Gut microbiota remodeling reverses aging-associated inflammation and dysregulation of systemic bile acid homeostasis in mice sex-specifically

Gut Microbes - Tập 11 Số 5 - Trang 1450-1474 - 2020
Junli Ma1, Ying Hong1, Ningning Zheng1, Guoxiang Xie2, Yuanzhi Lyu3, Yu Gu1, Chuchu Xi1, Linlin Chen1, Gaosong Wu1, Yue Li4, Xin Tao1, Jing Zhong1,5, Zhenzhen Huang6, Wenbin Wu6, Lin Yuan6, Min Lin6, Xiong Lü6, Weidong Zhang7,1, Jia Wang8,9, Lili Sheng1, Houkai Li1
1Functional Metabolomic and Gut Microbiome Laboratory, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China
2Human Metabolomics Institute, Inc, Shenzhen, Guangdong, China
3Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA, USA
4Department of Endocrinology, Shanghai Fifth People’s Hospital Affiliated to Fudan University, Shanghai, China
5Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Affiliated Cent Hospital Huzhou University, Huzhou, China
6Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, China
7Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai, China
8Hong Kong Traditional Chinese Medicine Phenome Research Centre, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
9Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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