H2O2-Responsive MB–BSA–Fe(III) Nanoparticles as Oxygen Generators for MRI-Guided Photodynamic Therapy
Tóm tắt
The local tumor hypoxia has become one of the main obstacles for photodynamic therapy (PDT).To break through this barrier, the fabrication of O2-evolving nanoplatform has been more significant. Herein, the uniform methylene blue (MB)–bovine serum albumin (BSA)–Fe(III) nanoparticles (MB–BSA–Fe(III) NPs) were successfully synthesized by biomineralization approach. MB–BSA–Fe(III) NPs show high loading capacity of MB, and Fe(ΙΙΙ) has excellent catalytic performance towards abundant H2O2 in cancer cells to generate O2, overcoming tumor hypoxia. All these combination effects remarkably increase the therapeutic efficiency of PDT, resulting in almost complete destruction of cancer cells. Most importantly, MB–BSA–Fe(III) NPs exhibit T2- magnetic resonance imaging, which have the potential for precise visualization of the tumor location. Our results demonstrate that MB–BSA–Fe(III) is a novel H2O2-responsive and O2-evolving nanoplatform and it has great potential for clinical applications such as cancer diagnosis, treatment or drug delivery.
Tài liệu tham khảo
Zhang Z, Wang J, Chen C. Near-infrared light-mediated nanoplatforms for cancer thermo-chemotherapy and optical imaging. Adv Mater. 2013;25:3869–80.
Peer D, Karp J, Hong S, Farokhzad O, Margalit R, Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat Nanotech. 2007;2:751–60.
Mitra A, Stables G. Topical photodynamic therapy for non-cancerous skin conditions. Photodiagn Photodyn. 2006;3:116–27.
Shen L, Huang Y, Chen D, Qiu F, Ma C, Jin X, Zhu X, Zhou G, Zhang Z. pH-responsive aerobic nanoparticles for effective photodynamic therapy. Theranostics. 2017;7:4537–50.
Liu Y, Liu Y, Bu W, Cheng C, Zuo C, Xiao Q, Sun Y, Ni D, Zhang C, Liu J, Shi J. Hypoxia induced by upconversion-based photodynamic therapy: towards highly effective synergistic bioreductive therapy in tumors. Angew Chem Int Ed. 2015;127:8223–7.
Ge J, Lan M, Zhou B, Liu W, Guo L, Wang H, Jia Q, Niu G, Huang X, Zhou H, Meng X, Wang P, Lee C, Zhang W, Han X. A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation. Nat. Commun. 2011;5:4596–603.
Schulze A, Harris A. How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature. 2012;491:364–73.
Wang Y, Yang T, Ke H, Zhu A, Wang Y, Wang J, Shen J, Liu G, Chen C, Zhao Y, Chen H. Nanocomposites: smart albumin-biomineralized nanocomposites for multimodal imaging and photothermal tumor ablation. Adv Mater. 2015;27:3841–9.
Wang Z, Huang P, Jacobson O, Wang Z, Liu Y, Lin L, Lin J, Lu N, Zhang H, Tian R, Niu G, Liu G, Chen X. Biomineralization-inspired synthesis of copper sulfide-ferritin nanocages as cancer theranostics. ACS Nano. 2016;10:3453–60.
Pan J, Wang Y, Pan H, Zhang C, Zhang X, Fu Y, Zhang X, Yu C, Sun S. X Yan. Mimicking drug–substrate interaction: a smart bioinspired technology for the fabrication of theranostic nanoprobes. Adv Funct Mater. 2017;27:1603440.
Chen Q, Liu Z. Albumin carriers for cancer theranostics: a conventional platform with new promise. Adv Mater. 2016;28:10557–66.
Wang D, Xue B, Kong X, Tu L, Liu X, Zhang Y, Chang Y, Luo Y, Zhao H, Zhang H. 808 nm driven Nd3+-sensitized upconversion nanostructures for photodynamic therapy and simultaneous fluorescence imaging. Nanoscale. 2015;7:190–7.
Kim J, Cho H, Jeon H, Kim D, Song C, Lee N, Choi S, Hyeon T. Continuous O2-evolving MnFe2O4 nanoparticle-anchored mesoporous silica nanoparticles for efficient photodynamic therapy in hypoxic cancer. J Am Chem Soc. 2017;139:10992–5.
Wang Y, Yang C, Yan X. Hydrothermal and biomineralization synthesis of a dual-modal nanoprobe for targeted near-infrared persistent luminescence and magnetic resonance imaging. Nanoscale. 2017;9:9049–55.
Chen Q, Feng L, Liu J, Zhu W, Dong Z, Wu Y, Liu Z. Intelligent albumin-MnO2 nanoparticles as pH-/H2O2-responsive dissociable nanocarriers to modulate tumor hypoxia for effective combination therapy. Adv Mater. 2016;28:7129–36.
Ma Z, Zhang M, Jia X, Bai J, Ruan Y, Wang C, Sun X, Jiang X. Fe(III) -doped two-dimensional C3N4 nanofusiform: a new O2-evolving and mitochondria-targeting photodynamic agent for MRI and enhanced antitumor therapy. Small. 2016;12:5477–87.
Yang G, Xu L, Chao Y, Xu J, Sun X, Wu Y, Peng R, Liu Z. Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses. Nat Commun. 2017;8:902–14.
Guo W, Qiu Z, Guo C, Ding D, Li T, Wang F, Sun J, Zheng N, Liu S. Multifunctional theranostic agent of Cu2(OH)PO4 quantum dots for photoacoustic image-guided photothermal/photodynamic combination cancer therapy. ACS Appl Mater Interfaces. 2017;9:9348–58.
Sheng Z, Hu D, Zheng M, Zhao P, Liu H, Gao D, Gong P, Gao G, Zhang P, Ma Y, Cai L. Smart human serum albumin-indocyanine green nanoparticles generated by programmed assembly for dual-modal imaging-guided cancer synergistic phototherapy. ACS Nano. 2014;8:12310–22.
Zhang C, Bu W, Ni D, Zhang S, Li Q, Yao Z, Zhang J, Yao H, Wang Z, Shi J. Synthesis of iron nanometallic glasses and their application in cancer therapy by a localized fenton reaction. Angew Chem Int Ed. 2016;128:2141–6.