Glutathione in liver diseases and hepatotoxicity
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Aoki, 2002, Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes, J. Biol. Chem., 277, 10244, 10.1074/jbc.M112355200
Armstrong, 2002, Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in Bcl-2 overexpressing HL60 cells, FASEB J., 16, 1263, 10.1096/fj.02-0097fje
Aw, 1986, Mechanism of inhibition of glutathione efflux by methionine from isolated rat hepatocytes, Am. J. Physiol., 251, 354
Bai, 2006, Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione, J. Biol. Chem., 281, 5128, 10.1074/jbc.M510484200
Baines, 2005, Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death, Nature, 434, 658, 10.1038/nature03434
Baines, 2007, Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death, Nat. Cell Biol., 9, 550, 10.1038/ncb1575
Ballatori, 1998, Roles of MRP2 and oatp1 in hepatocellular export of reduced glutathione, Semin. Liver Dis., 18, 377, 10.1055/s-2007-1007171
Briz, 2006, OATP8/1B3-mediated cotransport of bile acids and glutathione: an export pathway for organic anions from hepatocytes?, J. Biol. Chem., 281, 30326, 10.1074/jbc.M602048200
Cande, 2004, Apoptosis-inducing factor (AIF): caspase-independent after all, Cell Death Differ., 11, 591, 10.1038/sj.cdd.4401400
Colell, 2001, Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione, Hepatology, 34, 964, 10.1053/jhep.2001.28510
Colell, 1998, Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor, Gastroenterology, 115, 1541, 10.1016/S0016-5085(98)70034-4
Colell, 1997, Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and S–adenosyl–l–methionine, Hepatology, 26, 699
Coll, 2003, Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion, Hepatology, 38, 692, 10.1053/jhep.2003.50351
Costantini, 2000, Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis, Oncogene, 19, 307, 10.1038/sj.onc.1203299
Costantini, 1995, Selective inhibition of the mitochondrial permeability transition pore at the oxidation-reduction sensitive dithiol by monobromobimane, FEBS Lett., 362, 239, 10.1016/0014-5793(95)00256-9
Costantini, 1996, Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites, J. Biol. Chem., 271, 6746, 10.1074/jbc.271.12.6746
Davis, 2000, Signal transduction by the JNK group of MAP kinases, Cell, 103, 239, 10.1016/S0092-8674(00)00116-1
Dong, 1998, Defective T cell differentiation in the absence of Jnk1, Science, 282, 2092, 10.1126/science.282.5396.2092
Fernandez-Checa, 2002, S–Adenosyl–l-methionine and mitochondrial reduced glutathione depletion in alcoholic liver disease, Alcohol, 27, 179, 10.1016/S0741-8329(02)00229-X
Fernandez-Checa, 1989, Effects of chronic ethanol feeding on rat hepatocytic glutathione. Relationship of cytosolic glutathione to efflux and mitochondrial sequestration, J. Clin. Invest., 83, 1247, 10.1172/JCI114008
Ferret, 2001, Detoxification of reactive oxygen species by a nonpeptidyl mimic of superoxide dismutase cures acetaminophen-induced acute liver failure in the mouse, Hepatology, 33, 1173, 10.1053/jhep.2001.24267
Franco, 2006, SLCO/OATP-like transport of glutathione in FasL-induced apoptosis: glutathione efflux is coupled to an organic anion exchange and is necessary for the progression of the execution phase of apoptosis, J. Biol. Chem., 281, 29542, 10.1074/jbc.M602500200
Franco, 2007, Glutathione depletion is necessary for apoptosis in lymphoid cells independent of reactive oxygen species formation, J. Biol. Chem., 282, 30452, 10.1074/jbc.M703091200
Gaiddon, 1999, Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo, EMBO J., 18, 5609, 10.1093/emboj/18.20.5609
Garcia-Ruiz, 2003, Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice, J. Clin. Invest., 111, 197, 10.1172/JCI16010
Garcia-Ruiz, 1997, Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione, J. Biol. Chem., 272, 11369, 10.1074/jbc.272.17.11369
Geisler, 2007, Genetic inactivation of RelA/p65 sensitizes adult mouse hepatocytes to TNF-induced apoptosis in vivo and in vitro, Gastroenterology, 132, 2489, 10.1053/j.gastro.2007.03.033
Ghibelli, 1998, Rescue of cells from apoptosis by inhibition of active GSH extrusion, FASEB J., 12, 479, 10.1096/fasebj.12.6.479
Glineur, 2000, The conserved redox-sensitive cysteine residue of the DNA-binding region in the c-Rel protein is involved in the regulation of the phosphorylation of the protein, Biochem. J., 352 Pt 2, 583, 10.1042/0264-6021:3520583
Griffith, 1985, Origin and turnover of mitochondrial glutathione, Proc. Natl. Acad. Sci. USA, 82, 4668, 10.1073/pnas.82.14.4668
Gumpricht, 2000, Glutathione status of isolated rat hepatocytes affects bile acid-induced cellular necrosis but not apoptosis, Toxicol. Appl. Pharmacol., 164, 102, 10.1006/taap.2000.8894
Gunawan, 2006, c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity, Gastroenterology, 131, 165, 10.1053/j.gastro.2006.03.045
Ha, 1999, Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion, Proc. Natl. Acad. Sci. USA, 96, 13978, 10.1073/pnas.96.24.13978
Hammond, 2004, Activation of plasma membrane reduced glutathione transport in death receptor apoptosis of HepG2 cells, Toxicol. Appl. Pharmacol., 195, 12, 10.1016/j.taap.2003.10.008
Hammond, 2007, Glutathione export during apoptosis requires functional multidrug resistance-associated proteins, J. Biol. Chem., 282, 14337, 10.1074/jbc.M611019200
Haouzi, 2001, Prolonged, but not acute, glutathione depletion promotes Fas-mediated mitochondrial permeability transition and apoptosis in mice, Hepatology, 33, 1181, 10.1053/jhep.2001.24235
Hanawa, 2008, Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury, J. Biol. Chem., 283, 13565, 10.1074/jbc.M708916200
Hentze, 2000, Depletion of hepatic glutathione prevents death receptor-dependent apoptotic and necrotic liver injury in mice, Am. J. Pathol., 156, 2045, 10.1016/S0002-9440(10)65076-6
Hirota, 1999, Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB, J. Biol. Chem., 274, 27891, 10.1074/jbc.274.39.27891
Honda, 2005, Mitochondria and ischemia/reperfusion injury, Ann. NY Acad. Sci., 1047, 248, 10.1196/annals.1341.022
Ji, 2006, Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model, J. Hepatol., 45, 717, 10.1016/j.jhep.2006.05.009
Kallunki, 1994, JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation, Genes Dev., 8, 2996, 10.1101/gad.8.24.2996
Kamata, 2005, Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases, Cell, 120, 649, 10.1016/j.cell.2004.12.041
Kaplowitz, 2006, Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum, J. Gastroenterol. Hepatol., 21 Suppl 3, S7, 10.1111/j.1440-1746.2006.04581.x
Korenaga, 2005, Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production, J. Biol. Chem., 280, 37481, 10.1074/jbc.M506412200
Kuwana, 2002, Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane, Cell, 111, 331, 10.1016/S0092-8674(02)01036-X
Lash, 2006, Mitochondrial glutathione transport: physiological, pathological and toxicological implications, Chem Biol. Interact., 163, 54, 10.1016/j.cbi.2006.03.001
Lee, 2003, Acute liver failure in the United States, Semin. Liver Dis., 23, 217, 10.1055/s-2003-42641
Lluis, 2003, Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress, Gastroenterology, 124, 708, 10.1053/gast.2003.50089
Lluis, 2005, Critical role of mitochondrial glutathione in the survival of hepatocytes during hypoxia, J. Biol. Chem., 280, 3224, 10.1074/jbc.M408244200
Lou, 2007, Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms, J. Biol. Chem., 282, 29470, 10.1074/jbc.M706145200
Lu, 2007, Role of calcium and cyclophilin D in the regulation of mitochondrial permeabilization induced by glutathione depletion, Biochem. Biophys. Res. Commun., 363, 572, 10.1016/j.bbrc.2007.08.196
Lu, 1993, Thiol-disulfide effects on hepatic glutathione transport. Studies in cultured rat hepatocytes and perfused livers, J. Clin. Invest., 92, 1188, 10.1172/JCI116689
Lu, 1994, Specificity and directionality of thiol effects on sinusoidal glutathione transport in rat liver, Mol. Pharmacol., 46, 578
Maeda, 2003, IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha, Immunity, 19, 725, 10.1016/S1074-7613(03)00301-7
Mahagita, C., Grassl, S.M., Piyachaturawat, P., Ballatori, N., 2007. Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport. Am. J. Physiol. Gastrointest Liver Physiol. 293 (1), G271–G278 (Epub 2007 Apr 5).
Masubuchi, 2005, Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice, J. Hepatol., 42, 110, 10.1016/j.jhep.2004.09.015
Matsumaru, 2003, Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes, Hepatology, 37, 1425, 10.1053/jhep.2003.50230
Matthews, 1992, Thioredoxin regulates the DNA binding activity of NF-kappaB by reduction of a disulphide bond involving cysteine 62, Nucleic Acids Res., 20, 3821, 10.1093/nar/20.15.3821
Nadeau, 2007, Disulfide Bond-mediated multimerization of Ask1 and its reduction by thioredoxin-1 regulate H(2)O(2)-induced c-Jun NH(2)-terminal kinase activation and apoptosis, Mol. Biol. Cell, 18, 3903, 10.1091/mbc.E07-05-0491
Nagai, 2002, Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes, Hepatology, 36, 55, 10.1053/jhep.2002.33995
Nakae, 1990, Liposome-encapsulated superoxide dismutase prevents liver necrosis induced by acetaminophen, Am. J. Pathol., 136, 787
Nakagawa, 2005, Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death, Nature, 434, 652, 10.1038/nature03317
Nicotera, 2004, Regulation of the apoptosis-necrosis switch, Oncogene, 23, 2757, 10.1038/sj.onc.1207559
Nishi, 2002, Spatial redox regulation of a critical cysteine residue of NF-kappaB in vivo, J. Biol. Chem., 277, 44548, 10.1074/jbc.M202970200
Oleinik, 2007, Cooperation between JNK1 and JNK2 in activation of p53 apoptotic pathway, Oncogene, 26, 7222, 10.1038/sj.onc.1210526
Otani, 2005, Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells, Gastroenterology, 128, 96, 10.1053/j.gastro.2004.10.045
Ott, 2002, Cytochrome c release from mitochondria proceeds by a two-step process, Proc. Natl. Acad. Sci. USA, 99, 1259, 10.1073/pnas.241655498
Pessayre, 2007, Role of mitochondria in non-alcoholic fatty liver disease, J. Gastroenterol. Hepatol., 22 Suppl 1, S20, 10.1111/j.1440-1746.2006.04640.x
Petronilli, 1994, The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation–reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents, J. Biol. Chem., 269, 16638, 10.1016/S0021-9258(19)89437-1
Petrosillo, 2007, Mitochondrial dysfunction in rat with nonalcoholic fatty liver Involvement of complex I, reactive oxygen species and cardiolipin, Biochim. Biophys. Acta., 1767, 1260, 10.1016/j.bbabio.2007.07.011
Pham, 2004, Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species, Cell, 119, 529, 10.1016/j.cell.2004.10.017
Pineda-Molina, 2001, Glutathionylation of the p50 subunit of NF-kappaB: a mechanism for redox-induced inhibition of DNA binding, Biochemistry, 40, 14134, 10.1021/bi011459o
Saitoh, 1998, Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1, EMBO J., 17, 2596, 10.1093/emboj/17.9.2596
Sakon, 2003, NF-κB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death, EMBO J., 22, 3898, 10.1093/emboj/cdg379
Schwabe, 2003, c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration, Hepatology, 37, 824, 10.1053/jhep.2003.50135
Schwer, 2004, Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif, J. Virol., 78, 7958, 10.1128/JVI.78.15.7958-7968.2004
Tanaka, 1997, Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney: independence of tubular necrosis and sulfhydryl depletion, Lab Invest., 77, 145
Tang, 2001, Inhibition of JNK activation through NF-κB target genes, Nature, 414, 313, 10.1038/35104568
van den Dobbelsteen, 1996, Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody, J. Biol. Chem., 271, 15420, 10.1074/jbc.271.26.15420
Vercammen, 1998, Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor, J. Exp. Med., 187, 1477, 10.1084/jem.187.9.1477
Vercammen, 1998, Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways, J. Exp. Med., 188, 919, 10.1084/jem.188.5.919
Videla, 2004, Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients, Clin. Sci. (Lond), 106, 261, 10.1042/CS20030285
Weston, 2002, The JNK signal transduction pathway, Curr. Opin. Genet. Dev., 12, 14, 10.1016/S0959-437X(01)00258-1
Willis, 2007, Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak, Science, 315, 856, 10.1126/science.1133289
Wong, 1989, Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor, Cell, 58, 923, 10.1016/0092-8674(89)90944-6
Xanthoudakis, 1992, Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity, EMBO J., 11, 653, 10.1002/j.1460-2075.1992.tb05097.x
Xanthoudakis, 1992, Redox activation of fos–jun DNA binding activity is mediated by a DNA repair enzyme, EMBO J., 11, 3323, 10.1002/j.1460-2075.1992.tb05411.x
Yamada, 1997, Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor, Proc. Natl. Acad. Sci. USA, 94, 1441, 10.1073/pnas.94.4.1441
Yang, 1998, Differentiation of CD4+T cells to Th1 cells requires MAP kinase JNK2, Immunity, 9, 575, 10.1016/S1074-7613(00)80640-8
Youle, 2007, Cellular demolition and the rules of engagement Cell biology, Science, 315, 776, 10.1126/science.1138870