Gluten-free diet in the management of patients with irritable bowel syndrome, fibromyalgia and lymphocytic enteritis
Tóm tắt
An evaluation of the effect of 1 year of a gluten-free diet was performed in patients with irritable bowel syndrome and fibromyalgia syndrome displaying lymphocytic enteritis. Gluten withdrawal produced a slight but significant improvement of the functional symptoms, suggesting that gluten might be partly responsible for this clinical picture. This hypothesis should be confirmed by a double-blind placebo-controlled trial since it cannot be ruled out that the studied patients displayed a subjective sensation of improvement due to the placebo effect of gluten withdrawal. Further investigations are needed before recommending gluten withdrawal in patients with fibromyalgia and lymphocytic enteritis.
Tài liệu tham khảo
Rodrigo L, Blanco I, Bobes J, de Serres F: Effect of one year of a gluten-free diet on the clinical evolution of irritable bowel syndrome plus fibromyalgia in patients with associated lymphocytic enteritis: a case–control study. Arthritis Res Ther. 2014, 16: 421-
Whitehead WE, Palsson O, Jones KR: Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications?. Gastroenterology. 2002, 122: 1140-1156. 10.1053/gast.2002.32392.
Brown I, Mino-Kenudson M, Deshpande V, Lauwers GY: Intraepithelial lymphocytosis in architecturally preserved proximal small intestinal mucosa: an increasing diagnostic problem with a wide differential diagnosis. Arch Pathol Lab Med. 2006, 130: 1020-1025.
Catassi C, Bai JC, Bonaz B, Bouma G, Calabrò A, Carroccio A, Castillejo G, Ciacci C, Cristofori F, Dolinsek J, Francavilla R, Elli L, Green P, Holtmeier W, Koehler P, Koletzko S, Meinhold C, Sanders D, Schumann M, Schuppan D, Ullrich R, Vécsei A, Volta U, Zevallos V, Sapone A, Fasano A: Non-celiac gluten sensitivity: the new frontier of gluten related disorders. Nutrients. 2013, 5: 3839-3853. 10.3390/nu5103839.
Volta U, Bardella MT, Calabrò A, Troncone R, Corazza GR: An Italian prospective multicenter survey on patients suspected of having non-celiac gluten sensitivity. BMC Med. 2014, 12: 85-10.1186/1741-7015-12-85.
Godlee F: Gluten sensitivity: real or not?. BMJ. 2012, 345: e7982-10.1136/bmj.e7982.
Volta U, Tovoli F, Cicola R, Parisi C, Fabbri A, Piscaglia M, Fiorini E, Caio G: Serological tests in gluten sensitivity (nonceliac gluten intolerance). J Clin Gastroenterol. 2012, 46: 680-685. 10.1097/MCG.0b013e3182372541.
Verdu EF: Can gluten contribute to irritable bowel syndrome?. Am J Gastroenterol. 2011, 106: 516-518. 10.1038/ajg.2010.490.
Caio G, Volta U, Tovoli F, De Giorgio R: Effect of gluten-free diet on immune response to gliadin in patients with non-coeliac gluten sensitivity. BMC Gastroenterol. 2014, 12: 85-
Volta U, Caio G, Tovoli F, De Giorgio R: Non-celiac gluten sensitivity: questions still to be answered despite an increasing awareness. Cell Mol Immunol. 2013, 10: 383-392. 10.1038/cmi.2013.28.