Grass pollen immunotherapy induces highly cross‐reactive IgG antibodies to group V allergen from different grass species

Allergy: European Journal of Allergy and Clinical Immunology - Tập 50 Số 3 - Trang 281-283 - 1995
Ronald van Ree1, Piotr Z. Brewczyński2, K. Y. Tan3, H. J. C. Mulder‐Willems4, Paulus Sugeng Widjaja5, Steven O. Stapel1, Rob C. Aalberse1, A.M. Kroon6
1Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Amsterdam, The Netherlands
2Central Hospital of the Silesian Academy of Medicine, 2nd Clinic of Internal Medicine, Katowice‐Ligota, Poland
3Holy Hospital, Vlaardingen, The Netherlands
4Foundation Thrombosis Service and General Practitioners Laboratory, Rotterdam, The Netherlands
5Allergy Centre Amsterdam, Amsterdam, The Netherlands
6HAL Allergen Laboratories, Haarlem, The Netherlands

Tóm tắt

Sera from two groups of patients receiving grass pollen immunotherapy were tested on IgG reactivity with group V allergen from six different grass species. One group of patients was treated with a mixture of 10 grass species, and the other with a mixture of five. Only Lolium perenne, Dactylis glomerata, and Phleum pratense were present in both mixtures. Although Anthoxanthum odoratum and Secale cereale were absent from the mixture of five, IgG responses to Ant o V and Sec c V were comparable in both patient groups. This reactivity was inhibited for 92–99% with L. perenne extract, illustrating the cross‐reactive nature of the IgG antibodies. The presence of A. odoratum and S. cereale in the mixture resulted in only minor amounts of species‐specific anti‐group V IgG. These results indicate that application of just one grass species in immunotherapy might be sufficient to induce an IgG response that covers other relevant Gramineae species as well.

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Tài liệu tham khảo

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Thông tin xuất bản

Allergy: European Journal of Allergy and Clinical Immunology

Tập 50 Số 3

281-283

Thông tin tác giả