Gut barrier disruption and chronic disease

Lopez-Otin, 2021, Hallmarks of health, Cell, 184, 33, 10.1016/j.cell.2020.11.034 Knoop, 2018, Goblet cells: multifaceted players in immunity at mucosal surfaces, Mucosal Immunol., 11, 1551, 10.1038/s41385-018-0039-y Paone, 2020, Mucus barrier, mucins and gut microbiota: the expected slimy partners?, Gut, 69, 2232, 10.1136/gutjnl-2020-322260 Bevins, 2011, Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis, Nat. Rev. Microbiol., 9, 356, 10.1038/nrmicro2546 Allaire, 2018, The intestinal epithelium: central coordinator of mucosal immunity, Trends Immunol., 39, 677, 10.1016/j.it.2018.04.002 Yoon, 2014, Protective role of gut commensal microbes against intestinal infections, J. Microbiol., 52, 983, 10.1007/s12275-014-4655-2 Kosiewicz, 2014, Relationship between gut microbiota and development of T cell associated disease, FEBS Lett., 588, 4195, 10.1016/j.febslet.2014.03.019 Stefka, 2014, Commensal bacteria protect against food allergen sensitization, Proc. Natl. Acad. Sci. U. S. A., 111, 13145, 10.1073/pnas.1412008111 Camilleri, 2019, Leaky gut: mechanisms, measurement and clinical implications in humans, Gut, 68, 1516, 10.1136/gutjnl-2019-318427 Zuo, 2020, Tight junctions as targets and effectors of mucosal immune homeostasis, Cell Mol. Gastroenterol. Hepatol., 10, 327, 10.1016/j.jcmgh.2020.04.001 Madara, 1987, Structural basis for physiological regulation of paracellular pathways in intestinal epithelia, J. Membr. Biol., 100, 149, 10.1007/BF02209147 Hietbrink, 2009, Systemic inflammation increases intestinal permeability during experimental human endotoxemia, Shock, 32, 374, 10.1097/SHK.0b013e3181a2bcd6 Turner, 2009, Intestinal mucosal barrier function in health and disease, Nat. Rev. Immunol., 9, 799, 10.1038/nri2653 Guttman, 2009, Tight junctions as targets of infectious agents, Biochim. Biophys. Acta, 1788, 832, 10.1016/j.bbamem.2008.10.028 O'Hara, 2008, Mechanisms of intestinal tight junctional disruption during infection, Front. Biosci., 13, 7008 Odenwald, 2013, Intestinal permeability defects: is it time to treat?, Clin. Gastroenterol. Hepatol., 11, 1075, 10.1016/j.cgh.2013.07.001 Ye, 2016, Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility, Expert. Rev. Clin. Immunol., 12, 1091, 10.1080/1744666X.2016.1184972 Childers, 2014, Family history of inflammatory bowel disease among patients with ulcerative colitis: a systematic review and meta-analysis, J. Crohns Colitis, 8, 1480, 10.1016/j.crohns.2014.05.008 Velcich, 2002, Colorectal cancer in mice genetically deficient in the mucin Muc2, Science, 295, 1726, 10.1126/science.1069094 Van der Sluis, 2006, Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection, Gastroenterology, 131, 117, 10.1053/j.gastro.2006.04.020 Johansson, 2010, Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model, PLoS One, 5, 10.1371/journal.pone.0012238 Khan, 2020, Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice, Sci. Transl. Med., 12, 10.1126/scitranslmed.aay6218 van der Post, 2019, Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis, Gut, 68, 2142, 10.1136/gutjnl-2018-317571 Vrakas, 2017, Intestinal bacteria composition and translocation of bacteria in inflammatory bowel disease, PLoS One, 12, 10.1371/journal.pone.0170034 Leonard, 2017, Celiac disease and nonceliac gluten sensitivity: a review, JAMA, 318, 647, 10.1001/jama.2017.9730 Sallese, 2020, Beyond the HLA genes in gluten-related disorders, Front Nutr., 7, 10.3389/fnut.2020.575844 Uhde, 2016, Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease, Gut, 65, 1930, 10.1136/gutjnl-2016-311964 Slavin, 2008, Position of the American Dietetic Association: health implications of dietary fiber, J. Am. Diet. Assoc., 108, 1716, 10.1016/j.jada.2008.08.007 Eaton, 2006, The ancestral human diet: what was it and should it be a paradigm for contemporary nutrition?, Proc. Nutr. Soc., 65, 1, 10.1079/PNS2005471 Sonnenburg, 2014, Starving our microbial self: the deleterious consequences of a diet deficient in microbiota-accessible carbohydrates, Cell Metab., 20, 779, 10.1016/j.cmet.2014.07.003 Sonnenburg, 2005, Glycan foraging in vivo by an intestine-adapted bacterial symbiont, Science, 307, 1955, 10.1126/science.1109051 Peng, 2009, Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers, J. Nutr., 139, 1619, 10.3945/jn.109.104638 Martinez-Medina, 2014, Western diet induces dysbiosis with increased E. coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation, Gut, 63, 116, 10.1136/gutjnl-2012-304119 Jena, 2018, Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity, FASEB J., 32, 2866, 10.1096/fj.201700984RR Glade, 2016, A glance at ... dietary emulsifiers, the human intestinal mucus and microbiome, and dietary fiber, Nutrition, 32, 609, 10.1016/j.nut.2015.12.036 Raimondi, 2008, Bile acids modulate tight junction structure and barrier function of Caco-2 monolayers via EGFR activation, Am. J. Physiol. Gastrointest. Liver Physiol., 294, G906, 10.1152/ajpgi.00043.2007 Stenman, 2013, A novel mechanism for gut barrier dysfunction by dietary fat: epithelial disruption by hydrophobic bile acids, Am. J. Physiol. Gastrointest. Liver Physiol., 304, G227, 10.1152/ajpgi.00267.2012 Chassaing, 2015, Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome, Nature, 519, 92, 10.1038/nature14232 Cho, 2019, Fructose promotes leaky gut, endotoxemia, and liver fibrosis through ethanol-inducible cytochrome P450-2E1-mediated oxidative and nitrative stress, Hepatology, 73, 2180, 10.1002/hep.30652 Hu, 2017, Enteric dysbiosis-linked gut barrier disruption triggers early renal injury induced by chronic high salt feeding in mice, Exp. Mol. Med., 49, 10.1038/emm.2017.122 Shil, 2020, Artificial sweeteners disrupt tight junctions and barrier function in the intestinal epithelium through activation of the sweet taste receptor, T1R3, Nutrients, 12, 1862, 10.3390/nu12061862 Cani, 2007, Metabolic endotoxemia initiates obesity and insulin resistance, Diabetes, 56, 1761, 10.2337/db06-1491 Rohr, 2020, Negative effects of a high-fat diet on intestinal permeability: a review, Adv. Nutr., 11, 77, 10.1093/advances/nmz061 Amar, 2008, Energy intake is associated with endotoxemia in apparently healthy men, Am. J. Clin. Nutr., 87, 1219, 10.1093/ajcn/87.5.1219 Sato, 2017, Probiotic reduces bacterial translocation in type 2 diabetes mellitus: a randomised controlled study, Sci. Rep., 7, 12115, 10.1038/s41598-017-12535-9 Thaiss, 2018, Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection, Science, 359, 1376, 10.1126/science.aar3318 Pang, 2017, Significant positive association of endotoxemia with histological severity in 237 patients with non-alcoholic fatty liver disease, Aliment. Pharmacol. Ther., 46, 175, 10.1111/apt.14119 Wiedermann, 1999, Association of endotoxemia with carotid atherosclerosis and cardiovascular disease: prospective results from the Bruneck Study, J. Am. Coll. Cardiol., 34, 1975, 10.1016/S0735-1097(99)00448-9 Sorini, 2019, Loss of gut barrier integrity triggers activation of islet-reactive T cells and autoimmune diabetes, Proc. Natl. Acad. Sci. U. S. A., 116, 15140, 10.1073/pnas.1814558116 Bosi, 2006, Increased intestinal permeability precedes clinical onset of type 1 diabetes, Diabetologia, 49, 2824, 10.1007/s00125-006-0465-3 Fine, 2020, Mechanisms and consequences of gut commensal translocation in chronic diseases, Gut Microbes, 11, 217, 10.1080/19490976.2019.1629236 Yokogawa, 2014, Epicutaneous application of toll-like receptor 7 agonists leads to systemic autoimmunity in wild-type mice: a new model of systemic lupus erythematosus, Arthritis Rheumatol., 66, 694, 10.1002/art.38298 Manfredo Vieira, 2018, Translocation of a gut pathobiont drives autoimmunity in mice and humans, Science, 359, 1156, 10.1126/science.aar7201 Mangalam, 2017, Human gut-derived commensal bacteria suppress CNS inflammatory and demyelinating disease, Cell Rep., 20, 1269, 10.1016/j.celrep.2017.07.031 Ramirez-Bosca, 2015, Identification of bacterial DNA in the peripheral blood of patients with active psoriasis, JAMA Dermatol., 151, 670, 10.1001/jamadermatol.2014.5585 Tajik, 2020, Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis, Nat. Commun., 11, 1995, 10.1038/s41467-020-15831-7 Matei, 2021, Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease, Med. (N Y), 2, 864 Minami, 2011, Intakes of vitamin B6 and dietary fiber and clinical course of systemic lupus erythematosus: a prospective study of Japanese female patients, J. Epidemiol., 21, 246, 10.2188/jea.JE20100157 Ruff, 2020, Host-microbiota interactions in immune-mediated diseases, Nat. Rev. Microbiol., 18, 521, 10.1038/s41579-020-0367-2 Zegarra-Ruiz, 2019, A diet-sensitive commensal Lactobacillus strain mediates TLR7-dependent systemic autoimmunity, Cell Host Microbe, 25, 113, 10.1016/j.chom.2018.11.009 Marino, 2017, Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes, Nat. Immunol., 18, 552, 10.1038/ni.3713 Utzeri, 2017, Role of non-steroidal anti-inflammatory drugs on intestinal permeability and nonalcoholic fatty liver disease, World J. Gastroenterol., 23, 3954, 10.3748/wjg.v23.i22.3954 Llorente, 2017, Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus, Nat. Commun., 8, 837, 10.1038/s41467-017-00796-x Bajaj, 2019, Alcohol, liver disease and the gut microbiota, Nat. Rev. Gastroenterol. Hepatol., 16, 235, 10.1038/s41575-018-0099-1 Da Silva, 2014, Stress disrupts intestinal mucus barrier in rats via mucin O-glycosylation shift: prevention by a probiotic treatment, Am. J. Physiol. Gastrointest. Liver Physiol., 307, G420, 10.1152/ajpgi.00290.2013 Gareau, 2007, Neonatal maternal separation of rat pups results in abnormal cholinergic regulation of epithelial permeability, Am. J. Physiol. Gastrointest. Liver Physiol., 293, G198, 10.1152/ajpgi.00392.2006 Vanuytsel, 2014, Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism, Gut, 63, 1293, 10.1136/gutjnl-2013-305690 Sun, 2019, Stress triggers flare of inflammatory bowel disease in children and adults, Front. Pediatr., 7, 432, 10.3389/fped.2019.00432 Gareau, 2008, Pathophysiological mechanisms of stress-induced intestinal damage, Curr. Mol. Med., 8, 274, 10.2174/156652408784533760 Costantini, 2010, Efferent vagal nerve stimulation attenuates gut barrier injury after burn: modulation of intestinal occludin expression, J. Trauma, 68, 1349 Gao, 2019, Role of melatonin in sleep deprivation-induced intestinal barrier dysfunction in mice, J. Pineal Res., 67, 10.1111/jpi.12574 Pietroiusti, 2006, Shift work increases the frequency of duodenal ulcer in H. pylori infected workers, Occup. Environ. Med., 63, 773, 10.1136/oem.2006.027367 Knutsson, 2010, Gastrointestinal disorders among shift workers, Scand. J. Work Environ. Health, 36, 85, 10.5271/sjweh.2897 Kervezee, 2020, Metabolic and cardiovascular consequences of shift work: the role of circadian disruption and sleep disturbances, Eur. J. Neurosci., 51, 396, 10.1111/ejn.14216 Panda, 2016, Circadian physiology of metabolism, Science, 354, 1008, 10.1126/science.aah4967 Zarrinpar, 2016, Daily eating patterns and their impact on health and disease, Trends Endocrinol. Metab., 27, 69, 10.1016/j.tem.2015.11.007 Summa, 2013, Disruption of the circadian clock in mice increases intestinal permeability and promotes alcohol-induced hepatic pathology and inflammation, PLoS One, 8, 10.1371/journal.pone.0067102 Rudzki, 2020, The microbiota-gut-immune-glia (MGIG) axis in major depression, Mol. Neurobiol., 57, 4269, 10.1007/s12035-020-01961-y Schachter, 2017, Effects of obesity on depression: a role for inflammation and the gut microbiota, Brain Behav. Immun., 69, 1, 10.1016/j.bbi.2017.08.026 Maes, 2012, Increased IgA and IgM responses against gut commensals in chronic depression: further evidence for increased bacterial translocation or leaky gut, J. Affect. Disord., 141, 55, 10.1016/j.jad.2012.02.023 Maes, 2008, The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression, Neuro Endocrinol. Lett., 29, 117 Rao, 2009, A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome, Gut. Pathog., 1, 6, 10.1186/1757-4749-1-6 Severance, 2015, Gastroenterology issues in schizophrenia: why the gut matters, Curr. Psychiatry Rep., 17, 27, 10.1007/s11920-015-0574-0 Ohlsson, 2019, Leaky gut biomarkers in depression and suicidal behavior, Acta Psychiatr. Scand., 139, 185, 10.1111/acps.12978 Hsiao, 2013, Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders, Cell, 155, 1451, 10.1016/j.cell.2013.11.024 Costa, 2017, Systematic review: exercise-induced gastrointestinal syndrome-implications for health and intestinal disease, Aliment. Pharmacol. Ther., 46, 246, 10.1111/apt.14157 Stewart, 2017, Alterations in intestinal permeability: the role of the "leaky gut" in health and disease, J. Equine Vet. Sci., 52, 10, 10.1016/j.jevs.2017.02.009 Teerapornpuntakit, 2009, Endurance swimming stimulates transepithelial calcium transport and alters the expression of genes related to calcium absorption in the intestine of rats, Am. J. Physiol. Endocrinol. Metab., 296, E775, 10.1152/ajpendo.90904.2008 Otani, 2019, Gut integrity in critical illness, J. Intensive Care, 7, 17, 10.1186/s40560-019-0372-6 Sovran, 2019, Age-associated impairment of the mucus barrier function is associated with profound changes in microbiota and immunity, Sci. Rep., 9, 1437, 10.1038/s41598-018-35228-3 He, 2020, Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway, Nat. Commun., 11, 37, 10.1038/s41467-019-13911-x Wilmanski, 2021, Gut microbiome pattern reflects healthy ageing and predicts survival in humans, Nat. Metab., 3, 274, 10.1038/s42255-021-00348-0 Franceschi, 2017, Inflammaging and 'garb-aging', Trends Endocrinol. Metab., 28, 199, 10.1016/j.tem.2016.09.005 Franceschi, 2018, Inflammaging: a new immune-metabolic viewpoint for age-related diseases, Nat. Rev. Endocrinol., 14, 576, 10.1038/s41574-018-0059-4 Qi, 2017, Intestinal permeability biomarker zonulin is elevated in healthy aging, J. Am. Med. Dir. Assoc., 18, e1, 10.1016/j.jamda.2017.05.018 Thevaranjan, 2017, Age-associated microbial dysbiosis promotes intestinal permeability, systemic inflammation, and macrophage dysfunction, Cell Host Microbe, 21, 455, 10.1016/j.chom.2017.03.002 Brockmann, 2017, Regulation of TH17 cells and associated cytokines in wound healing, tissue regeneration, and carcinogenesis, Int. J. Mol. Sci., 18, 1033, 10.3390/ijms18051033 Kelly, 2015, Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders, Front. Cell. Neurosci., 9, 392, 10.3389/fncel.2015.00392 Rera, 2012, Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila, Proc. Natl. Acad. Sci. U. S. A., 109, 21528, 10.1073/pnas.1215849110 Dambroise, 2016, Two phases of aging separated by the Smurf transition as a public path to death, Sci. Rep., 6, 23523, 10.1038/srep23523 Doig, 1998, Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients, Am. J. Respir. Crit. Care Med., 158, 444, 10.1164/ajrccm.158.2.9710092 Fink, 2005, Epithelial barrier dysfunction: a unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level, Crit. Care Clin., 21, 177, 10.1016/j.ccc.2005.01.005 Sonnenburg, 2019, The ancestral and industrialized gut microbiota and implications for human health, Nat. Rev. Microbiol., 17, 383, 10.1038/s41579-019-0191-8 Krawczyk, 2018, Gut permeability might be improved by dietary fiber in individuals with nonalcoholic fatty liver disease (NAFLD) undergoing weight reduction, Nutrients, 10, 1793, 10.3390/nu10111793 Martel, 2020, Phytochemicals as prebiotics and biological stress inducers, Trends Biochem. Sci., 45, 462, 10.1016/j.tibs.2020.02.008 Wang, 2017, Curcumin improves intestinal barrier function: modulation of intracellular signaling, and organization of tight junctions, Am. J. Physiol. Cell Physiol., 312, C438, 10.1152/ajpcell.00235.2016 Mayangsari, 2018, Resveratrol ameliorates intestinal barrier defects and inflammation in colitic mice and intestinal cells, J. Agric. Food Chem., 66, 12666, 10.1021/acs.jafc.8b04138 Singh, 2019, Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway, Nat. Commun., 10, 89, 10.1038/s41467-018-07859-7 Kosińska, 2013, Modulation of tight junction integrity by food components, Food Res. Int., 54, 951, 10.1016/j.foodres.2012.12.038 Freed, 1999, Do dietary lectins cause disease?, BMJ, 318, 1023, 10.1136/bmj.318.7190.1023 Cario, 2004, Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C, Gastroenterology, 127, 224, 10.1053/j.gastro.2004.04.015 Ritchie, 2012, A meta-analysis of probiotic efficacy for gastrointestinal diseases, PLoS One, 7, 10.1371/journal.pone.0034938 Zhang, 2020, Efficacy of probiotics on stress in healthy volunteers: a systematic review and meta-analysis based on randomized controlled trials, Brain Behav., 10, 10.1002/brb3.1699 Butler, 2019, Man and the microbiome: a new theory of everything?, Annu. Rev. Clin. Psychol., 15, 371, 10.1146/annurev-clinpsy-050718-095432 Liu, 2018, Efficacy of probiotics on anxiety—a meta-analysis of randomized controlled trials, Depress. Anxiety, 35, 935, 10.1002/da.22811 Freedman, 2018, Multicenter trial of a combination probiotic for children with gastroenteritis, N. Engl. J. Med., 379, 2015, 10.1056/NEJMoa1802597 Schnadower, 2018, Lactobacillus rhamnosus GG versus placebo for acute gastroenteritis in children, N. Engl. J. Med., 379, 2002, 10.1056/NEJMoa1802598 Wu, 2019, Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis, Gut, 68, 248, 10.1136/gutjnl-2017-315458 Depommier, 2019, Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study, Nat. Med., 25, 1096, 10.1038/s41591-019-0495-2 Plovier, 2017, A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice, Nat. Med., 23, 107, 10.1038/nm.4236 Fink, 2014, Strategies to improve drug development for sepsis, Nat. Rev. Drug Discov., 13, 741, 10.1038/nrd4368 Noth, 2012, Anti-TNF-alpha antibodies improve intestinal barrier function in Crohn's disease, J. Crohns Colitis, 6, 464, 10.1016/j.crohns.2011.10.004 Zhou, 2019, Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome, Gut, 68, 996, 10.1136/gutjnl-2017-315136 Hamarneh, 2017, Intestinal alkaline phosphatase attenuates alcohol-induced hepatosteatosis in mice, Dig. Dis. Sci., 62, 2021, 10.1007/s10620-017-4576-0 Ott, 2017, Effect of caloric restriction on gut permeability, inflammation markers, and fecal microbiota in obese women, Sci. Rep., 7, 11955, 10.1038/s41598-017-12109-9 Wei, 2017, Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease, Sci. Transl. Med., 9, 10.1126/scitranslmed.aai8700 Rangan, 2019, Fasting-mimicking diet modulates microbiota and promotes intestinal regeneration to reduce inflammatory bowel disease pathology, Cell Rep., 26, 2704, 10.1016/j.celrep.2019.02.019 Ren, 2019, Alteration in gut microbiota caused by time-restricted feeding alleviate hepatic ischaemia reperfusion injury in mice, J. Cell. Mol. Med., 23, 1714, 10.1111/jcmm.14069 Willing, 2011, Shifting the balance: antibiotic effects on host-microbiota mutualism, Nat. Rev. Microbiol., 9, 233, 10.1038/nrmicro2536 Jakobsson, 2010, Short-term antibiotic treatment has differing long-term impacts on the human throat and gut microbiome, PLoS One, 5, 10.1371/journal.pone.0009836 Tanes, 2021, Role of dietary fiber in the recovery of the human gut microbiome and its metabolome, Cell Host Microbe, 29, 394, 10.1016/j.chom.2020.12.012 Brown, 2013, Meta-analysis of antibiotics and the risk of community-associated Clostridium difficile infection, Antimicrob. Agents Chemother., 57, 2326, 10.1128/AAC.02176-12 Droste, 2000, Does the use of antibiotics in early childhood increase the risk of asthma and allergic disease?, Clin. Exp. Allergy, 30, 1547, 10.1046/j.1365-2222.2000.00939.x Del Fiol, 2018, Obesity: a new adverse effect of antibiotics?, Front. Pharmacol., 9, 1408, 10.3389/fphar.2018.01408 Joshipura, 2017, Over-the-counter mouthwash use and risk of pre-diabetes/diabetes, Nitric Oxide, 71, 14, 10.1016/j.niox.2017.09.004 Joshipura, 2020, Over-the-counter mouthwash use, nitric oxide and hypertension risk, Blood Press., 29, 103, 10.1080/08037051.2019.1680270 Inczefi, 2020, Targeted intestinal tight junction hyperpermeability alters the microbiome, behavior, and visceromotor responses, Cell Mol. Gastroenterol. Hepatol., 10, 206, 10.1016/j.jcmgh.2020.02.008 Jakobsson, 2015, The composition of the gut microbiota shapes the colon mucus barrier, EMBO Rep., 16, 164, 10.15252/embr.201439263 Mor, 2017, Impact of glycemic control on risk of infections in patients with type 2 diabetes: a population-based cohort study, Am. J. Epidemiol., 186, 227, 10.1093/aje/kwx049 Giron, 2021, Plasma markers of disrupted gut permeability in severe COVID-19 patients, Front. Immunol, 12, 686240, 10.3389/fimmu.2021.686240 Lewis, 2020, Intestinal barrier dysfunction as a therapeutic target for cardiovascular disease, Am. J. Physiol. Heart Circ. Physiol., 319, H1227, 10.1152/ajpheart.00612.2020 Fasano, 2011, Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer, Physiol. Rev., 91, 151, 10.1152/physrev.00003.2008 Desai, 2016, A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility, Cell, 167, 1339, 10.1016/j.cell.2016.10.043 Boirivant, 2008, A transient breach in the epithelial barrier leads to regulatory T-cell generation and resistance to experimental colitis, Gastroenterology, 135, 1612, 10.1053/j.gastro.2008.07.028 Lee, 2018, Hypoxia-induced intestinal barrier changes in balloon-assisted enteroscopy, J. Physiol., 596, 3411, 10.1113/JP275277 Calabrese, 2001, Hormesis: a generalizable and unifying hypothesis, Crit. Rev. Toxicol., 31, 353, 10.1080/20014091111730 Son, 2008, Hormetic dietary phytochemicals, NeuroMolecular Med., 10, 236, 10.1007/s12017-008-8037-y Calabrese, 2017, How does hormesis impact biology, toxicology, and medicine?, NPJ Aging Mech. Dis., 3, 13, 10.1038/s41514-017-0013-z Martel, 2019, Hormetic effects of phytochemicals on health and longevity, Trends Endocrinol. Metab., 30, 335, 10.1016/j.tem.2019.04.001 Li, 2019, Hormesis in health and chronic diseases, Trends Endocrinol. Metab., 30, 944, 10.1016/j.tem.2019.08.007 Spaeth, 1990, Food without fiber promotes bacterial translocation from the gut, Surgery, 108, 240 Spaeth, 1990, Bulk prevents bacterial translocation induced by the oral administration of total parenteral nutrition solution, JPEN J. Parenter. Enteral Nutr., 14, 442, 10.1177/0148607190014005442 Boza, 1999, Food deprivation and refeeding influence growth, nutrient retention and functional recovery of rats, J. Nutr., 129, 1340, 10.1093/jn/129.7.1340 Deitch, 1994, Bacterial translocation: the influence of dietary variables, Gut, 35, S23, 10.1136/gut.35.1_Suppl.S23 MacFie, 2004, Current status of bacterial translocation as a cause of surgical sepsis, Br. Med. Bull., 71, 1, 10.1093/bmb/ldh029 Moore, 1989, Rapid barrier restitution in an in vitro model of intestinal epithelial injury, Lab. Investig., 60, 237 Wells, 2017, Homeostasis of the gut barrier and potential biomarkers, Am. J. Physiol. Gastrointest. Liver Physiol., 312, G171, 10.1152/ajpgi.00048.2015 Chen, 2017, Acrolein disrupts tight junction proteins and causes endoplasmic reticulum stress-mediated epithelial cell death leading to intestinal barrier dysfunction and permeability, Am. J. Pathol., 187, 2686, 10.1016/j.ajpath.2017.08.015 Man, 2015, Age-associated modifications of intestinal permeability and innate immunity in human small intestine, Clin. Sci. (Lond.), 129, 515, 10.1042/CS20150046 Bode, 1987, Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess, J. Hepatol., 4, 8, 10.1016/S0168-8278(87)80003-X Feng, 2019, Antibiotics induced intestinal tight junction barrier dysfunction is associated with microbiota dysbiosis, activated NLRP3 inflammasome and autophagy, PLoS One, 14, 10.1371/journal.pone.0218384 Chen, 2012, Myosin light chain kinase mediates intestinal barrier disruption following burn injury, PLoS One, 7 Viaud, 2013, The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide, Science, 342, 971, 10.1126/science.1240537 Deaver, 2018, Circadian disruption changes gut microbiome taxa and functional gene composition, Front. Microbiol., 9, 737, 10.3389/fmicb.2018.00737 Zheng, 2013, Corticosterone mediates stress-related increased intestinal permeability in a region-specific manner, Neurogastroenterol. Motil., 25, e127, 10.1111/nmo.12066 Li, 2017, Upregulation of intestinal barrier function in mice with DSS-induced colitis by a defined bacterial consortium is associated with expansion of IL-17A producing gamma delta T cells, Front. Immunol., 8, 824, 10.3389/fimmu.2017.00824 Camus, 1997, Mild endotoxaemia and the inflammatory response induced by a marathon race, Clin. Sci. (Lond.), 92, 415, 10.1042/cs0920415 Gill, 2015, Circulatory endotoxin concentration and cytokine profile in response to exertional-heat stress during a multi-stage ultra-marathon competition, Exerc. Immunol. Rev., 21, 114 Alscher, 2001, Enteral feeding decreases gut apoptosis, permeability, and lung inflammation during murine endotoxemia, Am. J. Physiol. Gastrointest. Liver Physiol., 281, G569, 10.1152/ajpgi.2001.281.2.G569 Hodin, 2011, Starvation compromises Paneth cells, Am. J. Pathol., 179, 2885, 10.1016/j.ajpath.2011.08.030 Kavanagh, 2013, Dietary fructose induces endotoxemia and hepatic injury in calorically controlled primates, Am. J. Clin. Nutr., 98, 349, 10.3945/ajcn.112.057331 Skodje, 2018, Fructan, rather than gluten, induces symptoms in patients with self-reported non-celiac gluten sensitivity, Gastroenterology, 154, 529, 10.1053/j.gastro.2017.10.040 Hollon, 2015, Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity, Nutrients, 7, 1565, 10.3390/nu7031565 Hall, 2001, Mechanisms of circulatory and intestinal barrier dysfunction during whole body hyperthermia, Am. J. Physiol. Heart Circ. Physiol., 280, H509, 10.1152/ajpheart.2001.280.2.H509 Pendyala, 2012, A high-fat diet is associated with endotoxemia that originates from the gut, Gastroenterology, 142, 1100, 10.1053/j.gastro.2012.01.034 Bowser, 2020, Serum endotoxin, gut permeability and skeletal muscle metabolic adaptations following a short term high fat diet in humans, Metabolism, 103, 10.1016/j.metabol.2019.154041 Laffin, 2019, A high-sugar diet rapidly enhances susceptibility to colitis via depletion of luminal short-chain fatty acids in mice, Sci. Rep., 9, 12294, 10.1038/s41598-019-48749-2 Ramadass, 2010, Sucrose co-administration reduces the toxic effect of lectin on gut permeability and intestinal bacterial colonization, Dig. Dis. Sci., 55, 2778, 10.1007/s10620-010-1359-2 Patel, 2002, Potato glycoalkaloids adversely affect intestinal permeability and aggravate inflammatory bowel disease, Inflamm. Bowel Dis., 8, 340, 10.1097/00054725-200209000-00005 Sigthorsson, 1998, Intestinal permeability and inflammation in patients on NSAIDs, Gut, 43, 506, 10.1136/gut.43.4.506 Frankel, 1995, Fiber: effect on bacterial translocation and intestinal mucin content, World J. Surg., 19, 144, 10.1007/BF00317001 Joly Condette, 2014, Increased gut permeability and bacterial translocation after chronic chlorpyrifos exposure in rats, PLoS One, 9, 10.1371/journal.pone.0102217 Konishi, 2003, Modulations of food-derived substances on intestinal permeability in Caco-2 cell monolayers, Biosci. Biotechnol. Biochem., 67, 2297, 10.1271/bbb.67.2297 Noval Rivas, 2019, Intestinal permeability and IgA provoke immune vasculitis linked to cardiovascular inflammation, Immunity, 51, 508, 10.1016/j.immuni.2019.05.021 Graham, 2019, Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis, Nat. Med., 25, 690, 10.1038/s41591-019-0393-7 Moussaoui, 2014, Changes in intestinal glucocorticoid sensitivity in early life shape the risk of epithelial barrier defect in maternal-deprived rats, PLoS One, 9, 10.1371/journal.pone.0088382 Suzuki, 2018, Survival of mice with gastrointestinal acute radiation syndrome through control of bacterial translocation, J. Immunol., 201, 77, 10.4049/jimmunol.1701515 Guzman-Stein, 1989, Abdominal radiation causes bacterial translocation, J. Surg. Res., 46, 104, 10.1016/0022-4804(89)90211-4 Ban, 2012, Protective role of p70S6K in intestinal ischemia/reperfusion injury in mice, PLoS One, 7, 10.1371/journal.pone.0041584 Zuo, 2014, Cigarette smoking is associated with intestinal barrier dysfunction in the small intestine but not in the large intestine of mice, J. Crohns Colitis, 8, 1710, 10.1016/j.crohns.2014.08.008 Fricker, 2018, Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction, JCI Insight, 3, 10.1172/jci.insight.94040 Stanley, 2016, Translocation and dissemination of commensal bacteria in post-stroke infection, Nat. Med., 22, 1277, 10.1038/nm.4194 Bansal, 2010, Stimulating the central nervous system to prevent intestinal dysfunction after traumatic brain injury, J. Trauma, 68, 1059 O'Boyle, 1998, Microbiology of bacterial translocation in humans, Gut, 42, 29, 10.1136/gut.42.1.29 Sequeira, 2015, Ascorbic acid may exacerbate aspirin-induced increase in intestinal permeability, Basic Clin. Pharmacol. Toxicol., 117, 195, 10.1111/bcpt.12388 Amasheh, 2010, TNFalpha-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFkappaB signaling, J. Cell Sci., 123, 4145, 10.1242/jcs.070896 Lewis, 2010, Enhanced translocation of bacteria across metabolically stressed epithelia is reduced by butyrate, Inflamm. Bowel Dis., 16, 1138, 10.1002/ibd.21177 Gigli, 2017, Cannabidiol restores intestinal barrier dysfunction and inhibits the apoptotic process induced by Clostridium difficile toxin A in Caco-2 cells, U. Eur. Gastroenterol. J., 5, 1108, 10.1177/2050640617698622 Feng, 2019, Curcumin prevents high-fat diet-induced hepatic steatosis in ApoE(-/-) mice by improving intestinal barrier function and reducing endotoxin and liver TLR4/NF-kappaB inflammation, Nutr. Metab. (Lond.), 16, 79, 10.1186/s12986-019-0410-3 Satchithanandam, 1990, Alteration of gastrointestinal mucin by fiber feeding in rats, J. Nutr., 120, 1179, 10.1093/jn/120.10.1179 Catterson, 2018, Short-term, intermittent fasting induces long-lasting gut health and TOR-independent lifespan extension, Curr. Biol., 28, 1714, 10.1016/j.cub.2018.04.015 Liu, 2020, Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment, Nat. Commun., 11, 855, 10.1038/s41467-020-14676-4 Sundqvist, 1982, Influence of fasting on intestinal permeability and disease activity in patients with rheumatoid arthritis, Scand. J. Rheumatol., 11, 33, 10.3109/03009748209098111 Craven, 2020, Allogenic fecal microbiota transplantation in patients with nonalcoholic fatty liver disease improves abnormal small intestinal permeability: a randomized control trial, Am. J. Gastroenterol., 115, 1055, 10.14309/ajg.0000000000000661 Woo, 2016, Fermented barley and soybean (BS) mixture enhances intestinal barrier function in dextran sulfate sodium (DSS)-induced colitis mouse model, BMC Complement. Altern. Med., 16, 498, 10.1186/s12906-016-1479-0 Monk, 2019, Fish oil supplementation to a high-fat diet improves both intestinal health and the systemic obese phenotype, J. Nutr. Biochem., 72, 10.1016/j.jnutbio.2019.07.007 Scaldaferri, 2014, Gelatin tannate ameliorates acute colitis in mice by reinforcing mucus layer and modulating gut microbiota composition: Emerging role for 'gut barrier protectors' in IBD?, U. Eur. Gastroenterol. J., 2, 113, 10.1177/2050640614520867 Chang, 2015, Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota, Nat. Commun., 6, 7489, 10.1038/ncomms8489 Dong, 2014, The intestinal epithelial insulin-like growth factor-1 receptor links glucagon-like peptide-2 action to gut barrier function, Endocrinology, 155, 370, 10.1210/en.2013-1871 Quan, 2004, Effect of glutamine on change in early postoperative intestinal permeability and its relation to systemic inflammatory response, World J. Gastroenterol., 10, 1992, 10.3748/wjg.v10.i13.1992 Lima, 2005, Intestinal barrier function and weight gain in malnourished children taking glutamine supplemented enteral formula, J. Pediatr. Gastroenterol. Nutr., 40, 28, 10.1097/00005176-200501000-00006 Ikeda, 2018, Hydrogen-rich saline regulates intestinal barrier dysfunction, dysbiosis, and bacterial translocation in a murine model of sepsis, Shock, 50, 640, 10.1097/SHK.0000000000001098 Chen, 2021, Gut flora-targeted photobiomodulation therapy improves senile dementia in an Ass-induced Alzheimer's disease animal model, J. Photochem. Photobiol. B, 216, 10.1016/j.jphotobiol.2021.112152 Sturgeon, 2017, Zonulin transgenic mice show altered gut permeability and increased morbidity/mortality in the DSS colitis model, Ann. N. Y. Acad. Sci., 1397, 130, 10.1111/nyas.13343 Arakawa, 2019, Lubiprostone as a potential therapeutic agent to improve intestinal permeability and prevent the development of atherosclerosis in apolipoprotein E-deficient mice, PLoS One, 14, 10.1371/journal.pone.0218096 Kato, 2017, Lubiprostone improves intestinal permeability in humans, a novel therapy for the leaky gut: a prospective randomized pilot study in healthy volunteers, PLoS One, 12, 10.1371/journal.pone.0175626 Cannon, 2016, Effects of mesalamine treatment on gut barrier integrity after burn injury, J. Burn. Care Res., 37, 283, 10.1097/BCR.0000000000000396 Khare, 2019, Mesalamine and azathioprine modulate junctional complexes and restore epithelial barrier function in intestinal inflammation, Sci. Rep., 9, 2842, 10.1038/s41598-019-39401-0 Igarashi, 2019, NAD(+) supplementation rejuvenates aged gut adult stem cells, Aging Cell, 18, 10.1111/acel.12935 Costantini, 2012, Targeting alpha-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury, Am. J. Pathol., 181, 478, 10.1016/j.ajpath.2012.04.005 Suzuki, 2009, Quercetin enhances intestinal barrier function through the assembly of zonula [corrected] occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells, J. Nutr., 139, 965, 10.3945/jn.108.100867 Diao, 2012, Rebamipide suppresses diclofenac-induced intestinal permeability via mitochondrial protection in mice, World J. Gastroenterol., 18, 1059, 10.3748/wjg.v18.i10.1059 Ma, 2020, Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice, Gut Microbes, 12, 1, 10.1080/19490976.2020.1832857 `Sayoc-Becerra, 2020, The JAK-inhibitor tofacitinib rescues human intestinal epithelial cells and colonoids from cytokine-induced barrier dysfunction, Inflamm. Bowel Dis., 26, 407, 10.1093/ibd/izz266 Krzyzaniak, 2011, Postinjury vagal nerve stimulation protects against intestinal epithelial barrier breakdown, J. Trauma, 70, 1168 Conlin, 2009, Vasoactive intestinal peptide ameliorates intestinal barrier disruption associated with Citrobacter rodentium-induced colitis, Am. J. Physiol. Gastrointest. Liver Physiol., 297, G735, 10.1152/ajpgi.90551.2008 Kong, 2008, Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier, Am. J. Physiol. Gastrointest. Liver Physiol., 294, G208, 10.1152/ajpgi.00398.2007 Raftery, 2015, Effects of vitamin D supplementation on intestinal permeability, cathelicidin and disease markers in Crohn's disease: results from a randomised double-blind placebo-controlled study, U. Eur. Gastroenterol. J., 3, 294, 10.1177/2050640615572176 Zhao, 2012, Protective role of 1,25(OH)2 vitamin D3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice, BMC Gastroenterol., 12, 57, 10.1186/1471-230X-12-57 Southcott, 2008, Yoghurts containing probiotics reduce disruption of the small intestinal barrier in methotrexate-treated rats, Dig. Dis. Sci., 53, 1837, 10.1007/s10620-008-0275-1 Wiegand, 2017, Zinc treatment is efficient against Escherichia coli alpha-haemolysin-induced intestinal leakage in mice, Sci. Rep., 7, 45649, 10.1038/srep45649