipei City, Taiwan
10Division of Molecular and Genomic Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County, 35053, Taiwan
11Department of Pathology, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan
12Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan
13Cancer Progression Research Center, National Yang-Ming University, Taipei, Taiwan

Tài liệu tham khảo

Adler, 1999, Elevated levels of circulating interleukin-6 and transforming growth factor-beta1 in patients with metastatic prostatic carcinoma, J. Urol., 161, 182, 10.1016/S0022-5347(01)62092-5 Aparicio, 2011, Neuroendocrine prostate cancer xenografts with large-cell and small-cell features derived from a single patient's tumor: morphological, immunohistochemical, and gene expression profiles, Prostate, 71, 846, 10.1002/pros.21301 Batista, 2013, Long noncoding RNAs: cellular address codes in development and disease, Cell, 152, 1298, 10.1016/j.cell.2013.02.012 Beltran, 2016, Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer, Nat. Med., 22, 298, 10.1038/nm.4045 Bhan, 2015, LncRNA HOTAIR: a master regulator of chromatin dynamics and cancer, Biochim. Biophys. Acta, 1856, 151 Burchardt, 1999, Transdifferentiation of prostate cancer cells to a neuroendocrine cell phenotype in vitro and in vivo, J. Urol., 162, 1800, 10.1016/S0022-5347(05)68241-9 Chang, 2014, Autophagy pathway is required for IL-6 induced neuroendocrine differentiation and chemoresistance of prostate cancer LNCaP cells, PLoS One, 9 Chang, 2017, REST is a crucial regulator for acquiring EMT-like and stemness phenotypes in hormone-refractory prostate cancer, Sci. Rep., 7, 42795, 10.1038/srep42795 Chen, 1998, NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis, Nat. Genet., 20, 136, 10.1038/2431 Chiyomaru, 2013, Genistein inhibits prostate cancer cell growth by targeting miR-34a and oncogenic HOTAIR, PLoS One, 8, 10.1371/journal.pone.0070372 Chong, 1995, REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons, Cell, 80, 949, 10.1016/0092-8674(95)90298-8 Cox, 1999, Acquisition of neuroendocrine characteristics by prostate tumor cells is reversible: implications for prostate cancer progression, Canc. Res., 59, 3821 de Kok, 2002, DD3(PCA3), a very sensitive and specific marker to detect prostate tumors, Canc. Res., 62, 2695 Delk, 2012, Interleukin-6: a bone marrow stromal cell paracrine signal that induces neuroendocrine differentiation and modulates autophagy in bone metastatic PCa cells, Autophagy, 8, 650, 10.4161/auto.19226 Derrien, 2012, The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression, Genome Res., 22, 1775, 10.1101/gr.132159.111 Dimitrova, 2014, LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint, Mol. Cell, 54, 777, 10.1016/j.molcel.2014.04.025 Ding, 2017, Long noncoding RNA HOTAIR modulates MiR-206-mediated Bcl-w signaling to facilitate cell proliferation in breast cancer, Sci. Rep., 7, 17261, 10.1038/s41598-017-17492-x Drachenberg, 1999, Circulating levels of interleukin-6 in patients with hormone refractory prostate cancer, Prostate, 41, 127, 10.1002/(SICI)1097-0045(19991001)41:2<127::AID-PROS7>3.0.CO;2-H Fatica, 2014, Long non-coding RNAs: new players in cell differentiation and development, Nature reviews, Genetics, 15, 7 Geisler, 2013, RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts, Nature reviews, Mol. Cell Biol., 14, 699 Grasso, 2012, The mutational landscape of lethal castration-resistant prostate cancer, Nature, 487, 239, 10.1038/nature11125 Gupta, 2010, Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis, Nature, 464, 1071, 10.1038/nature08975 Hieronymus, 2006, Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators, Canc. Cell, 10, 321, 10.1016/j.ccr.2006.09.005 Ho, 2016, Regulation of PCGEM1 by p54/nrb in prostate cancer, Sci. Rep., 6, 34529, 10.1038/srep34529 Hu, 2014, A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer, Canc. Cell, 26, 344, 10.1016/j.ccr.2014.07.009 Huarte, 2015, The emerging role of lncRNAs in cancer, Nat. Med., 21, 1253, 10.1038/nm.3981 Jin, 2004, NE-10 neuroendocrine cancer promotes the LNCaP xenograft growth in castrated mice, Canc. Res., 64, 5489, 10.1158/0008-5472.CAN-03-3117 Katayama, 2017, Long non-coding RNA HOTAIR promotes cell migration by upregulating insulin growth factor-binding protein 2 in renal cell carcinoma, Sci. Rep., 7, 12016, 10.1038/s41598-017-12191-z Khalil, 2009, Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression, Proc. Natl. Acad. Sci. U. S. A., 106, 11667, 10.1073/pnas.0904715106 Kivinummi, 2017, The expression of AURKA is androgen regulated in castration-resistant prostate cancer, Sci. Rep., 7, 17978, 10.1038/s41598-017-18210-3 Kogo, 2011, Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers, Canc. Res., 71, 6320, 10.1158/0008-5472.CAN-11-1021 Komiya, 2009, Neuroendocrine differentiation in the progression of prostate cancer, Int. J. Urol.: Official J. Jpn. Urol. Assoc., 16, 37, 10.1111/j.1442-2042.2008.02175.x Ku, 2017, Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance, Science, 355, 78, 10.1126/science.aah4199 Lai, 2017, A microsatellite repeat in PCA3 long non-coding RNA is associated with prostate cancer risk and aggressiveness, Sci. Rep., 7, 16862, 10.1038/s41598-017-16700-y Li, 2015, Infiltrating mast cells enhance prostate cancer invasion via altering LncRNA-HOTAIR/PRC2-androgen receptor (AR)-MMP9 signals and increased stem/progenitor cell population, Oncotarget, 6, 14179, 10.18632/oncotarget.3651 Liang, 2014, Down-regulation of RE-1 silencing transcription factor (REST) in advanced prostate cancer by hypoxia-induced miR-106b∼25, Exp. Cell Res., 320, 188, 10.1016/j.yexcr.2013.09.020 Lin, 2016, REST reduction is essential for hypoxia-induced neuroendocrine differentiation of prostate cancer cells by activating autophagy signaling, Oncotarget, 7, 26137, 10.18632/oncotarget.8433 Lipianskaya, 2014, Androgen-deprivation therapy-induced aggressive prostate cancer with neuroendocrine differentiation, Asian J. Androl., 16, 541, 10.4103/1008-682X.123669 Marangoni, 2015, Prostate-specific RNA aptamer: promising nucleic acid antibody-like cancer detection, Sci. Rep., 5, 12090, 10.1038/srep12090 Mu, 2017, SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer, Science, 355, 84, 10.1126/science.aah4307 Mulligan, 2008, CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation, Mol. Cell, 32, 718, 10.1016/j.molcel.2008.10.025 Nelson, 2016, A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle, Science, 351, 271, 10.1126/science.aad4076 Niu, 2010, Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer fails, Oncogene, 29, 3593, 10.1038/onc.2010.121 Petrovics, 2004, Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients, Oncogene, 23, 605, 10.1038/sj.onc.1207069 Ponting, 2009, Evolution and functions of long noncoding RNAs, Cell, 136, 629, 10.1016/j.cell.2009.02.006 Prensner, 2011, Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression, Nat. Biotechnol., 29, 742, 10.1038/nbt.1914 Prensner, 2013, The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex, Nat. Genet., 45, 1392, 10.1038/ng.2771 Prensner, 2014, The IncRNAs PCGEM1 and PRNCR1 are not implicated in castration resistant prostate cancer, Oncotarget, 5, 1434, 10.18632/oncotarget.1846 Reddy, 2009, RE-1-silencing transcription factor shows tumor-suppressor functions and negatively regulates the oncogenic TAC1 in breast cancer cells, Proc. Natl. Acad. Sci. U. S. A., 106, 4408, 10.1073/pnas.0809130106 Rinn, 2007, Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs, Cell, 129, 1311, 10.1016/j.cell.2007.05.022 Sharma, 2015, Bridging links between long noncoding RNA HOTAIR and HPV oncoprotein E7 in cervical cancer pathogenesis, Sci. Rep., 5, 11724, 10.1038/srep11724 Srikantan, 2000, PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer, Proc. Natl. Acad. Sci. U. S. A., 97, 12216, 10.1073/pnas.97.22.12216 Svensson, 2014, REST mediates androgen receptor actions on gene repression and predicts early recurrence of prostate cancer, Nucleic Acids Res., 42, 999, 10.1093/nar/gkt921 Terry, 2014, The many faces of neuroendocrine differentiation in prostate cancer progression, Front. Oncol., 4, 60, 10.3389/fonc.2014.00060 Toropainen, 2016, Global analysis of transcription in castration-resistant prostate cancer cells uncovers active enhancers and direct androgen receptor targets, Sci. Rep., 6, 33510, 10.1038/srep33510 Torre, 2015, Global cancer statistics, 2012, CA A Cancer J. Clin., 65, 87, 10.3322/caac.21262 Tsai, 2010, Long noncoding RNA as modular scaffold of histone modification complexes, Science, 329, 689, 10.1126/science.1192002 Westbrook, 2008, SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation, Nature, 452, 370, 10.1038/nature06780 Westbrook, 2005, A genetic screen for candidate tumor suppressors identifies REST, Cell, 121, 837, 10.1016/j.cell.2005.03.033 Wu, 2007, Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer, J. Biol. Chem., 282, 3571, 10.1074/jbc.M608487200 Yoon, 2013, Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination, Nat. Commun., 4, 2939, 10.1038/ncomms3939 Zhang, 2015, LncRNA HOTAIR enhances the androgen-receptor-mediated transcriptional Program and drives castration-resistant prostate cancer, Cell Rep., 13, 209, 10.1016/j.celrep.2015.08.069 Zhang, 2013, Long non-coding RNA: a new player in cancer, J. Hematol. Oncol., 6, 37, 10.1186/1756-8722-6-37 Zhu, 2014, Interleukin-6 induces neuroendocrine differentiation (NED) through suppression of RE-1 silencing transcription factor (REST), Prostate, 74, 1086, 10.1002/pros.22819