Guillain–Barré Syndrome Associated with SARS-CoV-2 Infection in a Pediatric Patient

Journal of Tropical Pediatrics - Tập 67 Số 3 - 2021
Carlos Henrique Michiles Frank1, Taynná Vernalha Rocha Almeida2, Elyana Almeida Marques3, Quézia de Sousa Monteiro4, Pablo Vinícius Silveira Feitoza5,6, Mayla Gabriela Silva Borba4,7, Heline Lira Vasconcelos1, Michele de Souza Bastos1,2, Marcus Lacerda8
1Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, AM, 69040-000 Brazil
2Programa de Pós-graduação em Ciências da Saúde, Faculdade de Medicina, Universidade Federal do Amazonas, Manaus, AM, 69080-900 Brazil
3Fundação Alfredo da Mata, Manaus, AM, 69065-130 Brazil
4Hospital e Pronto Socorro Delphina Rinaldi Abdel Aziz, Manaus, AM, 69093-415 Brazil
5Departamento de Clínica Cirúrgica, Faculdade de Medicina, Universidade Federal do Amazonas, AM, 69080-900 Brazil
6Programa de Pós-Graduação em Medicina (Neurologia), Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, 14049-900 Brazil
7Universidade do Estado do Amazonas, Manaus, AM, 69055-010 Brazil
8Instituto Leonidas and Maria Deane, Fiocruz Amazonas, Manaus, AM, 69057-070 Brazil

Tóm tắt

Abstract We report the case of a 15-year-old male patient presenting frontal headaches with retro-orbital pain accompanied by fever evolving to weakness and pain of the lower limbs, which ascended to upper limbs. A COVID-19 rapid test (IgG and IgM) and nasopharyngeal swab polymerase chain reaction (PCR) was positive for SARS-CoV-2. The blood tests, cerebral spinal fluid (CSF) analysis and CSF aerobic culture revealed no abnormalities. PCR testing of the CSF was negative for the most prevalent etiologies as well as for SARS-CoV-2. Electroneurography study was compatible with the acute motor axonal neuropathy variant of Guillain–Barré syndrome. No cases involving young patients have been presented to date. Therefore, this is the first reported pediatric case of SARS-CoV-2 infection associated with GBS. Evidence reveals that SARS-CoV-2 infection is not limited to the respiratory tract. Neurotropism could explain this important neurologic manifestation of COVID-19 in children.

Từ khóa


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Journal of Tropical Pediatrics

Tập 67 Số 3

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