Gut microbiome and tissue metabolomics reveal the compatibility effects of Xiaoyaosan on depression based on “gut-liver-kidney” axis

2019, Altered bile acid profile associates with cognitive impairment in alzheimer's disease-An emerging role for gut microbiome, Alzheimers Dement, 15, 76, 10.1016/j.jalz.2018.07.217 Aydin, 2021, An overview of the behavioral, neurobiological and morphological effects of topiramate in rats exposed to chronic unpredictable mild stress, Eur. J. Pharmacol., 912, 10.1016/j.ejphar.2021.174578 Beyoğlu, 2013, The metabolomic window into hepatobiliary disease, J. Hepatol., 59, 842, 10.1016/j.jhep.2013.05.030 Barandouzi, 2020, Altered composition of gut microbiota in depression: a systematic review, Front. Psychiatry., 11, 541, 10.3389/fpsyt.2020.00541 Cui, 2010, Optimal dose for anti-depression effect of Xiaoyaosan, Chin. J. Exp. Tradit. Med. Formulae., 16, 194 Chen, 2021, Safflower extract improves depression in mice by inhibiting the TLR4-NLRP3 inflammation signaling pathway, Ann Palliat Med, 10, 8015, 10.21037/apm-21-1728 2021, Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic, Lancet, 398, 1700, 10.1016/S0140-6736(21)02143-7 Ding, 2021, A next-generation probiotic: akkermansia muciniphila ameliorates chronic stress-induced depressive-like behavior in mice by regulating gut microbiota and metabolites, Appl. Microbiol. Biot., 105, 8411, 10.1007/s00253-021-11622-2 Duan, 2021, Characterization of gut microbiome in mice model of depression with divergent response to escitalopram treatment, Transl. Psychiat., 11, 303, 10.1038/s41398-021-01428-1 Du, 2022, Mechanisms of Zhenwu decoction for the treatment of renal fibrosis at various stages: what is the role of Corynebacterium?, Front. Microbiol., 13, 10.3389/fmicb.2022.913465 Elbassuoni, 2018, Evidence of the protective effect of l-arginine and vitamin D against monosodium glutamate-induced liver and kidney dysfunction in rats, Biomed. Pharmacother., 108, 799, 10.1016/j.biopha.2018.09.093 Geng, 2020, Systematic impacts of chronic unpredictable mild stress on metabolomics in rats, Sci. Rep-UK., 10, 700, 10.1038/s41598-020-57566-x Ito, 2019, Conventional culture methods with commercially available media unveil the presence of novel culturable bacteria, Gut Microbes, 10, 77, 10.1080/19490976.2018.1491265 Kadriu, 2019, Glutamatergic neurotransmission: pathway to developing novel rapid-acting antidepressant treatments, Int. J. Neuropsychoph., 22, 119, 10.1093/ijnp/pyy094 Kim, 2020, Relationships between depression, family function, physical symptoms, and illness uncertainty in female patients with chronic kidney disease, Nurs. Health Sci., 22, 548, 10.1111/nhs.12691 Kurtoglu Ozdes, 2020, A stereological study of the effects of antidepressants on postmenopausal rat kidney, Biotech. Histochem., 95, 262, 10.1080/10520295.2019.1680865 Kameoka, 2021, Benchmark of 16S rRNA gene amplicon sequencing using Japanese gut microbiome data from the V1-V2 and V3-V4 primer sets, BMC Genomics, 22, 527, 10.1186/s12864-021-07746-4 Liu, 2012, Anti-depressant effects of Xiaoyaosan on rat model of chronic unpredictable mild stress: a plasma metabonomics study based on NMR spectroscopy, J. Pharm. Pharmacol., 64, 578, 10.1111/j.2042-7158.2011.01412.x Liu, 2015, Plasma-metabolite-biomarkers for the therapeutic response in depressed patients by the traditional Chinese medicine formula Xiaoyaosan: a 1H NMR-based metabolomics approach, J. Affect. Disord., 185, 156, 10.1016/j.jad.2015.05.005 Lima-Ojeda, 2017, I am I and my bacterial circumstances: linking gut microbiome, neurodevelopment, and depression, Front. Psychiatry., 8, 153, 10.3389/fpsyt.2017.00153 Litvak, 2017, Dysbiotic Proteobacteria expansion: a microbial signature of epithelial dysfunction, Curr. Opin. Microbiol., 39, 1, 10.1016/j.mib.2017.07.003 Lau, 2018, The phosphate binder ferric citrate alters the gut microbiome in rats with chronic kidney disease, J. Pharmacol. Exp. Ther., 367, 3452, 10.1124/jpet.118.251389 Li, 2018, A novel forming method of traditional Chinese medicine dispersible tablets to achieve rapid disintegration based on the powder modification principle, Sci. Rep-UK., 8, 10319, 10.1038/s41598-018-28734-x Lu, 2018, Agomelatine-induced modulation of brain-derived neurotrophic factor (BDNF) in the rat hippocampus, Life Sci., 210, 177, 10.1016/j.lfs.2018.09.003 Liu, 2019, Brain metabonomics study of the antidepressant-like effect of Xiaoyaosan on the CUMS-depression rats by 1H NMR analysis, J. Ethnopharmacol., 235, 141, 10.1016/j.jep.2019.01.018 Liu, 2020, Plasma metabolomics of depressed patients and treatment with Xiaoyaosan based on mass spectrometry technique, J. Ethnopharmacol., 246, 10.1016/j.jep.2019.112219 Li, 2021, Analysis of the effects of Shengyang Sanhuo Decoction and its disassembled prescriptions on behavior and intestinal flora of mice with chronic fatigue syndrome, J. Tradit. Chin. Med., 44, 908 Liu, 2021, Anti-depressive effects of Xiaoyaosan, Shugan and Jianpi herbal treatments: role on the gut microbiome of CUMS rats, Phytomedicine, 87, 10.1016/j.phymed.2021.153581 Liu, 2021, Hepatic metabolomics of the compatibility effect of Xiaoyaosan on CUMS-induced depression based on the TCM theory of “Treating diseases via regulating the liver's function, J. Pharmaceut. Biomed., 201, 10.1016/j.jpba.2021.114123 Liu, 2021, Blautia-a new functional genus with potential probiotic properties?, Gut Microbes, 13, 1, 10.1080/19490976.2021.1875796 Liu, 2021, Lactiplantibacillus plantarum reduced renal calcium oxalate stones by regulating arginine metabolism in gut microbiota, Front. Microbiol., 12 Marmiroli, 2012, The glutamatergic neurotransmission in the central nervous system, Curr. Med. Chen., 19, 1269, 10.2174/092986712799462711 Mayoral-Mariles, 2012, Plasma amino acid levels discriminate between control subjects and mildly depressed elderly women, Arch. Med. Res., 43, 375, 10.1016/j.arcmed.2012.07.006 Meng, 2020, A novel approach based on metabolomics coupled with intestinal flora analysis and network pharmacology to explain the mechanisms of action of Bekhogainsam decoction in the improvement of symptoms of Streptozotocin-induced diabetic nephropathy in mice, Front. Pharmacol., 11, 633, 10.3389/fphar.2020.00633 Ozato, 2022, Two Blautia species associated with visceral fat accumulation: a one-year longitudinal study, Biology (Basel), 11, 318 Popolo, 2014, l-Arginine and its metabolites in kidney and cardiovascular disease, Amino Acids, 46, 2271, 10.1007/s00726-014-1825-9 Raj, 2019, The gut-liver-kidney axis: novel regulator of fatty liver associated chronic kidney disease, Pharmacol. Res., 152 Rosenthal, 2019, A network of SLC and ABC transporter and DME genes involved in remote sensing and signaling in the gut-liver-kidney axis, Sci. Rep-UK., 9, 11879, 10.1038/s41598-019-47798-x Singh, 2021, Anti-depressant like effects of quercetin 4’-O-glucoside from Allium cepa via regulation of brain oxidative stress and monoamine levels in mice subjected to unpredictable chronic mild stress, Nutr. Neurosci., 24, 35, 10.1080/1028415X.2019.1587247 Wang, 2018, Regulation of the kynurenine metabolism pathway by Xiaoyao San and the underlying effect in the hippocampus of the depressed rat, J. Ethnopharmacol., 214, 13, 10.1016/j.jep.2017.11.037 Wang, 2019, The prevalence of depression and the association between depression and kidney function and health-related quality of life in elderly patients with chronic kidney disease: a multicenter cross-sectional study, Clin. Interv. Aging., 14, 905, 10.2147/CIA.S203186 Xin, 2018, Research situation in compatibility mechanism of traditional Chinese medicine compound preparations, Chin. J. New Drugs., 27, 2895 Yang, 2019, MicroRNA-99a is a potential target for regulating hypothalamic synaptic plasticity in the peri/postmenopausal depression model, Cells, 8, 1081, 10.3390/cells8091081 Zhang, 2021, Decreased abundance of Akkermansia muciniphila leads to the impairment of insulin secretion and glucose homeostasis in lean type 2 diabetes, Adv. Sci. (Weinh.)., 8 Zhang, 2021, Association of depressive symptoms with rapid kidney function decline in adults with normal kidney function, Clin. J. Am. Soc. Nephro., 16, 889, 10.2215/CJN.18441120 Zhou, 2021, Xiaoyaosan decoction alleviated rat liver fibrosis via the TGFβ/Smad and Akt/FoxO3 signaling pathways based on network pharmacology analysis, J. Ethnopharmacol., 264, 10.1016/j.jep.2020.113021 Zhu, 2021, Xiaoyaosan exerts therapeutic effects on the colon of chronic restraint stress model rats via the regulation of immunoinflammatory activation induced by the TLR4/NLRP3 inflammasome signaling pathway, Evid. Based Compl. Alt., 2021