Vanesa Bijol1,2, Gonzalo P. Méndez, Vânia Nosé, Helmut G. Rennke1
1Department of Pathology, Brigham and Womens Hospital-Harvard Medical School, Boston, MA
2Department of Pathology, Brigham and Womens Hospital-Harvard Medical School, Boston, MA; Pathology and Lab Medicine, Emory University EUH, H188, 1364 Clifton Road NE, Atlanta, GA 30322
Tóm tắt
Acute interstitial nephritis is commonly seen in kidney biopsies of patients with acute renal failure; however, granulomatous interstitial nephritis (GIN) is rare. We identified 46 cases of GIN in a 17-year period in this institution and we investigated their most probable etiologies. Complete clinical information was available in 38 patients. Seventeen of 38 patients (44.7%) were classified as drug-induced. Renal sarcoidosis was responsible for 28.9% of cases, and the remaining 15.9% of cases included Wegeners granulomatosis, foreign body giant cell reaction, GIN secondary to intravesical bacillus Calmette-Guerin therapy for bladder cancer, and xanthogranulomatous pyelonephritis. Clinical investigation failed to reveal possible etiology in 4 patients (10.5%), classified as idiopathic. We concluded that three quarters of our cases were either drug-induced or due to sarcoidosis; only a small proportion of our cases occurred secondary to any other cause or to unknown factors.
