Sự lựa chọn số phận tế bào thần kinh so với tế bào sắc tố: Các tiền thân tế bào Schwann như một nguồn gốc tế bào của tế bào sắc tố

Cellular and Molecular Life Sciences - Tập 67 - Trang 3037-3055 - 2010
Igor Adameyko1, Francois Lallemend1
1Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden

Tóm tắt

Các nguyên bào sắc tố và tế bào Schwann đều có nguồn gốc từ quần thể tế bào đỉnh thần kinh đa khả năng. Mặc dù trước đây cả hai loại tế bào này được cho là hình thành qua các con đường và quá trình phân tử hoàn toàn khác nhau, một nghiên cứu gần đây đã tiết lộ rằng các loại tế bào khác nhau này có mối liên hệ mật thiết hơn nhiều so với những gì đã được giả thuyết trước đó, trong đó chúng chia sẻ một nguồn gốc chung từ các tiền thân tế bào đỉnh thần kinh, tức là tiền thân tế bào Schwann. Phát hiện này đặt ra những câu hỏi thú vị về mối quan hệ dòng dõi của các loại tế bào chưa từng liên quan như nguyên bào sắc tố và tế bào Schwann, và có thể cung cấp những hiểu biết lâm sàng về cơ chế của các rối loạn sắc tố cũng như các loại ung thư liên quan đến tế bào Schwann và nguyên bào sắc tố.

Từ khóa

#tế bào Schwann #nguyên bào sắc tố #tế bào đỉnh thần kinh #nguồn gốc tế bào #sự phát triển tế bào

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