Group-based multi-trajectory modeling

Statistical Methods in Medical Research - Tập 27 Số 7 - Trang 2015-2023 - 2018
Daniel S. Nagin1, Bobby Jones2, Valéria Lima Passos3, Richard E. Tremblay4
1The School of Public Policy & Management, Heinz College, Carnegie Mellon University, Pittsburgh, PA, USA
2Western Psychiatric Institute and Clinic/University of Pittsburgh Medical Center, Pittsburgh, PA USA
3Department of Methodology and Statistics, Maastricht University, Maastricht, The Netherlands
4School of Public Health Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland

Tóm tắt

Identifying and monitoring multiple disease biomarkers and other clinically important factors affecting the course of a disease, behavior or health status is of great clinical relevance. Yet conventional statistical practice generally falls far short of taking full advantage of the information available in multivariate longitudinal data for tracking the course of the outcome of interest. We demonstrate a method called multi-trajectory modeling that is designed to overcome this limitation. The method is a generalization of group-based trajectory modeling. Group-based trajectory modeling is designed to identify clusters of individuals who are following similar trajectories of a single indicator of interest such as post-operative fever or body mass index. Multi-trajectory modeling identifies latent clusters of individuals following similar trajectories across multiple indicators of an outcome of interest (e.g., the health status of chronic kidney disease patients as measured by their eGFR, hemoglobin, blood CO2 levels). Multi-trajectory modeling is an application of finite mixture modeling. We lay out the underlying likelihood function of the multi-trajectory model and demonstrate its use with two examples.

Từ khóa


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Statistical Methods in Medical Research

Tập 27 Số 7

2015-2023

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