Glomeruläre Läsionen bei Transplantatabstoßung
Tóm tắt
Abstoßungsreaktionen sind die häufigste Ursache für ein Transplantatversagen nach Nierentransplantation. Glomeruläre Läsionen finden sich dabei relativ selten. Die thrombotische Mikroangiopathie und die Transplantatglomerulitis treten früh nach Transplantation auf, die Transplantatglomerulopathie bildet sich in der Regel erst nach längerer Zeit aus. Die morphologischen Befunde, in deren Zentrum ein Endothelschaden steht, und mögliche pathogenetische Mechanismen werden diskutiert.
Tài liệu tham khảo
Feucht HE, Felber E, Gokel MJ et a. (1991) Vascular deposition of complement-split products in kidney allografts with cell-mediated rejection. Clin Exp Immunol 86: 464–470
Solez K, Colvin RB, Racusen LC et al. (2007) Banff ‚05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy (‚CAN‘). Am J Transplant 7: 518–526
Hamburger J, Corsnier J, Dormont J (1964) Observations in patients with a well tolerted homotransplanted kidney: possibility of a new secondary disease. Ann N Y Acad Sci 120: 558
Zollinger HU, Moppert J, Thiel G et al. (1973) Morphology and pathogenesis of glomerulopathy in cadaver kidney allografts treated with antilymphocyte globulin. Curr Top Path 57: 1–22
Zollinger HU, Mihatsch MJ (1978) Renal pathology in biopsy. Springer, Berlin Heidelberg New York, pp 573–581
Porter KA (1983) Renal transplantation. In: Heptinstall RH (ed) Pathology of the kidney, 3. edn. Little Brown, Boston Toronto, pp 1455–1547
Maryniak R, First RM, Weiss MA (1985) Transplant glomerulopathy: Evolution of morphologically distinct changes. Kidney Int 27: 799–806
Habib R, Zurowska A, Hinglais N et al. (1993) A specific glomerular lesion of the graft: allograft glomerulopathy. Kidney Int Suppl 42: S104–S111
Vracko R (1974) Basal lamina scaffold. anatomy and significance for maintenance of orderly tissue structure. Am J Pathol 77: 314–338
Colvin RB, Nickeleit V (2007) Renal transplant. In: Jennette JC, Olson JL, Schwartz MM, Silva FG (eds) Pathology of the kidney, 6. edn. Lippincott, Williams & Wilkins, Philadelphia, pp 1358–1375
Regele H, Böhmig GA, Habicht A et al. (2002) Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: a contribution of humoral immunity to chronic allograft rejection. J Am Soc Nephrol 13: 2371–2380
Nickeleit V, Zeiler M, Gutdat F et al. (2002) Detection of the complement degradation product Crd in renal allografts: diagnostic and therapeutic implications. J Am Soc Nephrol 13: 242–251
Zou Y, Stastny P, Caner S et al. (2007) Antibodies against MICA antigens and kidney-transplant rejection. N Engl J Med 357: 1293–1300
Dragun D, Müller DN, Bräsen JH et al. (2005) Angiotensin II type 1-receptro activating antibodies in renal-allograft rejection. N Engl J Med 352: 558–569
Joosten SA, Sijpkens YW, Ham V van et al. (2005) Antibody response against the glomerular basement membrane protein agrin in patients with transplant glomerulopathy. Am J Transplant 5: 383–393
Akalin E, Dikman S, Murphy B et al. (2003) Glomerular infiltration by CXCR3+ ICOS+ activated T cells in chronic allograft nephropathy with transplant glomerulopathy. Am J Transplant 3: 1116–1120
Segerer S, Djafarzadeh R, Gröne HJ et al. (2007) Selective binding and presentation of CCL5 by discrete tissue microenvironments during renal inflammation. J Am Soc Nephrol 18: 1835–1844