HLA alleles associated with COVID-19 susceptibility and severity in different populations: a systematic review

Egyptian Journal of Medical Human Genetics
Meryem Fakhkhari1, Hayat Caidi2, Khalid Sadki1
1Research Laboratory in Oral Biology and Biotechnology, Faculty of Dental Medicine, Mohammed V University in Rabat, Rabat, Morocco
2NARST Surveillance Unit, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA

Tóm tắt

Abstract Background COVID-19 is a respiratory disease caused by a novel coronavirus called as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Detected for the first time in December 2019 in Wuhan and it has quickly spread all over the world in a couple of months and becoming a world pandemic. Symptoms of the disease and clinical outcomes are very different in infected people. These differences highlight the paramount need to study and understand the human genetic variation that occurring viral infections. Human leukocyte antigen (HLA) is an important component of the viral antigen presentation pathway, and it plays an essential role in conferring differential viral susceptibility and severity of diseases. HLA alleles have been involved in the immune response to viral diseases such as SARS-CoV-2. Main body of the abstract Herein, we sought to evaluate this hypothesis by summarizing the association between HLA class I and class II alleles with COVID-19 susceptibility and/or severity reported in previous studies among different populations (Chinese, Italian, Iranian, Japanese, Spanish, etc.). The findings of all selected articles showed that several alleles have been found associated with COVID-19 susceptibility and severity. Even results across articles have been inconsistent and, in some cases, conflicting, highlighting that the association between the HLA system and the COVID‐19 outcome might be ethnic‐dependent, there were some alleles in common between some populations such as HLA-DRB1*15 and HLA-A*30:02. Conclusion These contradictory findings warrant further large, and reproducible studies to decipher any possible genetic predisposition underlying susceptibility to SARS-COV-2 and disease progression and host immune response.

Từ khóa


Tài liệu tham khảo

Weiner J et al (2021) Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01. EClinicalMedicine 40:101099. https://doi.org/10.1016/j.eclinm.2021.101099

Anastassopoulou C, Gkizarioti Z, Patrinos GP, Tsakris A (2020) Human genetic factors associated with susceptibility to SARS-CoV-2 infection and COVID-19 disease severity. Hum Genomics 14(1):1–8. https://doi.org/10.1186/s40246-020-00290-4

Iturrieta-Zuazo I et al (2020) Possible role of HLA class-I genotype in SARS-CoV-2 infection and progression: a pilot study in a cohort of Covid-19 Spanish patients. Clin Immunol Orlando Fla 219:108572. https://doi.org/10.1016/j.clim.2020.108572

Lin M et al (2003) Association of HLA class I with severe acute respiratory syndrome coronavirus infection. BMC Med Genet 4:1–7. https://doi.org/10.1186/1471-2350-4-9

Tavasolian F et al (2020) HLA, immune response, and susceptibility to COVID-19. Front Immunol 11:3581. https://doi.org/10.3389/fimmu.2020.601886

Poulton K et al (2020) A role for human leucocyte antigens in the susceptibility to SARS-Cov-2 infection observed in transplant patients. Int J Immunogenet 47(4):324–328. https://doi.org/10.1111/iji.12505

Blackwell JM, Jamieson SE, Burgner D (2009) HLA and infectious diseases. Clin Microbiol Rev 22(2):370–385. https://doi.org/10.1128/CMR.00048-08

Fricke-Galindo I, Falfán-Valencia R (2021) Genetics insight for COVID-19 susceptibility and severity: a review. Front Immunol 12:622176. https://doi.org/10.3389/fimmu.2021.622176

Deb P, Zannat K, Talukder S, Bhuiyan AH, Jilani MSA, Saif-Ur-Rahman KM (2022) Association of HLA gene polymorphism with susceptibility, severity, and mortality of COVID-19: a systematic review. HLA 99(4):281–312. https://doi.org/10.1111/tan.14560

Medhasi S, Chantratita N (2022) Human Leukocyte Antigen (HLA) system: genetics and association with bacterial and viral infections. J Immunol Res 2022:9710376. https://doi.org/10.1155/2022/9710376

Wang W, Zhang W, Zhang J, He J, Zhu F (2020) Distribution of HLA allele frequencies in 82 Chinese individuals with coronavirus disease-2019 (COVID-19). HLA 96(2):194–196. https://doi.org/10.1111/tan.13941

Yung Y et al (2021) Association of HLA-B22 serotype with SARS-CoV -2 susceptibility in Hong Kong Chinese patients. HLA 97(2):127–132. https://doi.org/10.1111/tan.14135

Barquera R et al (2020) Binding affinities of 438 HLA proteins to complete proteomes of seven pandemic viruses and distributions of strongest and weakest HLA peptide binders in populations worldwide. HLA 96(3):277–298. https://doi.org/10.1111/tan.13956

Novelli A et al (2020) HLA allele frequencies and susceptibility to COVID-19 in a group of 99 Italian patients. HLA 96(5):610–614. https://doi.org/10.1111/tan.14047

Kachuri L et al (2020) The landscape of host genetic factors involved in immune response to common viral infections. Genome Med 12(1):93. https://doi.org/10.1186/s13073-020-00790-x

Cocco E et al (2012) HLA-DRB1-DQB1 haplotypes confer susceptibility and resistance to multiple sclerosis in Sardinia. PLoS ONE 7(4):e33972. https://doi.org/10.1371/journal.pone.0033972

Alves C, Souza T, Meyer I, Toralles MBP, Brites C (2006) Immunogenetics and infectious diseases: special reference to the mayor histocompatibility complex. Braz J Infect Dis 10:122–131. https://doi.org/10.1590/S1413-86702006000200010

Ebrahimi S, Ghasemi-Basir HR, Majzoobi MM, Rasouli-Saravani A, Hajilooi M, Solgi G (2021) HLA-DRB1*04 may predict the severity of disease in a group of Iranian COVID-19 patients. Hum Immunol 82(10):719–725. https://doi.org/10.1016/j.humimm.2021.07.004

HamidiFarahani R, Esmaeilzadeh E, NezamiAsl A, Heidari MF, Hazrati E (2021) Frequency of HLA Alleles in a Group of Severe COVID-19 Iranian patients. Iran J Public Health. https://doi.org/10.18502/ijph.v50i9.7061

Migliorini F, Torsiello E, Spiezia F, Oliva F, Tingart M, Maffulli N (2021) Association between HLA genotypes and COVID-19 susceptibility, severity and progression: a comprehensive review of the literature. Eur J Med Res 26(1):1–9. https://doi.org/10.1186/s40001-021-00563-1

Saini G, Swahn MH, Aneja R (2021) Disentangling the coronavirus disease 2019 Health Disparities in African Americans: Biological, Environmental, and Social Factors. Open Forum Infect Dis 8(3):ofab064. https://doi.org/10.1093/ofid/ofab064

Littera R et al (2020) Human leukocyte antigen complex and other immunogenetic and clinical factors influence susceptibility or protection to SARS-CoV-2 infection and severity of the disease course: The Sardinian experience. Front Immunol. https://doi.org/10.3389/fimmu.2020.605688

Littera R et al (2006) HLA-dependent hypersensitivity to nevirapine in Sardinian HIV patients. AIDS 20(12):1621–1626. https://doi.org/10.1097/01.aids.0000238408.82947.09

Schindler E et al (2021) HLA genetic polymorphism in patients with coronavirus disease 2019 in Midwestern United States. HLA 98(4):370–379. https://doi.org/10.1111/tan.14387

Gill CJ et al (2022) Sustained high prevalence of COVID-19 deaths from a systematic post-mortem study in Lusaka, Zambia: one year later. medRxiv

Correale P et al (2020) HLA-B*44 and C*01 prevalence correlates with Covid19 spreading across Italy. Int J Mol Sci 21(15):5205. https://doi.org/10.3390/ijms21155205

Amoroso A et al (2021) HLA and AB0 polymorphisms may influence SARS-CoV-2 infection and COVID-19 severity. Transplantation 105(1):193–200. https://doi.org/10.1097/TP.0000000000003507

Dallmann-Sauer M et al (2020) The complex pattern of genetic associations of leprosy with HLA class I and class II alleles can be reduced to four amino acid positions. PLoS Pathog 16(8):e1008818. https://doi.org/10.1371/journal.ppat.1008818

Morris DL et al (2012) Unraveling multiple MHC gene associations with systemic lupus erythematosus: model choice indicates a role for HLA alleles and Non-HLA genes in Europeans. Am J Hum Genet 91(5):778–793. https://doi.org/10.1016/j.ajhg.2012.08.026

Naemi FMA, Al-adwani S, Al-khatabi H, Al-nazawi A (2021) Frequency of HLA alleles among COVID-19 infected patients: preliminary data from Saudi Arabia. Virology 560:1–7. https://doi.org/10.1016/j.virol.2021.04.011

Lorente L et al (2021) HLA genetic polymorphisms and prognosis of patients with COVID-19. Med Intensiv 45(2):96–103. https://doi.org/10.1016/j.medin.2020.08.004

Dutta M, Dutta P, Medhi S, Borkakoty B, Biswas D (2018) Polymorphism of HLA class I and class II alleles in influenza A(H1N1)pdm09 virus infected population of Assam, Northeast India. J Med Virol 90(5):854–860. https://doi.org/10.1002/jmv.25018

Anzurez A et al (2021) Association of HLA- DRB1 *09:01 with severe COVID-19. HLA 98(1):37–42. https://doi.org/10.1111/tan.14256

Khor S et al (2021) HLA-A*11:01:01:01, HLA-C*12:02:02:01-HLA-B*52:01:02:02, age and sex are associated with severity of Japanese COVID-19 with respiratory failure. Front Immunol. https://doi.org/10.3389/fimmu.2021.658570

Wang F et al (2020) Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility. Cell Discov 6(1):1–6. https://doi.org/10.1038/s41421-020-00231-4

Toyoshima Y, Nemoto K, Matsumoto S, Nakamura Y, Kiyotani K (2020) SARS-CoV-2 genomic variations associated with mortality rate of COVID-19. J Hum Genet 65(12):1075–1082. https://doi.org/10.1038/s10038-020-0808-9

Gutiérrez-Bautista JF et al (2021) Study of HLA-A, -B, -C, -DRB1 and -DQB1 polymorphisms in COVID-19 patients. J Microbiol Immunol Infect. https://doi.org/10.1016/j.jmii.2021.08.009

Ben Shachar S et al (2021) MHC haplotyping of SARS-CoV-2 patients: HLA subtypes are not associated with the presence and severity of COVID-19 in the Israeli population. J Clin Immunol 41(6):1154–1161. https://doi.org/10.1007/s10875-021-01071-x

Naemi FMA, Al-adwani S, Al-khatabi H, Al-nazawi A (2021) Association between the HLA genotype and the severity of COVID-19 infection among South Asians. J Med Virol 93(7):4430–4437. https://doi.org/10.1002/jmv.27003

Aladag E et al (2021) Human Ace D/I polymorphism could affect the clinicobiological course of COVID-19. J Renin Angiotensin Aldosterone Syst JRAAS 2021:5509280. https://doi.org/10.1155/2021/5509280

Möhlendick B et al (2021) ACE2 polymorphism and susceptibility for SARS-CoV-2 infection and severity of COVID-19. Pharmacogenet Genomics. https://doi.org/10.1097/FPC.0000000000000436

Faridzadeh A et al (2022) The role of ACE1 I/D and ACE2 polymorphism in the outcome of Iranian COVID-19 patients: a case-control study. Front Genet 13:955965. https://doi.org/10.3389/fgene.2022.955965

Sabater Molina M et al (2022) Polymorphisms in ACE, ACE2, AGTR1 genes and severity of COVID-19 disease. PLoS ONE 17(2):e0263140. https://doi.org/10.1371/journal.pone.0263140

Chen F, Zhang Y, Li X, Li W, Liu X, Xue X (2021) The impact of ACE2 polymorphisms on COVID-19 disease: susceptibility, severity, and therapy. Front Cell Infect Microbiol 11:753721. https://doi.org/10.3389/fcimb.2021.753721

Ishak A et al (2022) The association of COVID-19 severity and susceptibility and genetic risk factors: a systematic review of the literature. Gene 836:146674. https://doi.org/10.1016/j.gene.2022.146674

Yildirim Z, Sahin OS, Yazar S, BozokCetintas V (2021) Genetic and epigenetic factors associated with increased severity of Covid-19. Cell Biol Int 45(6):1158–1174. https://doi.org/10.1002/cbin.11572

Nhung VP et al (2022) Host genetic risk factors associated with COVID-19 susceptibility and severity in Vietnamese. Genes 13(10):1884. https://doi.org/10.3390/genes13101884

Thông tin
Thông tin xuất bản

Egyptian Journal of Medical Human Genetics

Thông tin tác giả