Graves' disease - The thyroid stimulating antibody and immunological networks

Adams, 1967, Occurrence in thyrotoxicosis of a γ globulin which protects LATS from neutralization by an extract of thyroid gland, J. clin. Endocr. Metab., 27, 173, 10.1210/jcem-27-2-173 Adams, 1956, Abnormal responses in the assay for thyrotropin, 34, 11 Adams, 1981, Organization and expression of murine immunoglobulin genes, Immunol. Rev., 59, 5, 10.1111/j.1600-065X.1981.tb00454.x Adlkofer, 1973, Heterogeneity of long-acting thyroid stimulating (LATS) activity, thyroglobulin antibodies and thyroid microsomal antibodies, Acta Endocr. (Copenh.), 73, 483 Aguet, 1978, Induction of specific immune unresponsiveness with purified mixed leukocyte culture activated T lympoblasts as autoimmunogen. II. An analysis of the effects measured at the cellular and serological levels, J. exp. Med., 147, 50, 10.1084/jem.147.1.50 Ahlgrist, 1976, 33 Alexander, 1966, Thyroidal suppression by triiodothyronine as a guide to duration of treatment of thyrotoxicosis with anti-thyroid drugs, Lancet, ii, 1041, 10.1016/S0140-6736(66)92024-1 Alt, 1982, Immunoglobulin heavy-chain expression and class switching in a murine leukemia cell line, Nature, 296, 325, 10.1038/296325a0 Amino, 1975, Insoluble particulate antigen(s) in cell-mediated immunity of autoimmune thyroid disease, Metabolism, 24, 45, 10.1016/0026-0495(75)90006-2 Amino, 1982, Aggravation of thyrotoxicosis in early pregnancy and after delivery in Graves' Disease, J. clin. Endoc. Metab., 55, 108, 10.1210/jcem-55-1-108 Andersen, 1968, Gamma G4 - globulin antibody causing inhibition of clotting Factor VIII, Nature, 217, 174, 10.1038/217174a0 Aoki, 1979, Lymphocyte blastogenic response to human thyroglobulin in Graves' disease, Hashimoto's thyroiditis and metastatic thyroid cancer, Clin. Exp. Immunol., 38, 523 Aoki, 1979, Studies on suppressor cell function in thyroid diseases, J. clin. Endocr. Metab., 48, 803, 10.1210/jcem-48-5-803 Atkinson, 1981, The stimulation of thyroid hormone secretion in vitro by thyroid-stimulating antibodies, J. clin. Endocr. Metab., 53, 1263, 10.1210/jcem-53-6-1263 Atkinson, 1982, Effect of radioiodine on stimulatory activity of Graves' immunoglobulins, Clin. Endocr., 16, 537, 10.1111/j.1365-2265.1982.tb03170.x Augustin, 1976, Expression of new idiotypes following neonatal idiotypic suppression of a dominant clone, Eur. J. Immunol., 6, 497, 10.1002/eji.1830060710 Avivi, 1982, Direct visualization of membrane clustering and endocytosis of thyrotropin into cultured thyroid cells, Mol. Cell. Endocr., 25, 55, 10.1016/0303-7207(82)90169-1 Baekkeskov, 1982, Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins, Nature, 298, 167, 10.1038/298167a0 Bakó, 1982 Balázs, 1979, Decrease of concanvalin-A activated and short lived suppressor T cell function in thyrotoxicosis, Biomed., 30, 143 Balázs, 1978, The possible influence of HLA-A1, B8 antigens on the course of Graves' disease, Biomed. Express., 29, 263 Banovac, 1981, Absence of thyroid-stimulating antibody and long acting thyroid stimulator in relatives of Graves' Disease patients, J. clin. Endocr. Metab., 53, 651, 10.1210/jcem-53-3-651 Bayley, 1977, Photoaffinity labelling, Meth. Enzym., 46, 69, 10.1016/S0076-6879(77)46012-9 Beall, 1982, Production of human antithyroglobulin in vitro IV. Specific stimulation by antigen, J. clin. Endocr. Metab., 54, 1, 10.1210/jcem-54-1-1 Beall, 1978, Serum protein inhibition of thyrotropin binding to human thyroid tissue, J. clin. Endocrl. Metab., 47, 267 Beall, 1979, Antithyroglobulin (ATG) production by peripheral blood leukocytes in vitro, J. clin. Endocrl. Metab., 48, 712, 10.1210/jcem-48-4-712 Beall, 1980, Production of human antithyroglobulin in vitro II. Regulation by T cells, Clin. Immunol. Immunopathol., 16, 498, 10.1016/0090-1229(80)90191-9 Bech, 1981, Influence of thyroglobulin on basal and stimulated human thyroid adenylate cyclase activity, J. clin. Endocrl. Metab., 53, 264, 10.1210/jcem-53-2-264 Bech, 1978, HLA antigens in Graves' Disease, Acta Endocrl., 86, 510 Bech, 1979, Thyroid adenylate cyclase stimulating immunoglobulins in thyroid diseases, Clin. Endocrl., 11, 47, 10.1111/j.1365-2265.1979.tb03045.x Bech, 1979, The influence of treatment on thyroid stimulating antibodies in Graves' Disease, A. Endocrl., 40 Beckner, 1981, Re-evaluation of the role of gangliosides in the binding and action of thyrotropin, 78, 4848 Benacerraf, 1980, Genetic control of the specificity of T lymphocytes and their regulatory products, 419 Benacerraf, 1980, A hypothesis to relate the specificity of T lymphocytes and the activity of I region-specific Ir genes in macrophages and B lymphocytes, J. Immunol., 120, 1809 Benacerraf, 1981, Role of MHC gene products in immune regulation, Science, 212, 1229, 10.1126/science.6165083 Benacerraf, 1979, Specific suppressor to antigen under I region control, 38, 2053 Berhanu, 1982, Photoaffinity labelling of insulin receptors in viable cultured human lymphocytes. Demonstration of receptor shedding and degradation, Diabetes, 31, 410, 10.2337/diabetes.31.5.410 Berman, 1980, Linkage between the frequency of muscular weakness and loci that regulate immune responsiveness in murine experimental myasthenia gravis, J. exp. Med., 152, 507, 10.1084/jem.152.3.507 Bevan, 1977, In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells, Nature, 269, 417, 10.1038/269417a0 Bidey, 1980, Inhibition by normal immunoglobulins of thyrotropin-stimulated production of cyclic AMP in slices of normal human thyroid, J. Endocr., 87, 271, 10.1677/joe.0.0870271 Bidey, 1981, Adenylate cyclase activity and the accumulation and release of adenosine 3′,5′-monophosphate in normal human thyroid tissue slice preparations: responses to thyrotrophin and thyroid-stimulating antibodies, J. clin. Endocrl. Metab., 53, 246, 10.1210/jcem-53-2-246 Binz, 1976, Specific transplantation tolerance induced by autoimmunization against the individuals own, naturally occurring idiotypic, antigen-binding receptors, J. exp. Med., 144, 1438, 10.1084/jem.144.6.1438 Binz, 1978, Induction of specific immune unresponsiveness with purified mixed leukocytes culture activated T lymphoblasts and autoimmune III. Proof for the existence of auto-antiiodiotypic killer T cells and transfer of suppression to normal syngenic recipients by T and B lymphocytes, J. exp. Med., 147, 63, 10.1084/jem.147.1.63 Binz, 1980, Lymphocyte receptors, IV, 94 Binz, 1981, T cell receptors with allomajor-histocompatibility complex specificity from rat and mouse. Similarity of size, plasmin susceptibility and localization of antigen-binding region, J. exp. Med., 154, 1261, 10.1084/jem.154.5.1261 Biozzi, 1972, Cytodynamics of the immune response in two lines of mice genetically selected for ‘high’ and ‘low’ antibody synthesis, J. exp. Med., 135, 1071, 10.1084/jem.135.5.1071 Biozzi, 1980, Genetic selection for relevant immunological functions, 432 Biró, 1981, Specific binding of thyroid-stimulating hormone by human serum globulins, J. Endocr., 88, 339, 10.1677/joe.0.0880339 Biró, 1982, Thyroid-stimulating antibodies in Graves' disease and the effect of thyrotropin-binding globulins on their determination, J. Endocrl., 92, 175, 10.1677/joe.0.0920175 Bitensky, 1974, Studies on thyroid stimulating hormone and the long-acting thyroid stimulating hormone, Clin. Endocrl., 3, 363, 10.1111/j.1365-2265.1974.tb01811.x Black, 1976, Idiotypic analysis of lymphocytes in vitro I. Specificity and heterogeneity of B and T lymphocytes reactive with anti-idiotypic antibody, J. exp. Med., 143, 846, 10.1084/jem.143.4.846 Bliddal, 1982, Thyroid stimulating immunoglobulins in Hashimoto's thyroiditis measured by radioactive assay and adenylate cyclase stimulation and their relationship to HLA-D alleles, J. clin. Endocrl. Metab., 10.1210/jcem-55-5-995 Bodmer, 1978, Evolution and function of the HLA system, Br. Med. Bull., 34, 309, 10.1093/oxfordjournals.bmb.a071518 Bolk, 1979, Thyroid-stimulating immunoglobulins do not cause non-autonomous, autonomous, or toxic multinodular goitre, Lancet, i, 61, 10.1016/S0140-6736(79)90118-1 Borges, 1982, A new method for assessing the thyrotropin binding inhibitory activity in the immunoglobulins and whole serum of patients with Graves' Disease, J. clin. Endocrl. Metab., 54, 552, 10.1210/jcem-54-3-552 Bottomly, 1980, Absence of an antigen-specific helper T cell required for the expression of the T15 idiotype in mice treated with anti-μ antibody, Eur. J. Immunol., 10, 159, 10.1002/eji.1830100217 Brack, 1978, A complete immunoglobulin gene is created by somatic recombination, Cell, 15, 1, 10.1016/0092-8674(78)90078-8 Brennan, 1980, Time-dependent stabilization of the TSH-TSH receptor complex, FEBS Lett., 111, 35, 10.1016/0014-5793(80)80755-1 Briones-Urbina, 1982, Association of hypergamaglobulinemia G with HLA-DR3 in Graves' disease, Tissue Antigens, 19, 20, 10.1111/j.1399-0039.1982.tb01412.x Britz, 1982, Specialized antigen-presenting cells. Splenic dendritic cells and peritoneal exudate cells induced by mycobacteria activate effector T cells that are resistant to suppression, J. exp. Med., 155, 1344, 10.1084/jem.155.5.1344 Brown, 1978, Do thyroid-stimulating immunoglobulins cause non-toxic and toxic multimodular goitre?, Lancet, I, 904, 10.1016/S0140-6736(78)90682-7 Burke, 1968, On the competitive interaction of long-acting thyroid stimulator and thyrotropin in vivo, J. clin. Endocrl. Metab., 28, 286, 10.1210/jcem-28-2-286 Calder, 1974, Evidence for circulating immune complexes in thyroid disease, Br. med. J., ii, 30, 10.1136/bmj.2.5909.30 Canonica, 1981, Human T-lymphocyte subpopulations in Hashimoto's disease, J. clin. Endocrn. Metab., 52, 533 Cantor, 1979, Immunological circuits: Cellular composition, 38, 2058 Capra, 1977, Towards a chemical definition of idiotypy, 36, 204 Capra, 1977, The antibody combining site, Sci. Amer., 236, 50, 10.1038/scientificamerican0177-50 Cathou, 1975, The conformation, interaction and biological roles of immunoglobulin subunits, 91 Chan, 1978, HLA and thyrotoxicosis (Graves' disease) in Chinese, Tissue Antigens, 12, 109, 10.1111/j.1399-0039.1978.tb01306.x Chapman, 1976, The effects of micro unit doses of thyrotropin on iodothyrinine release from mouse thyroid lobes in vitro, 217 Chestnut, 1981, Studies on the capacity of B cells to serve as antigen-presenting cells, J. Immunol., 126, 1075 Chopra, 1970, Graves' Disease with delayed hyperthyroidism: onset after several years of euthyroid ophthalmopathy, dermopathy and high serum LATS, Ann. intern. Med., 73, 985, 10.7326/0003-4819-73-6-985 Chopra, 1970, The thyroid gland in Graves' Disease: Victim or culprit?, Metabolism, 19, 760, 10.1016/0026-0495(70)90074-0 Claflin, 1974, Clonal nature of the immune response to phosphorylcholine, IV. Idiotypic uniformity of binding site associated antigenic determinants among mouse antiphosphorylcholine antibodies, J. exp. Med., 140, 673, 10.1084/jem.140.3.673 Claflin, 1975, Clonal nature of the immune response to phosphorylcholine (PC). Cross-idiotypic specificity among heavy chain of murine anti-PC antibodies and PC-binding myeloma protein, J. exp. Med., 141, 1073, 10.1084/jem.141.5.1073 Clark, 1982, Thyrotropin binding and adenylate cyclase activation in normal and neoplastic human thyroid tissue: Lack of effect of thyroglobulin, J. clin. Endocr. Metab., 54, 1157, 10.1210/jcem-54-6-1157 Clark, 1982, Generation of T cell colonies from responder strain 2 guinea pigs that recognize the copolymer L-glutamic acid, L-lysine in association with non-responder strain 13 Ia antigens, J. exp. Med., 155, 635, 10.1084/jem.155.2.635 Clark, 1982, T-cell colonies recognize antigen in association with specific epitopes on Ia molecules, Nature, 295, 412, 10.1038/295412a0 Cowdery, 1981, Serum antibody-binding antibodies produced during a primary antibody response, J. Immunol., 126, 2136 Czarnocka, 1981, Thyrotropin binding glycoprotein isolated from bovine thyroid, Acta Endocr. (Copenh.), 96, 335 Dahlberg, 1981, HLA-A, -B, -C and -DR antigens in patients with Graves' disease and their correlation with signs and clinical course, Acta Endocr., 97, 42 1977 Davies, 1981, Autoantibodies to the human thyrotropin receptor are not species specific, J. clin. Endocr. Metab., 52, 426, 10.1210/jcem-52-3-426 Davies, 1981, Protection studies at the TSH receptor: Evidence for receptor autoantibodies in Graves' disease Davies, 1982, Prediction of therapeutic responses to radioactive iodine in Graves' disease using TSH-receptor antibodies and HLA-status, Clin. Endocr., 16, 183, 10.1111/j.1365-2265.1982.tb03163.x Davies, 1978, Binding of thyroid stimulators to guinea pig testis and thyroid, Endocrinology, 103, 6, 10.1210/endo-103-1-6 Davies, 1978, Thyrotropin receptors in adipose tissue, retro-orbital tissue, and lymphocytes, Molec. cell. Endocr., 9, 303, 10.1016/0303-7207(78)90072-2 Davies, 1977, Value of thyroid stimulating antibody determinations in predicting short-term thyrotoxic relapses in Graves' Disease, Lancet, i, 1181, 10.1016/S0140-6736(77)92719-2 Dawes, 1978, Solubilization and partial characterization of human and porcine thyrotropin receptors, J. Endocr., 78, 89, 10.1677/joe.0.0780089 Deisenhofer, 1976, Crystallographic structural studies of a human Fc fragment. I. An electrondensity map at 4A resolution and a partial model, Hoppe-Seyler's Z. phys. Chem., 357, 435, 10.1515/bchm2.1976.357.1.435 de Krester, 1982, Demonstration of two distinct light chains in HLA-DR-associated antigens by two dimensional gel electrophoresis, Eur. J. Immunol., 12, 214, 10.1002/eji.1830120309 Delespesse, 1973, The leukocyte migration test in human thyroid autoimmunity. Correlations with other immunological reactions, Horm. Metab. Res., 5, 176, 10.1055/s-0028-1093967 Demaine, 1982, Immunoglobulin (GM) allotype frequencies in patients with renal failure, Transplantation, 10.1097/00007890-198209000-00009 Deutch, 1982, Identification and characterization of a latent pool of insulin receptors in 3T3-LI adipocytes, J. biol. Chem., 257, 5350, 10.1016/S0021-9258(19)83783-3 Devey, 1974, A critical study of the IgG subclasses of Rh anti-D antibodies formed in pregnancy in immunized volunteers, Immunology, 27, 1073 Docter, 1980, Thyrotropin binding inhibiting immunoglobulins in Graves' disease before, during, and after antithyroid therapy, and its relation to long acting thyroid stimulator, Clin. endocr., 12, 143, 10.1111/j.1365-2265.1980.tb02129.x 1981 Dorrington, 1978, Structure-function relationships in human immunoglobulin E, Immunol. Rev., 41, 3, 10.1111/j.1600-065X.1978.tb01458.x Dorrington, 1964, Reduction of γ2-globulin with long-acting thyroid-stimulating activity, Lancet, ii, 889, 10.1016/S0140-6736(64)90744-5 Dosch, 1979, Specific in vitro IgM response of human B cells: a complex regulator network modulated by antigen, Immunol. Rev., 45, 243, 10.1111/j.1600-065X.1979.tb00280.x Drummong, 1982, Separation of two thyrotropin binding components from porcine thyroid tissue by affinity chromatography: Characterization of high and low affinity sites, 79, 2202 Dunsworth, 1982, Heterogeneity of insulin-dependent diabetes-New evidence, Clin. Genet., 21, 233, 10.1111/j.1399-0004.1982.tb00756.x Edelman, 1970, The covalent structure of a human G-immunoglobulin XI. Functional implications, Biochemistry, 9, 3197, 10.1021/bi00818a012 1979, Lancet, ii, 78 1980, Lancet, i, 1393 Eggo, 1982, Isolation of TSH receptor proteins by photoaffinity labeling, Clin. Res., 30, 490A Eichmann, 1973, Idiotype expression and the inheritance of mouse antibody clones, J. exp. Med., 137, 603, 10.1084/jem.137.3.603 Eichmann, 1978, Expression and function of idiotypes on lymphocytes, Adv. Immunol., 26, 195, 10.1016/S0065-2776(08)60231-X Eichmann, 1975, Induction of T and B cell immunity by antiidiotypic antibodies, Eur. J. Immunol., 5, 661, 10.1002/eji.1830051002 Ellerson, 1976, Structure and function of immunoglobulin domains II. Isolation and characterization of a fragment corresponding to the Cγ2 homology region of human immunoglobulin G, J. Immunol., 116, 510 Endo, 1981, Development and evaluation of a method for the partial purification of immunoglobulins specific for Graves' disease, J. clin. Endocr. Metab., 52, 1113, 10.1210/jcem-52-6-1113 Endo, 1978, Detection and properties of TSH-binding inhibitor immunoglobulins in patients with Graves' disease and Hashimoto's thyroiditis, J. clin. Endocr. Metab., 46, 734, 10.1210/jcem-46-5-734 Erikson, 1981, Assignment of the genes for the human immunoglobulin chains to chromosome 22, Nature, 293, 173, 10.1038/294173a0 Ettienne-Decerf, 1981, A sensitive technique for determination of thyroid stimulating immunoglobulin (TSI) in unfractionated serum, Clin. Endocr., 14, 83, 10.1111/j.1365-2265.1981.tb00368.x Fahey, 1966, Antibodies and immunoglobulin, JAMA, 194, 71, 10.1001/jama.194.1.71 Farid, 1974, Studies of cell mediated immunity (CMI) in relatives of patients with Graves' disease, J. clin. Endocr. Metab., 39, 779, 10.1210/jcem-39-4-779 Farid, 1976, The association of HLA with autoimmune thyroid disease in Newfoundland. The influence of HLA homozygozity in Graves′ disease, Tissue Antigens, 8, 181, 10.1111/j.1399-0039.1976.tb00567.x Farid, 1977, Gm phenotypes in autoimmune thyroid disease, J. Immunogenet., 4, 429, 10.1111/j.1744-313X.1977.tb00927.x Farid, 1977, HLA and phenythiocarbamide (PTC) tasting in autoimmune thyroid disease, Tissue Antigens, 10, 414, 10.1111/j.1399-0039.1977.tb00780.x Farid, 1977, Thyroid autoimmune disease in a large Newfoundland family: The influence of HLA, J. clin. Endocr. Metab., 45, 1165, 10.1210/jcem-45-6-1165 Farid, 1978, The operation of immunological networks in Graves′ Disease, Tissue Antigens, 12, 205, 10.1111/j.1399-0039.1978.tb01324.x Farid, 1978, The association of HLA with juvenile diabetes mellitus in Newfoundland, Tissue Antigens, 12, 215, 10.1111/j.1399-0039.1978.tb01326.x Farid, 1979, Study of immunoglobulin G markers (Gm) of membrane-purified thyroid stimulating antibody of Graves′ disease, 293 Farid, 1980, Graves′ disease and HLA: Clinical and epidemiologic associations, Clin. Endocr., 13, 535, 10.1111/j.1365-2265.1980.tb03421.x Farid, 1980, Polyglandular autoimmune disease and HLA, Tissue Antigens, 16, 23, 10.1111/j.1399-0039.1980.tb00284.x Farid, 1980, HLA haplotypes in familial Graves′ disease, Tissue Antigens, 15, 492, 10.1111/j.1399-0039.1980.tb00213.x Farid, 1981, Graves′ Disease, 85 Farid, 1981, Thyroiditis, 145 Farid, 1981, The human major histocompatibility complex and endocrine disease, Endocr. Rev., 2, 50, 10.1210/edrv-2-1-50 Farid, 1981, The association of goitrous autoimmune thyroiditis with HLA-DR5, Tissue Antigens, 17, 265, 10.1111/j.1399-0039.1981.tb00700.x Farid, 1982, Two major genes, linked to HLA and Gm, control susceptibility to Graves′ disease, Nature, 295, 629, 10.1038/295629a0 Farid, 1983, Autoimmune endocrine disorders and the major histocompatibility complex, 59 Farid, 1982, Biologic activity of anti-thyrotropin anti-idiotypic antibodies, J. Cell Biochm., 13, 305, 10.1002/jcb.240190402 Fatham, 1981, Studies utilizing murine T cell clones: Ir genes, Ia antigens and MLR stimulating determinants, Immunol. Rev., 54, 57, 10.1111/j.1600-065X.1981.tb00434.x 1979 Fauci, 1980, Activation of human B lymphocytes XVI. Cellular requirements, interactions and immunoregulation of pokeweek-mitogen induced total immunoglobulin producing plaque-forming cells in peripheral blood, Cell. Immunol., 54, 230, 10.1016/0008-8749(80)90204-X Fayet, 1971, Thyrotrophin induced aggregation and re-organization into follicles of isolated porcine thyroid cells in culture. 2. Ultrastructural studies, Eur. J. Biochem., 24, 100, 10.1111/j.1432-1033.1971.tb19659.x Fenzi, 1979, Changes in thyroid stimulating immunoglobulins during antithyroid therapy, J. clin. Endocr. Metab., 48, 572, 10.1210/jcem-48-4-572 Fenzi, 1980, Thyroid plasma membrane antigens and TSH receptor, 26 Flood, 1980, Suppression of tumors rejection by autologous anti-idiolypic immunity, 77, 2209 Forni, 1980, IgM antibodies induce the production of antibodies of the same specificity, 77, 1125 Førre, 1976, Antibody activity of heavy and light chains and recombined IgG of human IgG anti-D, Scand. J. Immunol., 5, 155, 10.1111/j.1365-3083.1976.tb03002.x Førre, 1977, VH subgroup restriction in human erythrocyte antibodies: studies of anti-A, anti-B and anti-Duffy antibodies, Scand. J. Immunol., 6, 149, 10.1111/j.1365-3083.1977.tb00330.x Førre, 1977, Cross-idiotypic reactions among anti-Rh (D) antibodies, Scand. J. Immunol., 6, 997, 10.1111/j.1365-3083.1977.tb00335.x Førre, 1978, Variable heavy chain (VH) subgroups of human autoantibody molecules, Clin. Immunol. Immunopathol., 9, 120, 10.1016/0090-1229(78)90128-9 Foster, 1978, Structure and function of immunoglobulin domains VII. Studies on the structural requirements of human immunoglobulin G for granulocyte binding, J. Immunol., 120, 1952 Frangione, 1972, Partial duplication in the ‘hinge’ region of IgA, myeloma proteins, 69, 3673 Fresno, 1981, Antigen specific T lymphocyte clones II. Purification and biological characterization of an antigen-specific suppressive protein synthesized by cloned T cells, J. exp. Med., 153, 1260, 10.1084/jem.153.5.1260 Frischknecht, 1978, Induction of specific transplantation immune reactions using anti-idiotypic antibodies, J. exp. Med., 147, 500, 10.1084/jem.147.2.500 Fujiwara, 1981, Immune complex deposits in thyroid glands of patients with Graves' disease: I. Complement system in serum and thyroid gland of patients with Graves' disease, Clin. Immunol. Immunopathol., 19, 98, 10.1016/0090-1229(81)90051-9 Gardner, 1979, Serum thyroglobulin in normal subjects and patients with hyperthyroidism due to Graves' disease: Effects of T3, iodide, 131I and antithyroid drugs, Clin. Endocr., 11, 585, 10.1111/j.1365-2265.1979.tb03112.x Geha, 1980, Macrophage T cell interaction in man: Binding of antigen-specific human proliferating and helper T cells to antigen-pulsed macrophages, J. Immunol., 126, 781 Geha, 1981, Regulation of the immune response by idiotypic-antiidiotypic interactions, N. Engl. J. Med., 305, 25, 10.1056/NEJM198107023050105 Germain, 1981, A single major pathway of T-lymphocyte interactions in antigen-specific immune suppression, Scand. J. Immunol., 13, 1, 10.1111/j.1365-3083.1981.tb00104.x Gershon, 1979, Immune regulation, 38, 2051 Gerhson, 1981, Contrasuppression. A novel immunoregulatory activity, J. exp. Med., 153, 1533, 10.1084/jem.153.6.1533 Gill, 1980, Effects of immunoglobulins upon the interaction of thyrotropin with receptors in human fat tissue, Endocrinology, 107, 1813, 10.1210/endo-107-6-1813 Ginsberg, 1982, Evidence that the porcine thyrotropin (TSH) receptor contains an essential disulphide bridge, Molec. Cell. Endocr., 26, 95, 10.1016/0303-7207(82)90008-9 Givol, 1972, Combining sites of myeloma proteins with anti-hapten activity, 26, 77 Goidl, 1980, Production of auto-antiidiotypic antibody during the normal immune response: changes in the auto antiidiotypic antibody response and the idiotype repertoire associated with aging, 77, 6788 Goldhammer, 1982, Interaction of fluoride and guanine nucleotides with thyroid adenylate cyclase, Biochem. biophys. Acta, 701, 192, 10.1016/0167-4838(82)90113-3 Gossage, 1981, A comparative study of the binding of Graves' immunoglobulins by the patient's own and other thyroid membranes, Clin. Endocr., 14, 301, 10.1111/j.1365-2265.1981.tb00199.x Goyert, 1981, Isolation of I-A subregion-like molecules from subhuman primates of man, Nature, 294, 266, 10.1038/294266a0 Green, 1982, Genetic studies of insulin-dependent diabetes mellitus: segregation and linkage analysis, Tissue Antigens, 19, 213, 10.1111/j.1399-0039.1982.tb01442.x Guencheva, 1982, Soluble HLA antigens in normal human immunoglobulin preparations, Tissue Antigens, 19, 198, 10.1111/j.1399-0039.1982.tb01440.x Haber, 1972, The three dimensional stucture of immunoglobulins, 26, 61 Hannestad, 1977, Ligand-induced redistribution and augmentation of surface bound myeloma protein on MOPC315 plasmocytoma cells, Scand. J. Immunol., 6, 59, 10.1111/j.1365-3083.1977.tb00322.x Hardisty, 1981, Long-acting thyroid stimulator (LATS) and long acting thyroid stimulator protector (LATS-P) in untreated thyrotoxicosis, Clin. Endocr., 14, 631, 10.1111/j.1365-2265.1981.tb02975.x Hardisty, 1981, The effect of partial thyroidectomy for Graves' disease on serum long-acting thyroid stimulator protector (LATS-P), Clin. Endocr., 14, 181, 10.1111/j.1365-2265.1981.tb00614.x Hart, 1971, Comparison of the effects of thyrotropin and the long-acting thyroid stimulator on guinea pig adipose tissue, Endocrinol., 88, 26, 10.1210/endo-88-1-26 Hashizume, 1979, Adenosine 3′,5′-monophosphate-dependant protein kinase activity in soluble thyrotropin receptor complex, Endocrinology, 104, 1739, 10.1210/endo-104-6-1739 Hashizume, 1978, Thyroglobulin inhibition of thyrotropin binding to thyroid plasma membrane, J. clin. Endocr. Metab., 46, 679, 10.1210/jcem-46-4-679 Hiernaux, 1982, Lack of involvement of auto-antiidiotypic antibody in the regulation of oscillations and tolerance in the antibody response to Levan, Cell. Immunol., 67, 334, 10.1016/0008-8749(82)90225-8 Hinds, 1981, Thyroid stimulating immunoglobulin bioassay using culture human thyroid cells, J. clin. Endocr. Metab., 52, 1204, 10.1210/jcem-52-6-1204 Hiramatsu, 1982, Monoclonal antibodies against unique 1-region gene products expressed only on mature functional T cells, Nature, 296, 666, 10.1038/296666a0 Hirata, 1981, The regulation of lipomodulin, a phospholipase inhibitory protein in rabbit neutrophils by phosphorylation, J. biol. Chem., 256, 7730, 10.1016/S0021-9258(18)43335-2 Hirata, 1980, Phospholipid methylation and biological signal transmission, Science, 209, 1082, 10.1126/science.6157192 Hobart, 1981, Immunoglobulin heavy chain genes in humans are located on chromosome 14, Ann. Hum. Genet., 45, 331, 10.1111/j.1469-1809.1981.tb00346.x Hochtl, 1982, Recombined flanks of the variable and joining segments of immunoglobulin genes, 79, 1383 Hoddinott, 1982, Immunoglobulin levels, immunodeficiency and Type I diabetes mellitus, Diabetologia, 23, 326, 10.1007/BF00253738 Hoffman, 1982, Transient thyrotoxicosis in an infant delivered to a long-acting thyroid stimulator (LATS) and LATS protector-negative, thyroid-stimulating antibody-positive woman with Hashimoto's thyroiditis, J. clin. Endocr. Metab., 54, 354, 10.1210/jcem-54-2-354 Hoffman, 1982, Immunoglobulin G3 subclass production by rheumatoid synovial tissue cultures, J. clin. Invest., 69, 136, 10.1172/JCI110424 Holmes, 1978, Effects of human thyroid stimulating hormone and immunoglobulins on adenylate cyclase activity and the accumulation of cyclic AMP in human thyroid membranes and slices, J. Endocr., 79, 121, 10.1677/joe.0.0790121 Honjo, 1981, Rearrangements of immunoglobulin genes during differentiation and evolution, Immunol. Rev., 59, 33, 10.1111/j.1600-065X.1981.tb00455.x Huber, 1982, Ia.w39 expression correlates a specific lr function, J. Immunol., 128, 2349 Ichikawa, 1980, Immunoprecipitable antithyrotrophic receptive antibody in Graves' Disease Irvine, 1977, Correlation of HLA and thyroid antibodies with clinical course of thyrotoxicosis treated with antithyroid drugs, Lancet, ii, 898, 10.1016/S0140-6736(77)90833-9 Isakov, 1979, Differential immunogenetic expression of an H-2 linked histocompatibility antigen on different tissues, Transplantation, 28, 31, 10.1097/00007890-197907000-00007 Ishii, 1981, Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from non-responder strains, J. exp. Med., 154, 978, 10.1084/jem.154.3.978 Ishii, 1982, Absence of Ir gene control of T cells recognizing foreign antigens in the context of allogenic MHC molecules, Nature, 295, 531, 10.1038/295531a0 Islam, 1983, Biological activity of anti-thyrotropin anti-idiotypic antibody, Eur. J. Immunol., 13, 57, 10.1002/eji.1830130113 Islam, 1982, Structure of the thyroidal thyrotropin receptor, 301 Islam, 1983, Both TSH and thyroid stimulating antibody of Graves' Disease bind to an Mr 197,000 holoreceptor Manuscript, Endocrinol, 113, 436, 10.1210/endo-113-1-436 Islam, 1983 Jackson, 1982, Increased circulating Ia-antigen-bearing T cells in Type I diabetes mellitus, N. Engl. J. Med., 306, 785, 10.1056/NEJM198204013061305 Janeway, 1980, Cell cooperation during in vivo anti-hapten antibody responses. V. Two synergistic Ly-1+23− helper T cells with distinctive specificities, Eur. J. Immunol., 10, 231, 10.1002/eji.1830100402 Janeway, 1981, Idiotypes and their expression, Immunol. Today 2, 5, ii Jansson, 1982, Thyroid-infiltrating and blood T lymphocytes in Hashimoto's disease-Quantification of T cell subsets in fine-needle aspiratates using monoclonal antibodies, 218 Jaton, 1971, Variations in the primary structure of antibody during the course of immunization, Biochemistry, 10, 1583, 10.1021/bi00785a012 Jayaraman, 1982, T cell replacing factor substitutes for and I-J+ idiotype-specific T helper cell, J. exp. Med., 155, 641, 10.1084/jem.155.2.641 Jerne, 1974, Towards a network theory of the immune system, Ann. Immunol. (Paris), 125c, 373 Jones, 1978, Two-gene control of the expression of a murine Ia antigen, J. exp. Med., 148, 925, 10.1084/jem.148.4.925 Jones, 1981, Cooperative interaction of B lymphocytes with antigen-specific helper T lymphocytes is MHC restricted, Nature, 292, 547, 10.1038/292547a0 Jorgensen, 1977, Specificity of T and B lymphocytes for myeloma protein 315, Eur. J. Immunol., 7, 426, 10.1002/eji.1830070705 Kabat, 1971, Attempts to locate complementarity-determining residues in the variable positions of light and heavy chains, Ann. N.Y. Acad. Sci., 190, 382, 10.1111/j.1749-6632.1971.tb13550.x Kabat, 1978, Variable region genes for the immunoglobulin framework are assembled from small segments of DNA-A hypothesis, 75, 2429 Kagnoff, 1982, Two genetic loci control the murine immune response to A-gliadin, a wheat protein that activates coeliac sprue, Nature, 296, 158, 10.1038/296158a0 Kappler, 1981, Antigen-inducible H-2 restricted, interleukin-2 producing T cell hybridomas. Lack of independent antigen and H-2 recognition, J. exp. Med., 153, 1198, 10.1084/jem.153.5.1198 Karpatkin, 1973, Heavy chain subclass of human anti-platelet antibodies, Clin. Immunol. Immunopathol., 2, 1, 10.1016/0090-1229(73)90030-5 Kasagi, 1980, Adenylate cyclase activity in thyroid tissue from patients with untreated Graves' disease, J. clin. Endocr. Metab., 51, 492, 10.1210/jcem-51-3-492 Kataoka, 1982, The nucleotide sequences of re-arranged and germ line immunoglobulin VH genes of a mouse myeloma MC101 and evolution of VH genes in mouse, J. Biol. Chem., 257, 277, 10.1016/S0021-9258(19)68358-4 Kees, 1981, Idiotypes on major histocompatibility complex-restricred virus-immune cytotoxic T lymphocytes, J. exp. Med., 153, 1562, 10.1084/jem.153.6.1562 Kehry, 1980, The immunoglobulin mu chains of membrane-bound and secreted IgM molecules differ in their C-terminal segments, Cell, 21, 393, 10.1016/0092-8674(80)90476-6 Keller, 1980, Two types of functionally distinct, synergizing helper T cells, J. Immunol., 124, 1350 Kelsoe, 1980, Thymic requirement for cyclical idiotypic and reciprocal anti-idiotypic immune-response to a T-independent antigen, J. exp. Med., 151, 289, 10.1084/jem.151.2.289 Kendall-Taylor, 1975, LATS and human-specific thyroid stimulator, twin relation to Graves' Disease, J. clin. Endocr. Metab., 4, 319, 10.1016/S0300-595X(75)80024-7 Kerensky, 1982, Long-term human cytolytic T cell lines allospecific for HLA-DR6 antigen are OKT4+, 79, 2365 Kermode, 1981, Comparison of binding of bovine and human thyroid-stimulating hormone to receptor sites on human thyroid membranes, J. Endocr., 88, 205, 10.1677/joe.0.0880205 Kidd, 1980, Immunologic aspects of Graves' and Hashimoto's disease, Metabolism, 29, 80, 10.1016/0026-0495(80)90102-X Kindt, 1982, Beta-2 microglobulin and its association with histocompatibility antigens of the mouse and rabbit, 29, 187 Kitchin, 1959, PTC taste response and thyroid disease, Br. med. J., 1, 1069, 10.1136/bmj.1.5129.1069 Klein, 1979, The major histocompatibility complex of the mouse, Science, 203, 516, 10.1126/science.104386 Klein, 1981, The traditional and a new version of the mouse H-2 complex, Nature, 291, 455, 10.1038/291455a0 Knopp, 1970, Evidence for the induction of iodide transport in bovine thyroid cells treated with thyroid-stimulating hormone or dibutryl cyclic adenosine 3′,5′-monophosphate, J. biol. Chem., 245, 4403, 10.1016/S0021-9258(19)63809-3 Knox, 1976, Demonstration of the production of human thyroid-stimulating immunoglobulin (HTSI) by Graves' lymphocytes cultured in vitro with phytohaemgglutinin (PHA), Metabolism, 25, 1217, 10.1016/S0026-0495(76)80005-4 Knox, 1976, Thyroid antigen stimulates lymphocytes from patients with Graves' Disease to produce thyroid stimulating immunoglobulins (TSI), J. clin. Endocr. Metab., 43, 330, 10.1210/jcem-43-2-330 Köhler, 1977, Complementary idiotypy in the regulation of the immune response, 36, 221 Kohn, 1980, Thyrotropin receptors and gangliosides, Adv. Exp. Med. Biol., 125, 487, 10.1007/978-1-4684-7844-0_43 Koizumi, 1982, Solubilization, purification and partial characterization of thyrotropin receptor from bovine and human thyroid glands, Endocrinology, 110, 1381, 10.1210/endo-110-4-1381 Koshland, 1975, Structure and function of the J chain, Adv. Immunol., 20, 41, 10.1016/S0065-2776(08)60206-0 Kraig, 1983, T and B cells that recognize the same antigen do not transcribe similar heavy chain variable region gene segments, J. exp. Med., 158, 192, 10.1084/jem.158.1.192 Kriss, 1968, Inactivation of long-acting thyroid stimulator (LATS) by anti-kappa and anti-lambda antisera, J. clin. Endocr. Metab., 28, 1440, 10.1210/jcem-28-10-1440 Kriss, 1964, Isolation and identification of the long-acting thyroid stimulator and its relation to hyperthyroidism and circumscribed pretibial myxedema, J. clin. Endocr. Metab., 24, 1005, 10.1210/jcem-24-10-1005 Kronenberg, 1983, Three T cell hybridomas do not contain detectable heavy chain variable gene transcripts, J. exp. Med., 158, 210, 10.1084/jem.158.1.210 Kurosawa, 1982, Organzation, structure and assembly of immunoglobulin heavy chain diversity DNA segments, J. exp. Med., 155, 201, 10.1084/jem.155.1.201 Kurosawa, 1981, Identification of D segments of immunoglobulin heavy-chain genes and their re-arrangement in T lymphocytes, Nature, 290, 565, 10.1038/290565a0 Kuzuya, 1979, Correlation between thyroid stimulators and 3,5,3′-triiodothyronine suppressibility in patients during treatment for hyperthyroidism with thionamide drugs: comparison of assays by thyroid-stimulating and thyrotropin-displacing activities, J. clin. Endocr. Metab., 48, 706, 10.1210/jcem-48-4-706 Lacetti, 1982, Multicomponent structure of the glycoprotein component of the thyrotrophin receptor, 142 L'Age-Stehr, 1981, Priming of T helper cells by antigen-activated B cells. B cell primed Lyt-1+ helper cells are restricted to cooperate with B cells expressing the IgVH phenotype of the priming B cells, J. exp. Med., 153, 1236, 10.1084/jem.153.5.1236 Lamki, 1981, Cell-mediated immunity in Graves' disease and Hashinoto's thyroiditis as shown by the demonstration of migration inhibition factor (MIF), J. clin. Endocr. Metab., 36, 358, 10.1210/jcem-36-2-358 Larhammar, 1981, Evolutionary relationships between HLA-DR antigens, β-chains, HLA-A, B, C antigen subunits and immunoglobulin chains, Scand. J. Immunol., 14, 617, 10.1111/j.1365-3083.1981.tb00603.x Larsen, 1981, Basic features of the HLA system, 11 Laurberg, 1975, T3 release from thyroid slices as an assay for thyroid stimulators, Scand. J. clin. Lab. Invest., 35, 723, 10.3109/00365517509095803 Lawley, 1981, Defective Fc receptor functions associated with HLA-B8/DRw3 haplotypes. Studies in patients with dermatitis herpetiformis and normal subjects, N. Engl. J. Med., 304, 185, 10.1056/NEJM198101223040401 Leder, 1982, The genetics of antibody diversity, Sci. Am., 246, 102, 10.1038/scientificamerican0582-102 Legrand, 1982, HLA and Gm linked genes affecting the degradation rate of antigens (sheep red blood cells) endocytized by macrophases, Hum. Immunol., 4, 1, 10.1016/0198-8859(82)90045-3 Lehner, 1981, Association between HLA-DR angitens and helper cell activity in the control of dental caries, Nature, 292, 770, 10.1038/292770a0 Lerner, 1980, Monoclonal antibody against an Ir gene product?, J. exp. Med., 152, 1085, 10.1084/jem.152.4.1085 Lieberman, 1974, Genetics of a new IgVH (T15 idiotype) marker in the mouse regulating the natural antibody to phosphorycholine, J. exp. Med., 139, 983, 10.1084/jem.139.4.983 Lieberman, 1972, Genetic factors controlling anti-sheep erythrocytes antibody response and immunoglobulin synthesis in back cross and F2 progeny of mice genetically selected for “high” or “low” antibody synthesis, J. exp. Med., 136, 790, 10.1084/jem.136.4.790 Lonai, 1981, Two separate genes regulate self-Ia and carrier recognition in H-2 restricted helper factors secreted by hybridoma cells, J. exp. Med., 154, 1910, 10.1084/jem.154.6.1910 Lonergan, 1973, Isoelectric focusing of long-acting thyroid stimulator immunoglobulin G, J. clin. Endocr. Metab., 36, 439, 10.1210/jcem-36-3-439 Loveridge, 1979, The cytochemical bioassay for thyroid-stimulating antibody of Graves' disease. Further experience, J. clin. Endocr. Metab., 49, 610, 10.1210/jcem-49-4-610 Lynch, 1972, Myeloma proteins as tumor-specific transplantation antigens, 69, 1540 Macario, 1975, Sequential changes and persistance of antibody molecules during the immune response with special reference to binding properties of the antigen combining site, Immunochemistry, 12, 249, 10.1016/0019-2791(75)90239-6 Madsen, 1979, TSH and thyroid stimulating antibodies (TSAb) activate thyroid adenylate cyclase through different pathways, Acta Med. Scand. Suppl., 624, 35 Makinen, 1978, Evidence that the TSH receptor acts as a mitogenic antigen in Graves' disease, Nature, 275, 314, 10.1038/275314a0 Manley, 1981, Receptor heterogeneity in the human thyroid: differences between thyrotropin binding sites in membranes and nuclear fractions, J. Endocr., 91, 163, 10.1677/joe.0.0910163 Manley, 1974, The thyrotropin receptor in guinea pig thyroid homogenate: interaction with the long-acting thyroid stimulator, J. Endoc., 61, 437, 10.1677/joe.0.0610437 Marchalonis, 1982, The T-cell antigen receptor: the minimal hypothesis revisited, Immunol. Today, 3, 10, 10.1016/0167-5699(82)90118-9 Marchant, 1978, B3, 305 Mariotti, 1979, Study of circulating immune complexes in thyroid diseases. Comparison of Raji cell radioimmunoassay and specific thyroglobulin-antithyroglobylin radioassay, J. clin. Endocr. Metab., 49, 679, 10.1210/jcem-49-5-679 Marx, 1982, Cloning of the MHC, Science, 216, 400, 10.1126/science.7071587 Matis, 1982, Immune response gene function correlates with the expression of an Ia antigen. II. A quantitative deficiency in Ae:Eα complex-expression causes a corresponding defect in antigen-presenting cell function, J. exp. Med., 155, 508, 10.1084/jem.155.2.508 Matsuura, 1980, Familial neonatal transient hypothyroidism due to maternal TSH-binding immunoglobulins, New Engl. J. Med., 303, 738, 10.1056/NEJM198009253031306 McBride, 1982, Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes, J. exp. Med., 155, 1480, 10.1084/jem.155.5.1480 McGregor, 1979, Effects of radioiodine on thyrotropin binding inhibiting immunoglobulins in Graves' disease, Clin. Endocr., 11, 437, 10.1111/j.1365-2265.1979.tb03095.x McGregor, 1980, Prediction of relapse in hyperthyroid Graves' disease, Lancet, I, 1101, 10.1016/S0140-6736(80)91551-2 McKenna, 1982, HLA and hyperthyroidism in Ireland, Tissue Antigens, 19, 97, 10.1111/j.1399-0039.1982.tb01423.x McKenzie, 1958, Delayed thyroid response to serum from thryrotoxic patients, Endocrinology, 62, 865, 10.1210/endo-62-6-865 McKenzie, 1960, Further evidence for a thyroid activator in hyperthyroidism, J. clin. Endocr. Metab., 20, 380, 10.1210/jcem-20-3-380 McKenzie, 1965, The gamma globulin of Graves' disease: Thyroid stimulation by fragment and fraction, Trans Assoc. Am. Physns., 78, 174 McKenzie, 1974, Long-acting thyroid stimulator of Graves' disease, Vol. 3, 285 McKenzie, 1980, Thyroid-stimulating antibody (TSAb) in Graves' Disease, Thyroid Today, Vol. 3, # 5 McKenzie, 1965, The origin of the long-acting thyroid stimulator, 445 McKenzie, 1976, A reconsideration of a thyroid-stimulating immunoglobulin as the cause of hyperthyroidism in Graves' disease, J. clin. Endocr. Metab., 42, 778, 10.1210/jcem-42-4-778 McKenzie, 1978, LATS in Graves' disease, Recent Prog. Horm. Res., 33, 29 McLachlan, 1981, Use of plaque assays to study thyroglobulin-autoantibody synthesis by human peripheral blood lymphocytes, Scand. J. Immunol., 14, 233, 10.1111/j.1365-3083.1981.tb00560.x McLachlan, 1978, A system for studying thyroid stimulating antibody production in vitro, J. clin. Lab. Immunol., 1, 45 McLachlan, 1980, In vitro studies on the control of thyroid autoantibody synthesis, J. clin. Lab. Immunol., 3, 15 McNabb, 1976, Structure and function of immunoglobulin domains V. Binding of immunoglobulin G and fragments to placental membrane preparations, J. Immunol., 117, 882 McNicholas, 1982, Immune response gene function correlate with the expression of an Ia antigen. I. Preferential association of certain Aϵ and Eα chains results in a quantitative deficiency in expression of a Aρ:Eα complex, J. exp. Med., 155, 490, 10.1084/jem.155.2.490 Meek, 1964, Characterization of the long-acting thyroid stimulator of Graves' disease, 52, 342 Mehdi, 1978, Preparation of radiolabeled thyroid-stimulating immunoglobulin (TSI) by recombining TSI heavy chains with 125I-labeled light chains: direct evidence that the product binds to the membrane thyrotropin receptor and stimulates adenylate cyclase, Endocrinology, 103, 296, 10.1210/endo-103-1-296 Mehdi, 1973, Binding of thyroid stimulators to human thyroid membranes, Biochem. Soc. Trans., 1, 1005, 10.1042/bst0011005 Mentnech, 1980, Correlation of Gm allotype with the incidence of anti-IgG antibody in coal worker's pneumoconiosis, Clin. Immunol. Immunopathol., 17, 274, 10.1016/0090-1229(80)90096-3 Michaelsen, 1974, Unusual molecular properties of human IgG3 proteins due to an extended hinge region, J. biol. Chem., 249, 2778, 10.1016/S0021-9258(19)42697-5 Michaelsen, 1975, Structural requirements in the Fc region of rabbit IgG antibodies necessary to induce cytotoxicity by human lymphocytes, Scand. J. Immunol., 4, 71, 10.1111/j.1365-3083.1975.tb02601.x Miller, 1979, Suppressor cell function in autoimmune thyroid disease, 196 Milstein, 1970, Structure and evolution of immunoglobulins, Prog. biophys. Molec. Biol., 21, 211, 10.1016/0079-6107(70)90026-X Mitchell, 1976, Neonatal thyrotoxicosis associated with transplacental passage of human thyroid stimulating immunoglobylins (HTSI), Arch. Dis. Chil., 51, 565, 10.1136/adc.51.7.565 Miyai, 1966, Concentration of long-acting thyroid stimulator (LATS) by subfractionation of G globulin from Graves' disease serum, J. clin. Endocr. Metab., 26, 504, 10.1210/jcem-26-5-504 Moens, 1978, Hashimoto's thyroiditis is associated with HLA-DRW3, N. Engl. J. Med., 292, 133, 10.1056/NEJM197807202990306 Moens, 1979, The association of HLA-B8 with atrophic thyroiditis, Tissue Antigens, 13, 342, 10.1111/j.1399-0039.1979.tb00806.x Morell, 1977, Evidence for an association between uncommon Gm phenotypes and neuroblastoma, Lancet, I, 23, 10.1016/S0140-6736(77)91657-9 Mori, 1982, Decrease of immunoglobulin G-Fc receptor bearing T lymphocytes in Graves' disease, J. clin. Endocr. Metab., 55, 399, 10.1210/jcem-55-3-399 Morgan, 1982, Regulation of the immune response by the Fc portion of immunoglobulin, 29, 401 Morimoto, 1980, Alterations in immunoregulatory T cell subsets in active systemic lupus erythematosus, J. clin. Invest., 66, 1171, 10.1172/JCI109948 Mourant, 1978, Blood groups and disease. A study of associations of disease with blood groups and other polymorphisms Mouton, 1980, Variations in the phenotypic expression of an H-2 linked gene contributing to the control of IgE and haemagglutinating antibody responses to ovalbumin, Ann. Immunol., 131 d, 205 Mukhtar, 1975, Relation of thyroid-stimulating immunoglobulins to thyroid function and the effects of surgery, radioiodine and antithyroid drug, Lancet, i, 713, 10.1016/S0140-6736(75)91629-3 Munro, 1978, The role of thyroid stimulating immunoglobulins of Graves' disease in neonatal thyrotoxicosis, Br. J. Obst. Gyn., 85, 837, 10.1111/j.1471-0528.1978.tb15839.x Munro, 1973, Cell-mediated immunity in the exophthalmos of Graves' disease as demonstrated by the migration inhibition factor (MIF) test, J. clin. Endocr. Metab., 37, 286, 10.1210/jcem-37-2-286 Nadler, 1981, Monoclonal antibody identifies a new Ia-like (p. 29, 34) polymorphic system linked to HLA-D/DR, Nature, 290, 591, 10.1038/290591a0 Nagy, 1981, Macrophage or T cell - That is the question, Immunol. Today, 2, 228, 10.1016/0167-5699(81)90006-2 Nakao, 1980, IgG heavy chain allotypes (Gm) in autoimmune diseases, Clin. Exp. Immunol., 42, 20 Nakao, 1982, IgG heavy chain allotypes (Gm) in atrophic and goitrous thyroiditis, J. Immunogenet., 10.1111/j.1744-313X.1982.tb00987.x Nakao, 1980, Gm allotypes in myasenthia gravis, Lancet, i, 677, 10.1016/S0140-6736(80)92829-9 Nakao, 1981, IgG heavy chain (Gm) allotypes and immune-response to insulin in insulin-requiring diabetes mellitus, N. Engl. J. Med., 304, 407, 10.1056/NEJM198102123040706 Natvig, 1968, Genetic markers of human immunoglobulins, Ser. Haematol., 1, 66 Natvig, 1973, Human immunoglobulins: classes, subclasses, genetic variants and idiotypes, Adv. Immunol., 16, 1, 10.1016/S0065-2776(08)60295-3 Natvig, 1976, Restriction of human immune antibodies to heavy chain variable subgroups, Scand. J. Immunol., 5, 667, 10.1111/j.1365-3083.1976.tb03016.x Neilson, 1982, Suppression of interstitial nephritis by auto-anti-idiotypic immunity, J. exp. Med., 155, 179, 10.1084/jem.155.1.179 Nevo, 1975, Association of typhoid fever and response to vaccination with the polymorphic systems in man, 649 Nutt, 1981, Influence of Igh-linked gene products on the generation of T helper cells in the response to sheep erythrocytes, J. exp. Med., 153, 1225, 10.1084/jem.153.5.1225 Ochi, 1968, Studies on the immunological properties of LATS, Endocrinology, 83, 845, 10.1210/endo-83-4-845 O'Donnell, 1978, Thyrotropin displacement activity of serum immunoglobulins from patients with Graves' disease, J. clin. Endocr. Metab., 46, 770, 10.1210/jcem-46-5-770 Okita, 1980, Sensitization of T lymphocytes in Graves' and Hashimoto's diseases, J. clin. Endocr. Metab., 51, 316, 10.1210/jcem-51-2-316 Okita, 1981, T-lymphocyte sensitization in Graves' and Hashimoto's diseases confirmed by an indirect migration inhibition factor test, J. clin. Endocr. Metab., 52, 523, 10.1210/jcem-52-3-523 Okita, 1981, Suppressor T-lymphocyte deficiency in Graves' disease and Hashimoto's thyroiditis, J. clin. Endocr. Metab., 52, 528, 10.1210/jcem-52-3-528 Okita, 1981, Suppressor T lymphocyte dysfunction in Graves' disease: role of the H-2 histamine receptor-bearing suppressor T lymphocytes, J. clin. Metab., 53, 1002, 10.1210/jcem-53-5-1002 Onaya, 1973, New in vitro tests to detect the thyroid stimulator in sera from hyperthyroid patients by measuring colloid droplet formation and cyclic AMP in human thyroid slices, J. clin. Endocr. Metab., 36, 859, 10.1210/jcem-36-5-859 Orgiazzi, 1976, Human thyroid adenyl cyclase-stimulating activity in immunoglobulin G of patients with Graves' disease, J. clin. Endocr. Metab., 42, 341, 10.1210/jcem-42-2-341 Osoba, 1978, HLA-B8 phenotype associated with an increased mixed leukocyte reaction, Immunogenetics, 6, 425, 10.1007/BF01563934 Owen, 1981, The T suppressor cell allo-antigen Tsud maps near immunoglobulin allotype genes and may be a heavy chain constant region marker on a T cell receptor, J. exp. Med., 153, 801, 10.1084/jem.153.4.801 Owen, 1982, Tthyd, a new thymocyte alloantigen linked to Igh-1. Implications for a switch mechanism for T cell antigen receptors, J. exp. Med., 155, 52, 10.1084/jem.155.1.52 Ozaea, 1979, Relationships among immunoglobulin markers in Graves' disease, J. clin. Endocr. Metab., 48, 381, 10.1210/jcem-48-3-381 Ozawa, 1979, The role of sulfhydryl groups in thyrotropin binding and adenylate cyclase activities of thyroid plasma membranes, Endocrinology, 105, 1221, 10.1210/endo-105-5-1221 Paavonen, 1981, Sex hormone regulation of in vitro immune response. Estradiol enhances human B cell maturation via inhibition of suppressor T cells in pokeweed mitogen-stimulated cultures, J. exp. Med., 154, 1935, 10.1084/jem.154.6.1935 Pacifico, 1980, T cell hybrids with arsonate specificity I. Initial characterization of antigen-specific T cell products that bear a cross-reactive idiotype and determinants encoded by the murine major histocompatibility complex, J. exp. Med., 152, 1289, 10.1084/jem.152.5.1289 Pandey, 1979, Association between immunoglobulin allotypes and immune responses to Haemophilus influenzae and meningococcus polysaccharides, Lancet, i, 190, 10.1016/S0140-6736(79)90584-1 Pandey, 1981, Immunoglobulin G heavy chain (Gm) allotypes in multiple sclerosis, J. clin. Invest., 67, 1797, 10.1172/JCI110220 Pandey, 1982, Heterozygzity at Gm loci associated with humoral immunity to osteosarcoma, J. exp. Med., 155, 1228, 10.1084/jem.155.4.1228 Pandey, 1980, Linkage relationship between variable and constant region allotypic detreminants of human immunoglobylin heavy chains, Nature, 286, 406, 10.1038/286406a0 Pandey, 1981, Immunoglobulin allotypes and immune response to meningococcal group B polysaccharide, J. clin. Invest., 68, 1378, 10.1172/JCI110387 Pekonen, 1980, Role of carbohydrates in thyrotropin binding sites, Horm. Metab. Res., 12, 310, 10.1055/s-2007-996277 Pekonen, 1978, Thyrotropin binding to cultured lymphocytes and thyroid cells, Endocrinology, 103, 1668, 10.1210/endo-103-5-1668 Pekonen, 1979, Thyrotropin receptors on bovine thyroid membranes: two types with different affinities and specificities, Endocrinology, 105, 352, 10.1210/endo-105-2-352 Pepper, 1979, Polymorphic variants of the third component of complement in Graves' disease, Hum. Hered., 29, 279, 10.1159/000153058 Pepper, 1981, The putative anti-thyrotropin receptor antibodies of Grave' disease. 1. Gm allotypes, J. Immunogenet., 8, 89, 10.1111/j.1744-313X.1981.tb00746.x Petersen, 1977, The interaction of human thyroid-stimulating antibodies with solubilised human thyrotropin receptor, FEBS Letters, 83, 63, 10.1016/0014-5793(77)80642-X Pinchera, 1980, Antigen-antibody systems involved in thyroid autoimmunity, 57 Pinchera, 1969, Effects of antithyroid therapy on the long-acting thyroid stimulator and the anti-thyroglobulir antibodies, J. clin. Endocr. Metab., 29, 231, 10.1210/jcem-29-2-231 Povey, 1976, Thyrotropin receptor binding, intracellular cyclic AMP levels, and iodine release in isolated thyroid cells, FEBS Letters, 72, 251, 10.1016/0014-5793(76)80980-5 Powell-Jones, 1979, Contribution of Negative co-operativity to the thyrotropin-receptor interaction in normal human thyroid: kinetic evaluation, 76, 705 Rabbitts, 1981, Human antibody genes: V gene variability and CH gene switching strategies, Immunol. Rev., 59, 69, 10.1111/j.1600-065X.1981.tb00456.x Rapoport, 1978, Production of a non-immunoglobulin thyroid stimulator by human lymphocytes during mixed culture with human thyroid cells, J. biol. Chem., 253, 631, 10.1016/S0021-9258(17)38254-6 Rapoport, 1982, Evidence for species specificity in the interaction between thyrotropin and thyroid-stimulating immunoglobulin and their receptor in thyroid tissue, J. clin. Endocr. Metab., 54, 1059, 10.1210/jcem-54-5-1059 Rees Smith, 1976, Immunology of thyrotropin receptor, Immunol. Commun., 5, 345, 10.3109/08820137609033853 Rees Smith, 1976, Thyroid-stimulating immunoglobulins and hyperthyroidism in Graves' Disease, 411 Reinherz, 1981, The characterization and function of human immunoregulatory T lymphocyte subsets, Immunol. Today, 2, 69, 10.1016/0167-5699(81)90019-0 Rentsch, 1980, Topographical heterogeneity of basal and thyrotropin-stimulated adenosine 3′,5′-monophosphate in human nodular goitre, J. clin. Endocr. Metab., 53, 514, 10.1210/jcem-53-3-514 Rickards, 1981, The interaction of Graves' IgG with the thyrotropin receptor, FEBS Letters, 127, 17, 10.1016/0014-5793(81)80330-4 Robboy, 1970, Circulating anticoagulants to Factor VIII, Am. J. Med., 49, 742, 10.1016/S0002-9343(70)80056-0 Robertson, 1982, The evolutionary past of the major histocompatibility complex and the future of cellular immunology, Nature, 297, 629, 10.1038/297629a0 Rogers, 1981, Immunoglobulin heavy chain genes: demethylation accompanies class switching, 78, 7497 Rolink, 1978, Detection of two allotype-(Ig-1)-linked minor histocompatibility loci by the use of H-2-restricted cytotoxic lymphocytes of congenic mice, Immunogenetics, 7, 321, 10.1007/BF01844022 Rosenthal, 1982, Determinant selection and macrophage function, Immunol. Today, 3, 33, 10.1016/0167-5699(82)90056-1 Rosenthal, 1980, The role of the macrophage in genetic control of the immune response, 458 Rosenwasser, 1981, The xid gene controls Ia w39-associated immune response gene function, J. exp. Med., 153, 1113, 10.1084/jem.153.5.1113 Roth, 1982, The evolutionary origins of hormones, neurotransmitters, and other extracellular chemical messengers: implications for mammalian biology, N. Engl. J. Med., 306, 523, 10.1056/NEJM198203043060907 Roubinian, 1978, Effect of castration and sex hormone treatment on survival, antinucleic acid antibodies and glomerulonephritis in NZB/NZW F1 mice, J. exp. Med., 147, 1568, 10.1084/jem.147.6.1568 Rowley, 1981, Regulation by complementary idiotypes. Ig protects the clone producing it, J. exp. Med., 153, 1377, 10.1084/jem.153.6.1377 Rowley, 1980, An immunologic network, Contemp. Top. Immunobiol., 9, 205, 10.1007/978-1-4615-9131-3_8 Sachs, 1981, Genetic control in the immune response to staphylococcal nuclease XI. Effects of in vivo administration of anti-idiotypic antibodies, Euro. J. Immunol., 11, 509, 10.1002/eji.1830110613 Salier, 1981, Preferential synthesis of the Glm (1) allotype of IgGl in the central nervous system of multiple sclerosis patients, Science, 213, 1400, 10.1126/science.6973823 Salier, 1980, Quantitative studies of Gm allotypes. V. Simultaneous presence of latent Gm allotypes and deficient Gm genes in a family with hypogamaglobulinemic probands, J. Immunogenet., 7, 123, 10.1111/j.1744-313X.1980.tb00714.x Saltiel, 1981, Regulation of thyroid adenylate cyclase: guanyl nucleotide modulation of thyrotropin receptor-adenylate cyclase function, Endocrinology, 109, 1578, 10.1210/endo-109-5-1578 Saltiel, 1980, Apparent “negative cooperativity” kinetics in the absence of a non-linear scatchard plot of thyrotropin-receptor interaction in a human thyroid adenoma, Biochem. biophys. Res. Commun., 95, 395, 10.1016/0006-291X(80)90751-2 Sarmáy, 1980, The involvement of a preformed cytoplasmic receptor pool in the re-expression of Fc receptors following their interaction with various antibodies, Cell Immunol., 56, 452, 10.1016/0008-8749(80)90120-3 Sasazuki, 1982, Matters arising: Two major genes, linked to HLA and Gm, control susceptibility to Graves' disease, Nature, 295, 629, 10.1038/295629b0 Sato, 1978, The influence of normal human IgG and of thyroid-stimulating antibody (TSAB) on the binding of thyrotropin to thyroid plasma membranes, Endocr. Res. Commun., 5, 259, 10.1080/07435807809061091 Schanfield, 1980, Immunoglobulins: Genetic markers, 79 Schafield, 1981, Susceptibility to juvenile onset diabetes in families: DR, Gm, Km and gender, Am. J. Hum. Genet., 33, 133A Schleusener, 1978, Relationship between thyroid status and Graves' disease-specific immunoglobulins, J. clin. Endocr. Metab., 47, 379, 10.1210/jcem-47-2-379 Schleusener, 1982, HLA-DR3 and HLA-DR5 associated thyrotoxicosis — two different types of toxic diffuse goitre, J. clin. Endocr. Metab. Schreiber, 1980, Anti-alprenolol anti-idiotypic antibodies bind to β-adrenergic receptors and modulate catecholamine-sensitive adenylate cyclase, 77, 7385 Schwartz, 1981 Sege, 1978, Use of anti-idiotypic antibodies as cell-surface receptor probes, 75, 2443 Sell, 1980, Antibodies and immunoglobulins Shevach, 1982, Is determinant selection dead?, Immunology Today, 3, 31, 10.1016/0167-5699(82)90055-X Shinozawa, 1982, A method for detecting and quantitating Graves' disease-specific immunoglobulin, 112 Shishiba, 1982, Discrepancy between thyroid stimulating and thyrotropin-binding inhibitory activities of Graves' immunoglobulin Gs assessed in the mouse, J. clin. Endocr. Metab., 54, 858, 10.1210/jcem-54-4-858 Shishiba, 1973, Direct evidence for human thyroidal stimulation by LATS protector, J. clin. Endocr. Metab., 36, 517, 10.1210/jcem-36-3-517 Sienbenlist, 1981, Human immunoglobulin D segments encoded in tandem multigenic families, Nature, 294, 631, 10.1038/294631a0 Simpson, 1982, T cell function: Ly phenotype and the MHC, Nature, 295, 366, 10.1038/295366a0 Slingerland, 1979, Long-term anti-thyroid treatment in hyperthyroidism, JAMA, 242, 2408, 10.1001/jama.242.22.2408 Smith, 1974, Thyroid-stimulating immunoglobulins in Graves' Disease, Lancet, ii, 427, 10.1016/S0140-6736(74)91815-7 Smith, 1969, The thyroid stimulating properties of long-acting thyroid stimulator γ-globulin subunits, Biochim. biophys. Acta, 192, 277, 10.1016/0304-4165(69)90366-3 Sogn, 1977, The use of idiotypes as markers for antibody variable regions in the rabbit, 36, 214 Solomon, 1980, Is TSH a LATS-protector? Evidence suggesting different sites of binding of TSH and thyroid stimulating immunoglobulin (TSIs) in thyroid tissue, 124 Solomon, 1953, Prognosis of hyperthyroidism treated with anti-thyroid drugs, JAMA, 152, 201, 10.1001/jama.1953.03690030001001 Spurll, 1982, A family of T cell alloantigens linked to Igh-1, Nature, 293, 742, 10.1038/293742a0 Sridama, 1981, Decreased suppressor T cells (OKT8+) and increased null-cells/monocyte subset (OKTM1+) in Graves' disease and Hashmoto's thyroiditis Steinberg, 1981, The cellular and genetic basis of murine lupus, Immunol. Rev., 55, 121, 10.1111/j.1600-065X.1981.tb00341.x Steinberg, 1962, Progress in the study of genetically determined human gamma globulin types (the Gm and Inv groups), Prog. Med. Genet., 2, 1 Stenszky, 1981, HLA control of thyroglobulin-induced blast-transformation in Graves' disease, Hum. Hered., 31, 322, 10.1159/000153230 Stenzky, 1983, Identification of subsets of patients with Graves' disease by cluster analysis, Clin. Endocr., 18, 335, 10.1111/j.1365-2265.1983.tb00577.x Strakosch, 1978, Thyroid stimulating antibodies in patients with subacute thyroiditis, J. clin. Endocr. Metab., 46, 345, 10.1210/jcem-46-2-345 Strosberg, 1981, Immunological studies of hormone receptors: A two-way approach, Immunol. Today, 2, 75, 10.1016/0167-5699(81)90020-7 Sugenoya, 1979, Correlation between thyrotripin displacing activity and human thyroid-stimulating activity by immunoglobulins from patients with Graves' disease and other thyroid disorders, J. clin. Endocr. Metab., 48, 398, 10.1210/jcem-48-3-398 Sugenoya, 1979, Macrophage-lymphocyte interaction in Graves' Disease and Hashimoto's thyroidit thyroiditis, Acta Endocr. (Copenh.), 91, 99 Sunday, 1981, Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl VIII. Suppressor cell pathways in cutaneous sensitivity responses, J. exp. Med., 153, 811, 10.1084/jem.153.4.811 Sunshine, 1980, Dendritic cells induce T cell proliferation to synthetic antigens under Ir gene control, J. exp. Med., 152, 1817, 10.1084/jem.152.6.1817 Swain, 1981, Significance of Ly+ phenotypes: Ly+2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function, 78, 7101 Swain, 1981, The Lyt phenotype of a long-term allospecific T cell line. Both helper and killer activities to 1A are mediated by Ly-1 cells, Eur. J. Immunol., 11, 175, 10.1002/eji.1830110304 Sy, 1979, Active suppression of 1-fluoro-2, 4-dinitrobenzene-immune T cells. Requirement of an auxilliary T cell induced by antigen, J. exp. Med., 149, 1197, 10.1084/jem.149.5.1197 Tada, 1979, The role of antigen-specific T cell factors in the immune response, Adv. Immunol., 28, 1, 10.1016/S0065-2776(08)60799-3 Tada, 1978, Two distinct types of helper T cells involved in the secondary antibody response: Indpendent and synergistic effects of Ia− and Ia+ helper T cells, J. exp. Med., 147, 446, 10.1084/jem.147.2.446 Takatsu, 1980, Antigen-induced T cell-replacing factor (TRF). I. Functional characterization of TRF-producing helper T cell subset and genetic studies on TRF production, J. Immunol., 124, 2414 Tamai, 1978, Responses to TRH and T3 suppression tests in euthyroid subjects with a family history of Graves' disease, J. clin. Endocr. Metab., 47, 475, 10.1210/jcem-47-3-475 Tate, 1975, Characteristics of a solubilized thyrotropin receptor from bovine thyroid plasma membranes, J. biol. Chem., 250, 6527, 10.1016/S0021-9258(19)41097-1 Tate, 1975, Thyrotropin receptors in thyroid plasma membranes: characteristics of thyrotropin binding and solubilization of thyrotropin receptor activity by tryptic digestion, J. biol. Chem., 250, 6509, 10.1016/S0021-9258(19)41094-6 Taylor, 1982, Regulation of antibody responses by antibody towards the immunogen, Immunol. Today, 3, 47, 10.1016/0167-5699(82)90060-3 Teale, 1979, Autoimmune disease and the theory of clonal abortion. Is it still relevant?, Lancet, ii, 284, 10.1016/S0140-6736(79)90296-4 Teng, 1980, Changes in thyroid-stimulating antibody activity in Graves' disease with antithyroid drug and its relationship to relapse: a prospective study, J. clin. Endocr. Metab., 50, 144, 10.1210/jcem-50-1-144 Teng, 1977, Thyroid stimulating immunoglobulins in ophthalmic Graves' Disease, Clin. Endocr., 6, 207, 10.1111/j.1365-2265.1977.tb03316.x Teng, 1980, Thyroid-stimulating immunoglobulins in neonatal Graves' disease, Arch. Dis. Child., 55, 894, 10.1136/adc.55.11.894 Theofilopoulos, 1979, The biology and detection of immune complexes, Adv. Immunol., 28, 89, 10.1016/S0065-2776(08)60800-7 Theofilopoulos, 1981, Etiopathogenesis of murine SLE, Immunol. Rev., 55, 179, 10.1111/j.1600-065X.1981.tb00343.x Thielmans, 1981, Autoimmune thyroiditis: A condition related to a decrease in T-suppressor cells, Clin. Endocr., 15, 259, 10.1111/j.1365-2265.1981.tb00664.x Thomas, 1981, Fine specificity of genetic regulation of guinea pig T lymphocyte responses to angiotensin II and related peptides, J. exp. Med., 153, 583, 10.1084/jem.153.3.583 Thompson, 1976, The HLA system as a model for studying the interaction between selection, migration and linkage, 465 Thomsen, 1981, Association of pernicious anemia and intrinsic factor antibody with HLA-D, Tissue Antigens, 17, 97, 10.1111/j.1399-0039.1981.tb00672.x Tokuhisa, 1982, Two distinct allotypic determinants on the antigen-specific suppressor and enhancing T cell factors that are encoded by genes linked to the immunoglobulin heavy chain locus, J. exp. Med., 155, 126, 10.1084/jem.155.1.126 Tom, 1981, Reduced C4 in HLA-B8 positive patients with Graves' disease, Hum. Hered., 31, 227, 10.1159/000153213 Topliss, 1982, Graves' disease (GD) and insulin dependent diabetes mellitus (IDDM) are each associated with separate specific defects in suppressor T lymphocyte function, 132 Topliss, 1982, Allosuppressor T lymphocytes abolish migration inhibition factor production in autoimmune thyroid disease: evidence from radiosensitivity experiments, Clin. Endocr., 15, 333 Totterman, 1977, Cell-mediated autoimmunity in thyroid desease as studied by the leukocyte migration test: correlation to clinical state and effect of treatment, Acta Endocr. (Copenh.), 86, 89 Towbin, 1979, Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications, 76, 4350 Tramontano, 1982, Thyrotropin induces changes in the morphology and the organization of microfilament structures in cultured thyroid cells, Exp. Cell Res., 137, 269, 10.1016/0014-4827(82)90027-1 Trokoudes, 1981, Properties of human thyroidal and extrathyroidal TSH receptors, Acta Endocr. (Copenh.), 97, 473 Trokoudes, 1979, Thyroid stimulating hormone (TSH) binding to extrathyroidal human tissues: TSH and thyroid stimulating immunoglobulin effects on adenosine 3′,5′- monophosphate in testicular and adrenal tissue, J. clin. Endocr. Metab., 48, 919, 10.1210/jcem-48-6-919 Tunbridge, 1983, Prevalence of autoimmune endocrine disease, 93 Uller, 1978, Effect of therapy on serum thyroglobulin levels in patients with Graves' disease, J. clin. Endocr. Metab., 46, 747, 10.1210/jcem-46-5-747 Uno, 1981, Two major genes, linked to HLA and Gm, control susceptibility to Graves' disease, Nature, 292, 768, 10.1038/292768a0 Urbain, 1982, Some thoughts on idiotypic networks and immunoregulation, Immunol. Today, 3, 88, 10.1016/S0167-5699(82)80021-2 Urbain, 1977, Idiotypic regulation of the immune system by induction of antibodies against anti-iditypic andibodies, 74, 5126 van Der Heide, 1980, Circulating immune complexes and thyroid stimulating immunoglobulins before, during and after antithyroid drug therapy in patients with Graves' disease, Lancet, i, 1376, 10.1016/S0140-6736(80)92652-5 Vandvik, 1977, IgGl subclass restriction of oligoclonal measles virus-specific IgG antibodies in a patient with subacute sclerosing panencephalitis and in patients with multiple sclerosis, Scand. J. Immunol., 6, 651, 10.1111/j.1365-3083.1977.tb02145.x Volpé, 1978, The pathogenesis of Graves' disease: an overview, Clin. Endocr. Metab., 7, 3, 10.1016/S0300-595X(78)80033-4 Von Westarp, 1980, Human thyrotropin receptor purification by affinity chromatography, 151 Walfish, 1982, Association of HLA-DR3 and HLA-DR5 antigens in the painless thyroiditis with transient thyrotoxicosis syndromes Walker, 1982, Human histocompatibility antigens: Isolation and chemical characterization, J. Immunol. Meth., 49, R 25, 10.1016/0022-1759(82)90123-5 Wall, 1969, Long-acting thyroid stimulator in euthyroid relatives of thyrotoxic patients, Lancet, ii, 1024, 10.1016/S0140-6736(69)90638-2 Wall, 1980, Peripheral blood lymphocyte transformation in response to human thyroid fractions in patients with Graves' hyperthyroidism and ophthalmopathy, Acta Endocr. (Copenh.), 93, 419 Wall, 1980, Effect of experimental hyperthyroidism on B and T lymphocyte reactivity in bacterial, fungal and tissue antigens, 215 Wall, 1981, Blood micronuclear cells with suppressor activity in patients with thyroid disorders: increased levels of T gamma cells in subacute thyroiditis, J. clin. Lab. Immunol., 6, 115 Wall, 1982, Nature of the thyrotropin displacement activity in subacute thyroiditis, J. clin. Endocr. Metab., 54, 349, 10.1210/jcem-54-2-349 Wartofsky, 1973, Low remission after therapy for Graves' disease. Possible relation of dietary iodine with antithyroid therapy results, JAMA, 226, 1083, 10.1001/jama.226.9.1083 Weetman, 1982, Thyroid hormones fail to influence experimental autoimmune thyroiditis, Clin. exp. Immunol., 50, 51 Weinstein, 1981, Testosterone effect on bone marrow, thymus, and suppressor T cells in the (NZB × NZW) F1 mice: Its relevance to autoimmunity, J. Immunol., 126, 998 Weiss, 1982, A specific plaque-forming cell assay for human thyroglobulin antibody-secreting immunocytes, J. clin. Endocr. Metab., 54, 282, 10.1210/jcem-54-2-282 Weissel, 1980, HLA-DR and Hashimoto's thyroiditis, Tissue Antigens, 16, 256, 10.1111/j.1399-0039.1980.tb00302.x Wells, 1971, Relation of the human antibody response to flagellin to Gm genotype, J. Immunol., 107, 1505 Wenzel, 1981, Mitogenic response of peripheral blood lymphocytes from patients with Graves' disease incubated with solubilized thyroid cell membranes containing TSH receptor and with thyroglobulin, Immunobiol., 160, 302, 10.1016/S0171-2985(81)80056-3 Whittingham, 1980, Interactive effect of Gm allotypes and HLA-B locus antigens on the human antibody response to a bacterial antigens, Clin. exp. Immunol., 40, 8 Whittingham, 1981, Interaction of HLA and Gm in autoimmune chronic active hepatitis, Clin. exp. Immunol., 43, 80 Wigzell, 1978, Possible roles of auto-anti-idiotypic immunity in auto-immune disease, 327 Williamson, 1976, The biological origin of antibody diversity, Ann. Rev. Biochem., 45, 467, 10.1146/annurev.bi.45.070176.002343 Williamson, 1982, Genes coding for T-lymphocyte receptors, Immunol. Today, 3, 68, 10.1016/S0167-5699(82)80037-6 Woodland, 1978, Idiotype-specific T helper cells are required to induce idiotype-positive memory cells to secrete antibody, Eur. J. Immunol., 8, 600, 10.1002/eji.1830080812 Woolf, 1980, Transient painless thyroiditis with hyperthyroidism: a variant of lymphocytic thyroiditis?, Endocr. Rev., 1, 411, 10.1210/edrv-1-4-411 Yamashita, 1972, Effects of long-acting thyroid stimulator on thyrotropin stimulation of adenyl cyclase activity in thyroid plasma membranes, J. clin. Invest., 51, 463, 10.1172/JCI106834 Yamauchi, 1982, Molecular composition of an antigen-specific, Ly-1 T suppressor inducer factor. One molecule binds antigen and is I-J−, another is I-J+, does not bind antigen and imparts an Igh-variable region-linked restriction, J. exp. Med., 155, 655, 10.1084/jem.155.3.655 Yasmeen, 1976, Structure and function of immunoglobulin domains. IV. The distribution of some effector functions among the C2 and C3 homology regions of human immunoglobulin, G. J. Immunol., 116, 518 Yavin, 1981, Monoclonal antibodies to the thyrotropin receptor: Implications for receptor structure and the action of autoantibodies in Graves' disease, 78, 3180 Yeo, 1978, HLA and thyrotoxic periodic paralysis, Br. Med. J., 2, 930, 10.1136/bmj.2.6142.930 Zakarija, 1980, The thyroid-stimulating antibody of Graves' disease: evidence for restricted heterogeneity, Horm. Res., 13, 1, 10.1159/000179266 Zakarija, 1980, The restricted heterogeneity of thyroid stimulating antibody (TSab), T Zakarija, 1978, Absorption of thyroid stimulating antibody (TSAb) of Graves' disease by homologous and heterologous thyroid tissue, J. clin. Endocr. Metab., 47, 906, 10.1210/jcem-47-4-906 Zakarija, 1978, Isoelectric focusing of thyroid-stimulating antibody of Graves' disease, Endocrinology, 103, 1469, 10.1210/endo-103-4-1469 Zakarija, 1980, Clinical significance of assay of thyroid stimulating antibody in Graves' disease, Ann. Int. Med., 93, 28, 10.7326/0003-4819-93-1-28 Zakarija, 1982, Delayed neonatal thyrotoxicosis: evidence implicating an antibody inhibitory to thyroid-stimulating antibody (TSab), 113 Zinkernagel, 1977, The concept that surveillance of self is mediated via the same set of genes that determine recognition of allogenetic cells, 41, 505 Zinkernagel, 1978, 148, 805