Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions

Neuro-Oncology - Tập 22 Số 8 - Trang 1073-1113 - 2020
Patrick Y. Wen1, Michael Weller2, Eudocia Q. Lee1, Brian M. Alexander1, Jill S. Barnholtz‐Sloan3, Floris Barthel4, Tracy T. Batchelor5, Ranjit S. Bindra6, Susan M. Chang7, E. Antonio Chiocca8, Timothy F. Cloughesy9, John DeGroot10, Evanthia Galanis11, Mark R. Gilbert12, Monika E. Hegi13, Craig Horbinski14, Raymond Y. Huang15, Andrew B. Lassman16, Émilie Le Rhun17,18, Michael Lim19, Minesh P. Mehta20, Ingo K. Mellinghoff21, Giuseppe Minniti22, David A. Nathanson23, Michael Platten24, Matthias Preusser25, Patrick Roth2, Marc Sanson26, David Schiff27, Susan Short28, Martin J.B. Taphoorn29, Joerg C. Tonn30, Jonathan Tsang23, Roel G.W. Verhaak4, Andreas von Deimling31, Wolfgang Wick32, Gelareh Zadeh33, David A. Reardon1, Kenneth Aldape34, Martin J. van den Bent35
1Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
2Department of Neurology and Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland
3Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio, USA
4The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA
5Department of Neurology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute and Harvard Medical School
6Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut, USA
7University of California, San Francisco, San Francisco, California USA
8Department of Neurosurgery, Brigham and Women’s Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
9David Geffen School of Medicine, Department of Neurology, University of California Los Angeles, Los Angeles, California, USA
10Department of Neuro-Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA
11Mayo Clinic Rochester, Minnesota USA
12Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
13Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
14Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
15Division of Neuroradiology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
16Department of Neurology and Herbert Irving Comprehensive Cancer Center, NewYork-Presbyterian Hospital/Columbia University Irving Medical Center, New York, New York, USA
17University of Lille, Inserm, Neuro-oncology, General and Stereotaxic Neurosurgery service, University Hospital of Lille, Lille, France
18University of Lille, Inserm, Neuro-oncology, General and Stereotaxic Neurosurgery service, University Hospital of Lille, Lille, France; Breast Cancer Department, Oscar Lambret Center, Lille, France and Department of Neurology & Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland
19Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
20Miami Cancer Institute, Miami, Florida, USA
21Department of Neurology and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
22Radiation Oncology Unit, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy
23Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, USA
24Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Heidelberg, Germany
25Division of Oncology, Department of Medicine, Medical University of Vienna, Vienna, Austria
26Sorbonne Université, Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière – Charles Foix, Service de Neurologie 2-Mazarin, Paris, France
27University of Virginia School of Medicine, Division of Neuro-Oncology, Department of Neurology, University of Virginia, Charlottesville, Virginia, USA
28Leeds Institute of Medical Research at St James’s, University of Leeds, Leeds, UK
29Department of Neurology, Medical Center Haaglanden, The Hague and Department of Neurology, Leiden University Medical Center, the Netherlands
30Department of Neurosurgery, University Hospital, LMU Munich, Munich, Germany
31Neuropathology and Clinical Cooperation Unit Neuropathology, University Heidelberg and German Cancer Center, Heidelberg, Germany
32Department of Neurology and Neuro-oncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany
33MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, Toronto, Canada
34Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
35Department of Neurology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands

Tóm tắt

AbstractGlioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have been important advances in understanding the molecular pathogenesis and biology of these tumors, but this has not translated into significantly improved outcomes for patients. In this consensus review from the Society for Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of isocitrate dehydrogenase wildtype (IDHwt) glioblastomas will be discussed. In addition, novel therapies such as targeted molecular therapies, agents targeting DNA damage response and metabolism, immunotherapies, and viral therapies will be reviewed, as well as the current challenges and future directions for research.

Từ khóa


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