Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase

Neuroscience Letters - Tập 147 Số 1 - Trang 58-62 - 1992
Diane P. Hanger1, K. Hughes2, James R. Woodgett2, Jean‐Pierre Brion3, Brian H. Anderton1
1Department of Neuroscience, Institute of Psychiatry, London, UK
2Ludwig Institute for Cancer Research, London, UK
3Laboratoire d'Anatomie Pathologique et de Microscopie Electronique, Université Libre de Bruxelles, Bruxelles Belgium

Tóm tắt

Từ khóa


Tài liệu tham khảo

Biernat, 1992, The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule-binding region, EMBO J., 11, 1593, 10.1002/j.1460-2075.1992.tb05204.x

Binder, 1985, The distribution of tau in the mammalian central nervous system, J. Cell Biol., 101, 1371, 10.1083/jcb.101.4.1371

Brion, 1992, Isolated PHF and PHF-tau (A68) polypeptides in Alzheimer's disease contain epitopes from the whole sequence of different tau isoforms and modified sites recognized by RT97 and 8D8 anti-neurofilament antibodies, Neurobiol. Aging, 13, S54, 10.1016/0197-4580(92)90342-U

Brion, 1991, Tau in Alzheimer neurofibrillary tangles: N- and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site, Biochem. J., 273, 127, 10.1042/bj2730127

Brion, 1991, A68 proteins in Alzheimer's disease are composed of several tau isoforms in a phosphorylated state which affects their electrophoretic mobilities, Biochem. J., 279, 831, 10.1042/bj2790831

Coleman, 1990, Phosphate-dependent monoclonal antibodies to neurofilaments and Alzheimer neurofibrillary tangles recognize a synthetic phosphopeptide, J. Neurochem., 54, 1548, 10.1111/j.1471-4159.1990.tb01203.x

Drewes, 1992, Mitogenactivated protein (MAP) kinase transforms tau protein into an Alzheimer-like state, EMBO J., 11, 2131, 10.1002/j.1460-2075.1992.tb05272.x

Flament, 1989, Direct demonstration of abnormal phosphorylation of Tau microtubular proteins in Alzheimer's disease, C.R. Acad. Sci. III., 308, 77

Gache, 1990, Protein TAU variants present in paired helical filaments (PHFs) of Alzheimer brains, FEBS Lett., 272, 65, 10.1016/0014-5793(90)80450-W

Gallo, 1992, Expression and phosphorylation of a three-repeat isoform of tau in transfected non-neuronal cells, Biochem. J., 286, 399, 10.1042/bj2860399

Goedert, 1990, Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization, EMBO J., 9, 4225, 10.1002/j.1460-2075.1990.tb07870.x

Goedert, 1992, Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms, Neuron, 8, 159, 10.1016/0896-6273(92)90117-V

Goedert, 1989, Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease, Neuron, 3, 519, 10.1016/0896-6273(89)90210-9

Greenberg, 1992, Hydrofluoric acid-treated τphf proteins display the same biochemical properties as normal τ, J. Biol. Chem., 267, 564, 10.1016/S0021-9258(18)48531-6

Grundke-Iqbal, 1986, Abnormal phosphorylation of the microtubule-associated protein τ (tau) in Alzheimer cytoskeletal pathology, 83, 4913

Hanger, 1991, Tau in Alzheimer's disease and Down's syndrome is insoluble and abnormally phosphorylated, Biochem. J., 275, 99, 10.1042/bj2750099

Hanger, 1992, Cyclic AMP-dependent protein kinase induces a shift in the electrophoretic mobility of human tau, Neurobiol. Aging, 13, S54, 10.1016/0197-4580(92)90339-Y

Hughes, 1991, Baculovirus-mediated expression and characterisation of rat glycogen synthase kinase-3β, the mammalian homologue of the Drosophila melanogaster zeste-white 3sgg homeotic gene product, Eur. J. Biochem., 203, 305, 10.1111/j.1432-1033.1992.tb19860.x

Iqbal, 1989, Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease, 86, 5646

Ishiguro, 1991, A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitope, Neurosci. Lett., 128, 195, 10.1016/0304-3940(91)90259-V

Ishiguro, 1992, Tau protein kinase I converts normal tau protein into A68-like component of paired helical filaments, J. Biol. Chem., 267, 10897, 10.1016/S0021-9258(19)50102-8

Kanemaru, 1992, Fetal-type phosphorylation of the tau in paired helical filaments, J. Neurochem., 58, 1667, 10.1111/j.1471-4159.1992.tb10039.x

Kosik, 1988, Epitopes that span the tau molecule are shared with paired helical filaments, Neuron, 1, 817, 10.1016/0896-6273(88)90129-8

Lee, 1991, A68: a major subunit of paired helical filaments and derivatized forms of normal tau, Science, 251, 675, 10.1126/science.1899488

Lichtenberg-Kraag, 1992, Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau, 89, 5384

Miller, 1986, Alzheimer's paired helical filaments share epitopes with neurofilament side arms, EMBO J., 5, 269, 10.1002/j.1460-2075.1986.tb04209.x

Roder, 1991, Two novel kinases phosphorylate tau and the KSP site of heavy neurofilament subunits in high stoichiometric ratios, J. Neurosci., 11, 3325, 10.1523/JNEUROSCI.11-11-03325.1991

Steiner, 1990, Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2+-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles, EMBO J., 9, 3539, 10.1002/j.1460-2075.1990.tb07563.x

Ulrich, 1987, Alzheimer dementia and Pick's disease: neurofibrillary tangles and Pick bodies are associated with identical phosphorylated neurofilament epitopes, Acta Neuropathol., 73, 240, 10.1007/BF00686617

Wood, 1986, Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau, 83, 4040

Woodgett, 1990, Molecular cloning and expression of glycogen synthase kinase-3/Factor A, EMBO J., 9, 2431, 10.1002/j.1460-2075.1990.tb07419.x

Woodgett, 1991, A common denominator linking glycogen metabolism, nuclear oncogenes and development, Trends Biochem. Sci., 16, 177, 10.1016/0968-0004(91)90071-3