Global Change and Helminth Infections in Grazing Ruminants in Europe: Impacts, Trends and Sustainable Solutions
Tóm tắt
Infections with parasitic helminths (nematodes and trematodes) represent a significant economic and welfare burden to the global ruminant livestock industry. The increasing prevalence of anthelmintic resistance means that current control programmes are costly and unsustainable in the long term. Recent changes in the epidemiology, seasonality and geographic distribution of helminth infections have been attributed to climate change. However, other changes in environment (e.g., land use) and in livestock farming, such as intensification and altered management practices, will also have an impact on helminth infections. Sustainable control of helminth infections in a changing world requires detailed knowledge of these interactions. In particular, there is a need to devise new, sustainable strategies for the effective control of ruminant helminthoses in the face of global change. In this paper, we consider the impact of helminth infections in grazing ruminants, taking a European perspective, and identify scientific and applied priorities to mitigate these impacts. These include the development and deployment of efficient, high-throughput diagnostic tests to support targeted intervention, modelling of geographic and seasonal trends in infection, more thorough economic data and analysis of the impact of helminth infections and greater translation and involvement of end-users in devising and disseminating best practices. Complex changes in helminth epidemiology will require innovative solutions. By developing and using new technologies and models, the use of anthelmintics can be optimised to limit the development and spread of drug resistance and to reduce the overall economic impact of helminth infections. This will be essential to the continued productivity and profitability of livestock farming in Europe and its contribution to regional and global food security.
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FAOSTAT (2009). Available online:http://faostat.fao.org/.
Baulcombe, D., Crute, I., Dunwell, J., Gale, M., Jones, J., Pretty, J., Sutherland, W., and Toulmin, C. (2009). Reaping the Benefits—Science and the Sustainable Intensification of Global Agriculture, Royal Society Policy Document.
Chiotti, 1995, Extending the boundaries of climate change research—A discussion on agriculture, J. Rural Stud., 11, 335, 10.1016/0743-0167(95)00023-G
Nieuwhof, 2005, Costs of the major endemic diseases in Great Britain and the potential benefits of reduction in disease impact, Anim. Sci., 81, 23, 10.1079/ASC41010023
Schweizer, 2005, The economic effects of bovine fasciolosis in Switzerland, Vet. Rec., 157, 188, 10.1136/vr.157.7.188
Selzer, P.M. (2009). Antiparasitic and Antibacterial Drug Discovery. From Molecular Targets to Drug Candidates, Wiley-Blackwell.
Charlier, 2009, Gastrointestinal nematode infections in adult dairy cattle: Impact on production, diagnosis and control, Vet. Parasitol., 164, 70, 10.1016/j.vetpar.2009.04.012
Rehbein, 2013, Nematode burdens of pastured cattle treated once at turnout with eprinomectin extended-release injection, Vet. Parasitol., 192, 321, 10.1016/j.vetpar.2012.11.038
Morgan, 2008, The influence of temperature on the development, hatching and survival of Nematodirus battus larvae, Parasitology, 135, 269, 10.1017/S0031182007003812
Mejia, 2011, Comparison of three methods for gastrointestinal nematode diagnosis determination in grazing dairy cattle in relation to milk production, Vet. Parasitol., 183, 174, 10.1016/j.vetpar.2011.06.027
Charlier, 2012, ParaCalc®—A novel tool to evaluate the economic importance of worm infections on the dairy farm, Vet. Parasitol., 184, 204, 10.1016/j.vetpar.2011.09.008
Charlier, 2012, The economic effects of whole-herd versus selective anthelmintic treatment strategies in dairy cows, J. Dairy Sci., 95, 2977, 10.3168/jds.2011-4719
Mason, 2012, The effect of repeated, four-weekly eprinomectin treatment on milk production in pasture-based, seasonally-calving dairy cattle, Vet. Parasitol., 189, 250, 10.1016/j.vetpar.2012.05.003
Sargison, 2010, Climate change and infectious disease: Helminthological challenge to farmed ruminants in temperate regions, Animal, 4, 377, 10.1017/S1751731109990991
Sargison, 2007, Haemonchosis and teladorsagiosis in a Scottish sheep flock putatively associated with the over-wintering of hypobiotic fourth stage larvae, Vet. Parasitol., 147, 326, 10.1016/j.vetpar.2007.04.011
Kenyon, 2009, Sheep helminth parasitic disease in South-Eastern Scotland arising as a possible consequence of climate change, Vet. Parasitol., 163, 293, 10.1016/j.vetpar.2009.03.027
Lindqvist, 2001, The dynamics, prevalence and impact of nematode infections in organically raised sheep in Sweden, Acta Vet. Scand., 42, 377, 10.1186/1751-0147-42-377
Rioux, 2008, Climate change: Effects on animal disease systems and implications for surveillance and control, Rev. Sci. Tech. Int. Off. of Epizoot., 27, 339
Morgan, 2009, Climate change and parasitic disease: Farmer mitigation?, Trends Parasitol., 7, 308, 10.1016/j.pt.2009.03.012
Leathwick, 1992, A model for nematodiasis in New Zealand lambs, Int. J. Parasitol., 22, 789, 10.1016/0020-7519(92)90129-9
Reynecke, 2011, Dynamics of the free-living stages of sheep intestinal parasites on pasture in the North Island of New Zealand. 2. Weather variables associated with development, Vet. J., 59, 287
Leathwick, 2012, Managing anthelmintic resistance—Use of a combination anthelmintic and leaving some lambs untreated to slow the development of resistance to ivermectin, Parasitology, 187, 285
Dobson, 2011, A multi-species modelto assess the effect of refugia on worm control and anthelmintic resistance insheep grazing systems, Aust. Vet. J., 89, 200, 10.1111/j.1751-0813.2011.00719.x
Laurenson, 2013, Modelling the short- and long-term impacts of drenching frequency and targeted selective treatment on the performance of grazing lambs and the emergence of anthelmintic resistance, Parasitology, 140, 780, 10.1017/S0031182012002181
Fox, 2011, Predicting impacts of climate change on Fasciola hepatica risk, PLoS One, 6, e16126, 10.1371/journal.pone.0016126
Jackson, 2006, Alternative approaches to control—Quo vadit?, Vet. Parasitol., 139, 371, 10.1016/j.vetpar.2006.04.025
Kaplan, 2004, Drug resistance in nematodes of veterinary importance: A status report, Trends Parasitol., 20, 477, 10.1016/j.pt.2004.08.001
Familton, 2001, Anthelmintic-resistant Cooperia species in cattle, Vet. Rec., 149, 719
Sutherland, 2010, Anthelmintic resistance in nematode parasites of cattle—A global issue?, Trends Parasitol, 27, 176, 10.1016/j.pt.2010.11.008
Demeler, 2009, Monitoring the efficacy of ivermectin and albendazole against gastro intestinal nematodes of cattle in Northern Europe, Vet. Parasitol., 160, 109, 10.1016/j.vetpar.2008.10.030
Charlier, 2010, The use of a simplified faecal egg count reduction test for assessing anthelmintic efficacy on Belgian and German cattle farms, Vet. Parasitol., 169, 352, 10.1016/j.vetpar.2010.01.015
Bartley, 2004, Characterisation of two triple resistant field isolates of Teladorsagia from Scottish lowland sheep farms, Vet. Parasitol., 123, 189, 10.1016/j.vetpar.2004.06.018
Sargison, 2007, Observations on the emergence of multiple anthelmintic resistance in sheep flocks in the south-east of Scotland, Vet. Parasitol., 45, 65, 10.1016/j.vetpar.2006.10.024
Wolstenholme, 2004, Drug resistance in veterinary helminths, Trends Parasitol., 20, 469, 10.1016/j.pt.2004.07.010
Kaminsky, 2008, A new class of anthelmintics effective against drug-resistant nematodes, Nature, 452, 176, 10.1038/nature06722
Little, 2010, Field efficacy and safety of an oral formulation of the novel combination anthelmintic, derquantel-abamectin, in sheep in New Zealand, N. Z. Vet. J., 58, 121, 10.1080/00480169.2010.67513
Steinfeld, H., Gerber, P., Wassenaar, T., Castel, V., Rosales, M., and de Haan, C. (2006). Livestock’s Long Shadow: Environmental Issues and Options, Report presented to the Food and Agricultural Organisation of the United Nations (FAO).
Gill, 2010, Mitigating climate change: The role of domestic livestock, Animal, 4, 323, 10.1017/S1751731109004662
Thornton, 2010, Livestock production: Recent trends, future prospects, Philos. Trans. R. Soc. B Biol. Sci., 365, 2853, 10.1098/rstb.2010.0134
Taylor, 2002, Anthelmintic resistance detection methods, Vet. Parasitol., 103, 183, 10.1016/S0304-4017(01)00604-5
Gasser, 2008, Toward practical, DNA-based diagnostic methods for parasitic nematodes of livestock—Bionomic and biotechnical implications, Biotechnol. Adv., 26, 325, 10.1016/j.biotechadv.2008.03.003
Zarlenga, 2001, A multiplex PCR assay for differentiating economically important gastrointestinal nematodes of cattle, Vet. Parasitol., 97, 199, 10.1016/S0304-4017(01)00410-1
Wimmer, 2004, Non-invasive assessment of parasitic nematode species diversity in wild Soay sheep using molecular markers, Int. J. Parasitol., 34, 625, 10.1016/j.ijpara.2003.11.022
Learmount, 2009, Development and validation of real-time PCR methods for diagnosis of Teladorsagia circumcincta and Haemonchus contortus in sheep, Vet. Parasitol., 166, 268, 10.1016/j.vetpar.2009.08.017
Dobson, 2009, Geometric means provide a biased efficacy result when conducting a faecal egg count reduction test (FECRT), Vet. Parasitol., 161, 162, 10.1016/j.vetpar.2008.12.007
Coles, 2006, The detection of anthelmintic resistance in nematodes of veterinary importance, Vet. Parasitol., 136, 167, 10.1016/j.vetpar.2005.11.019
Blackhall, 2007, Single nucleotide polymorphism (SNP) markers for benzimidazole resistance in veterinary nematodes, Parasitology, 134, 1077, 10.1017/S0031182007000054
Walsh, 2009, Molecular detection of benzimidazole resistance in Haemonchus contortus using real-time PCR and pyrosequencing, Parasitology, 136, 349, 10.1017/S003118200800543X
Skuce, 2010, Benzimidazole resistance allele haplotype diversity in United Kingdom isolates of Teladorsagia circumcincta supports a hypothesis of multiple origins of resistance by recurrent mutation, Int. J. Parasitol., 40, 1247, 10.1016/j.ijpara.2010.03.016
Gustaffson, 2009, Anthelmintic resistance in Swedish sheep flocks based on a comparison of the results from the faecal egg count reduction test and resistant allele frequencies of the beta-tubulin gene, Vet. Parasitol., 161, 60, 10.1016/j.vetpar.2008.12.001
Beech, 2010, Anthelmintic resistance: Markers for resistance, or susceptibility?, Parasitology, 138, 160, 10.1017/S0031182010001198
Gilleard, 2006, Understanding anthelmintic resistance: The need for genomics and genetics, Int. J. Parasitol., 36, 1227, 10.1016/j.ijpara.2006.06.010
Vignali, 2000, Multiplexed particle-based flow cytometric assays, J. Immunol. Methods, 243, 243, 10.1016/S0022-1759(00)00238-6
Pickering, 2002, Comparison of a multiplex flow cytometric assay with Enzyme-Linked Immunosorbent Assay for quantification of antibodies to Tetanus, Diphtheria and Haemophilus influenza Type b, Clin. Diagn. Lab. Immunol., 9, 872
Dunbar, 2003, Quantitative, multiplexed detection of bacterial pathogens: DNA and protein applications of the Luminex LabMAPTM system, J. Microbiol. Methods, 53, 245, 10.1016/S0167-7012(03)00028-9
Morgan, 2004, Cytometric bead array: A multiplexed assay platform with applications in various areas of biology, Clin. Immunol., 110, 252, 10.1016/j.clim.2003.11.017
Dunbar, 2006, Application of Luminex xMAPTM technology for rapid, high-throughput multiplexed nucleic acid detection, Clinia Chim. Acta, 363, 71, 10.1016/j.cccn.2005.06.023
Charlier, 2009, Evaluation of anti-Ostertagia ostertagi antibodies in individual milk samples as decision parameter for selective anthelmintic treatment in dairy cows, Prev. Vet. Med., 93, 147, 10.1016/j.prevetmed.2009.10.002
McCann, 2010, Seroprevalence and spatial distribution of Fasciola hepatica-infected dairy herds in England and Wales, Vet. Rec., 166, 612, 10.1136/vr.b4836
Andersen, 2013, SvSXP: A Strongylus vulgaris antigen with potential for prepatent diagnosis, Parasites Vectors, 6, 84, 10.1186/1756-3305-6-84
Ganheim, 2004, Acute phase proteins in response to Dictyocaulus viviparus infection in calves, Acta Vet. Scand., 45, 79, 10.1186/1751-0147-45-79
Charlier, 2011, Serum pepsinogen levels to monitor gastrointestinal nematode infections in cattle revisited, Res. Vet. Sci., 90, 451, 10.1016/j.rvsc.2010.06.029
Bandyopadhyay, 2007, Rapid microsphere assay for identification of Cryptosporidium hominis and Cryptosporidium parvum in stool and environmental samples, J. Clin. Microbiol., 45, 2835, 10.1128/JCM.00138-07
Li, 2010, A novel multiplex PCR coupled with Luminex assay for the simultaneous detection of Cryptosporidium spp., Cryptosporidium parvum and Giardia duodenalis, Vet. Parasitol, 173, 11, 10.1016/j.vetpar.2010.05.024
Stark, 2010, An evaluation of a multiplex tandem real-time PCR for the detection of Cryptosporidium spp, Dientamoeba fragilis, Entamoeba histolytica, and Giardia intestinalis from clinical stool samples, J. Clin. Microbiol., 49, 257, 10.1128/JCM.01796-10
Iseki, 2007, Development of a multiplex loop-mediated isothermal amplification (mLAMP) method for the simultaneous detection of bovine Babesia parasites, J. Microbiol. Methods, 71, 281, 10.1016/j.mimet.2007.09.019
Parida, 2008, Loop mediated isothermal amplification (LAMP): A new generation of innovative gene amplification technique; perspectives in clinical diagnosis of infectious diseases, Rev. Med. Virol., 18, 407, 10.1002/rmv.593
Aonuma, 2009, Loop-mediated isothermal amplification applied to filarial parasites detection in the mosquito vectors: Dirofilaria immitis as a study model, Parasites Vectors, 2, 15, 10.1186/1756-3305-2-15
Mori, 2009, Loop-mediated isothermal amplification (LAMP): A rapid, accurate and cost-effective diagnostic method for infectious diseases, J. Infect. Chemother., 15, 62, 10.1007/s10156-009-0669-9
Ollerenshaw, 1959, A method of forecasting the incidence of fascioliasis in Anglesey, Vet. Rec., 71, 591
Cornell, 2005, Modelling nematode populations: 20 years of progress, Trends Parasitol., 21, 542, 10.1016/j.pt.2005.08.019
Fuentes, 2006, Remote sensing and climate data as a key for understanding fasciolosis transmission in the Andes: Review and update of an ongoing interdisciplinary project, Geospat. Health, 1, 59, 10.4081/gh.2006.281
Rose, 2011, Modelling the impact of climate change on spatial patterns of disease risk: Sheep blowfly strike by Lucilia sericata in Great Britain, Int. J. Parasitol., 41, 739, 10.1016/j.ijpara.2011.01.012
Biggeri, 2007, Multivariate spatially-structured variability of ovine helminth infections, Geospat. Health, 2, 97, 10.4081/gh.2007.258
Rinaldi, 2006, New insights into the application of geographical information systems and remote sensing in veterinary parasitology, Geospat. Health, 1, 33, 10.4081/gh.2006.279
Bergquist, 2010, Health research based on geospatial tools: A timely approach in a changing environment, J. Helminthol., 84, 1, 10.1017/S0022149X09990484
Geospatial health: Health applications in geospatial science. Available online:http://www.geospatialhealth.unina.it.
Morgan, 2004, Ruminating on complexity: Macroparasites of wildlife and livestock, Trends Ecol. Evol., 19, 181, 10.1016/j.tree.2004.01.011
Morgan, 2012, Climate and the epidemiology of gastrointestinal nematode infections of sheep in Europe, Vet. Parasitol., 189, 8, 10.1016/j.vetpar.2012.03.028
David, 2008, Back to the future: Developing hypotheses on the effects of climate change on ovine parasitic gastroenteritis from historical data, Vet. Parasitol., 158, 73, 10.1016/j.vetpar.2008.08.006
Smith, 1994, Modeling of parasite populations—Gastrointestinal nematode models, Vet. Parasitol., 54, 127, 10.1016/0304-4017(94)90087-6
Morgan, 2010, Variation in the hatching behaviour of Nematodirus battus: Polymorphic bet hedging?, Int. J. Parasitol., 40, 675, 10.1016/j.ijpara.2009.11.002
Kenyon, 2009, The role of targeted selective treatments in the development of refugia-based approaches to the control of gastrointestinal nematodes of small ruminants, Vet. Parasitol., 164, 3, 10.1016/j.vetpar.2009.04.015
Cooper, 2012, ProSafeBeef and anthelmintic drug residues-a case study in collaborative application of multi-analyte mass spectrometry to enhance consumer safety, Anal. Bioanal. Chem., 404, 1623, 10.1007/s00216-012-6310-2
Imperiale, 2011, Residual concentrations of the flukicidal compound triclabendazole in dairy cows’ milk and cheese, Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess., 28, 438, 10.1080/19440049.2010.551422
Greer, 2009, Development and field evaluation of a decision support model for anthelmintic treatments as part of a targeted selective treatment (TST) regime in lambs, Vet. Parasitol., 164, 12, 10.1016/j.vetpar.2009.04.017
Cringoli, 2009, Evaluation of targeted selective treatments in sheep in Italy: Effects on faecal worm egg count and milk production in four case studies, Vet. Parasitol., 164, 36, 10.1016/j.vetpar.2009.04.010
Gallidis, 2009, The use of targeted selective treatments against gastrointestinal nematodes in milking sheep and goats in Greece based on parasitological and performance criteria, Vet. Parasitol., 164, 53, 10.1016/j.vetpar.2009.04.011
Morrison, 2009, Targeted selective treatments for gastrointestinal nematodes in first-season grazing cattle based on mid-season daily weight gains, Vet. Parasitol., 164, 80, 10.1016/j.vetpar.2009.04.016
Leask, 2013, The effect of application of the FAMACHA© system on selected production parameters in sheep, Small Rumin. Res., 110, 1, 10.1016/j.smallrumres.2012.07.026
Gaba, 2012, Can efficient management of sheep gastro-intestinal nematodes be based on random treatment?, Vet. Parasitol., 190, 178, 10.1016/j.vetpar.2012.06.011
Terrill, 2012, Experiences with integrated concepts for the control of Haemonchus contortus in sheep and goats in the United States, Vet. Parasitol., 186, 28, 10.1016/j.vetpar.2011.11.043
Reynecke, 2011, Blueprint for an automated specific decision support system for countering anthelmintic resistance in Haemonchus spp. at farm level, Vet. Parasitol., 177, 212, 10.1016/j.vetpar.2009.10.025