HEPATIC AMINOPYRINE N-DEMETHYLASE SYSTEM: INTERACTION OF AMINOPYRINE WITH MICROSOMAL CYTOCHROME P-450

Conney, 1971, Metabolism of normal body constituents by drug metabolizing enzymes in liver microsomes, 401 Fingl, 1975, Biotransformation of drugs, 11 Gunsalus, 1975, Cytochrome P-450cam substrate and effector interactions, Ann. N.Y, Acad. Sci., 212, 107, 10.1111/j.1749-6632.1973.tb47590.x Estabrook, 1973, Studies on the molecular function of cytochrome P-450 during drug metabolism, Drug Metab. Disp., 1, 98 Schenkman, 1967, Spectral studies of drug interaction with hepatic microsomal cytochromes, Mol. Pharmacol., 3, 113 Coon, 1969, Fatty acid w-oxidation in a soluble microsomal enzyme system containing P-450, 151 Yoshida, 1975, Studies on the substrate-induced spectral change of cytochrome P-450 in liver microsomes, J. Biochem., Tokyo, 78, 455, 10.1093/oxfordjournals.jbchem.a130928 Orrenius, 1965, On the mechanism of drug hydroxy-lation in rat liver microsomes, J. Cell Biol., 26, 713, 10.1083/jcb.26.3.713 Korten, 1973, Acute interaction drugs. I. The effects of volatile anesthetics on the kinetics of aniline hydroxylase and aminopyrine demethylase in rat hepatic microsomes, Biochem. Pharmacol., 22, 2105, 10.1016/0006-2952(73)90109-3 Matsubara, 1977, Hepatic aminopyrine N-demethylase system. Further studies of assay procedure, Japan. J. Pharmacol., 27, 127, 10.1254/jjp.27.127 Matsubara, 1977, Hepatic aminopyrine N-demethylase system. Effect of cyanide on microsomal N-demethylase activity, Japan. J. Pharmacol., 27, 701, 10.1254/jjp.27.701 Imai, 1967, Studies on the substrate interactions with P-450 in drug hydroxylation by liver microsomes, J. Biochem., Tokyo, 62, 239, 10.1093/oxfordjournals.jbchem.a128654 Pelkonen, 1973, Drug metabolism and drug-induced spectral interactions in human fetal liver microsomes, Biochem. Pharmacol., 22, 2357, 10.1016/0006-2952(73)90337-7 Short, 1976, Fetal and neonatal development of the microsomal mono-oxygenase system, Drug Metab. Rev., 5, 1, 10.3109/03602537608995838 Iba, 1977, Characteristics of the liver microsomal drug-metabolizing system of newborn rats, Mol. Pharmacol., 13, 1092 Hachino, 1981, pH-Dependent interaction of microsomal cytochrome P-450 with substrates. I. Effect of pH upon the interaction of exogenous substrates with membrane-bound cytochrome P-450, Chem.-Biol. Interact., 37, 181, 10.1016/0009-2797(81)90175-7 Gornall, 1949, Determination of serum proteins by means of the biuret reaction, J. biol. Chem., 177, 751, 10.1016/S0021-9258(18)57021-6 Omura, 1964, The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature, J. biol. Chem., 239, 2370, 10.1016/S0021-9258(20)82244-3 Schenkman, 1970, Studies on the nature of the type I and type II spectral changes in liver microsomes, Biochemistry, 9, 2081, 10.1021/bi00812a009 Inaba, 1980, Antipyrine metabolism in man. Simultaneous determination of norantipyrine and 4-hydroxyantipyrine in urine by gas chromatography, Canad. J. Physiol. Pharmacol., 58, 17, 10.1139/y80-004 Imai, 1966, Substrate interaction with hydroxylase system in liver microsomes, Biochem. biophys. Res. Commun., 22, 620, 10.1016/0006-291X(66)90191-4 Orrenius, 1972, On the significance of drug-induced spectral changes in liver microsomes, 55 Philpot, 1976, Separation and purification of two forms of hepatic cytochrome P-450 from untreated rabbits, Mol. Pharmacol., 12, 483 Warner, 1978, Chromatographic and electrophoretic hetero-geity of the cytochrome P-450 solubilized from untreated rat liver, Drug Metab. Disp., 6, 353 Gibson, 1978, Purification and properties of cytochrome P-450 obtained from untreated rats by lauric acid affinity chromatography, J. biol. Chem., 253, 5957, 10.1016/S0021-9258(17)34562-3 Teschke, 1976, Hepatic microsomal ethanol oxidizing system: Isolation and reconstitution, 103 Gibson, 1980, The influence of fatty acids and membrane lipids on the spin state of purified cytochrome P-450, 119 Jefcoate, 1971, pH-Dependent changes in the spin state of cytochrome P-450 from adrenal mitochondria, FEBS Lett., 12, 279, 10.1016/0014-5793(71)80199-0