Growth Factor Independence 1 Antagonizes a p53-Induced DNA Damage Response Pathway in Lymphoblastic Leukemia

Adams, 1985, The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice, Nature, 318, 533, 10.1038/318533a0 Bartek, 2007, DNA damage signalling guards against activated oncogenes and tumour progression, Oncogene, 26, 7773, 10.1038/sj.onc.1210881 Bartkova, 2007, DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours, Oncogene, 26, 7414, 10.1038/sj.onc.1210553 Blyth, 2001, Runx2: a novel oncogenic effector revealed by in vivo complementation and retroviral tagging, Oncogene, 20, 295, 10.1038/sj.onc.1204090 Chakraborty, 2008, Retroviral gene insertion in breast milk mediated lymphomagenesis, Virology, 377, 100, 10.1016/j.virol.2008.04.008 Coustan-Smith, 2009, Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia, Lancet Oncol., 10, 147, 10.1016/S1470-2045(08)70314-0 Cullion, 2009, Targeting the Notch1 and mTOR pathways in a mouse T-ALL model, Blood, 113, 6172, 10.1182/blood-2008-02-136762 Dabrowska, 2009, Loss of MicroRNA targets in the 3′ untranslated region as a mechanism of retroviral insertional activation of growth factor independence 1, J. Virol., 83, 8051, 10.1128/JVI.00427-09 Di Micco, 2006, Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication, Nature, 444, 638, 10.1038/nature05327 Ferrando, 2002, Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia, Cancer Cell, 1, 75, 10.1016/S1535-6108(02)00018-1 Fiolka, 2006, Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development, EMBO Rep., 7, 326, 10.1038/sj.embor.7400618 Gilks, 1993, Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein, Mol. Cell. Biol., 13, 1759, 10.1128/MCB.13.3.1759 Gökbuget, 2009, Treatment of adult acute lymphoblastic leukemia, Semin. Hematol., 46, 64, 10.1053/j.seminhematol.2008.09.003 Halazonetis, 2008, An oncogene-induced DNA damage model for cancer development, Science, 319, 1352, 10.1126/science.1140735 Hameyer, 2007, Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues, Physiol. Genomics, 31, 32, 10.1152/physiolgenomics.00019.2007 Horman, 2009, Gfi1 integrates progenitor versus granulocytic transcriptional programming, Blood, 113, 5466, 10.1182/blood-2008-09-179747 Huang, 2007, p53 is regulated by the lysine demethylase LSD1, Nature, 449, 105, 10.1038/nature06092 Khandanpour, 2012, The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice, Blood, 120, 4006, 10.1182/blood-2011-02-334722 Kundu, 2005, Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma, Blood, 106, 3621, 10.1182/blood-2005-04-1447 Kurash, 2008, Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo, Mol. Cell, 29, 392, 10.1016/j.molcel.2007.12.025 Li, 2010, Repression of Id2 expression by Gfi-1 is required for B-cell and myeloid development, Blood, 116, 1060, 10.1182/blood-2009-11-255075 Margolin, 2009, ChIP-on-chip significance analysis reveals large-scale binding and regulation by human transcription factor oncogenes, Proc. Natl. Acad. Sci. USA, 106, 244, 10.1073/pnas.0806445106 Medyouf, 2011, High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling, J. Exp. Med., 208, 1809, 10.1084/jem.20110121 Morcos, 2008, Vivo-Morpholinos: a non-peptide transporter delivers Morpholinos into a wide array of mouse tissues, Biotechniques, 45, 613, 10.2144/000113005 Murtaugh, 2003, Notch signaling controls multiple steps of pancreatic differentiation, Proc. Natl. Acad. Sci. USA, 100, 14920, 10.1073/pnas.2436557100 O’Neil, 2007, FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors, J. Exp. Med., 204, 1813, 10.1084/jem.20070876 Palomero, 2006, NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth, Proc. Natl. Acad. Sci. USA, 103, 18261, 10.1073/pnas.0606108103 Pargmann, 2007, Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphocyte function, Eur. J. Immunol., 37, 3551, 10.1002/eji.200737130 Person, 2003, Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2, Nat. Genet., 34, 308, 10.1038/ng1170 Priceputu, 2006, Structurally distinct ligand-binding or ligand-independent Notch1 mutants are leukemogenic but affect thymocyte development, apoptosis, and metastasis differently, J. Immunol., 177, 2153, 10.4049/jimmunol.177.4.2153 Saleque, 2007, Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1, Mol. Cell, 27, 562, 10.1016/j.molcel.2007.06.039 Scheijen, 1997, Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice, J. Virol., 71, 9, 10.1128/JVI.71.1.9-16.1997 Schmidt, 1996, MoMuLV proviral integrations identified by Sup-F selection in tumors from infected myc/pim bitransgenic mice correlate with activation of the gfi-1 gene, Nucleic Acids Res., 24, 2528, 10.1093/nar/24.13.2528 Schmidt, 1998, Zinc finger protein GFI-1 has low oncogenic potential but cooperates strongly with pim and myc genes in T-cell lymphomagenesis, Oncogene, 17, 2661, 10.1038/sj.onc.1202191 Sharma, 2006, Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc, Mol. Cell. Biol., 26, 8022, 10.1128/MCB.01091-06 Spooner, 2009, A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates, Immunity, 31, 576, 10.1016/j.immuni.2009.07.011 Subramanian, 2005, Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles, Proc. Natl. Acad. Sci. USA, 102, 15545, 10.1073/pnas.0506580102 Thompson, 2007, The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia, J. Exp. Med., 204, 1825, 10.1084/jem.20070872 Uren, 2008, Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks, Cell, 133, 727, 10.1016/j.cell.2008.03.021 Van Vlierberghe, 2008, The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia, Blood, 111, 4668, 10.1182/blood-2007-09-111872 Velu, 2009, Gfi1 regulates miR-21 and miR-196b to control myelopoiesis, Blood, 113, 4720, 10.1182/blood-2008-11-190215 Weng, 2004, Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia, Science, 306, 269, 10.1126/science.1102160 Weng, 2006, c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma, Genes Dev., 20, 2096, 10.1101/gad.1450406 West, 2011, Regulation of p53 function by lysine methylation, Epigenomics, 3, 361, 10.2217/epi.11.21 Yuan, 2001, AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations, Proc. Natl. Acad. Sci. USA, 98, 10398, 10.1073/pnas.171321298 Yücel, 2003, The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus, J. Exp. Med., 197, 831, 10.1084/jem.20021417 Zarebski, 2008, Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1, Immunity, 28, 370, 10.1016/j.immuni.2007.12.020 Zhu, 2006, Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion, Proc. Natl. Acad. Sci. USA, 103, 18214, 10.1073/pnas.0608981103 Zörnig, 1996, Zinc finger protein GFI-1 cooperates with myc and pim-1 in T-cell lymphomagenesis by reducing the requirements for IL-2, Oncogene, 12, 1789