Gut microbiota in the pathogenesis and therapeutic approaches of diabetes

Pitocco, 2020, The role of gut microbiota in mediating obesity and diabetes mellitus, Eur Rev Med Pharmacol Sci, 24, 1548 Le Chatelier, 2013, Richness of human gut microbiome correlates with metabolic markers, Nature, 500, 541, 10.1038/nature12506 Gadaleta, 2022, Bile salt hydrolase-competent probiotics in the management of IBD: unlocking the ‘bile acid code’, Nutrients, 14, 3212, 10.3390/nu14153212 Liu, 2021, The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis, Pharmacol Res, 165, 10.1016/j.phrs.2021.105420 Xiong, 2004, Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41, Proc Natl Acad Sci U S A, 101, 1045, 10.1073/pnas.2637002100 Perry, 2016, Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome, Nature, 534, 213, 10.1038/nature18309 Karlsson, 2013, Gut metagenome in European women with normal, impaired and diabetic glucose control, Nature, 498, 99, 10.1038/nature12198 Vinolo, 2012, Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice, Am J Physiol Endocrinol Metab, 303, E272, 10.1152/ajpendo.00053.2012 Vrieze, 2014, Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity, J Hepatol, 60, 824, 10.1016/j.jhep.2013.11.034 Tirosh, 2019, The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans, Sci Transl Med, 11, 10.1126/scitranslmed.aav0120 Yoshida, 2018, Bacteroides vulgatus and Bacteroides dorei reduce gut microbial lipopolysaccharide production and inhibit atherosclerosis, Circulation, 138, 2486, 10.1161/CIRCULATIONAHA.118.033714 Crudele, 2021, Visceral adiposity and cancer: role in pathogenesis and prognosis, Nutrients, 13, 2101, 10.3390/nu13062101 Pedersen, 2016, Human gut microbes impact host serum metabolome and insulin sensitivity, Nature, 535, 376, 10.1038/nature18646 Inagaki, 2006, Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor, Proc Natl Acad Sci U S A, 103, 3920, 10.1073/pnas.0509592103 Scheithauer, 2020, Gut microbiota as a trigger for metabolic inflammation in obesity and type 2 diabetes, Front Immunol, 11, 10.3389/fimmu.2020.571731 Raygan, 2018, The effects of probiotic supplementation on metabolic status in type 2 diabetic patients with coronary heart disease, Diabetol Metab Syndr, 10, 51, 10.1186/s13098-018-0353-2 Crudele, 2023, Low HDL-cholesterol levels predict hepatocellular carcinoma development in individuals with liver fibrosis, JHEP Rep, 5 Gurung, 2020, Role of gut microbiota in type 2 diabetes pathophysiology, eBioMedicine, 51, 10.1016/j.ebiom.2019.11.051 Qin, 2012, A metagenome-wide association study of gut microbiota in type 2 diabetes, Nature, 490, 55, 10.1038/nature11450 Jian, 2022, Gut microbiota predicts body fat change following a low-energy diet: a PREVIEW intervention study, Genome Med, 14, 54, 10.1186/s13073-022-01053-7 Zeevi, 2015, Personalized nutrition by prediction of glycemic responses, Cell, 163, 1079, 10.1016/j.cell.2015.11.001 Berry, 2020, Human postprandial responses to food and potential for precision nutrition, Nat Med, 26, 964, 10.1038/s41591-020-0934-0 Asnicar, 2021, Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals, Nat Med, 27, 321, 10.1038/s41591-020-01183-8 Dao, 2016, Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology, Gut, 65, 426, 10.1136/gutjnl-2014-308778 Haro, 2016, Two healthy diets modulate gut microbial community improving insulin sensitivity in a human obese population, J Clin Endocrinol Metab, 101, 233, 10.1210/jc.2015-3351 Zimmermann, 2019, Mapping human microbiome drug metabolism by gut bacteria and their genes, Nature, 570, 462, 10.1038/s41586-019-1291-3 Do, 2016, Beneficial effects of voglibose administration on body weight and lipid metabolism via gastrointestinal bile acid modification, Endocr J, 63, 691, 10.1507/endocrj.EJ15-0747 Smith, 2019, Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice, BMC Microbiol, 19, 130, 10.1186/s12866-019-1494-7 Zhang, 2017, Effects of acarbose on the gut microbiota of prediabetic patients: a randomized, double-blind, controlled crossover trial, Diabetes Ther Res Treat Educ Diabetes Relat Disord, 8, 293 Su, 2015, Acarbose treatment affects the serum levels of inflammatory cytokines and the gut content of bifidobacteria in Chinese patients with type 2 diabetes mellitus, J Diabetes, 7, 729 Aoki, 2017, A proliferative probiotic Bifidobacterium strain in the gut ameliorates progression of metabolic disorders via microbiota modulation and acetate elevation, Sci Rep, 7, 10.1038/srep43522 Zhao, 2018, A glucagon-like peptide-1 receptor agonist lowers weight by modulating the structure of gut microbiota, Front Endocrinol, 9, 233, 10.3389/fendo.2018.00233 Zhang, 2018, Featured article: structure moderation of gut microbiota in liraglutide-treated diabetic male rats, Exp Biol Med Maywood NJ, 243, 34, 10.1177/1535370217743765 Moreira, 2018, Liraglutide modulates gut microbiota and reduces NAFLD in obese mice, J Nutr Biochem, 62, 143, 10.1016/j.jnutbio.2018.07.009 Adeshirlarijaney, 2020, Considering gut microbiota in treatment of type 2 diabetes mellitus, Gut Microb, 11, 253, 10.1080/19490976.2020.1717719 Liao, 2019, Alteration of gut microbiota induced by DPP-4i treatment improves glucose homeostasis, eBioMedicine, 44, 665, 10.1016/j.ebiom.2019.03.057 Yan, 2016, Microflora disturbance during progression of glucose intolerance and effect of sitagliptin: an animal study, J Diabetes Res, 2016 van Bommel, 2020, Effects of 12-week treatment with dapagliflozin and gliclazide on faecal microbiome: results of a double-blind randomized trial in patients with type 2 diabetes, Diabetes Metab, 46, 164, 10.1016/j.diabet.2019.11.005 Lee, 2018, SGLT2 inhibition via dapagliflozin improves generalized vascular dysfunction and alters the gut microbiota in type 2 diabetic mice, Cardiovasc Diabetol, 17, 62, 10.1186/s12933-018-0708-x Wu, 2017, Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug, Nat Med, 23, 850, 10.1038/nm.4345 Hills, 2019, Gut microbiome: profound implications for diet and disease, Nutrients, 11, E1613, 10.3390/nu11071613 Elbere, 2020, Baseline gut microbiome composition predicts metformin therapy short-term efficacy in newly diagnosed type 2 diabetes patients, PLoS One, 15, 10.1371/journal.pone.0241338 Cao, 2020, Effects of non-insulin anti-hyperglycemic agents on gut microbiota: a systematic review on human and animal studies, Front Endocrinol, 11, 10.3389/fendo.2020.573891 Mueller, 2021, Metformin affects gut microbiome composition and function and circulating short-chain fatty acids: a randomized trial, Diabetes Care, 44, 1462, 10.2337/dc20-2257 Huang, 2018, Anthropometric and metabolic improvements in human type 2 diabetes after introduction of an Okinawan-based Nordic diet are not associated with changes in microbial diversity or SCFA concentrations, Int J Food Sci Nutr, 69, 729, 10.1080/09637486.2017.1408059 de la Cuesta-Zuluaga, 2017, Metformin is associated with higher relative abundance of mucin-degrading Akkermansia muciniphila and several short-chain fatty acid-producing microbiota in the gut, Diabetes Care, 40, 54, 10.2337/dc16-1324 Li, 2021, Brown adipose tissue is the key depot for glucose clearance in microbiota depleted mice, Nat Commun, 12, 4725, 10.1038/s41467-021-24659-8 Ejtahed, 2019, Metformin induces weight loss associated with gut microbiota alteration in non-diabetic obese women: a randomized double-blind clinical trial, Eur J Endocrinol, 180, 165, 10.1530/EJE-18-0826 Marzano, 2022, Farnesoid X receptor activation by the novel agonist TC-100 (3α, 7α, 11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid) preserves the intestinal barrier integrity and promotes intestinal microbial reshaping in a mouse model of obstructed bile acid flow, Biomed Pharmacother Biomedecine Pharmacother, 153 Gadaleta, 2020, Fibroblast Growth Factor 19 modulates intestinal microbiota and inflammation in presence of Farnesoid X Receptor, eBioMedicine, 54, 10.1016/j.ebiom.2020.102719 Pathak, 2018, Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism, Hepatol Baltim Md, 68, 1574, 10.1002/hep.29857 Gadaleta, 2019, Metabolic Messengers: fibroblast growth factor 15/19, Nat Metab, 1, 588, 10.1038/s42255-019-0074-3 Degirolamo, 2016, Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23, Nat Rev Drug Discov, 15, 51, 10.1038/nrd.2015.9 Crudele, 2023, Total serum FGF-21 levels positively relate to visceral adiposity differently from its functional intact form, Front Endocrinol, 14, 10.3389/fendo.2023.1159127 Sun, 2018, Gut microbiota and intestinal FXR mediate the clinical benefits of metformin, Nat Med, 24, 1919, 10.1038/s41591-018-0222-4 Forslund, 2015, Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota, Nature, 528, 262, 10.1038/nature15766 Degirolamo, 2014, Microbiota modification with probiotics induces hepatic bile acid synthesis via downregulation of the Fxr-Fgf15 axis in mice, Cell Rep, 7, 12, 10.1016/j.celrep.2014.02.032 Bryrup, 2019, Metformin-induced changes of the gut microbiota in healthy young men: results of a non-blinded, one-armed intervention study, Diabetologia, 62, 1024, 10.1007/s00125-019-4848-7 Arumugam, 2011, Enterotypes of the human gut microbiome, Nature, 473, 174, 10.1038/nature09944 De Matteis, 2023, Identification of a novel score for adherence to the mediterranean diet that is inversely associated with visceral adiposity and cardiovascular risk: the chrono med diet score (CMDS), Nutrients, 15, 1910, 10.3390/nu15081910 Dziewiecka, 2022, Physical activity induced alterations of gut microbiota in humans: a systematic review, BMC Sports Sci Med Rehabil, 14, 122, 10.1186/s13102-022-00513-2 Tiderencel, 2020, Probiotics for the treatment of type 2 diabetes: a review of randomized controlled trials., Diabetes Metab Res Rev, 36, 10.1002/dmrr.3213 Salgaço, 2019, Relationship between gut microbiota, probiotics, and type 2 diabetes mellitus, Appl Microbiol Biotechnol, 103, 9229, 10.1007/s00253-019-10156-y Cani, 2017, Next-generation beneficial microbes: the case of Akkermansia muciniphila, Front Microbiol, 8, 1765, 10.3389/fmicb.2017.01765 Asemi, 2013, Effect of multispecies probiotic supplements on metabolic profiles, hs-CRP, and oxidative stress in patients with type 2 diabetes, Ann Nutr Metab, 63, 1, 10.1159/000349922 Reimer, 2014, Combining sitagliptin/metformin with a functional fiber delays diabetes progression in Zucker rats, J Endocrinol, 220, 361, 10.1530/JOE-13-0484 Christensen, 2020, Microbial enterotypes beyond genus level: Bacteroides species as a predictive biomarker for weight change upon controlled intervention with arabinoxylan oligosaccharides in overweight subjects, Gut Microb, 12, 10.1080/19490976.2020.1847627 Gupta, 2017, Fecal microbiota transplantation, JAMA, 318, 102, 10.1001/jama.2017.6466 Svensson, 2022, The efficacy of faecal microbiota transplant and rectal bacteriotherapy in patients with recurrent clostridioides difficile infection: a retrospective cohort study, Cells, 11, 3272, 10.3390/cells11203272 Luo, 2020, Fecal microbiota transplantation for clostridioides difficile in high-risk older adults is associated with early recurrence, Dig Dis Sci, 65, 3647, 10.1007/s10620-020-06147-z de Groot, 2020, Donor metabolic characteristics drive effects of faecal microbiota transplantation on recipient insulin sensitivity, energy expenditure and intestinal transit time, Gut, 69, 502, 10.1136/gutjnl-2019-318320 Sabico, 2019, Effects of a 6-month multi-strain probiotics supplementation in endotoxemic, inflammatory and cardiometabolic status of T2DM patients: a randomized, double-blind, placebo-controlled trial, Clin Nutr Edinb Scotl, 38, 1561, 10.1016/j.clnu.2018.08.009 Szulińska, 2018, Dose-dependent effects of multispecies probiotic supplementation on the lipopolysaccharide (LPS) level and cardiometabolic profile in obese postmenopausal women: a 12-week randomized clinical trial, Nutrients, 10, E773, 10.3390/nu10060773 Kobyliak, 2018, Effect of alive probiotic on insulin resistance in type 2 diabetes patients: randomized clinical trial, Diabetes Metab Syndr, 12, 617, 10.1016/j.dsx.2018.04.015 Didesch, 2016, Peripheral neuropathy after fecal microbiota transplantation for Clostridium difficile infection: a case report, PM R, 8, 813, 10.1016/j.pmrj.2016.01.009