Ginsenosides: potential therapeutic source for fibrosis-associated human diseases

Journal of Ginseng Research - Tập 44 - Trang 386-398 - 2020
Xiaobing Li1, Nan Mo1, Zhenzhen Li2
1College of Basic Medicine, Henan University of Traditional Chinese Medicine, Zhengzhou, China
2Medical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

Tài liệu tham khảo

Wynn, 2004, Fibrotic disease and the T(H)1/T(H)2 paradigm, Nat Rev Immunol, 4, 583, 10.1038/nri1412 Rockey, 2015, Fibrosis--a common pathway to organ injury and failure, N Engl J Med, 372, 1138, 10.1056/NEJMra1300575 Jun, 2018, Resolution of organ fibrosis, J Clin Invest, 128, 97, 10.1172/JCI93563 Gurtner, 2008, Wound repair and regeneration, Nature, 453, 314, 10.1038/nature07039 Stramer, 2007, The inflammation-fibrosis link? A Jekyll and Hyde role for blood cells during wound repair, J Invest Dermatol, 127, 1009, 10.1038/sj.jid.5700811 Hochreiter-Hufford, 2013, Clearing the dead: apoptotic cell sensing, recognition, engulfment, and digestion, Cold Spring Harb Perspect Biol, 5, a008748, 10.1101/cshperspect.a008748 Weiskirchen, 2019, Organ and tissue fibrosis: molecular signals, cellular mechanisms and translational implications, Mol Aspects Med, 65, 2, 10.1016/j.mam.2018.06.003 Wynn, 2016, Macrophages in tissue repair, regeneration, and fibrosis, Immunity, 44, 450, 10.1016/j.immuni.2016.02.015 Thannickal, 2003, Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase, J Biol Chem, 278, 12384, 10.1074/jbc.M208544200 Kim, 2018, TGF-beta1 signaling and tissue fibrosis, Cold Spring Harb Perspect Biol, 10, 10.1101/cshperspect.a022293 Kapetanaki, 2013, Influence of age on wound healing and fibrosis, J Pathol, 229, 310, 10.1002/path.4122 Romani, 2017, Thymosin alpha1 represents a potential potent single-molecule-based therapy for cystic fibrosis, Nat Med, 23, 590, 10.1038/nm.4305 Plasschaert, 2018, A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte, Nature, 560, 377, 10.1038/s41586-018-0394-6 Wong, 2015, Recent advances in ginseng as cancer therapeutics: a functional and mechanistic overview, Nat Prod Rep, 32, 256, 10.1039/C4NP00080C Ru, 2015, Chemical constituents and bioactivities of Panax ginseng (C. A. Mey.), Drug Discov Ther, 9, 23, 10.5582/ddt.2015.01004 Cho, 2013, Characteristic study on the chemical components of Korean curved ginseng products, J Ginseng Res, 37, 349, 10.5142/jgr.2013.37.349 Shibata, 2001, Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds, J Korean Med Sci, 16, S28, 10.3346/jkms.2001.16.S.S28 Shin, 2015, Chemical diversity of ginseng saponins from Panax ginseng, J Ginseng Res, 39, 287, 10.1016/j.jgr.2014.12.005 Aung, 2017, Understanding the effectiveness of natural compound mixtures in cancer through their molecular mode of action, Int J Mol Sci, 18, 10.3390/ijms18030656 Yun, 2010, Non-organ-specific preventive effect of long-term administration of Korean red ginseng extract on incidence of human cancers, J Med Food, 13, 489, 10.1089/jmf.2009.1275 Yun, 2003, Experimental and epidemiological evidence on non-organ specific cancer preventive effect of Korean ginseng and identification of active compounds, Mutat Res, 523–524, 63, 10.1016/S0027-5107(02)00322-6 Yun, 2001, Epidemiological study on cancer prevention by ginseng: are all kinds of cancers preventable by ginseng?, J Korean Med Sci, 16, S19, 10.3346/jkms.2001.16.S.S19 Cui, 2006, Association of ginseng use with survival and quality of life among breast cancer patients, Am J Epidemiol, 163, 645, 10.1093/aje/kwj087 Yennurajalingam, 2015, High-Dose Asian Ginseng (Panax Ginseng) for Cancer-Related Fatigue: A Preliminary Report, Integr Cancer Ther, 14, 419, 10.1177/1534735415580676 Zhou, 2016, Prospective Study of Transcatheter Arterial Chemoembolization (TACE) with Ginsenoside Rg3 versus TACE Alone for the Treatment of Patients with Advanced Hepatocellular Carcinoma, Radiology, 280, 630, 10.1148/radiol.2016150719 Li, 2011, Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53, Cancer Lett, 301, 185, 10.1016/j.canlet.2010.11.015 Sun, 2016, Roles and mechanisms of ginsenoside in cardiovascular diseases: progress and perspectives, Sci China Life Sci, 59, 292, 10.1007/s11427-016-5007-8 Zheng, 2017, Ginsenoside Rb1 for myocardial ischemia/reperfusion injury: preclinical evidence and possible mechanisms, Oxid Med Cell Longev, 2017, 6313625, 10.1155/2017/6313625 Kim, 2017, Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases, J Ginseng Res, 41, 435, 10.1016/j.jgr.2016.08.004 Sheng, 2015, The impact of ginsenosides on cognitive deficits in experimental animal studies of Alzheimer's disease: a systematic review, BMC Complement Altern Med, 15, 386, 10.1186/s12906-015-0894-y Song, 2017, A preclinical systematic review of ginsenoside-rg1 in experimental Parkinson's disease, Oxid Med Cell Longev, 2017, 2163053, 10.1155/2017/2163053 Wynn, 2008, Cellular and molecular mechanisms of fibrosis, J Pathol, 214, 199, 10.1002/path.2277 Gourdie, 2016, Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease, Nat Rev Drug Discov, 15, 620, 10.1038/nrd.2016.89 Levin, 2017, Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy, Lancet, 390, 1888, 10.1016/S0140-6736(17)30788-2 Rangarajan, 2018, Metformin reverses established lung fibrosis in a bleomycin model, Nat Med, 24, 1121, 10.1038/s41591-018-0087-6 Udomsinprasert, 2019, Vitamin D and liver fibrosis: molecular mechanisms and clinical studies, Biomed Pharmacother, 109, 1351, 10.1016/j.biopha.2018.10.140 Kim, 2002, Burden of liver disease in the United States: summary of a workshop, Hepatology, 36, 227, 10.1053/jhep.2002.34734 Peng, 2009, Relationship between anti-fibrotic effect of Panax notoginseng saponins and serum cytokines in rat hepatic fibrosis, Biochem Biophys Res Commun, 388, 31, 10.1016/j.bbrc.2009.07.099 Lim, 2005, Effects of population, age, and cultivation methods on ginsenoside content of wild American ginseng (Panax quinquefolium), J Agric Food Chem, 53, 8498, 10.1021/jf051070y Hou, 2014, Ginseng extract and ginsenoside Rb1 attenuate carbon tetrachloride-induced liver fibrosis in rats, BMC Complement Altern Med, 14, 415, 10.1186/1472-6882-14-415 Han, 2018, Ginsenoside 25-OCH3-PPD Promotes Activity of LXRs To Ameliorate P2X7R-Mediated NLRP3 Inflammasome in the Development of Hepatic Fibrosis, J Agric Food Chem, 66, 7023, 10.1021/acs.jafc.8b01982 Beaven, 2011, Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease, Gastroenterology, 140, 1052, 10.1053/j.gastro.2010.11.053 Wu, 2011, 25-OCH3-PPD induces the apoptosis of activated t-HSC/Cl-6 cells via c-FLIP-mediated NF-kappaB activation, Chem Biol Interact, 194, 106, 10.1016/j.cbi.2011.08.010 Su, 2019, Signaling pathways involved in p38-ERK and inflammatory factors mediated the anti-fibrosis effect of AD-2 on thioacetamide-induced liver injury in mice, Food Funct, 10, 3992, 10.1039/C8FO02405G Bataller, 2005, Liver fibrosis, J Clin Invest, 115, 209, 10.1172/JCI24282 Geng, 2010, Ginsenoside-Rg1 from Panax notoginseng prevents hepatic fibrosis induced by thioacetamide in rats, Eur J Pharmacol, 634, 162, 10.1016/j.ejphar.2010.02.022 Li, 2014, Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol- and CCl4-induced hepatic fibrosis, Acta Pharmacol Sin, 35, 1031, 10.1038/aps.2014.41 Lo, 2011, Ginsenoside Rb1 inhibits cell activation and liver fibrosis in rat hepatic stellate cells, J Med Food, 14, 1135, 10.1089/jmf.2010.1485 Higashi, 2017, Hepatic stellate cells as key target in liver fibrosis, Adv Drug Deliv Rev, 121, 27, 10.1016/j.addr.2017.05.007 Chen, 2017, Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats, Sci Rep, 7, 41144, 10.1038/srep41144 Wei, 2018, Ginsenoside Rg1 ameliorates liver fibrosis via suppressing epithelial to mesenchymal transition and reactive oxygen species production in vitro and in vivo, Biofactors, 10.1002/biof.1432 Park, 2017, 20S-Protopanaxadiol, an aglycosylated ginsenoside metabolite, induces hepatic stellate cell apoptosis through liver kinase B1-AMP-activated protein kinase activation, J Ginseng Res, 41, 392, 10.1016/j.jgr.2017.01.012 Yuan, 2018, Preventive effects of total saponins of Panax japonicus on fatty liver fibrosis in mice, Arch Med Sci, 14, 396, 10.5114/aoms.2016.63260 Berk, 2007, ECM remodeling in hypertensive heart disease, J Clin Invest, 117, 568, 10.1172/JCI31044 Gyongyosi, 2017, Myocardial fibrosis: biomedical research from bench to bedside, Eur J Heart Fail, 19, 177, 10.1002/ejhf.696 Nguyen, 2017, Cardiac fibrosis and arrhythmogenesis, Compr Physiol, 7, 1009, 10.1002/cphy.c160046 Kim, 2018, Pharmacological and medical applications of Panax ginseng and ginsenosides: a review for use in cardiovascular diseases, J Ginseng Res, 42, 264, 10.1016/j.jgr.2017.10.004 Zhang, 2013, The ginsenoside Rg1 prevents transverse aortic constriction-induced left ventricular hypertrophy and cardiac dysfunction by inhibiting fibrosis and enhancing angiogenesis, J Cardiovasc Pharmacol, 62, 50, 10.1097/FJC.0b013e31828f8d45 Li, 2013, The effects and mechanism of ginsenoside Rg1 on myocardial remodeling in an animal model of chronic thromboembolic pulmonary hypertension, Eur J Med Res, 18, 16, 10.1186/2047-783X-18-16 Xu, 2018, Ginsenoside Rg1 prevents doxorubicin-induced cardiotoxicity through the inhibition of autophagy and endoplasmic reticulum stress in mice, Int J Mol Sci, 19, 10.3390/ijms19113658 Wei, 2007, Gelatin microspheres encapsulated with a nonpeptide angiogenic agent, ginsenoside Rg1, for intramyocardial injection in a rat model with infarcted myocardium, J Control Release, 120, 27, 10.1016/j.jconrel.2007.04.005 Li, 2019, Cardioprotection of salvianolic acid B and ginsenoside Rg1 combination on subacute myocardial infarction and the underlying mechanism, Phytomedicine, 57, 255, 10.1016/j.phymed.2018.12.040 Zheng, 2017, Ginsenoside Rb1 improves cardiac function and remodeling in heart failure, Exp Anim, 66, 217, 10.1538/expanim.16-0121 Huynh, 2010, Cardiac-specific IGF-1 receptor transgenic expression protects against cardiac fibrosis and diastolic dysfunction in a mouse model of diabetic cardiomyopathy, Diabetes, 59, 1512, 10.2337/db09-1456 Lo, 2017, Ginsenoside Rh2 improves cardiac fibrosis via PPARdelta-STAT3 signaling in type 1-like diabetic rats, Int J Mol Sci, 18, 10.3390/ijms18071364 Wang, 2019, Ginsenoside Re improves isoproterenol-induced myocardial fibrosis and heart failure in rats, Evid Based Complement Alternat Med, 2019, 3714508 Zhang, 2019, Ginsenoside Rd contributes the attenuation of cardiac hypertrophy in vivo and in vitro, Biomed Pharmacother, 109, 1016, 10.1016/j.biopha.2018.10.081 Yang, 2019, Ginsenoside-Rb3 inhibits endothelial-mesenchymal transition of cardiac microvascular endothelial cells, Herz, 44, 60, 10.1007/s00059-017-4628-4 Shen, 2014, Shensong Yangxin Capsule prevents diabetic myocardial fibrosis by inhibiting TGF-beta1/Smad signaling, J Ethnopharmacol, 157, 161, 10.1016/j.jep.2014.09.035 Zhang, 2018, Cardioprotection of Sheng Mai Yin a classic formula on adriamycin induced myocardial injury in Wistar rats, Phytomedicine, 38, 1, 10.1016/j.phymed.2017.09.001 Mutsaers, 2016, Editorial: organ fibrosis: triggers, pathways, and cellular plasticity, Front Med (Lausanne), 3, 55 Xie, 2008, Influence of ginsenoside Rg1, a panaxatriol saponin from Panax notoginseng, on renal fibrosis in rats with unilateral ureteral obstruction, J Zhejiang Univ Sci B, 9, 885, 10.1631/jzus.B0820024 Xie, 2009, Ginsenoside Rb1, a panoxadiol saponin against oxidative damage and renal interstitial fibrosis in rats with unilateral ureteral obstruction, Chin J Integr Med, 15, 133, 10.1007/s11655-009-0133-9 Xie, 2010, Ginsenoside Rg1 modulation on thrombospondin-1 and vascular endothelial growth factor expression in early renal fibrogenesis in unilateral obstruction, Phytother Res, 24, 1581, 10.1002/ptr.3190 Li, 2015, Ginsenoside-Rg1 inhibits endoplasmic reticulum stress-induced apoptosis after unilateral ureteral obstruction in rats, Ren Fail, 37, 890, 10.3109/0886022X.2015.1015427 Li, 2018, Ginsenoside-Rg1 protects against renal fibrosis by regulating the Klotho/TGF-beta1/Smad signaling pathway in rats with obstructive nephropathy, Biol Pharm Bull, 41, 585, 10.1248/bpb.b17-00934 Du, 2016, Panax notoginseng saponins protect kidney from diabetes by up-regulating silent information regulator 1 and activating antioxidant proteins in rats, Chin J Integr Med, 22, 910, 10.1007/s11655-015-2446-1 Du, 2018, Combination of Ginsenoside Rg1 and Astragaloside IV reduces oxidative stress and inhibits TGF-beta1/Smads signaling cascade on renal fibrosis in rats with diabetic nephropathy, Drug Des Devel Ther, 12, 3517, 10.2147/DDDT.S171286 Liu, 2015, Ginsenoside Rg1 protects chronic cyclosporin a nephropathy from tubular cell apoptosis by inhibiting endoplasmic reticulum stress in rats, Transplant Proc, 47, 566, 10.1016/j.transproceed.2014.10.047 Lim, 2014, Ginseng treatment attenuates autophagic cell death in chronic cyclosporine nephropathy, Nephrology (Carlton), 19, 490, 10.1111/nep.12273 Doh, 2013, Ginseng treatment attenuates chronic cyclosporine nephropathy via reducing oxidative stress in an experimental mouse model, Am J Nephrol, 37, 421, 10.1159/000349921 Xie, 2009, Ginsenoside Rg1, a major active component isolated from Panax notoginseng, restrains tubular epithelial to myofibroblast transition in vitro, J Ethnopharmacol, 122, 35, 10.1016/j.jep.2008.11.020 Hong, 2014, Delayed treatment with oleanolic acid attenuates tubulointerstitial fibrosis in chronic cyclosporine nephropathy through Nrf2/HO-1 signaling, J Transl Med, 12, 50, 10.1186/1479-5876-12-50 Richeldi, 2017, Idiopathic pulmonary fibrosis, Lancet, 389, 1941, 10.1016/S0140-6736(17)30866-8 Zhang, 2018, Effects of panax notoginseng saponin on the pathological ultrastructure and serum IL-6 and IL-8 in pulmonary fibrosis in rabbits, J Cell Biochem, 119, 8410, 10.1002/jcb.27045 Tsai, 2011, Panax notoginseng Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice, Evid Based Complement Alternat Med, 2011, 404761, 10.1155/2011/404761 Zhan, 2016, Protective effect of ginsenoside Rg1 on bleomycin-induced pulmonary fibrosis in rats: involvement of caveolin-1 and TGF-beta1 signal pathway, Biol Pharm Bull, 39, 1284, 10.1248/bpb.b16-00046 Guan, 2017, Ginsenoside Rg1 ameliorates cigarette smoke-induced airway fibrosis by suppressing the TGF-beta1/Smad pathway in vivo and in vitro, Biomed Res Int, 2017, 6510198, 10.1155/2017/6510198 Yang, 2019, Inhibitory effects of total ginsenoside on bleomycin-induced pulmonary fibrosis in mice, Biomed Pharmacother, 114, 108851, 10.1016/j.biopha.2019.108851 Cheng, 2014, In vivo early intervention and the therapeutic effects of 20(s)-ginsenoside rg3 on hypertrophic scar formation, PLoS One, 9, e113640, 10.1371/journal.pone.0113640 Cheng, 2013, In vivo inhibition of hypertrophic scars by implantable ginsenoside-Rg3-loaded electrospun fibrous membranes, Acta Biomater, 9, 9461, 10.1016/j.actbio.2013.07.040 Cui, 2013, Electrospun poly(L-lactide) fiber with ginsenoside rg3 for inhibiting scar hyperplasia of skin, PLoS One, 8, 10.1371/journal.pone.0068771 Sun, 2014, Use of ginsenoside Rg3-loaded electrospun PLGA fibrous membranes as wound cover induces healing and inhibits hypertrophic scar formation of the skin, Colloids Surf B Biointerfaces, 115, 61, 10.1016/j.colsurfb.2013.11.030 Tang, 2018, Ginsenoside Rg3 inhibits keloid fibroblast proliferation, angiogenesis and collagen synthesis in vitro via the TGFbeta/Smad and ERK signaling pathways, Int J Mol Med, 41, 1487 Tark, 2015, Effects of ginsenoside Rb1 on hypertrophic scar remodeling in rabbit model, Eur J Pharmacol, 750, 151, 10.1016/j.ejphar.2015.01.011 Dai, 2014, Panax notoginseng saponins inhibit areca nut extract-induced oral submucous fibrosis in vitro, J Oral Pathol Med, 43, 464, 10.1111/jop.12158 Kim, 2017, Ginsenoside Rg3 Decreases Fibrotic and Invasive Nature of Endometriosis by Modulating miRNA-27b: In Vitro and In Vivo Studies, Sci Rep, 7, 17670, 10.1038/s41598-017-17956-0 Greenspan, 1983, Ginseng and vaginal bleeding, JAMA, 249, 2018, 10.1001/jama.1983.03330390026012 Kabalak, 2004, Menometrorrhagia and tachyarrhythmia after using oral and topical ginseng, J Womens Health (Larchmt), 13, 830, 10.1089/jwh.2004.13.830 Oh, 2010, Effects of Korean red ginseng on sexual arousal in menopausal women: placebo-controlled, double-blind crossover clinical study, J Sex Med, 7, 1469 Coon, 2002, Panax ginseng: a systematic review of adverse effects and drug interactions, Drug Saf, 25, 323, 10.2165/00002018-200225050-00003 Miller, 1998, Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions, Arch Intern Med, 158, 2200, 10.1001/archinte.158.20.2200 Scaglione, 1996, Efficacy and safety of the standardised Ginseng extract G115 for potentiating vaccination against the influenza syndrome and protection against the common cold [corrected], Drugs Exp Clin Res, 22, 65 Siegel, 1980, Ginseng and high blood pressure, JAMA, 243, 32, 10.1001/jama.1980.03300270020020 Siegel, 1979, Ginseng abuse syndrome. Problems with the panacea, JAMA, 241, 1614, 10.1001/jama.1979.03290410046024 Biswas, 2017, A literature update elucidating production of Panax ginsenosides with a special focus on strategies enriching the anti-neoplastic minor ginsenosides in ginseng preparations, Appl Microbiol Biotechnol, 101, 4009, 10.1007/s00253-017-8279-4 Li, 2011, Identification of 20(S)-protopanaxadiol metabolites in human liver microsomes and human hepatocytes, Drug Metab Dispos, 39, 472, 10.1124/dmd.110.036723 Xu, 2015, Liposome-based delivery systems for ginsenoside Rh2: in vitro and in vivo comparisons, J Nanopart Res, 17, 10.1007/s11051-015-3214-z Han, 2006, Oral absorption of ginsenoside Rb1 using in vitro and in vivo models, Planta Med, 72, 398, 10.1055/s-2005-916211 Liu, 2009, Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats, Drug Metab Dispos, 37, 2290, 10.1124/dmd.109.029819 Artursson, 1993, Selective paracellular permeability in two models of intestinal absorption: cultured monolayers of human intestinal epithelial cells and rat intestinal segments, Pharm Res, 10, 1123, 10.1023/A:1018903931777 Yanni, 2007 Chen, 2014, Novel multicore niosomes based on double pH-sensitive mixed micelles for Ginsenoside Rh2 delivery, Artif Cells Nanomed Biotechnol, 42, 205, 10.3109/21691401.2013.794358 Xiong, 2008, Self-micelle formation and the incorporation of lipid in the formulation affect the intestinal absorption of Panax notoginseng, Int J Pharm, 360, 191, 10.1016/j.ijpharm.2008.04.016 Li, 2015, Pharmacokinetics and efficiency of brain targeting of ginsenosides Rg1 and Rb1 given as Nao-Qing microemulsion, Drug Dev Ind Pharm, 41, 224, 10.3109/03639045.2013.858734 Cai, 2014, Enhanced local bioavailability of single or compound drugs delivery to the inner ear through application of PLGA nanoparticles via round window administration, Int J Nanomedicine, 9, 5591, 10.2147/IJN.S72555