Gut microbiome dysbiosis and endotoxemia - Additional pathophysiological explanation for increased COVID-19 severity in obesity

Asehnoune, 2004, Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B, J. Immunol., 172, 2522, 10.4049/jimmunol.172.4.2522 Belančić, 2018, Obesity-related low-grade chronic inflammation: implementation of the dietary inflammatory index in clinical practice is the milestone?, Medicina Fluminensis, 54, 373, 10.21860/medflum2018_207350 Belančić, 2020, Potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity, Obes Med, 19 Boutagy, 2016, Metabolic endotoxemia with obesity: is it real and is it relevant?, Biochimie, 124, 11, 10.1016/j.biochi.2015.06.020 dHennezel, 2017, Total lipopolysaccharide from the human gut microbiome silences toll-like receptor signaling, mSystems, 2 Koliada, 2017, Association between body mass index and Firmicutes/Bacteroidetes ratio in an adult Ukrainian population, BMC Microbiol., 17, 120, 10.1186/s12866-017-1027-1 Ley, 2006, Microbial ecology: human gut microbes associated with obesity, Nature, 444, 1022, 10.1038/4441022a Mazgaeen, 2020, Recent advances in lipopolysaccharide recognition systems, Int. J. Mol. Sci., 21, 379, 10.3390/ijms21020379 Moreira, 2012, Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxemia, Br. J. Nutr., 108, 801, 10.1017/S0007114512001213 Nagpal, 2018, Obesity-linked gut microbiome dysbiosis associated with derangements in gut permeability and intestinal cellular homeostasis independent of diet, J Diabetes Res, 2018, 10.1155/2018/3462092 Petruk, 2020, SARS-CoV-2 Spike protein binds to bacterial lypopolysaccharide and boosts proinflammatory activity, bioRxiv Popkin, 2020, Individuals with obesity and COVID-19: a global perspective on the epidemiology and biological relationships, Obes. Rev., 10.1111/obr.13128 Qin, 2010, A human gut microbial gene catalog established by metagenomic sequencing, Nature, 464, 59, 10.1038/nature08821 Rohr, 2020, Negative effects of a high-fat diet on intestinal permeability: a review, Adv Nutr, 11, 77, 10.1093/advances/nmz061 Verdam, 2013, Human intestinal microbiota composition is associated with local and systemic inflammation in obesity, Obesity, 21, E607, 10.1002/oby.20466