Green Approach: Characterization, Antibacterial, Antitumor and Detoxification Potentials of Exopolysaccharides-Mediated Silver Nanoparticles Produced by Penicillium citrinum AUMC 11627
Tóm tắt
Developing a green effective approach and a suitable applicative process for increasing the efficiency of microbial nanomaterial synthesis is an emerging prospect for future industrial production. This was accomplished by employing exopolysaccharides (EPS) to obtain potent silver nanoparticles using Penicillium citrinum (EPS−AgNPs) as a reducing and stabilizing agent. EPS−AgNPs were analyzed by UV–Vis spectrophotometry, which showed a peak of absorbance at 420 nm. TEM was used to determine the morphology of the EPS−AgNPs and showed that the particles were 14.4 nm in size, well dispersed, and spherical. The stabilization of (EPS−AgNPs) was caused by amides and amines groups, which were confirmed via Fourier transform infrared. Moreover, the EPS−AgNPs showed excellent antibacterial activities against various human pathogenic bacterial strains in comparison to the potent antibiotics. Additionally, EPS−AgNPs were examined for their anticancer properties. Furthermore, EPS−AgNPs had a significant impact on the ochratoxin production. Finally, our findings confirm the benefits of adopting a bio green technique for the synthesis of antibacterial and detoxifying nanoparticles, which are predicted to provide new pathways for various cancers and infectious microbial diseases treatment.
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