Gut microbiota composition is associated with body weight, weight gain and biochemical parameters in pregnant women

British Journal of Nutrition - Tập 104 Số 1 - Trang 83-92 - 2010
Arlette Santacruz1, María Carmen Collado1, Luz García‐Valdés2, María Moreno2, Jose A. Martín‐Lagos2, Tania Anjos2, M. Martí-Romero3, Rosario López3, J. Florido3, Cristina Campoy2, Yolanda Sanz1
1Microbial Ecophysiology and Nutrition Group, Institute of Agrochemistry and Food Technology (IATA), Spanish National Research Council (CSIC), Valencia, Spain
2Department of Paediatrics, School of Medicine, University of Granada, Granada, Spain
3Department of Obstetrics and Gynecology, School of Medicine, University of Granada, Granada, Spain

Tóm tắt

Obesity is associated with complications during pregnancy and increased health risks in the newborn. The objective of the present study was to establish possible relationships between gut microbiota, body weight, weight gain and biochemical parameters in pregnant women. Fifty pregnant women were classified according to their BMI in normal-weight (n34) and overweight (n16) groups. Gut microbiota composition was analysed by quantitative real-time PCR in faeces and biochemical parameters in plasma at 24 weeks of pregnancy. Reduced numbers ofBifidobacteriumandBacteroidesand increased numbers ofStaphylococcus,EnterobacteriaceaeandEscherichia coliwere detected in overweight compared with normal-weight pregnant women.E. colinumbers were higher in women with excessive weight gain than in women with normal weight gain during pregnancy, whileBifidobacteriumandAkkermansia muciniphilashowed an opposite trend. In the whole population, increased total bacteria andStaphylococcusnumbers were related to increased plasma cholesterol levels. IncreasedBacteroidesnumbers were related to increased HDL-cholesterol and folic acid levels, and reduced TAG levels. IncreasedBifidobacteriumnumbers were related to increased folic acid levels. IncreasedEnterobacteriaceaeandE. colinumbers were related to increased ferritin and reduced transferrin, whileBifidobacteriumlevels showed the opposite trend. Therefore, gut microbiota composition is related to body weight, weight gain and metabolic biomarkers during pregnancy, which might be of relevance to the management of the health of women and infants.

Từ khóa


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Thông tin
Thông tin xuất bản

British Journal of Nutrition

Tập 104 Số 1

83-92

Thông tin tác giả