Glycolysis-Mediated Changes in Acetyl-CoA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells

Amit, 2011, Dynamic suspension culture for scalable expansion of undifferentiated human pluripotent stem cells, Nat. Protoc., 6, 572, 10.1038/nprot.2011.325

Blair, 2011, The liberation of embryonic stem cells, PLoS Genet., 7, e1002019, 10.1371/journal.pgen.1002019

Cezar, 2007, Identification of small molecules from human embryonic stem cells using metabolomics, Stem Cells Dev., 16, 869, 10.1089/scd.2007.0022

Dejosez, 2012, Pluripotency and nuclear reprogramming, Annu. Rev. Biochem., 81, 737, 10.1146/annurev-biochem-052709-104948

Drukker, 2012, Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells, Nat. Biotechnol., 30, 531, 10.1038/nbt.2239

Folmes, 2011, Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming, Cell Metab., 14, 264, 10.1016/j.cmet.2011.06.011

Hezroni, 2011, H3K9 histone acetylation predicts pluripotency and reprogramming capacity of ES cells, Nucleus, 2, 300, 10.4161/nucl.2.4.16767

Liu, 2012, Deregulated MYC expression induces dependence upon AMPK-related kinase 5, Nature, 483, 608, 10.1038/nature10927

Meissen, 2012, Induced pluripotent stem cells show metabolomic differences to embryonic stem cells in polyunsaturated phosphatidylcholines and primary metabolism, PLoS ONE, 7, e46770, 10.1371/journal.pone.0046770

Melcer, 2012, Histone modifications and lamin A regulate chromatin protein dynamics in early embryonic stem cell differentiation, Nat. Commun., 3, 910, 10.1038/ncomms1915

Metallo, 2013, Understanding metabolic regulation and its influence on cell physiology, Mol. Cell, 49, 388, 10.1016/j.molcel.2013.01.018

Panopoulos, 2012, The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming, Cell Res., 22, 168, 10.1038/cr.2011.177

Pearson, 2007, Cancer patients opt for unapproved drug, Nature, 446, 474, 10.1038/446474a

Shyh-Chang, 2013, Influence of threonine metabolism on S-adenosylmethionine and histone methylation, Science, 339, 222, 10.1126/science.1226603

Vander Heiden, 2009, Understanding the Warburg effect: the metabolic requirements of cell proliferation, Science, 324, 1029, 10.1126/science.1160809

Varum, 2011, Energy metabolism in human pluripotent stem cells and their differentiated counterparts, PLoS ONE, 6, e20914, 10.1371/journal.pone.0020914

Ware, 2009, Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells, Cell Stem Cell, 4, 359, 10.1016/j.stem.2009.03.001

Wellen, 2009, ATP-citrate lyase links cellular metabolism to histone acetylation, Science, 324, 1076, 10.1126/science.1164097

Xia, 2009, MetaboAnalyst: a web server for metabolomic data analysis and interpretation, Nucleic Acids Res., 37, W652, 10.1093/nar/gkp356

Xu, 2013, Characterizing the metabolic heterogeneity in human breast cancer xenografts by 3D high resolution fluorescence imaging, Springerplus, 2, 73, 10.1186/2193-1801-2-73

Yanes, 2010, Metabolic oxidation regulates embryonic stem cell differentiation, Nat. Chem. Biol., 6, 411, 10.1038/nchembio.364

Zhang, 2011, UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells, EMBO J., 30, 4860, 10.1038/emboj.2011.401

Zhu, 2010, Reprogramming of human primary somatic cells by OCT4 and chemical compounds, Cell Stem Cell, 7, 651, 10.1016/j.stem.2010.11.015