Growth Cone Travel in Space and Time: the Cellular Ensemble of Cytoskeleton, Adhesion, and Membrane

Neuron - Tập 73 - Trang 1068-1081 - 2012
Eric A. Vitriol1, James Q. Zheng1
1Departments of Cell Biology and Neurology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA

Tài liệu tham khảo

Aizawa, 2001, Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse, Nat. Neurosci., 4, 367, 10.1038/86011 Akin, 2008, Capping protein increases the rate of actin-based motility by promoting filament nucleation by the Arp2/3 complex, Cell, 133, 841, 10.1016/j.cell.2008.04.011 Andrianantoandro, 2006, Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin, Mol. Cell, 24, 13, 10.1016/j.molcel.2006.08.006 Arakawa, 2003, Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons, J. Cell Biol., 161, 381, 10.1083/jcb.200210149 Aratyn-Schaus, 2010, Transient frictional slip between integrin and the ECM in focal adhesions under myosin II tension, Curr. Biol., 20, 1145, 10.1016/j.cub.2010.05.049 Bamburg, 1987, Distribution and cellular localization of actin depolymerizing factor, J. Cell Biol., 105, 2817, 10.1083/jcb.105.6.2817 Bard, 2008, A molecular clutch between the actin flow and N-cadherin adhesions drives growth cone migration, J. Neurosci., 28, 5879, 10.1523/JNEUROSCI.5331-07.2008 Bear, 2002, Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility, Cell, 109, 509, 10.1016/S0092-8674(02)00731-6 Bechara, 2008, FAK-MAPK-dependent adhesion disassembly downstream of L1 contributes to semaphorin3A-induced collapse, EMBO J., 27, 1549, 10.1038/emboj.2008.86 Bentley, 1994, Cytoskeletal events in growth cone steering, Curr. Opin. Neurobiol., 4, 43, 10.1016/0959-4388(94)90030-2 Bernstein, 2010, ADF/cofilin: a functional node in cell biology, Trends Cell Biol., 20, 187, 10.1016/j.tcb.2010.01.001 Bloom, 2011, Membrane trafficking events underlying axon repair, growth, and regeneration, Mol. Cell. Neurosci., 48, 339, 10.1016/j.mcn.2011.04.003 Bonanomi, 2008, Identification of a developmentally regulated pathway of membrane retrieval in neuronal growth cones, J. Cell Sci., 121, 3757, 10.1242/jcs.033803 Bradke, 1999, The role of local actin instability in axon formation, Science, 283, 1931, 10.1126/science.283.5409.1931 Brown, 2006, Probing the integrin-actin linkage using high-resolution protein velocity mapping, J. Cell Sci., 119, 5204, 10.1242/jcs.03321 Buck, 2002, Growth cone turning induced by direct local modification of microtubule dynamics, J. Neurosci., 22, 9358, 10.1523/JNEUROSCI.22-21-09358.2002 Bulina, 2006, A genetically encoded photosensitizer, Nat. Biotechnol., 24, 95, 10.1038/nbt1175 Bunge, 1973, Fine structure of nerve fibers and growth cones of isolated sympathetic neurons in culture, J. Cell Biol., 56, 713, 10.1083/jcb.56.3.713 Burnette, 2008, Myosin II activity facilitates microtubule bundling in the neuronal growth cone neck, Dev. Cell, 15, 163, 10.1016/j.devcel.2008.05.016 Burridge, 2004, Rho and Rac take center stage, Cell, 116, 167, 10.1016/S0092-8674(04)00003-0 Cai, 2008, Spatial and temporal regulation of focal adhesion kinase activity in living cells, Mol. Cell. Biol., 28, 201, 10.1128/MCB.01324-07 Carlier, 1997, Actin depolymerizing factor (ADF/cofilin) enhances the rate of filament turnover: implication in actin-based motility, J. Cell Biol., 136, 1307, 10.1083/jcb.136.6.1307 Cassimeris, 1987, Dynamic instability of microtubules, BioEssays, 7, 149, 10.1002/bies.950070403 Chacón, 2011, FAK: dynamic integration of guidance signals at the growth cone, Cell Adh. Migr., 5, 52, 10.4161/cam.5.1.13681 Chan, 2008, Traction dynamics of filopodia on compliant substrates, Science, 322, 1687, 10.1126/science.1163595 Chhabra, 2007, The many faces of actin: matching assembly factors with cellular structures, Nat. Cell Biol., 9, 1110, 10.1038/ncb1007-1110 Ciani, 2004, A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules, J. Cell Biol., 164, 243, 10.1083/jcb.200309096 Cooper, 2008, New insights into mechanism and regulation of actin capping protein, Int. Rev. Cell Mol. Biol., 267, 183, 10.1016/S1937-6448(08)00604-7 Dammermann, 2003, The minus end in sight, Curr. Biol., 13, R614, 10.1016/S0960-9822(03)00530-X Davis, 2009, Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth, PLoS Biol., 7, e1000208, 10.1371/journal.pbio.1000208 Dent, 1999, Reorganization and movement of microtubules in axonal growth cones and developing interstitial branches, J. Neurosci., 19, 8894, 10.1523/JNEUROSCI.19-20-08894.1999 Dent, 2011, The growth cone cytoskeleton in axon outgrowth and guidance, Cold Spring Harb. Perspect. Biol., 3, 10.1101/cshperspect.a001800 Dequidt, 2007, Fast turnover of L1 adhesions in neuronal growth cones involving both surface diffusion and exo/endocytosis of L1 molecules, Mol. Biol. Cell, 18, 3131, 10.1091/mbc.e06-12-1101 DesMarais, 2005, Cofilin takes the lead, J. Cell Sci., 118, 19, 10.1242/jcs.01631 Dickson, 2001, Rho GTPases in growth cone guidance, Curr. Opin. Neurobiol., 11, 103, 10.1016/S0959-4388(00)00180-X Diefenbach, 1999, Membrane recycling in the neuronal growth cone revealed by FM1-43 labeling, J. Neurosci., 19, 9436, 10.1523/JNEUROSCI.19-21-09436.1999 Diefenbach, 2002, Myosin 1c and myosin IIB serve opposing roles in lamellipodial dynamics of the neuronal growth cone, J. Cell Biol., 158, 1207, 10.1083/jcb.200202028 Dwivedy, 2007, Ena/VASP function in retinal axons is required for terminal arborization but not pathway navigation, Development, 134, 2137, 10.1242/dev.002345 Fukata, 2002, Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170, Cell, 109, 873, 10.1016/S0092-8674(02)00800-0 Geiger, 2011, Molecular architecture and function of matrix adhesions, Cold Spring Harb. Perspect. Biol., 3, 10.1101/cshperspect.a005033 Ghosh, 2004, Cofilin promotes actin polymerization and defines the direction of cell motility, Science, 304, 743, 10.1126/science.1094561 Giannone, 2009, Multi-level molecular clutches in motile cell processes, Trends Cell Biol., 19, 475, 10.1016/j.tcb.2009.07.001 Gomez, 2006, The molecular basis for calcium-dependent axon pathfinding, Nat. Rev. Neurosci., 7, 115, 10.1038/nrn1844 Goode, 2000, Functional cooperation between the microtubule and actin cytoskeletons, Curr. Opin. Cell Biol., 12, 63, 10.1016/S0955-0674(99)00058-7 Gordon-Weeks, 2004, Microtubules and growth cone function, J. Neurobiol., 58, 70, 10.1002/neu.10266 Grabham, 2007, Cytoplasmic dynein and LIS1 are required for microtubule advance during growth cone remodeling and fast axonal outgrowth, J. Neurosci., 27, 5823, 10.1523/JNEUROSCI.1135-07.2007 Grigera, 2005, FAK phosphorylation sites mapped by mass spectrometry, J. Cell Sci., 118, 4931, 10.1242/jcs.02696 Gu, 2006, The microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting, Neuron, 52, 803, 10.1016/j.neuron.2006.10.022 Gu, 2010, ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity, Nat. Neurosci., 13, 1208, 10.1038/nn.2634 Gupton, 2002, Converging populations of f-actin promote breakage of associated microtubules to spatially regulate microtubule turnover in migrating cells, Curr. Biol., 12, 1891, 10.1016/S0960-9822(02)01276-9 Hall, 2000, Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton, Philos. Trans. R. Soc. Lond. B Biol. Sci., 355, 965, 10.1098/rstb.2000.0632 Harrison, 1910, The outgrowth of the nerve fiber as a mode of protoplasmic movement, J. Exp. Zool., 9, 787, 10.1002/jez.1400090405 Hart, 1997, Vertebrates have conserved capping protein alpha isoforms with specific expression patterns, Cell Motil. Cytoskeleton, 38, 120, 10.1002/(SICI)1097-0169(1997)38:2<120::AID-CM2>3.0.CO;2-B Hedgecock, 1987, Genetics of cell and axon migrations in Caenorhabditis elegans, Development, 100, 365, 10.1242/dev.100.3.365 Hedgecock, 1990, The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans, Neuron, 4, 61, 10.1016/0896-6273(90)90444-K Helenius, 2006, The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends, Nature, 441, 115, 10.1038/nature04736 Hengst, 2007, Function and translational regulation of mRNA in developing axons, Semin. Cell Dev. Biol., 18, 209, 10.1016/j.semcdb.2007.01.003 Henle, 2011, Asymmetric PI(3,4,5)P3 and Akt signaling mediates chemotaxis of axonal growth cones, J. Neurosci., 31, 7016, 10.1523/JNEUROSCI.0216-11.2011 Hines, 2010, Asymmetric endocytosis and remodeling of beta1-integrin adhesions during growth cone chemorepulsion by MAG, Nat. Neurosci., 13, 829, 10.1038/nn.2554 Hirokawa, 2010, Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease, Neuron, 68, 610, 10.1016/j.neuron.2010.09.039 Homma, 2003, Kinesin superfamily protein 2A (KIF2A) functions in suppression of collateral branch extension, Cell, 114, 229, 10.1016/S0092-8674(03)00522-1 Howard, 2007, Microtubule polymerases and depolymerases, Curr. Opin. Cell Biol., 19, 31, 10.1016/j.ceb.2006.12.009 Hsieh, 2006, Myelin-associated inhibitors regulate cofilin phosphorylation and neuronal inhibition through LIM kinase and Slingshot phosphatase, J. Neurosci., 26, 1006, 10.1523/JNEUROSCI.2806-05.2006 Hu, 2007, Differential transmission of actin motion within focal adhesions, Science, 315, 111, 10.1126/science.1135085 Huber, 2003, Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance, Annu. Rev. Neurosci., 26, 509, 10.1146/annurev.neuro.26.010302.081139 Huttenlocher, 2011, Integrins in cell migration, Cold Spring Harb. Perspect. Biol., 3, a005074, 10.1101/cshperspect.a005074 Ishii, 1992, UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans, Neuron, 9, 873, 10.1016/0896-6273(92)90240-E Jacobson, 2008, Chromophore-assisted laser inactivation in cell biology, Trends Cell Biol., 18, 443, 10.1016/j.tcb.2008.07.001 Kabayama, 2009, Ca2+ induces macropinocytosis via F-actin depolymerization during growth cone collapse, Mol. Cell. Neurosci., 40, 27, 10.1016/j.mcn.2008.08.009 Kabayama, 2011, Syntaxin 1B suppresses macropinocytosis and semaphorin 3A-induced growth cone collapse, J. Neurosci., 31, 7357, 10.1523/JNEUROSCI.2718-10.2011 Kalil, 2005, Touch and go: guidance cues signal to the growth cone cytoskeleton, Curr. Opin. Neurobiol., 15, 521, 10.1016/j.conb.2005.08.005 Kamiguchi, 2007, The role of cell adhesion molecules in axon growth and guidance, Adv. Exp. Med. Biol., 621, 95, 10.1007/978-0-387-76715-4_7 Kapustina, 2010, Modeling capping protein FRAP and CALI experiments reveals in vivo regulation of actin dynamics, Cytoskeleton (Hoboken), 67, 519 Karginov, 2010, Engineered allosteric activation of kinases in living cells, Nat. Biotechnol., 28, 743, 10.1038/nbt.1639 Kater, 1988, Calcium regulation of the neuronal growth cone, Trends Neurosci., 11, 315, 10.1016/0166-2236(88)90094-X Kennedy, 1994, Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord, Cell, 78, 425, 10.1016/0092-8674(94)90421-9 Kennedy, 2010, Rapid blue-light-mediated induction of protein interactions in living cells, Nat. Methods, 7, 973, 10.1038/nmeth.1524 Kholmanskikh, 2006, Calcium-dependent interaction of Lis1 with IQGAP1 and Cdc42 promotes neuronal motility, Nat. Neurosci., 9, 50, 10.1038/nn1619 Kolodkin, 2011, Mechanisms and molecules of neuronal wiring: a primer, Cold Spring Harb. Perspect. Biol., 3, 10.1101/cshperspect.a001727 Kolpak, 2009, Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning, J. Neurosci., 29, 10488, 10.1523/JNEUROSCI.2355-09.2009 Korey, 2000, From the growth cone surface to the cytoskeleton: one journey, many paths, J. Neurobiol., 44, 184, 10.1002/1097-4695(200008)44:2<184::AID-NEU8>3.0.CO;2-N Kuhn, 2000, Regulating actin dynamics in neuronal growth cones by ADF/cofilin and rho family GTPases, J. Neurobiol., 44, 126, 10.1002/1097-4695(200008)44:2<126::AID-NEU4>3.0.CO;2-Z Lee, 2004, The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance, Neuron, 42, 913, 10.1016/j.neuron.2004.05.020 Lee, 2009, Regulation of acetylcholine receptor clustering by ADF/cofilin-directed vesicular trafficking, Nat. Neurosci., 12, 848, 10.1038/nn.2322 Levskaya, 2009, Spatiotemporal control of cell signalling using a light-switchable protein interaction, Nature, 461, 997, 10.1038/nature08446 Li, 2004, Activation of FAK and Src are receptor-proximal events required for netrin signaling, Nat. Neurosci., 7, 1213, 10.1038/nn1329 Ligon, 2003, The microtubule plus-end proteins EB1 and dynactin have differential effects on microtubule polymerization, Mol. Biol. Cell, 14, 1405, 10.1091/mbc.e02-03-0155 Lin, 2008, Function and regulation of local axonal translation, Curr. Opin. Neurobiol., 18, 60, 10.1016/j.conb.2008.05.004 Lin, 1994, Cytoskeletal reorganization underlying growth cone motility, Curr. Opin. Neurobiol., 4, 640, 10.1016/0959-4388(94)90004-3 Liu, 2004, Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction, Nat. Neurosci., 7, 1222, 10.1038/nn1331 Lowery, 2009, The trip of the tip: understanding the growth cone machinery, Nat. Rev. Mol. Cell Biol., 10, 332, 10.1038/nrm2679 Lucas, 1998, Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium, J. Cell Sci., 111, 1351, 10.1242/jcs.111.10.1351 Ma, 2001, Serine phosphorylation of focal adhesion kinase in interphase and mitosis: a possible role in modulating binding to p130(Cas), Mol. Biol. Cell, 12, 1, 10.1091/mbc.12.1.1 Maccioni, 1995, Role of microtubule-associated proteins in the control of microtubule assembly, Physiol. Rev., 75, 835, 10.1152/physrev.1995.75.4.835 Maciver, 1998, How ADF/cofilin depolymerizes actin filaments, Curr. Opin. Cell Biol., 10, 140, 10.1016/S0955-0674(98)80097-5 Mack, 2000, The microtubule-associated protein MAP1B is involved in local stabilization of turning growth cones, Mol. Cell. Neurosci., 15, 51, 10.1006/mcne.1999.0802 Maness, 2007, Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration, Nat. Neurosci., 10, 19, 10.1038/nn1827 Marek, 2002, Transgenically encoded protein photoinactivation (FlAsH-FALI): acute inactivation of synaptotagmin I, Neuron, 36, 805, 10.1016/S0896-6273(02)01068-1 Marsick, 2010, Activation of ADF/cofilin mediates attractive growth cone turning toward nerve growth factor and netrin-1, Dev. Neurobiol., 70, 565, 10.1002/dneu.20800 Meberg, 1998, Actin depolymerizing factor and cofilin phosphorylation dynamics: response to signals that regulate neurite extension, Cell Motil. Cytoskeleton, 39, 172, 10.1002/(SICI)1097-0169(1998)39:2<172::AID-CM8>3.0.CO;2-8 Medeiros, 2006, Myosin II functions in actin-bundle turnover in neuronal growth cones, Nat. Cell Biol., 8, 215, 10.1038/ncb1367 Mejillano, 2004, Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end, Cell, 118, 363, 10.1016/j.cell.2004.07.019 Meldolesi, 2011, Neurite outgrowth: this process, first discovered by Santiago Ramon y Cajal, is sustained by the exocytosis of two distinct types of vesicles, Brain Res. Brain Res. Rev., 66, 246, 10.1016/j.brainresrev.2010.06.004 Ming, 2002, Adaptation in the chemotactic guidance of nerve growth cones, Nature, 417, 411, 10.1038/nature745 Mitra, 2005, Focal adhesion kinase: in command and control of cell motility, Nat. Rev. Mol. Cell Biol., 6, 56, 10.1038/nrm1549 Miyoshi, 2006, Actin turnover-dependent fast dissociation of capping protein in the dendritic nucleation actin network: evidence of frequent filament severing, J. Cell Biol., 175, 947, 10.1083/jcb.200604176 Morfini, 1997, Suppression of KIF2 in PC12 cells alters the distribution of a growth cone nonsynaptic membrane receptor and inhibits neurite extension, J. Cell Biol., 138, 657, 10.1083/jcb.138.3.657 Myers, 2011, Focal adhesion kinase promotes integrin adhesion dynamics necessary for chemotropic turning of nerve growth cones, J. Neurosci., 31, 13585, 10.1523/JNEUROSCI.2381-11.2011 Myers, 2011, Regulation of axonal outgrowth and pathfinding by integrin-ECM interactions, Dev. Neurobiol., 71, 901, 10.1002/dneu.20931 Ng, 2002, Rac GTPases control axon growth, guidance and branching, Nature, 416, 442, 10.1038/416442a Noda, 1995, KIF2 is a new microtubule-based anterograde motor that transports membranous organelles distinct from those carried by kinesin heavy chain or KIF3A/B, J. Cell Biol., 129, 157, 10.1083/jcb.129.1.157 Parsons, 2003, Focal adhesion kinase: the first ten years, J. Cell Sci., 116, 1409, 10.1242/jcs.00373 Pfenninger, 2003, Regulation of membrane expansion at the nerve growth cone, J. Cell Sci., 116, 1209, 10.1242/jcs.00285 Piper, 2006, Signaling mechanisms underlying Slit2-induced collapse of Xenopus retinal growth cones, Neuron, 49, 215, 10.1016/j.neuron.2005.12.008 Pollard, 2003, Cellular motility driven by assembly and disassembly of actin filaments, Cell, 112, 453, 10.1016/S0092-8674(03)00120-X Pollard, 2009, Actin, a central player in cell shape and movement, Science, 326, 1208, 10.1126/science.1175862 Pollard, 2000, Molecular mechanisms controlling actin filament dynamics in nonmuscle cells, Annu. Rev. Biophys. Biomol. Struct., 29, 545, 10.1146/annurev.biophys.29.1.545 Poskanzer, 2003, Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo, Nature, 426, 559, 10.1038/nature02184 Racchetti, 2010, Rapid neurite outgrowth in neurosecretory cells and neurons is sustained by the exocytosis of a cytoplasmic organelle, the enlargeosome, J. Cell Sci., 123, 165, 10.1242/jcs.059634 Rajfur, 2002, Dissecting the link between stress fibres and focal adhesions by CALI with EGFP fusion proteins, Nat. Cell Biol., 4, 286, 10.1038/ncb772 Ramón y Cajal, 1890, Notas anatómicas. I. Sobre la aparición de las expansiones celulares en la médula embrionaria, Gac. Sanit. Barc., 12, 413 Ramón y Cajal, 1909 Ren, 2004, Focal adhesion kinase in netrin-1 signaling, Nat. Neurosci., 7, 1204, 10.1038/nn1330 Robles, 2006, Focal adhesion kinase signaling at sites of integrin-mediated adhesion controls axon pathfinding, Nat. Neurosci., 9, 1274, 10.1038/nn1762 Rochlin, 1999, Polymerizing microtubules activate site-directed F-actin assembly in nerve growth cones, Mol. Biol. Cell, 10, 2309, 10.1091/mbc.10.7.2309 Rodriguez, 2003, Conserved microtubule-actin interactions in cell movement and morphogenesis, Nat. Cell Biol., 5, 599, 10.1038/ncb0703-599 Roll-Mecak, 2010, Microtubule-severing enzymes, Curr. Opin. Cell Biol., 22, 96, 10.1016/j.ceb.2009.11.001 Sabo, 2003, Mobility and cycling of synaptic protein-containing vesicles in axonal growth cone filopodia, Nat. Neurosci., 6, 1264, 10.1038/nn1149 Schaefer, 2002, Filopodia and actin arcs guide the assembly and transport of two populations of microtubules with unique dynamic parameters in neuronal growth cones, J. Cell Biol., 158, 139, 10.1083/jcb.200203038 Schafer, 2004, Cell biology: barbed ends rule, Nature, 430, 734, 10.1038/430734a Schafer, 1994, Differential localization and sequence analysis of capping protein beta-subunit isoforms of vertebrates, J. Cell Biol., 127, 453, 10.1083/jcb.127.2.453 Seong, 2011, Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer, Nat. Commun., 2, 406, 10.1038/ncomms1414 Shaw, 2007, Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions, Cell, 128, 547, 10.1016/j.cell.2006.12.037 Shu, 2011, A genetically encoded tag for correlated light and electron microscopy of intact cells, tissues, and organisms, PLoS Biol., 9, e1001041, 10.1371/journal.pbio.1001041 Slack-Davis, 2007, Cellular characterization of a novel focal adhesion kinase inhibitor, J. Biol. Chem., 282, 14845, 10.1074/jbc.M606695200 Smith, 1988, Neuronal cytomechanics: the actin-based motility of growth cones, Science, 242, 708, 10.1126/science.3055292 Suter, 1998, An emerging link between cytoskeletal dynamics and cell adhesion molecules in growth cone guidance, Curr. Opin. Neurobiol., 8, 106, 10.1016/S0959-4388(98)80014-7 Sydor, 1996, Talin and vinculin play distinct roles in filopodial motility in the neuronal growth cone, J. Cell Biol., 134, 1197, 10.1083/jcb.134.5.1197 Tanabe, 2005, Multiphoton excitation-evoked chromophore-assisted laser inactivation using green fluorescent protein, Nat. Methods, 2, 503, 10.1038/nmeth770 Tessier-Lavigne, 1988, Chemotropic guidance of developing axons in the mammalian central nervous system, Nature, 336, 775, 10.1038/336775a0 Thoumine, 2008, Interplay between adhesion turnover and cytoskeleton dynamics in the control of growth cone migration, Cell Adh. Migr., 2, 263, 10.4161/cam.2.4.7274 Toettcher, 2011, The promise of optogenetics in cell biology: interrogating molecular circuits in space and time, Nat. Methods, 8, 35, 10.1038/nmeth.f.326 Tojima, 2007, Attractive axon guidance involves asymmetric membrane transport and exocytosis in the growth cone, Nat. Neurosci., 10, 58, 10.1038/nn1814 Tojima, 2010, Asymmetric clathrin-mediated endocytosis drives repulsive growth cone guidance, Neuron, 66, 370, 10.1016/j.neuron.2010.04.007 Tojima, 2011, Second messengers and membrane trafficking direct and organize growth cone steering, Nat. Rev. Neurosci., 13, 1 Tönges, 2011, ROCKing regeneration: Rho kinase inhibition as molecular target for neurorestoration, Front. Mol. Neurosci., 4, 39, 10.3389/fnmol.2011.00039 Toomre, 2010, A new wave of cellular imaging, Annu. Rev. Cell Dev. Biol., 26, 285, 10.1146/annurev-cellbio-100109-104048 Van Troys, 2008, Ins and outs of ADF/cofilin activity and regulation, Eur. J. Cell Biol., 87, 649, 10.1016/j.ejcb.2008.04.001 Vitriol, 2007, Enhanced EGFP-chromophore-assisted laser inactivation using deficient cells rescued with functional EGFP-fusion proteins, Proc. Natl. Acad. Sci. USA, 104, 6702, 10.1073/pnas.0701801104 Wang, 1996, Function of myosin-V in filopodial extension of neuronal growth cones, Science, 273, 660, 10.1126/science.273.5275.660 Waterman-Storer, 1997, Actomyosin-based retrograde flow of microtubules in the lamella of migrating epithelial cells influences microtubule dynamic instability and turnover and is associated with microtubule breakage and treadmilling, J. Cell Biol., 139, 417, 10.1083/jcb.139.2.417 Watson, 2006, Microtubule plus-end loading of p150(Glued) is mediated by EB1 and CLIP-170 but is not required for intracellular membrane traffic in mammalian cells, J. Cell Sci., 119, 2758, 10.1242/jcs.02999 Wen, 2006, Directional guidance of nerve growth cones, Curr. Opin. Neurobiol., 16, 52, 10.1016/j.conb.2005.12.005 Wen, 2007, BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin, J. Cell Biol., 178, 107, 10.1083/jcb.200703055 Witte, 2008, Microtubule stabilization specifies initial neuronal polarization, J. Cell Biol., 180, 619, 10.1083/jcb.200707042 Wolfenson, 2011, Actomyosin-generated tension controls the molecular kinetics of focal adhesions, J. Cell Sci., 124, 1425, 10.1242/jcs.077388 Woo, 2006, Rac1 and RhoA promote neurite outgrowth through formation and stabilization of growth cone point contacts, J. Neurosci., 26, 1418, 10.1523/JNEUROSCI.4209-05.2006 Wu, 2009, A genetically encoded photoactivatable Rac controls the motility of living cells, Nature, 461, 104, 10.1038/nature08241 Yu, 2005, Regulation of microtubule severing by katanin subunits during neuronal development, J. Neurosci., 25, 5573, 10.1523/JNEUROSCI.0834-05.2005 Yu, 2008, The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches, Mol. Biol. Cell, 19, 1485, 10.1091/mbc.e07-09-0878 Zhang, 2003, Rho-dependent contractile responses in the neuronal growth cone are independent of classical peripheral retrograde actin flow, Neuron, 40, 931, 10.1016/S0896-6273(03)00754-2 Zhang, 2011, Drosophila katanin is a microtubule depolymerase that regulates cortical-microtubule plus-end interactions and cell migration, Nat. Cell Biol., 13, 361, 10.1038/ncb2206 Zhou, 2004, NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC, Neuron, 42, 897, 10.1016/j.neuron.2004.05.011 Zweifel, 2005, Functions and mechanisms of retrograde neurotrophin signalling, Nat. Rev. Neurosci., 6, 615, 10.1038/nrn1727