HIV-Related Atherosclerosis: State-of-the-Art-Review

Current Problems in Cardiology - Tập 48 - Trang 101783 - 2023
Ashot Avagimyan1, Nana Pogosova2, Lev Kakturskiy3, Mohammad Sheibani4,5, Olga Urazova6, Artem Trofimenko7, Grizelda Navarsdyan8, Zinaida Jndoyan9, Kristina Abgaryan10, Federica Fogacci11, Mattia Galli12, Luciano Agati13, Zhanna Kobalava14, Davood Shafie15, Mario Marzilli16, Liana Gogiashvili17, Nizal Sarrafzadegan18
1Assistant Professor, Anatomical Pathology and Clinical Morphology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
2Professor, Deputy of General Director for Science and Preventive Cardiology, National Medical Research Centre of Cardiology after E. Chazov, Moscow, Russia
3Professor, Scientific Director, Research Institute of Human Morphology FSBI «Petrovskiy NRCS, Moscow, Russia
4Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
5Razi Drug Research Centre, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
6Professor, Head of Pathophysiology Department, Siberian State Medical University, Tomsk, Russia
7Associate Professor, Pathophysiology Department, Kuban State Medical University, Krasnodar, Russia
8Professor, Pathophysiology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
9Professor, Head of Internal Diseases Propedeutics Department, Yerevan State Medical University after M. Heratsi, Armenia
10Associate Professor, Medical Microbiology Department, Yerevan State Medical University after M.Heratsi, Armenia
11Research Fellow, Atherosclerosis and Metabolic Disorders Research Unit, University of Bologna, Bologna, Italy
12Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy
13Professor of Cardiology Department, Head of Cardiology Unit Azienda Policlinico Umberto II, Sapienza University, Rome, Italy
14Professor, Head of Internal Disease, Cardiology and Clinical Pharmacology Department, Peoples’ Friendship University of Russia (RUDN), Moscow, Russia
15Isfahan Cardiovascular Research Institute, Isfahan, Iran
16Professor, Head of Cardiovascular Medicine Division, University of Pisa, Pisa, Italy
17Professor, Head of Experimental and Clinical Pathology Department, Al. Natishvili Institute of Experimental Morphology, I. Javakhishvili Tbilisi State University, Tbilisi, Georgia
18Professor, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Tài liệu tham khảo

UNAIDS fact sheet: https://www.unaids.org/ru/resources/fact-sheet WHO statement: https://www.who.int/data/gho/data/themes/hiv-aids#: EACS (European AIDS Clinical Society). Guidelines. Version 11.0. 2021. https://www.eacsociety.org/media/final2021eacsguidelinesv11.0_oct2021.pdf Labh, 2021, Emerging trends in the long-acting antiretroviral therapy: current status and therapeutic challenges, Curr HIV Res, 19, 4, 10.2174/1570162X18666200824104140 Taylor, 2019, CROI 2019: advances in antiretroviral therapy, Top Antivir Med, 27, 50 Menéndez-Arias, 2022, Update and latest advances in antiretroviral therapy, Trends Pharmacol Sci, 43, 16, 10.1016/j.tips.2021.10.004 York, 2019, Undetectable equals untransmittable, Nat Rev Microbiol, 17, 399 Corbacho, 2021, The pharmacological management of cardiovascular disease in people living with HIV (PLWH), Expert Opin Pharmacother, 22, 743, 10.1080/14656566.2020.1856075 Ballocca, 2017, Cardiovascular disease in patients with HIV, Trends Cardiovasc Med, 27, 558, 10.1016/j.tcm.2017.06.005 Post, 2014, Associations between HIV infection and subclinical coronary atherosclerosis, Ann Intern Med, 160, 458, 10.7326/M13-1754 Lo, 2010, Increased prevalence of subclinical coronary atherosclerosis detected by coronary computed tomography angiography in HIV-infected men, AIDS, 24, 243, 10.1097/QAD.0b013e328333ea9e Zanni, 2013, Increased coronary atherosclerotic plaque vulnerability by coronary computed tomography angiography in HIV-infected men, AIDS, 27, 1263, 10.1097/QAD.0b013e32835eca9b Lundgren, 2015, Initiation of antiretroviral therapy in early asymptomatic HIV infection, N Engl J Med, 373, 795, 10.1056/NEJMoa1506816 D'Ascenzo, 2015, High prevalence at computed coronary tomography of non-calcified plaques in asymptomatic HIV patients treated with HAART: a meta-analysis, Atherosclerosis, 240, 197, 10.1016/j.atherosclerosis.2015.03.019 Avagimyan, 2021, Hyperhomocysteinemia as a link of chemotherapy-related endothelium impairment, Curr Probl Cardiol Avagimyan, 2022, The Keystones of Right Ventricular Arrhythmogenic Cardiomyopathy-Induced Morphological Disarrangement, Curr Probl Cardiol, 47, 10.1016/j.cpcardiol.2022.101133 Abbasi, 2021, Liquid crystal based binding assay for detecting HIV-1 surface glycoprotein, Front Chem., 9, 10.3389/fchem.2021.668870 Anand, 2018, HIV proteins and endothelial dysfunction: implications in cardiovascular disease, Front Cardiovasc Med, 5, 185, 10.3389/fcvm.2018.00185 Roggero, 2001, Binding of human immunodeficiency virus type 1 gp120 to CXCR4 induces mitochondrial transmembrane depolarization and cytochrome c-mediated apoptosis independently of fas signaling, J Virol, 75, 7637, 10.1128/JVI.75.16.7637-7650.2001 Poznyak, 2022, Atherosclerosis in HIV patients: what do we know so far?, Int J Mol Sci, 23, 2504, 10.3390/ijms23052504 Hijmans, 2019, Effects of HIV-1 gp120 and TAT-derived microvesicles on endothelial cell function, J ApplPhysiol, 126, 1242 Rodríguez, 2019, The role of Lysyl oxidase enzymes in cardiac function and remodeling, Cells, 8, 1483, 10.3390/cells8121483 Masaki, 2006, Endothelin and endothelial dysfunction, Proc Jpn Acad Ser B Phys Biol Sci, 82, 17, 10.2183/pjab.82.17 Pirillo, 2013, LOX-1, OxLDL, and atherosclerosis, Mediators Inflamm, 2013, 10.1155/2013/152786 Mitra, 2011, Oxidized LDL, LOX-1 and atherosclerosis, Cardiovasc Drugs Ther., 25, 419, 10.1007/s10557-011-6341-5 Madzime, 2021, Interactions of HIV and antiretroviral therapy with neutrophils and platelets, Front Immunol., 12, 10.3389/fimmu.2021.634386 Marincowitz, 2019, Vascular endothelial dysfunction in the wake of HIV and ART, FEBS J, 286, 1256, 10.1111/febs.14657 Longenecker, 2018, Vascular disease and aging in HIV: time to extend the treatment cascade, Vasc Med, 23, 476, 10.1177/1358863X18789767 Ungvari, 2020, Mechanisms of vascular aging, A geroscience perspective: JACC focus seminar, J Am Coll Cardiol, 75, 931, 10.1016/j.jacc.2019.11.061 Rusnati, 2002, HIV-1 tat protein and endothelium: from protein/cell interaction to AIDS-associated pathologies, Angiogenesis, 5, 141, 10.1023/A:1023892223074 Libby, 2017, Interleukin-1 beta as a target for atherosclerosis therapy: biological basis of CANTOS and beyond, J Am Coll Cardiol, 70, 2278, 10.1016/j.jacc.2017.09.028 Hijmans, 2019, Effects of HIV-1 gp120 and TAT-derived microvesicles on endothelial cell function, J Appl Physiol, 126, 1242, 10.1152/japplphysiol.01048.2018 Park, 2016, Blockade of monocyte-endothelial trafficking by transduced Tat-superoxide dismutase protein, Int J Mol Med, 37, 387, 10.3892/ijmm.2015.2444 Prasad, 2015, Curcumin and its analogues: a potential natural compound against HIV infection and AIDS, Food Funct., 6, 3412, 10.1039/C5FO00485C Hsue, 2016, Inflammation and fibrosis in HIV: getting to the heart of the matter, Circ Cardiovasc Imaging, 9, 10.1161/CIRCIMAGING.116.004427 Cui, 2014, HIV protein Nef causes dyslipidemia and formation of foam cells in mouse models of atherosclerosis, FASEB J, 28, 2828, 10.1096/fj.13-246876 Duffy, 2009, HIV Nef protein causes endothelial dysfunction in porcine pulmonary arteries and human pulmonary artery endothelial cells, J Surg Res, 156, 257, 10.1016/j.jss.2009.02.005 Pushkarsky, 2017, Short communication: accumulation of neutral lipids in liver and aorta of Nef-transgenic mice, AIDS Res Hum Retroviruses, 33, 57, 10.1089/aid.2016.0128 Wang, 2015, Increased cardiovascular disease risk in the HIV-positive population on ART: potential role of HIV-Nef and Tat, Cardiovasc Pathol, 24, 279, 10.1016/j.carpath.2015.07.001 Chistiakov, 2017, Mechanisms of foam cell formation in atherosclerosis, J Mol Med (Berl), 95, 1153, 10.1007/s00109-017-1575-8 Maisa, 2015, Monocytes from HIV-infected individuals show impaired cholesterol efflux and increased foam cell formation after transendothelial migration, AIDS, 29, 1445, 10.1097/QAD.0000000000000739 Thomas, 2020, Monocytes from men living with HIV exhibit heightened atherogenic potential despite long-term viral suppression with antiretroviral therapy, AIDS, 34, 513, 10.1097/QAD.0000000000002460 Kearns, 2017, HIV-1-associated atherosclerosis: unraveling the missing link, J Am Coll Cardiol, 69, 3084, 10.1016/j.jacc.2017.05.012 Hemmat, 2018, Viral infection and atherosclerosis, Eur J Clin Microbiol Infect Dis, 37, 2225, 10.1007/s10096-018-3370-z Rosenfeld, 2011, Pathogens and atherosclerosis: update on the potential contribution of multiple infectious organisms to the pathogenesis of atherosclerosis, Thromb Haemost, 106, 858 Jung, 2022, Atherosclerosis by Virus Infection-A Short Review, Biomedicines, 10, 2634, 10.3390/biomedicines10102634 Jaworowski, 2019, How monocytes contribute to increased risk of atherosclerosis in virologically-suppressed HIV-positive individuals receiving combination antiretroviral therapy, Front Immunol., 10, 1378, 10.3389/fimmu.2019.01378 Margiana, 2022, Functions and therapeutic interventions of non-coding RNAs associated with TLR signaling pathway in atherosclerosis, Cell Signal, 100, 10.1016/j.cellsig.2022.110471 Ding, 2012, Toll-like receptor 4 deficiency decreases atherosclerosis but does not protect against inflammation in obese low-density lipoprotein receptor-deficient mice, Arterioscler Thromb Vasc Biol, 32, 1596, 10.1161/ATVBAHA.112.249847 Ishibashi, 2013, TLR3 deficiency protects against collagen degradation and medial destruction in murine atherosclerotic plaques, Atherosclerosis, 229, 52, 10.1016/j.atherosclerosis.2013.03.035 Karper, 2012, Blocking toll-like receptors 7 and 9 reduces postinterventional remodeling via reduced macrophage activation, foam cell formation, and migration, Arterioscler Thromb Vasc Biol, 32, e72, 10.1161/ATVBAHA.112.249391 Cole, 2011, Unexpected protective role for toll-like receptor 3 in the arterial wall, Proc Natl Acad Sci U S A, 108, 2372, 10.1073/pnas.1018515108 Salagianni, 2012, Toll-like receptor 7 protects from atherosclerosis by constraining “inflammatory” macrophage activation, Circulation, 126, 952, 10.1161/CIRCULATIONAHA.111.067678 Chow, 2016, Non-classical monocytes predict progression of carotid artery bifurcation intima-media thickness in HIV-infected individuals on stable antiretroviral therapy, HIV Clin Trials, 16, 114, 10.1080/15284336.2016.1162386 Pushkarsky, 2017, Short communication: accumulation of neutral lipids in the liver and aorta of Nef-transgenic mice, AIDS Res Hum Retroviruses, 33, 57, 10.1089/aid.2016.0128 Bernard, 2014, HIV-derived ssRNA binds to TLR8 to induce inflammation-driven macrophage foam cell formation, PloS One, 9, 10.1371/journal.pone.0104039 Koziolova, 2019, HIV-associated cardiovascular pathology, Russ J Cardiol, 5, 148, 10.15829/1560-4071-2019-11-148-154 Arzhakova, 2019, Coronary heart disease in HIV-Infected Patients, Ration Pharmacother Cardiol, 15, 900, 10.20996/1819-6446-2019-15-6-900-905 Lin, 2015, HIV inhibits endothelial reverse cholesterol transport through impacting subcellular Caveolin-1 trafficking, Retrovirology, 12, 62, 10.1186/s12977-015-0188-y Adzhubei, 2021, Direct interaction between ABCA1 and HIV-1 Nef: molecular modeling and virtual screening for inhibitors, Comput Struct Biotechnol J, 19, 3876, 10.1016/j.csbj.2021.06.050 Mukhamedova, 2016, Analysis of ABCA1 and cholesterol efflux in HIV-infected cells, Methods Mol Biol, 1354, 281, 10.1007/978-1-4939-3046-3_19 Bautista-Martínez, 2022, Contribution of APOA5, APOC3, CETP, ABCA1 and SIK3 genetic variants to hypertriglyceridemia development in Mexican HIV-patients receiving antiretroviral therapy, Pharmacogenet Genomics, 32, 101, 10.1097/FPC.0000000000000458 Adzhubei, 2018, Modelling interaction between HIV-1 Nef and calnexin, AIDS, 32, 2103, 10.1097/QAD.0000000000001951 Musikhina, 2019, Biochemical markers of inflammation in patients with acute coronary syndrome, Ateroscleroz., 15, 56 Ryabov, 2021, Atherosclerosis. Macrophages. Viral infections, Sib J Clin Exp Med, 36, 14, 10.29001/2073-8552-2021-36-2-14-22 Florent, 2023, Mechanisms of systemic low-grade inflammation in HIV patients on long-term suppressive antiretroviral therapy: the inflammasome hypothesis, AIDS, 37, 1035, 10.1097/QAD.0000000000003546 Shao, 2015, NLRP3 inflammasome and its inhibitors: a review, Front Pharmacol, 6, 262, 10.3389/fphar.2015.00262 Mangan, 2018, Targeting the NLRP3 inflammasome in inflammatory diseases, Nat Rev Drug Discov, 17, 588, 10.1038/nrd.2018.97 Séror, 2011, Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection, J Exp Med, 208, 1823, 10.1084/jem.20101805 Paoletti, 2019, HIV-1 envelope overcomes NLRP3-mediated inhibition of F-actin polymerization for viral entry, Cell Rep, 28, 3381, 10.1016/j.celrep.2019.02.095 Ekabe, 2021, The role of inflammasome activation in early HIV infection, J Immunol Res, 2021, 10.1155/2021/1487287 Suetomi, 2019, Inflammation in nonischemic heart disease: initiation by cardiomyocyte CaMKII and NLRP3 inflammasome signaling, Am J Physiol Heart Circ Physiol, 317, 877, 10.1152/ajpheart.00223.2019 Wang, 2020, NLRP3 inflammasome, an immune-inflammatory target in pathogenesis and treatment of cardiovascular diseases, Clin Transl Med, 10, 91, 10.1002/ctm2.13 Grebe, 2018, NLRP3 inflammasome and the IL-1 pathway in atherosclerosis, Circ Res, 122, 1722, 10.1161/CIRCRESAHA.118.311362 Hoseini, 2018, NLRP3 inflammasome: its regulation and involvement in atherosclerosis, J Cell Physiol, 233, 2116, 10.1002/jcp.25930 Martínez, 2018, The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation, Atherosclerosis, 269, 262, 10.1016/j.atherosclerosis.2017.12.027 Gong, 2011, Down-regulation of HIV-1 infection by inhibition of the MAPK signaling pathway, Virol Sin, 26, 114, 10.1007/s12250-011-3184-y Yang, 1999, ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB, J Biol Chem, 274, 27981, 10.1074/jbc.274.39.27981 Wu, 2021, The involvement of gaseous signaling molecules in plant MAPK cascades: function and signal transduction, Planta, 254, 127, 10.1007/s00425-021-03792-0 Sluiter, 2021, Endothelial barrier function and leukocyte transmigration in atherosclerosis, Biomedicines, 9, 328, 10.3390/biomedicines9040328 Dorota, 2014, Mitogen-activated protein kinases in atherosclerosis, Postepy Hig Med Dosw (online), 68, 10, 10.5604/17322693.1085463 Narasimhan, 2009, VEGF stimulates the ERK 1/2 signaling pathway and apoptosis in cerebral endothelial cells after ischemic conditions, Stroke, 40, 1467, 10.1161/STROKEAHA.108.534644 Kong, 2022, Effects of imbalance of lipid metabolism through NF-KB pathway on atherosclerosis and vascular aging in rats, Cell MolBiol (Noisy-le-grand), 67, 144, 10.14715/cmb/2021.67.5.20 Nixon, 2020, Systemic HIV and SIV latency reversal via non-canonical NF-κBsignalling in vivo, Nature, 578, 160, 10.1038/s41586-020-1951-3 Yang, 1999, Regulation of human immunodeficiency virus type 1 infectivity by the ERK mitogen-activated protein kinase signaling pathway, J Virol, 73, 3460, 10.1128/JVI.73.4.3460-3466.1999 Muslin, 2008, MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets, ClinSci (Lond), 115, 203, 10.1042/CS20070430 Sun, 2017, The non-canonical NF-κB pathway in immunity and inflammation, Nat Rev Immunol, 17, 545, 10.1038/nri.2017.52 Pache, 2020, Pharmacological activation of non-canonical NF-κB signaling activates latent HIV-1 reservoirs in vivo, Cell Rep Med, 1 Gupta, 2020, Role of the NF-kappaB signaling cascade and NF-kappaB-targeted genes in failing human hearts, J Mol Med (Berl), 98, 613, 10.1007/s00109-020-01901-2 Avagimyan, 2019, The role of viral infection in the mechanisms of initiation of atherogenesis and destabilization of atheroma, Cardiol Belarus, 11, 947 Hartmann, 2013, Spindle-shaped CD163+ rosetting macrophages replace CD4+ T-cells in HIV-related classical Hodgkin lymphoma, Mod Pathol, 26, 648, 10.1038/modpathol.2012.217 Skytthe, 2020, Targeting of CD163+ macrophages in inflammatory and malignant diseases, Int J Mol Sci, 21, 5497, 10.3390/ijms21155497 Guo, 2018, CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis, J Clin Invest, 128, 1106, 10.1172/JCI93025 Sluimer, 2009, Thin-walled microvessels in human coronary atherosclerotic plaques show incomplete endothelial junctions relevance of compromised structural integrity for intraplaque microvascular leakage, J Am Coll Cardiol, 53, 1517, 10.1016/j.jacc.2008.12.056 Guaraldi, 2011, Epicardial adipose tissue is an independent marker of cardiovascular risk in HIV-infected patients, AIDS, 25, 1199, 10.1097/QAD.0b013e3283474b9f