Gout-associated uric acid crystals activate the NALP3 inflammasome

Nature - Tập 440 Số 7081 - Trang 237-241 - 2006
Fabio Martinon1, Virginie Pétrilli2, Annick Mayor2, Aubry Tardivel2, Jürg Tschopp2
1Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
2Department of Biochemistry, University of Lausanne, Epalinges, Switzerland

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Wollaston, H. W. On gouty and urinary concretions. Phil. Trans. 87, 386–400 (1797)

Shi, Y., Evans, J. E. & Rock, K. L. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425, 516–521 (2003)

Galon, J., Aksentijevich, I., McDermott, M. F., O'Shea, J. J. & Kastner, D. L. TNFRSF1A mutations and autoinflammatory syndromes. Curr. Opin. Immunol. 12, 479–486 (2000)

Martinon, F. & Tschopp, J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 117, 561–574 (2004)

Stojanov, S. & Kastner, D. L. Familial autoinflammatory diseases: genetics, pathogenesis and treatment. Curr. Opin. Rheumatol. 17, 586–599 (2005)

Dinarello, C. A. Blocking IL-1 in systemic inflammation. J. Exp. Med. 201, 1355–1359 (2005)

Shoham, N. G. et al. Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway. Proc. Natl Acad. Sci. USA 100, 13501–13506 (2003)

Chae, J. J. et al. Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis. Mol. Cell 11, 591–604 (2003)

Burns, K., Martinon, F. & Tschopp, J. New insights into the mechanism of IL-1β maturation. Curr. Opin. Immunol. 15, 26–30 (2003)

Martinon, F., Burns, K. & Tschopp, J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Mol. Cell 10, 417–426 (2002)

Mariathasan, S. et al. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430, 213–218 (2004)

Tschopp, J., Martinon, F. & Burns, K. NALPs: a novel protein family involved in inflammation. Nature Rev. Mol. Cell Biol. 4, 95–104 (2003)

Martinon, F., Agostini, L., Meylan, E. & Tschopp, J. Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr. Biol. 14, 1929–1934 (2004)

Martinon, F. & Tschopp, J. NLRs join TLRs as innate sensors of pathogens. Trends Immunol. 26, 447–454 (2005)

Yamamoto, M. et al. ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules. Genes Cells 9, 1055–1067 (2004)

Faires, J. S. & McCarty, D. J. Acute arthritis in man and dog after intrasynovial infection of sodium urate crystals. Lancet 280, 682–685 (1962)

Dalbeth, N. & Haskard, D. O. Mechanisms of inflammation in gout. Rheumatology (Oxford) 44, 1090–1096 (2005)

Meng, Z. H., Hudson, A. P., Schumacher, H. R. Jr, Baker, J. F. & Baker, D. G. Monosodium urate, hydroxyapatite, and calcium pyrophosphate crystals induce tumour necrosis factor-alpha expression in a mononuclear cell line. J. Rheumatol. 24, 2385–2388 (1997)

Chapman, P. T. et al. Endothelial activation in monosodium urate monohydrate crystal-induced inflammation: in vitro and in vivo studies on the roles of tumor necrosis factor alpha and interleukin-1. Arthritis Rheum. 40, 955–965 (1997)

Hoffman, H. M. et al. Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet 364, 1779–1785 (2004)

Hawkins, P. N., Lachmann, H. J. & McDermott, M. F. Interleukin-1-receptor antagonist in the Muckle–Wells syndrome. N. Engl. J. Med. 348, 2583–2584 (2003)

Molad, Y. Update on colchicine and its mechanism of action. Curr. Rheumatol. Rep. 4, 252–256 (2002)

Malawista, S. E. & Seegmiller, J. E. The effect of pretreatment with colchicine on the inflammatory response to microcrystalline urate: A model for gouty inflammation. Ann. Intern. Med. 62, 648–657 (1965)

Getting, S. J. et al. Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. J. Pharmacol. Exp. Ther. 283, 123–130 (1997)

Goldfinger, S. E., Howell, R. R. & Seegmiller, J. E. Suppression of metabolic accompaniments of phagocytosis by colchicine. Arthritis Rheum. 8, 1112–1122 (1965)

Liu-Bryan, R., Scott, P., Sydlaske, A., Rose, D. M. & Terkeltaub, R. Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation. Arthritis Rheum. 52, 2936–2946 (2005)

Janeway, C. A. Jr & Medzhitov, R. Innate immune recognition. Annu. Rev. Immunol. 20, 197–216 (2002)

Matzinger, P. The danger model: a renewed sense of self. Science 296, 301–305 (2002)

Hoffman, H. M., Mueller, J. L., Broide, D. H., Wanderer, A. A. & Kolodner, R. D. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome. Nature Genet. 29, 301–305 (2001)

Agostini, L. et al. NALP3 forms an IL-1β-processing inflammasome with increased activity in Muckle–Wells autoinflammatory disorder. Immunity 20, 319–325 (2004)