Ginsenoside Re inhibits myocardial fibrosis by regulating miR-489/myd88/NF-κB pathway

Tschöpe, 2019, Myocardial fibrosis as a matter of cell differentiation: opportunities for new antifibrotic strategies, Eur Heart J, 40, 979, 10.1093/eurheartj/ehy307 Thum, 2014, Noncoding RNAs and myocardial fibrosis, Nat Rev Cardiol, 11, 655, 10.1038/nrcardio.2014.125 Pan, 2018, HOTAIR promotes myocardial fibrosis through regulating URI1 expression via Wnt pathway, Eur Rev Med Pharmacol Sci, 22, 6983 Tallquist, 2017, Redefining the identity of cardiac fibroblasts, Nat Rev Cardiol, 14, 484, 10.1038/nrcardio.2017.57 Frangogiannis, 2019, Can myocardial fibrosis Be reversed?, J Am Coll Cardiol, 73, 2283, 10.1016/j.jacc.2018.10.094 Rodriguez, 2019, Deletion of delta-like 1 homologue accelerates fibroblast-myofibroblast differentiation and induces myocardial fibrosis, Eur Heart J, 40, 967, 10.1093/eurheartj/ehy188 Prabhu, 2016, The biological basis for cardiac repair after myocardial infarction: from inflammation to fibrosis, Circ Res, 119, 91, 10.1161/CIRCRESAHA.116.303577 Travers, 2016, Cardiac fibrosis: the fibroblast awakens, Circ Res, 118, 1021, 10.1161/CIRCRESAHA.115.306565 van den Borne, 2010, Myocardial remodeling after infarction: the role of myofibroblasts, Nat Rev Cardiol, 7, 30, 10.1038/nrcardio.2009.199 Daniels, 2009, Connective tissue growth factor and cardiac fibrosis, Acta Physiol, 195, 321, 10.1111/j.1748-1716.2008.01936.x Martos, 2007, Diastolic heart failure: evidence of increased myocardial collagen turnover linked to diastolic dysfunction, Circulation, 115, 888, 10.1161/CIRCULATIONAHA.106.638569 Yong, 2015, Mechanoregulation of cardiac myofibroblast differentiation: implications for cardiac fibrosis and therapy, Am J Physiol Heart Circ Physiol, 309, H532, 10.1152/ajpheart.00299.2015 Dean, 2005, Connective tissue growth factor and cardiac fibrosis after myocardial infarction, J Histochem Cytochem, 53, 1245, 10.1369/jhc.4A6560.2005 Schirone, 2017, A review of the molecular mechanisms underlying the development and progression of cardiac remodeling, Oxid Med Cell Longev, 2017, 3920195, 10.1155/2017/3920195 Liu, 2019, MicroRNA-378 attenuates myocardial fibrosis by inhibiting MAPK/ERK pathway, Eur Rev Med Pharmacol Sci, 23, 4398 Mallory, 2004, MicroRNAs: something important between the genes, Curr Opin Plant Biol, 7, 120, 10.1016/j.pbi.2004.01.006 Bartel, 2004, MicroRNAs: genomics, biogenesis, mechanism, and function, Cell, 116, 281, 10.1016/S0092-8674(04)00045-5 Liu, 2009, Bioinformatic analysis of microRNA biogenesis and function related proteins in eleven animal genomes, J Genet Genomics, 36, 591, 10.1016/S1673-8527(08)60151-4 Yang, 2014, Deep RNA sequencing reveals dynamic regulation of myocardial noncoding RNAs in failing human heart and remodeling with mechanical circulatory support, Circulation, 129, 1009, 10.1161/CIRCULATIONAHA.113.003863 Zhou, 2016, MicroRNA-208b alleviates post-infarction myocardial fibrosis in a rat model by inhibiting GATA4, Med Sci Mon Int Med J Exp Clin Res, 22, 1808 Chen, 2019, MicroRNA-199a regulates myocardial fibrosis in rats by targeting SFRP5, Eur Rev Med Pharmacol Sci, 23, 3976 Kikkawa, 2010, miR-489 is a tumour-suppressive miRNA target PTPN11 in hypopharyngeal squamous cell carcinoma (HSCC), Br J Cancer, 103, 877, 10.1038/sj.bjc.6605811 Zhang, 2016, miR-489 acts as a tumor suppressor in human gastric cancer by targeting PROX1, Am J Cancer Res, 6, 2021 Li, 2016, miR-489 suppresses proliferation and invasion of human bladder cancer cells, Oncol Res, 24, 391, 10.3727/096504016X14666990347518 Li, 2017, miR-489 inhibits proliferation, cell cycle progression and induces apoptosis of glioma cells via targeting SPIN1-mediated PI3K/AKT pathway, Biomed Pharmacother, 93, 435, 10.1016/j.biopha.2017.06.058 Wu, 2016, miR-489 inhibits silica-induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRF, Sci Rep, 6, 30921, 10.1038/srep30921 Feng, 2010, Bone marrow MyD88 signaling modulates neutrophil function and ischemic myocardial injury, Am J Physiol Cell Physiol, 299, C760, 10.1152/ajpcell.00155.2010 Li, 2011, Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4, J Biol Chem, 286, 31308, 10.1074/jbc.M111.246124 Li, 2009, MyD88-dependent nuclear factor-kappaB activation is involved in fibrinogen-induced hypertrophic response of cardiomyocytes, J Hypertens, 27, 1084, 10.1097/HJH.0b013e3283293c93 Wendlandt, 2012, The role of microRNAs miR-200b and miR-200c in TLR4 signaling and NF-kappaB activation, Innate Immun, 18, 846, 10.1177/1753425912443903 Mack, 2018, Inflammation and fibrosis, Matrix Biol, 68–69, 106, 10.1016/j.matbio.2017.11.010 Wang, 2014, The long noncoding RNA CHRF regulates cardiac hypertrophy by targeting miR-489, Circ Res, 114, 1377, 10.1161/CIRCRESAHA.114.302476 Zheng, 2012, Roles and mechanisms of ginseng in protecting heart, Chin J Integr Med, 18, 548, 10.1007/s11655-012-1148-1 Xie, 2005, Antihyperglycemic effects of total ginsenosides from leaves and stem of Panax ginseng, Acta Pharmacol Sin, 26, 1104, 10.1111/j.1745-7254.2005.00156.x Joo, 2010, Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method, J Pharmaceut Biomed Anal, 51, 278, 10.1016/j.jpba.2009.08.013 Lee, 2020, Ginsenoside Re mitigates 6-hydroxydopamine-induced oxidative stress through upregulation of GPX4, Molecules, 25 Gao, 2019, Ginsenoside Re inhibits PDGF-BB-induced VSMC proliferation via the eNOS/NO/cGMP pathway, Biomed Pharmacother, 115, 108934, 10.1016/j.biopha.2019.108934 Cai, 2016, Ginsenoside Re attenuates neuroinflammation in a symptomatic ALS animal model, Am J Chin Med, 44, 401, 10.1142/S0192415X16500233 Peng, 2012, Ginsenoside Re: pharmacological effects on cardiovascular system, Cardiovasc Ther, 30, e183, 10.1111/j.1755-5922.2011.00271.x Wang, 2019, Ginsenoside Re improves isoproterenol-induced myocardial fibrosis and heart failure in rats, Evid Based Complement Alternat Med, 2019, 3714508 Yu, 2020, Ginsenoside Re preserves cardiac function and ameliorates left ventricular remodeling in a rat model of myocardial infarction, J Cardiovasc Pharmacol, 75, 91, 10.1097/FJC.0000000000000752 Huang, 2018, Liraglutide improves myocardial fibrosis after myocardial infarction through inhibition of CTGF by activating cAMP in mice, Eur Rev Med Pharmacol Sci, 22, 4648 V, 2019, Collagen receptor cross-talk determines α-smooth muscle actin-dependent collagen gene expression in angiotensin II-stimulated cardiac fibroblasts, J Biol Chem, 294, 19723, 10.1074/jbc.RA119.009744 Bowie, 2000, Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries, Biochem Pharmacol, 59, 13, 10.1016/S0006-2952(99)00296-8 Jain, 2013, Mitochondrial reactive oxygen species regulate transforming growth factor-beta signaling, J Biol Chem, 288, 770, 10.1074/jbc.M112.431973 Lijnen, 2000, Induction of cardiac fibrosis by transforming growth factor-beta(1), Mol Genet Metabol, 71, 418, 10.1006/mgme.2000.3032 Meng, 2016, TGF-beta: the master regulator of fibrosis, Nat Rev Nephrol, 12, 325, 10.1038/nrneph.2016.48 Wang, 2019, Stevioside attenuates isoproterenol-induced mouse myocardial fibrosis through inhibition of the myocardial NF-κB/TGF-β1/Smad signaling pathway, Food Funct, 10, 1179, 10.1039/C8FO01663A Chen, 2016, Protective effects of ginsenoside Re on lipopolysaccharide-induced cardiac dysfunction in mice, Food Funct, 7, 2278, 10.1039/C5FO01357G Lee, 2012, Ginsenoside Re ameliorates inflammation by inhibiting the binding of lipopolysaccharide to TLR4 on macrophages, J Agric Food Chem, 60, 9595, 10.1021/jf301372g