Gut Microbiota and the Paradox of Cancer Immunotherapy

2014, World Cancer Report 2014

Hanahan, 2000, The hallmarks of cancer, Cell, 100, 57, 10.1016/S0092-8674(00)81683-9

Bissell, 2001, Putting tumours in context, Nat Rev Cancer, 1, 46, 10.1038/35094059

Hanahan, 2011, Hallmarks of cancer: the next generation, Cell, 144, 646, 10.1016/j.cell.2011.02.013

Erdman, 2010, Roles for inflammation and regulatory T cells in colon cancer, Toxicol Pathol, 38, 76, 10.1177/0192623309354110

Hanahan, 2012, Accessories to the crime: functions of cells recruited to the tumor microenvironment, Cancer Cell, 21, 309, 10.1016/j.ccr.2012.02.022

Balkwill, 2001, Inflammation and cancer: back to Virchow?, Lancet, 357, 539, 10.1016/S0140-6736(00)04046-0

Balkwill, 2004, Cancer: an inflammatory link, Nature, 431, 405, 10.1038/431405a

Balkwill, 2004, Cancer and the chemokine network, Nat Rev Cancer, 4, 540, 10.1038/nrc1388

Erdman, 2010, Cancer inflammation and regulatory T cells, Int J Cancer, 127, 768, 10.1002/ijc.25430

Colotta, 2009, Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability, Carcinogenesis, 30, 1073, 10.1093/carcin/bgp127

Curiel, 2008, Regulatory T cells and treatment of cancer, Curr Opin Immunol, 20, 241, 10.1016/j.coi.2008.04.008

Whiteside, 2012, What are regulatory T cells (Treg) regulating in cancer and why?, Semin Cancer Biol, 22, 327, 10.1016/j.semcancer.2012.03.004

Mougiakakos, 2010, Regulatory T cells in cancer, Adv Cancer Res, 107, 57, 10.1016/S0065-230X(10)07003-X

Colombo, 2007, Regulatory-T-cell inhibition versus depletion: the right choice in cancer immunotherapy, Nat Rev Cancer, 7, 880, 10.1038/nrc2250

Nishikawa, 2014, Regulatory T cells in cancer immunotherapy, Curr Opin Immunol, 27C, 1, 10.1016/j.coi.2013.12.005

Gajewski, 2012, Innate immune sensing of cancer: clues from an identified role for type I IFNs, Cancer Immunol Immunother, 61, 1343, 10.1007/s00262-012-1305-6

Sakaguchi, 2008, Regulatory T cells and immune tolerance, Cell, 133, 775, 10.1016/j.cell.2008.05.009

Roncador, 2005, Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level, Eur J Immunol, 35, 1681, 10.1002/eji.200526189

Gavin, 2006, Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development, Proc Natl Acad Sci U S A, 103, 6659, 10.1073/pnas.0509484103

Miyara, 2009, Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor, Immunity, 30, 899, 10.1016/j.immuni.2009.03.019

Kleinewietfeld, 2013, The plasticity of human Treg and Th17 cells and its role in autoimmunity, Semin Immunol, 25, 305, 10.1016/j.smim.2013.10.009

Curiel, 2004, Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival, Nat Med, 10, 942, 10.1038/nm1093

Hodi, 2010, Overcoming immunological tolerance to melanoma: targeting CTLA-4, Asia Pac J Clin Oncol, 6, S16, 10.1111/j.1743-7563.2010.01271.x

Hodi, 2008, Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients, Proc Natl Acad Sci U S A, 105, 3005, 10.1073/pnas.0712237105

Liakou, 2008, CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients, Proc Natl Acad Sci U S A, 105, 14987, 10.1073/pnas.0806075105

Quezada, 2006, CTLA4 blockade and Gm-Csf combination immunotherapy alters the intratumor balance of effector and regulatory T cells, J Clin Invest, 116, 1935, 10.1172/JCI27745

Kavanagh, 2008, CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion, Blood, 112, 1175, 10.1182/blood-2007-11-125435

Schwartzentruber, 2011, gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma, N Engl J Med, 364, 2119, 10.1056/NEJMoa1012863

Salama, 2009, Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer, J Clin Oncol, 27, 186, 10.1200/JCO.2008.18.7229

Badoual, 2009, Revisiting the prognostic value of regulatory T cells in patients with cancer, J Clin Oncol, 27, e5, 10.1200/JCO.2009.23.0680

Whiteside, 2012, Disarming suppressor cells to improve immunotherapy, Cancer Immunol Immunother, 61, 283, 10.1007/s00262-011-1171-7

Leffers, 2009, Prognostic significance of tumor-infiltrating T-lymphocytes in primary and metastatic lesions of advanced stage ovarian cancer, Cancer Immunol Immunother, 58, 449, 10.1007/s00262-008-0583-5

Wilke, 2010, Prognostic significance of regulatory T cells in tumor, Int J Cancer, 127, 748, 10.1002/ijc.25464

Erdman, 2003, CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice, Am J Pathol, 162, 691, 10.1016/S0002-9440(10)63863-1

Erdman, 2003, CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice, Cancer Res, 63, 6042

Erdman, 2005, CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice, Cancer Res, 65, 3998, 10.1158/0008-5472.CAN-04-3104

Rao, 2006, Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice, Cancer Res, 66, 7395, 10.1158/0008-5472.CAN-06-0558

Poutahidis, 2007, Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma, Carcinogenesis, 28, 2614, 10.1093/carcin/bgm180

Poutahidis, 2009, CD4+ lymphocytes modulate prostate cancer progression in mice, Int J Cancer, 125, 868, 10.1002/ijc.24452

Erdman, 2010, Unifying roles for regulatory T cells and inflammation in cancer, Int J Cancer, 126, 1651, 10.1002/ijc.24923

Poutahidis, 2013, Microbial reprogramming inhibits western diet-associated obesity, PLoS One, 8, e68596, 10.1371/journal.pone.0068596

Rao, 2007, Breast cancer: should gastrointestinal bacteria be on our radar screen?, Cancer Res, 67, 847, 10.1158/0008-5472.CAN-06-3468

Erdman, 2009, Nitric oxide and TNF-alpha trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice, Proc Natl Acad Sci U S A, 106, 1027, 10.1073/pnas.0812347106

Lakritz, 2013, Beneficial bacteria stimulate host immune cells to counteract dietary and genetic predisposition to mammary cancer in mice, Int J Cancer, 10.1002/ijc.28702

Rao, 2006, Proinflammatory CD4+ CD45RB(hi) lymphocytes promote mammary and intestinal carcinogenesis in Apc(Min/+) mice, Cancer Res, 66, 57, 10.1158/0008-5472.CAN-05-3445

Poutahidis, 2013, Pathogenic intestinal bacteria enhance prostate cancer development via systemic activation of immune cells in mice, PLoS One, 8, e73933, 10.1371/journal.pone.0073933

Houghton, 2010, Mutations in bone marrow-derived stromal stem cells unmask latent malignancy, Stem Cells Dev, 19, 1153, 10.1089/scd.2009.0439

Terzic, 2010, Inflammation and colon cancer, Gastroenterology, 138, e5, 10.1053/j.gastro.2010.01.058

Zhu, 2011, Gut microbiota and probiotics in colon tumorigenesis, Cancer Lett, 309, 119, 10.1016/j.canlet.2011.06.004

Arthur, 2012, Intestinal inflammation targets cancer-inducing activity of the microbiota, Science, 338, 120, 10.1126/science.1224820

Song, 2014, Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis, Immunity, 40, 140, 10.1016/j.immuni.2013.11.018

Iida, 2013, Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment, Science, 342, 967, 10.1126/science.1240527

Viaud, 2013, The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide, Science, 342, 971, 10.1126/science.1240537

Rook, 2011, Infection, immunoregulation, and cancer, Immunol Rev, 240, 141, 10.1111/j.1600-065X.2010.00987.x

Folkman, 2004, Cancer without disease, Nature, 427, 787, 10.1038/427787a

Poutahidis, 2013, Microbial symbionts accelerate wound healing via the neuropeptide hormone oxytocin, PLoS One, 8, e78898, 10.1371/journal.pone.0078898

Levkovich, 2013, Probiotic bacteria induce a ‘glow of health.’, PLoS One, 8, e53867, 10.1371/journal.pone.0053867

Poutahidis, 2014, Probiotic “glow of health”: more than skin deep, Benef Microbes, 5, 109, 10.3920/BM2013.0042