Gradual increase in self-stimulation response rates: Effect of electrode loci
Tóm tắt
Nine male rats, each with electrodes implanted in a telencephalic region and seven of them also with successful placements in a more caudal brain reward region, were taught to self-stimulate. Rates in the caudate nucleus and medial frontal cortex showed a gradual increase over daily sessions, but self-stimulation in lateral hypothalamus, substantia nigra, and reticular formation did not have this property. In the telencephalon, rates in the first five testing sessions were low, averaging 138 barpresses/10-min session. ICSS rates gradually rose during approximately the next 15 sessions, leveling off at an average of 453/10 min. Seizures were sometimes observed as rates increased at telencephalic points. Cumulative recordings showed that the long-term overall increase in response rate was partly due to a rate increase that occurred within some individual sessions, although during the last test days, a fast, steady rate dominated the entire session. The possibilities are discussed that the plasticity in ICSS is related to the kindling phenomenon or to dyskinesias which result from chronic administration of drugs presumed to have their main locus of action in the corpus striatum.
Tài liệu tham khảo
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