Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

Alexeev, 2018, Microbiota-derived indole metabolites promote human and murine intestinal homeostasis through regulation of interleukin-10 receptor, Am. J. Pathol., 188, 1183, 10.1016/j.ajpath.2018.01.011

Alkhalaf, 2015, Biosynthetic manipulation of tryptophan in bacteria: pathways and mechanisms, Chem. Biol., 22, 317, 10.1016/j.chembiol.2015.02.005

Binienda, 2017, Efficacy and safety of serotonin receptor ligands in the treatment of irritable bowel syndrome: a review, Curr. Drug Targets, 19

Blacher, 2017, Microbiome-modulated metabolites at the interface of host immunity, J. Immunol., 198, 572, 10.4049/jimmunol.1601247

Cervantes-Barragan, 2017, Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+ T cells, Science, 357, 806, 10.1126/science.aah5825

Cervenka, 2017, Kynurenines: tryptophan’s metabolites in exercise, inflammation, and mental health, Science, 357, 10.1126/science.aaf9794

Chaves Filho, 2018, IDO chronic immune activation and tryptophan metabolic pathway: a potential pathophysiological link between depression and obesity, Prog. Neuropsychopharmacol. Biol. Psychiatry, 80, 234, 10.1016/j.pnpbp.2017.04.035

Chimerel, 2014, Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells, Cell Rep., 9, 1202, 10.1016/j.celrep.2014.10.032

Clarke, 2012, A distinct profile of tryptophan metabolism along the kynurenine pathway downstream of toll-like receptor activation in irritable bowel syndrome, Front. Pharmacol., 3, 90, 10.3389/fphar.2012.00090

Clarke, 2013, The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner, Mol. Psychiatry, 18, 666, 10.1038/mp.2012.77

Crane, 2015, Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis, Nat. Med., 21, 166, 10.1038/nm.3766

Devlin, 2016, Modulation of a circulating uremic solute via rational genetic manipulation of the gut microbiota, Cell Host Microbe, 20, 709, 10.1016/j.chom.2016.10.021

Dodd, 2017, A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites, Nature, 551, 648, 10.1038/nature24661

Fan, 2017, Close association between intestinal microbiota and irritable bowel syndrome, Eur. J. Clin. Microbiol. Infect. Dis., 36, 2303, 10.1007/s10096-017-3060-2

Favennec, 2015, The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation, Obesity (Silver Spring), 23, 2066, 10.1002/oby.21199

Fitzgerald, 2008, Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity, Neurogastroenterol. Motil., 20, 1291, 10.1111/j.1365-2982.2008.01195.x

Fujisawa, 2016, Association of aryl hydrocarbon receptor-related gene variants with the severity of autism spectrum disorders, Front. Psychiatry, 7, 184, 10.3389/fpsyt.2016.00184

Galligan, 2018, Beneficial actions of microbiota-derived tryptophan metabolites, Neurogastroenterol. Motil., 30, 10.1111/nmo.13283

Gao, 2018, Impact of the gut microbiota on intestinal immunity mediated by tryptophan metabolism, Front. Cell. Infect. Microbiol., 8, 13, 10.3389/fcimb.2018.00013

Ghia, 2009, Serotonin has a key role in pathogenesis of experimental colitis, Gastroenterology, 137, 1649, 10.1053/j.gastro.2009.08.041

Golubeva, 2017, Microbiota-related changes in bile acid & tryptophan metabolism are associated with gastrointestinal dysfunction in a mouse model of autism, EBioMedicine, 24, 166, 10.1016/j.ebiom.2017.09.020

Hodge, 2012, Obesity, whole blood serotonin and sex differences in healthy volunteers, Obes. Facts, 5, 399, 10.1159/000339981

Hubbard, 2015, Indole and tryptophan metabolism: endogenous and dietary routes to Ah receptor activation, Drug Metab. Dispos., 43, 1522, 10.1124/dmd.115.064246

Hung, 2017, Indoxyl sulfate: a novel cardiovascular risk factor in chronic kidney disease, J. Am. Heart Assoc. Cardiovasc. Cerebrovasc. Dis., 6, e005022

Hyland, 2014, Microbiota-host interactions in irritable bowel syndrome: epithelial barrier, immune regulation and brain-gut interactions, World J. Gastroenterol., 20, 8859

Islam, 2017, Dietary tryptophan alleviates dextran sodium sulfate-induced colitis through aryl hydrocarbon receptor in mice, J. Nutr. Biochem., 42, 43, 10.1016/j.jnutbio.2016.12.019

Kałużna-Czaplińska, 2017, How important is tryptophan in human health?, Crit. Rev. Food Sci. Nutr.

Kennedy, 2017, Kynurenine pathway metabolism and the microbiota-gut-brain axis, Neuropharmacology, 112, 399, 10.1016/j.neuropharm.2016.07.002

Kerckhoffs, 2012, SERT and TPH-1 mRNA expression are reduced in irritable bowel syndrome patients regardless of visceral sensitivity state in large intestine, Am. J. Physiol. Gastrointest. Liver Physiol., 302, G1053, 10.1152/ajpgi.00153.2011

Kim, 2010, l-Tryptophan exhibits therapeutic function in a porcine model of dextran sodium sulfate (DSS)-induced colitis, J. Nutr. Biochem., 21, 468, 10.1016/j.jnutbio.2009.01.019

Lamas, 2016, CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands, Nat. Med., 22, 598, 10.1038/nm.4102

Lamas, 2018, Aryl hydrocarbon receptor and intestinal immunity, Mucosal Immunol., 10.1038/s41385-018-0019-2

Lee, 2015, Roles of indole as an interspecies and interkingdom signaling molecule, Trends Microbiol., 23, 707, 10.1016/j.tim.2015.08.001

Lim, 2016, Altered kynurenine pathway metabolism in autism: implication for immune-induced glutamatergic activity, Autism Res., 9, 621, 10.1002/aur.1565

Mallmann, 2018, Dysregulation of tryptophan catabolism in metabolic syndrome, Metab. Syndr. Relat. Disord., 16, 135, 10.1089/met.2017.0097

Manocha, 2012, Serotonin and GI disorders: an update on clinical and experimental studies, Clin. Transl. Gastroenterol., 3, e13, 10.1038/ctg.2012.8

Mawe, 2013, Serotonin signaling in the gastrointestinal tract: functions, dysfunctions, and therapeutic targets, Nat. Rev. Gastroenterol. Hepatol., 10, 473, 10.1038/nrgastro.2013.105

Metghalchi, 2015, Indoleamine 2,3-dioxygenase fine-tunes immune homeostasis in atherosclerosis and colitis through repression of interleukin-10 production, Cell Metab., 22, 460, 10.1016/j.cmet.2015.07.004

Monteleone, 2011, Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract, Gastroenterology, 141, 237, 10.1053/j.gastro.2011.04.007

Muller, 2016, The serotonin system in autism spectrum disorder: from biomarker to animal models, Neuroscience, 321, 24, 10.1016/j.neuroscience.2015.11.010

Nikolaus, 2017, Increased tryptophan metabolism is associated with activity of inflammatory bowel diseases, Gastroenterology, 153, 1504, 10.1053/j.gastro.2017.08.028

O'Farrell, 2017, Stress-related regulation of the kynurenine pathway: relevance to neuropsychiatric and degenerative disorders, Neuropharmacology, 112, 307, 10.1016/j.neuropharm.2015.12.004

Oxenkrug, 2013, Insulin resistance and dysregulation of tryptophan–kynurenine and kynurenine–nicotinamide adenine dinucleotide metabolic pathways, Mol. Neurobiol., 48, 294, 10.1007/s12035-013-8497-4

Qiu, 2012, The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells, Immunity, 36, 92, 10.1016/j.immuni.2011.11.011

Reigstad, 2015, Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells, FASEB J., 29, 1395, 10.1096/fj.14-259598

Rothhammer, 2016, Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and CNS inflammation via the aryl hydrocarbon receptor, Nat. Med., 22, 586, 10.1038/nm.4106

Schiering, 2017, Feedback control of AHR signaling regulates intestinal immunity, Nature, 542, 242, 10.1038/nature21080

Schwarcz, 2012, Kynurenines in the mammalian brain: when physiology meets pathology, Nat. Rev. Neurosci., 13, 465, 10.1038/nrn3257

Spohn, 2017, Non-conventional features of peripheral serotonin signaling, Nat. Rev. Gastroenterol. Hepatol., 14, 412, 10.1038/nrgastro.2017.51

Stasi, 2014, Serotonin receptors and their role in the pathophysiology and therapy of irritable bowel syndrome, Tech. Coloproctol., 18, 613, 10.1007/s10151-013-1106-8

Sumara, 2012, Gut-derived serotonin is a multifunctional determinant to fasting adaptation, Cell Metab., 16, 588, 10.1016/j.cmet.2012.09.014

Takamatsu, 2013, IDO1 plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice, J. Immunol., 191, 3057, 10.4049/jimmunol.1203306

Voigt, 2015, Serotonin controlling feeding and satiety, Behav. Brain Res., 277, 14, 10.1016/j.bbr.2014.08.065

Vujkovic-Cvijin, 2013, Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism, Sci. Transl. Med., 5, 193ra91, 10.1126/scitranslmed.3006438

Williams, 2014, Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine, Cell Host Microbe, 16, 495, 10.1016/j.chom.2014.09.001

Wlodarska, 2017, Indoleacrylic acid produced by commensal Peptostreptococcus species suppresses inflammation, Cell Host Microbe, 22, 25, 10.1016/j.chom.2017.06.007

Yano, 2015, Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis, Cell, 161, 264, 10.1016/j.cell.2015.02.047

Zelante, 2013, Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22, Immunity, 39, 372, 10.1016/j.immuni.2013.08.003

Zhang, 2016, Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions, Genome Med., 8, 46, 10.1186/s13073-016-0296-x

Zhang, 2013, Tryptophan biosynthesis protects mycobacteria from CD4 T cell-mediated killing, Cell, 155, 1296, 10.1016/j.cell.2013.10.045