H2‐receptor antagonists in the treatment of functional (nonulcer) dyspepsia: a meta‐analysis of randomized controlled clinical trials

Alimentary Pharmacology and Therapeutics - Tập 15 Số 9 - Trang 1291-1299 - 2001
Heather Redstone1, Nicholas Barrowman2, S J Veldhuyzen van Zanten1
1Division of Gastroenterology, Dalhousie University, Halifax, Nova Scotia
2Thomas Chalmers Centre for Systematic Review, Ottawa Ontario

Tóm tắt

Aim:To perform a meta‐analysis evaluating the efficacy of H2‐receptor antagonists in functional (nonulcer) dyspepsia.Selection of studies:A Medline search was used to identify placebo controlled randomized clinical trials, using the subject headings dyspepsia and H2‐receptor antagonist.Outcome measures:Global assessment by the patient of dyspepsia symptoms, improvement of epigastric pain and complete relief of epigastric pain.Results:Twenty‐two studies met the inclusion criteria, 15 of which reported the active drug to be superior to placebo. Many studies suffered from suboptimal study design. The odds ratio in favour of active drug was 1.48 (95% confidence interval: 0.9–2.3) for global assessment of dyspepsia symptoms, 2.3 (95% CI: 1.6–3.3) for improvement of epigastric pain, and 1.8 (95% CI: 1.2–2.8) for complete relief of epigastric pain.Conclusion:There is some evidence that H2‐receptor antagonists are superior to placebo in functional dyspepsia, but larger studies evaluating higher doses of H2‐receptor antagonists and of longer duration are necessary to determine the exact effect size.

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Tài liệu tham khảo

NyrenO LindbergG LindstromE et al.Economic costs of functional dyspepsia. In: PharmacoEconomics. Langhorne PA: Ad is International Ltd. 1992: 312–24.

Talley NJ, 1991, Functional dyspepsia: a classification with guidelines for diagnosis and management, Gastroenterol Int, 4, 145

10.1056/NEJM199012203232507

10.1002/(SICI)1097-0258(19980430)17:8<841::AID-SIM781>3.0.CO;2-D

10.1016/0197-2456(86)90046-2

10.3109/00365529708996530

10.3109/00365529509101587

10.3109/00365529108998616

10.3109/00365528809093840

10.1111/j.1572-0241.1998.00368.x

10.3109/00365529309101568

10.3109/00365529108996251

10.3109/00365528809099156

10.3109/00365528809093874

10.3109/00365529208999947

10.1111/j.0954-6820.1985.tb02696.x

10.3109/00365528509089627

10.1097/00004836-198608000-00006

10.3109/00365529108998597

10.1007/BF01296918

Muller P, 1994, Ranitidine in the treatment of non‐ulcer dyspepsia. A placebo‐controlled study in the Federal Republic Germany, Arzneimittelforschung, 44, 1130

10.3109/00365528509089708

10.1056/NEJM198602063140603

10.3109/00365528609093787

10.3109/00365528709090977

10.3109/00365528509103951

10.1046/j.1365-2036.1996.50192000.x

10.1136/bmj.292.6521.665

10.1185/03007998909110140

10.1016/0016-5085(86)90451-8

DeLattre M, 1985, Symptomatic treatment of non‐ulcer dyspepsia with cimetidine, Curr Ther Res, 37, 980

LaBrooyS LovellD MisiewiczJJ.The treatment of non‐ulcer dyspepsia. In: Wastell C Lance P eds. Cimetidine. The Westminster Hospital Symposium. London: Churchill Livingstone 1978: 131–40.

10.1097/00004836-198904000-00011

10.1097/00004836-199806000-00022

PoynardT MoryB LevoirW PiguouJP NaveauS ChaputJC.Randomized clinical trials in patients with dyspepsia. In: Non‐ulcer Dyspepsia: Pathophysiological Therapeutic Approaches. Paris: John Libbey Eurotext 1991: 227–37.

SooS MoayyediP DeeksJ DelaneyB InnesM FormanD.Pharmacological interventions for non‐ulcer dyspepsia (Cochrane Review).The Cochrane Library2001;1.

Veldhuyzen van Zanten SJO, 1996, Drug treatment of functional dyspepsia: a systematic analysis of trial methodology with recommendations for design of future trials, Am J Gastroenterol, 91, 660

Veldhuyzen van Zanten SJO, 1999, Design of treatment trials for functional gastrointestinal disorders, Gut, 45, 1169

10.3109/00365529309101568

10.1046/j.1365-2036.1998.00410.x

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Alimentary Pharmacology and Therapeutics

Tập 15 Số 9

1291-1299

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