HDAC inhibitors induce apoptosis in glucocorticoid-resistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway

Michael Tsapis1, Michèle Lieb1, Fabio Manzo1, Pattabhiraman Shankaranarayanan1, Raoul Herbrecht2, Patrick Lutz3, Hinrich Gronemeyer1
1Department of Cell Biology and Signal Transduction, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)/CNRS/INSERM/ULP, BP 10142, F-67404 Illkirch Cedex, C.U. de Strasbourg, France
2Départment of Hematology and Oncology, Hôpital de Hautepierre, Strasbourg, France
3Départment of Onco-Hematology, Pediatric Service 3, Hôpital de Hautepierre, Strasbourg, France

Tài liệu tham khảo

Altucci, 2005, Acute myeloid leukemia: Therapeutic impact of epigenetic drugs, Int. J. Biochem. Cell. Biol., 37, 1752, 10.1016/j.biocel.2005.04.019 Backs, 2006, CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy, J. Clin. Invest., 10.1172/JCI27438 Gurvich, 2004, Histone deacetylase is a target of valproic acid-mediated cellular differentiation, Cancer Res., 64, 1079, 10.1158/0008-5472.CAN-03-0799 Inoue, 2006, Inhibition of histone deacetylase class I but not class II is critical for the sensitization of leukemic cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis, Cancer Res., 66, 6785, 10.1158/0008-5472.CAN-05-4563 Insinga, 2005, Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway, Nat. Med., 11, 71, 10.1038/nm1160 Mai, 2005, Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides, J. Med. Chem., 48, 3344, 10.1021/jm049002a Marks, 2004, Histone deacetylase inhibitors: Development as cancer therapy, Novartis Found Symp., 259, 269, 10.1002/0470862637.ch20 McKinsey, 2006, Class II histone deacetylases confer signal responsiveness to the ankyrin-repeat proteins ANKRA2 and RFXANK, Mol. Biol. Cell., 17, 438, 10.1091/mbc.E05-07-0612 Minucci, 2006, Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer, Nat. Rev. Cancer, 6, 38, 10.1038/nrc1779 Nebbioso, 2005, Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells, Nat. Med., 11, 77, 10.1038/nm1161 Vega, 2004, Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis, Cell, 119, 555, 10.1016/j.cell.2004.10.024 Verdin, 2003, Class II histone deacetylases: Versatile regulators, Trends Genet., 19, 286, 10.1016/S0168-9525(03)00073-8 Yang, 2005, Class II histone deacetylases: From sequence to function, regulation, and clinical implication, Mol. Cell. Biol., 25, 2873, 10.1128/MCB.25.8.2873-2884.2005