Gongronema latifolium leaf extract modulates hyperglycaemia, inhibits redox imbalance and inflammation in alloxan-induced diabetic nephropathy

Journal of Diabetes & Metabolic Disorders - Tập 19 Số 1 - Trang 469-481 - 2020
Oluwafemi Adeleke Ojo1,2, Olukemi Adetutu Osukoya2, Lisa Ilobekemen Ekakitie2, Basiru Olaitan Ajiboye2, Babatunji Emmanuel Oyinloye3,2, Precious Eseose Agboinghale2, Abidemi Paul Kappo4
1Department of Biochemistry, Phytomedicine and Biochemical Toxicology Research Laboratory, Landmark University, Omu-Aran, Nigeria
2Department of Biochemistry, Phytomedicine, Biochemical Toxicology and Biotechnology Research Laboratory, College of Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
3Department of Biochemistry and Microbiology, Biotechnology and Structural Biology (BSB) Group, University of Zululand, KwaDlangezwa, South Africa
4Molecular Biophysics and Structural Biology Group, Department of Biochemistry, Faculty of Science, University of Johannesburg, Johannesburg, South Africa

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American Diabetes Association. Classification and diagnosis of diabetes: standards of medical Care in Diabetes. Diabetes Care. 2018;41(Suppl. 1):S13–27.

Baradara A, Madihi Y, Merrikhi A, Rafieian-Kopaei M, Nasri H. Serum lipoprotein in diabetic patients with various renal function not yet on dialysis. Pak J Med Sci. 2013;29:354–7.

Cho NH, Shaw JE, Karuranga S, Huang Y, da Rocha Fernandes JD, Ohlrogge AW, et al. IDF diabetes atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271–81.

Uloko AE, Musa BM, Ramalan MA, Gezawa ID, Puepet FH, Uloko AT, et al. Prevalence and risk factors for diabetes mellitus in Nigeria: a systematic review and meta-analysis. Diabetes Ther. 2018;9:1307–16.

Ojo OA, Ojo AB, Ajiboye BO, Oyinloye BE, Imiere OD, Adeyonu O. Ameliorative potentials of Blighia sapida K.D. Koenig bark against pancreatic-cell dysfunction in alloxan-induced diabetic rats. J Complement Integr Med. 2017;14:20160145.

Prabhakar YK, Janardhan YE, Sreenivasulu D, Raju K, Kumar KJ, Prabhusaran N. Ameliorative effects of Mentha aquatica on diabetic and nephroprotective potential activities in STZ-induced renal injury. Comp Clin Pathol. 2020;29:189–99.

Ojo OA, Ajiboye BO, Oyinloye BE, Ojo AB, Olarewaju OI. Protective effect of Irvingia gabonensis stem bark extract on cadmium-induced nephrotoxicity in rats. Interdisciplinary Toxicol. 2014a;7(4):208–14.

Ojo OA, Oyinloye BE, Ajiboye BO, Ojo AB, Akintayo CO, Okezie B. Dichlorvos induced nephrotoxicity in rat kidney: protective effects of Alstonia boonei stem bark. Int J Pharm. 2014b;1(7):429–37.

Pi J, Zhang Q, Fu J, Woods CG, Hou Y, Corkey BE, et al. ROS signaling, oxidative stress and NRF2 in pancreatic beta-cell function. Toxicol Appl Pharm. 2010;244(1):77–83.

Lipinski B. Pathophysiology of oxidative stress in diabetes mellitus. J Diabetes Compl. 2001;15(4):203–10.

Saeed N, Khan MR, Shabbir M. Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L. BMC Compl Altern Med. 2012;12(1):221.

Miranda-Díaz AG, Pazarín-Villaseñor L, Yanowsky-Escatell FG, Andrade-Sierra J. Oxidative Stress in Diabetic Nephropathy with Early Chronic Kidney Disease. J Diabetes Res. 2016;2016.

Zhang H, Sun S-C. NF-κB in inflammation and renal diseases. Cell Biosci. 2015;5:63.

Liu T, Zhang L, Joo D, Sun S-C. NF-κB signaling in inflammation. Signal Transduct Target Ther. 2017;2:17023.

Emordi JE, Agbaje EO, Oreagba IA, Iribhogbe OI. Antidiabetic and hypolipidemic activities of hydroethanolic root extract of Uvaria chamae in streptozotocin induced diabetic albino rats. BMC Complement Altern Med. 2016;16:1.

Yu XY, Chen HM, Liang JL, Lin QX, Tan HH, Fu YH, et al. Hyperglycemic Myocardial Damage Is Mediated by Proinflammatory Cytokine: Macrophage Migration Inhibitory Factor. PLoS ONE. 2011;6:e16239.

Ajiboye BO, Ojo OA, Akuboh OS, Okesola MA, Idowu O, Amuzat AO. Anti-hyperglycemic and anti-inflammatory activities of polyphenolic-rich extract of Syzygium cumini Linn leaves in alloxan-induced diabetic rats. J Evid Based Integrative Med. 2018a;23:1–8.

Morebise O, Fafunso M. A., Makinde JM, Olagide OA, awe EO. Anti-inflammatory property of the leaves of Gongronema latifolium. Phytother. Res. 2002;16:75–7.

Gamaniel KS, Akah PA. Analysis of the gastrointestinal relaxing effect of the stem extract of Gongronema latifolium. Phytomed. 1996;2:293–6.

Nwangwu SCO, Josiah JS, Abubakar ET, Ajeigbe OK, Osakwe OE, Akintola AA. Comparative effects of aqueous and ethanolic leaf extracts of Gongronema latifoliumon serum kidney and liver biomarkers of normal male rats. Asian J Biol Sci. 2011;4:540–7.

Nwangwu SCO, Nwangwu UC, Josiah SJ, Ezenduka C. Hepatoprotective and hypolipidemic potentials of aqueous and ethanolic leaf extracts of Gongronema latifolium on normal male rats. J Sci Eng Technol. 2010;17:9572–83.

Ugochukwu NH, Babady NE, Cobourne M, Gasses SR. The effect of Gongronema latifolium extract on serum lipid profile and oxidative stress in hepatocyte of diabetic rats. J Biosci. 2003;28:1–5.

Ugwu CE, Olajide JE, Alumanah JC, Ezeanyika LU. Comparative effects of the leaves of Gongronema latifolium and Telfairia occidentalis incorporated diets on the lipid profiles of rats. Global J Pure Appli Sci. 2010;16:319–24.

Ajiboye BO, Oyinloye BE, Agboinghale PE, Onikanni SA, Asogwa E, Kappo PA. Antihyperglycaemia and related gene expressions of aqueous extract of Gongronema latifolium leaf in alloxan-induced diabetic rats. Pharm Biol. 2019;57(1):604–11.

Ogundipe OO, Moody JO, Akinyemi TO, Raman A. Hypoglycemic potentials of methanolic extracts of selected plant foods in alloxanized mice. Plant Foods Hum Nutr. 2003;58(3):1–7.

Schneider CR, Sheidt K, Brietmaier E. Four new pregnant glycosides from Gongronema latifolium (Asclepidaceous). J Parkische Chem Chenisker-Zutung. 2003;353:532–6.

Ajayi IA, Oderinde RA, Kajogbola DO, Ukponi JU. Oil content and fatty acid composition of some underutilized legumes from Nigeria. Food Chem. 2006;99(1):115–20.

Eleyinmi AF. Chemical composition and anti-bacterial activity of Gongronema latifolium. J Zhejiang Univer Sci. 2007;8(5):352–8.

Yakubu MT, Ogunro OB. Effects of aqueous extract of Fadogia agrestis stem in alloxan-induced diabetic rats. Bangladesh J Pharmacol. 2014;9:356–63.

Ajiboye BO, Ojo OA, Adeyonu O, Imiere O, Oyinloye BE, Ogunmodede O. Ameliorative activity of Ethanolic extract of Artocarpus heterophyllus stem bark on Alloxan-induced diabetic rats. Adv Pharm Bull. 2018b;8(1):141–7.

Ahmad MS, Pischetsrieder M, Ahmed N. Aged garlic extract and S-allyl cysteine prevent formation of advanced glycation end products. Eur J Pharmacol. 2007;561:32–8.

Anderson L, Dinesen B, Jorgonsen PN, Poulsen F, Roder ME. Enzyme immune assay for intact human insulin in serum or plasma. Clin Chem. 1993;39:578–82.

Sinha AK. Colorimetric assay of catalase. Anal Biochem. 1972;47:389–94.

Zelko IN, Manriani YJ, Folz RJ. Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution and expression. Free Radic Biol Med. 2002;33:337–49.

Jurkovič S, Osredkar J, Marc J. Molecular impact of glutathione peroxidases in antioxidant processes. Biochem Med. 2008;18(2):162–74.

Livingstone C, Davis J. Review: targeting therapeutics against glutathione depletion in diabetes and its complications. Br J Diabetes Vasc Dis. 2007;7(6):258–65.

Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem. 1974;249(22):7130–9.

Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95(2):351–8.

Mizutani H, Ishihara Y, Izawa A, Fujihara Y, Kobayashi S, Gotou H, et al. Lipopolysaccharide of Aggregatibacter actinomycetemcomitans up-regulates inflammatory cytokines, prostaglandin E synthesis and osteoclast formation in interleukin-1 receptor antagonist-deficient mice. J Periodontal Res. 2013;48:748–56.

Yakubu MT, Uwazie N, Igunnu A. Anti-diabetic activity of aqueous extract of Senna alata (fabacea) flower in alloxan-induced diabetic male rats. Cameroon J Biol Biochem Sci. 2016;24:7–17.

Okoduwa IR, Umar IA, James DB, Inuwa HM. Anti-diabetic potential of Ocimum gratissimum leaf fractions in fortified diet-fed Streptozotocin treated rat model of Type-2 diabetes. Medicines. 2017;4:73.

Ajiboye BO, Ojo OA, Adeyonu O, Imiere O, Fadaka A, Osukoya A. Ameliorative activity of ethanolic extract of Artocarpus heterophyllus stem bark on pancreatic beta-cell dysfunction in alloxan-induced diabetic rats. J Evid Based Complement Altern Med. 2017;22(4):538–43.

Ramya N, Peddanna K, Prabhakar YK, Apparao C. Evaluation of anti-hyperglycemic activity of Narengi Crenulata leaf in STZ induced diabetic rats. Asian J Biomed Pharm Sci. 2014;4(39):35–9.

Prabhakar YK, Subhan Ali MD, Kumar MV, Tilak TK, Appa Rao CH. Evaluation of antioxidant activities of aqueous extract of stem bark of Boswellia ovalifoliolata in Streptozotocin induced diabetic rats. J Pharm Chem. 2013;7(4):19–24.

Prabhakar YK, Sreenivasulu D, Sreenath K, Prabhusaran N. In vivo antihyperglycemic, antihyperlipidemic, antioxidative stress and antioxidant potential activities of Syzygium paniculatum Gaertn. In Streptozotocin induced diabetic rats. Heliyon. 2019;5(3):1–22.

Natava R, Srutineni VP, Shaik AN, Sirasanagandla S, Prabhakar YK, Mohammad SA, et al. In-vivo studies on the Antidiabetic activity of stem bark of Homalium zeylanicum in STZ induced diabetic rats. Asian J Biochem Pharm Res. 2014;4(3):76–90.

Kumar MV, Prabhakar YK, Saritha M, Tilak TK, Nabi SA, Ali MD, et al. Effect of flavonoid rich fraction of Andrographis echioides in Streptozotocin-induced diabetic rats. J Pharm Chem. 2016;10(1):16–20.

Ojo AB, Adanlawo IG, Ojo OA. Ameliorative potentials of saponins from Helianthus annuus roots on hepatoproductive and some kidney function indices of alloxan-induced diabetic rats. PharmacologyOnline. 2016;3:73–9.

Ajiboye BO, Chikezie GS, Aganzi IY, Ojo OA, Onikanni SA, Afolabi OB, et al. Effect of Artocarpus altilis fruit based-diet on liver and kidney function indices on alloxan-induced diabetic rats. Mediterr J Nutr Metab. 2016;9:23–35.

Ojo AB, Adanlawo IG, Ojo OA. Efficacy of saponins from Helianthus annuus roots on Normoglycemic, antiperoxidative and antihyperlipidemic effects in alloxan-induced diabetic rats. Int J Pharmacogn Phytochem Res. 2017;9(1):83–8.

Ajiboye BO, Edobor G, Ojo OA, Onikanni SA, Olarewaju OI, Muhammad NO. Effect of aqueous leaf extract of Senecio biafrae on hyperglycaemic and serum lipid profile of alloxan-induced diabetic rats. Inter J Dis Disor. 2014;2(1):059–64.

Vincent AM, Russell JW, Low P, Feldma EL. Oxidative stress in the pathogenesis of diabetic neuropathy. Endocr Rev. 2004;25:612–28.

Azeez OI, Oyagbemi AA, Oyeyemi MO, Odetola AA. Ameliorative effects of cnidoscolus aconitifolius on alloxan toxicity in wistar rats. Afr Health Sci. 2010;10(3):283–91.

Ravi K, Ramachandran B, Subramanian S. Protective effect of Eugenia jambolana seed kernel on tissue antioxidants in streptozotocin-induced diabetic rats. Biol Pharm Bull. 2004;27:1212–7.

Visweswara Rao P, Madhavi K, Dhananjaya Naidu M, Gan SH. Rhinacanthus nasutus improves the levels of liver carbohydrate, protein, glycogen, and liver markers in streptozotocin-induced diabetic rats. Evid Based Complement Alternat Med. 2013;2013:102901.

Ayepola OR, Brooks NL, Oguntibeju OO. Kolaviron improved resistance to oxidative stress and inflammation in the blood (erythrocyte, serum, and plasma) of streptozotocin-induced diabetic rats. Sci World J. 2014:921080.

Gratas-Delamarche A. Derbre´ F, Vincent S, Cillard J. physical inactivity, insulin resistance, and the oxidative-inflammatory loop. Free Radic Res. 2014;48:93–108.

Del Giudice M, Gangestad SW. Rethinking IL-6 and CRP: Whythey are more than inflammatory biomarkers, and why it matters. Brain Behav Immun. 2018;70:61–75.

Schett G. Physiological effects of modulating the interleukin-6 axis. Rheumatology. 2018;57:ii43–50.

Adeneye AA, Adeyemi OO. Further evaluation of antihyperglycaemic activity of Hunteria umbellata (K. Schum) Hallier f. seed extract in experimental diabetes. J Ethnopharmacol. 2009;126:238–43.

Adeneye AA, Crooks PA, Fadhel-Albayati Z, Miller AF, Zito SW, Adeyemi OO, et al. Antihyperglycemic profile of erinidine isolated from Hunteria umbellata seed. Afr J Tradit Complement Altern Med. 2013;10:189–202.