Growth arrest and apoptosis induced by quercetin is not linked to adipogenic conversion of human preadipocytes

Scalbert, 2000, Dietary intake and bioavailability of polyphenols, J Nutr, 130, 2073S, 10.1093/jn/130.8.2073S Mertens-Talcott, 2003, Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells, J Nutr, 133, 2669, 10.1093/jn/133.8.2669 Ong, 2004, Quercetin-induced growth inhibition and cell death in nasopharyngeal carcinoma cells are associated with increase in Bad and hypophosphorylated retinoblastoma expressions, Oncol Rep, 11, 727 Reed, 2000, Warner-Lambert/Parke-Davis award lecture. Mechanism of apoptosis, Am J Pathol, 157, 1415, 10.1016/S0002-9440(10)64779-7 Gross, 1999, BCL-2 family members and the mitochondria in apoptosis, Genes Dev, 13, 1899, 10.1101/gad.13.15.1899 Baldwin, 2001, Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB, J Clin Invest, 107, 241, 10.1172/JCI11991 Yamamoto, 2001, Therapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer, J Clin Invest, 107, 135, 10.1172/JCI11914 Font de Mora, 1997, Mitogen-activated protein kinase activation is not necessary for, but antagonizes, 3T3-L1 adipocytic differentiation, Mol Cell Biol, 17, 6068, 10.1128/MCB.17.10.6068 Bony, 1998, Modulation of insulin-like growth factor I mitogenic signaling in 3T3-L1 preadipocyte differentiation, Endocrinology, 139, 1638, 10.1210/en.139.4.1638 Bony, 2000, The critical role of Shc in insulin-like growth factor 1–mediated mitogenesis and differentiation in 3T3-L1 preadipocytes, Endocrinology, 14, 805 Qiu, 2001, DNA synthesis and mitotic clonal expansion is not a required step for 3T3-L1 preadipocyte differentiation into adipocytes, J Biol Chem, 276, 11988, 10.1074/jbc.M011729200 Bony, 2001, Src family tyrosine kinases participate in insulin-like growth factor 1 mitogenic signaling in 3T3-L1 cells, Cell Growth Differ, 12, 379 Tang, 2003, Mitotic clonal expansion: a synchronous process required for adipogenesis, Proc Natl Acad Sci U S A, 100, 44, 10.1073/pnas.0137044100 Gregoire, 1998, Understanding adipocyte differentiation, Physiol Rev, 78, 783, 10.1152/physrev.1998.78.3.783 Weiss, 1980, Regulation of fatty acid synthetase concentration and activity during adipocyte differentiation, J Biol Chem, 255, 4751, 10.1016/S0021-9258(19)85560-6 Paulauskis, 1988, Cloning and expression of mouse fatty acid synthase and other specific mRNAs. Developmental and hormonal regulation in 3T3 cells, J Biol Chem, 263, 7049, 10.1016/S0021-9258(18)68602-8 Wang, 2001, Green tea epigallocatechin gallate: a natural inhibitor of fatty-acid synthase, Biochem Biophys Res Commun, 288, 1200, 10.1006/bbrc.2001.5923 Li, 2004, Inhibitory effects of flavonoids on animal fatty acid synthase, J Biochem, 135, 85, 10.1093/jb/mvh010 Brusselmans, 2003, Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells, Int J Cancer, 106, 856, 10.1002/ijc.11317 Brusselmans, 2005, Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity, J Biol Chem, 280, 5636, 10.1074/jbc.M408177200 Hung, 2005, Antimitogenic effect of green tea(−)-epigallocatechin gallate on 3T3-L1 preadipocytes depends on the ERK and Cdk2 pathways, Am J Physiol Cell Physiol, 288, C1094, 10.1152/ajpcell.00569.2004 Lin, 2005, Green tea polyphenol epigallocatechin gallate inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes, Obes Res, 13, 982, 10.1038/oby.2005.115 Hwang, 2005, Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase, Biochem Biophys Res Commun, 338, 694, 10.1016/j.bbrc.2005.09.195 Furuyashiki, 2004, Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARgamma2 and C/EBPalpha in 3T3-L1 cells, Biosci Biotechnol Biochem, 68, 2353, 10.1271/bbb.68.2353 Li, 2006, Epigallocatechin gallate increases the formation of cytosolic lipid droplets and decreases the secretion of apoB-100 VLDL, J Lipid Res, 47, 67, 10.1194/jlr.M500424-JLR200 Torii, 2003, Establishment of a human preadipose cell line, HPB-AML-I: refractory to PPARγ-mediated adipogenic stimulation, J Cell Physiol, 197, 42, 10.1002/jcp.10326 Kaplow, 1955, A histochemical procedure for localizing and evaluating leukocyte alkaline phosphatase activity in smears of blood and marrow, Blood, 10, 1023, 10.1182/blood.V10.10.1023.1023 Chawla, 1994, Peroxisome proliferator–activated receptor (PPAR)γ: adipose-predominant expression and induction early in adipocyte differentiation, Endocrinology, 135, 798, 10.1210/en.135.2.798 Pellecchia, 2004, Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols: new avenues for cancer chemoprevention and chemotherapy, Curr Pharm Des, 10, 1387, 10.2174/1381612043384880 Shen, 2003, Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase 3 cascade, J Cell Biochem, 89, 1044, 10.1002/jcb.10559 Berndtsson, 2005, Phosphorylation of BAD at Ser-128 during mitosis and paclitaxel-induced apoptosis, FEBS Lett, 579, 3090, 10.1016/j.febslet.2005.04.067 Kamei, 1996, Influence of OH group and sugar bounded to flavonoids on flavonoid-mediated suppression of tumor growth in vitro, Cancer Biother Radiopharm, 11, 247, 10.1089/cbr.1996.11.247 Morikawa, 2003, Inhibitory effect of quercetin on carrageenan-induced inflammation in rats, Life Sci, 74, 709, 10.1016/j.lfs.2003.06.036 Manach, 1995, Quercetin metabolites in plasma of rats fed diets containing rutin or quercetin, J Nutr, 125, 1911, 10.1093/jn/125.7.1911 Entenmann, 1996, Relationship between replication and differentiation in cultured human adipocyte precursor cells, Am J Physiol Cell Physiol, 270, C1011, 10.1152/ajpcell.1996.270.4.C1011 Coolican, 1997, The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways, J Biol Chem, 272, 6653, 10.1074/jbc.272.10.6653 Porras, 1998, p42/p44 mitogen-activated protein kinases activation is required for the insulin-like growth factor–1/insulin induced proliferation, but inhibits differentiation, in rat fetal brown adipocytes, Mol Endocrinol, 12, 825, 10.1210/me.12.6.825 Fink, 2004, Induction of adipocyte-like phenotype in human mesenchymal stem cells by hypoxia, Stem Cells, 22, 1346, 10.1634/stemcells.2004-0038 Nelson-Dooley, 2005, Novel treatments for obesity and osteoporosis: targeting apoptotic pathways in adipocytes, Curr Med Chem, 12, 2215, 10.2174/0929867054864886