Ginseng and obesity

Journal of Ginseng Research - Tập 42 - Trang 1-8 - 2018
Zhipeng Li1, Geun Eog Ji1,2
1Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul, Republic of Korea
2Research Institute, BIFIDO Co., Ltd., Hongchun, Republic of Korea

Tài liệu tham khảo

Yoon, 2006, Epidemic obesity and type 2 diabetes in Asia, Lancet, 368, 1681, 10.1016/S0140-6736(06)69703-1 Bojanowska, 2016, Can we selectively reduce appetite for energy-dense foods? An overview of pharmacological strategies for modification of food preference behavior, Curr Neuropharmacol, 14, 118, 10.2174/1570159X14666151109103147 Wood, 2011, 26 Kim, 2002, Intestinal microflora activate the pharmacological effects of herbal medicines, Nat Prod Sci, 8, 35 Tawab, 2003, Degradation of ginsenosides in humans after oral administration, Drug Metab Disposition, 31, 1065, 10.1124/dmd.31.8.1065 Thaler, 2010, Inflammation and obesity pathogenesis: the hypothalamus heats up, Endocr Rev, 151, 4109, 10.1210/en.2010-0336 Manousopoulou, 2016, Hypothalamus proteomics from mouse models with obesity and anorexia reveals therapeutic targets of appetite regulation, Nut Diab, 6, e204, 10.1038/nutd.2016.10 Wu, 2014, Central inflammation and leptin resistance are attenuated by ginsenoside Rb1 treatment in obese mice fed a high-fat diet, PLoS One, 9, e92618, 10.1371/journal.pone.0092618 Lee, 2010, Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice, Cytotechnology, 62, 367, 10.1007/s10616-010-9288-7 Kim, 2009, Comparison of the antiobesity effects of the protopanaxadiol- and protopanaxatriol-type saponins of red ginseng, Phytother Res, 23, 78, 10.1002/ptr.2561 Yun, 2007, Vinegar-processed ginseng radix improves metabolic syndrome induced by a high fat diet in ICR mice, Arch Pharm Res, 30, 587, 10.1007/BF02977653 Lee, 2013, Anti-obesity effects of black ginseng extract in high fat diet-fed mice, J Ginseng Res, 37, 308, 10.5142/jgr.2013.37.308 Zhang, 2014, Protopanaxatriol, a novel PPARγ antagonist from Panax ginseng, alleviates steatosis in mice, Sci Rep, 4 Seo, 2016, Black ginseng extract exerts anti-hyperglycemic effect via modulation of glucose metabolism in liver and muscle, J Ethnopharmacol, 190, 231, 10.1016/j.jep.2016.05.060 Lee, 2013, Korean red ginseng (Panax ginseng) prevents obesity by inhibiting angiogenesis in high fat diet-induced obese C57BL/6J mice, Food Chem Toxicol, 53, 402, 10.1016/j.fct.2012.11.052 Yuan, 2012, Pectinase-processed Ginseng radix (GINST) ameliorates hyperglycemia and hyperlipidemia in high fat diet-fed ICR mice, Biomol Ther, 20, 220, 10.4062/biomolther.2012.20.2.220 Lee, 2014, Ginseng treatment reverses obesity and related disorders by inhibiting angiogenesis in female db/db mice, J Ethnopharmacol, 155, 1342, 10.1016/j.jep.2014.07.034 Shen, 2013, Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats, J Lipid Res, 54, 1430, 10.1194/jlr.M035907 Liu, 2008, Saponins (Ginsenosides) from stems and leaves of Panax quinquefolium prevented high-fat diet-induced obesity in mice, Phytomedicine, 15, 1140, 10.1016/j.phymed.2008.07.002 Liu, 2010, Anti-obesity effects of protopanaxdiol types of ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet, Fitoterapia, 81, 1079, 10.1016/j.fitote.2010.07.002 Ko, 2008, Analysis of ginsenoside composition of ginseng berry and seed, Food Sci Biotechnol, 17, 1379 Karu, 2007, Weight gain reduction in mice fed Panax ginseng saponin, a pancreatic lipase inhibitor, J agric Food Chem, 55, 2824, 10.1021/jf0628025 Jung, 2014, Anti-obesity and anti-inflammatory effects of high hydrostatic pressure extracts of ginseng in high-fat diet induced obese rats, J Funct Foods, 10, 169, 10.1016/j.jff.2014.06.007 Chang, 2007, Effect of ginsenosides on glucose uptake in human Caco-2 cells is mediated through altered Na+/glucose cotransporter 1 expression, J Agric Food Chem, 55, 1993, 10.1021/jf062714k Wang, 2015, An essential role of cAMP response element binding protein in ginsenoside Rg1-mediated inhibition of Na+/glucose cotransporter 1 gene expression, Mol Pharmacol, 88, 1072, 10.1124/mol.114.097352 Winder, 1999, AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes, Am J Physiol Endocrinol Metab, 277, E1, 10.1152/ajpendo.1999.277.1.E1 Do, 2009, Fermented ginseng attenuates hepatic lipid accumulation and hyperglycemia through AMPK activation, Food Sci Biotechnol, 18, 172 Lee, 2015, Effects of Korean Red Ginseng extract on hepatic lipid accumulation in HepG2 cells, Biosci Biotechnol Biochem, 79, 816, 10.1080/09168451.2014.997186 Quan, 2012, Ginsenoside Re lowers blood glucose and lipid levels via activation of AMP-activated protein kinase in HepG2 cells and high-fat diet fed mice, Int J Mol Med, 29, 73 Kim, 2010, Ginsenoside Rg1 suppresses hepatic glucose production via AMP-activated protein kinase in HepG2 cells, Biol Pharm Bull, 33, 325, 10.1248/bpb.33.325 Quan, 2010, Korean red ginseng attenuates hepatic lipid accumulation via AMPK activation in human hepatoma cells, Food Sci Biotechnol, 19, 207, 10.1007/s10068-010-0028-8 Lee, 2007, Korean Red Ginseng activates AMPK in skeletal muscle and liver, Diabetes, 56, pA448 Lee, 2012, Ginsenoside Rg3 reduces lipid accumulation with AMP-activated protein kinase (AMPK) activation in HepG2 cells, Int J Mol Sci, 13, 5729, 10.3390/ijms13055729 Chang, 2013, The inhibitory effect of ginsenoside Rg1 on glucose and lipid production in human HepG2 cells, Adaptive Med, 5, 181, 10.4247/AM.2013.ABD068 Lee, 2014, Effect of the high hydrostatic pressure extract of Korean ginseng on hepatic lipid metabolism and AMP-activated protein kinase activation in HepG2 cells (1045.25), FASEB J, 28 Sekiya, 1987, Enhancement of adipose differentiation of mouse 3T3-L1 fibroblasts by ginsenosides, Phytother Res, 1, 58, 10.1002/ptr.2650010203 Masuno, 1996, Ginsenosides increase secretion of lipoprotein lipase by 3T3-L1 adipocytes, Biosci Biotechnol Biochem, 60, 1962, 10.1271/bbb.60.1962 Shang, 2007, Ginsenoside Rb 1 promotes adipogenesis in 3T3-L1 cells by enhancing PPARγ 2 and C/EBPα gene expression, Life Sci, 80, 618, 10.1016/j.lfs.2006.10.021 Han, 2006, Ginsenoside 20 (S)-protopanaxatriol (PPT) activates peroxisome proliferator-activated receptor. GAMMA. (PPAR. GAMMA.) in 3T3-L1 Adipocytes, Biol Pharm Bull, 29, 110, 10.1248/bpb.29.110 Hwang, 2007, Anti-obesity effects of ginsenoside Rh2 are associated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte, Biochem Biophys Res Commun, 364, 1002, 10.1016/j.bbrc.2007.10.125 Park, 2008, Ginsenosides Rb1 and Rg1 suppress triglyceride accumulation in 3T3-L1 adipocytes and enhance β-cell insulin secretion and viability in Min6 cells via PKA-dependent pathways, Biosci Biotechnol Biochem, 72, 2815, 10.1271/bbb.80205 Shang, 2008, Ginsenoside Rb1 stimulates glucose uptake through insulin-like signaling pathway in 3T3-L1 adipocytes, J Endocrinol, 198, 561, 10.1677/JOE-08-0104 Hwang, 2009, Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-γ signal pathways, Phytother Res, 23, 262, 10.1002/ptr.2606 Kim, 2009, The ginsenoside-Rb2 lowers cholesterol and triacylglycerol levels in 3T3-L1 adipocytes cultured under high cholesterol or fatty acids conditions, BMB Rep, 42, 194, 10.5483/BMBRep.2009.42.4.194 Huang, 2010, Effect and mechanism of ginsenosides CK and Rg1 on stimulation of glucose uptake in 3T3-L1 adipocytes, J Agric Food Chem, 58, 6039, 10.1021/jf9034755 Niu, 2009, Increase of adipogenesis by ginsenoside (Rh2) in 3T3-L1 cell via an activation of glucocorticoid receptor, Horm Metab Res, 41, 271, 10.1055/s-0028-1103277 Kim, 2009, Effects of in vitro-digested ginsenosides on lipid accumulation in 3T3-L1 adipocytes, Planta Med, 75, 596, 10.1055/s-0029-1185358 Kim, 2007, Ginseng saponin-Re and Coix lachrymajobi var. mayuen regulate obesity related genes expressions, TNF-alpha, leptin, lipoprotein lipase and resistin in 3T3-L1 adipocytes, J Life Sci, 17, 1523 Kim, 2006, The effects of ginseng saponin-Re, Rc and green tea catechine; ECGC (epigallocatechin gallate) on leptin, hormone sensitive lipase and resistin mRNA expressions in 3T3-L1 adipocytes, Korean J Nutr, 39, 748 Yeo, 2011, Ginseng (Panax quinquefolius) reduces cell growth, lipid acquisition and increases adiponectin expression in 3T3-L1 cells, Evid Based Complement Alternat Med, 2011, 10.1093/ecam/neq051 Yeo, 2011, A quantified ginseng (Panax ginseng CA Meyer) extract influences lipid acquisition and increases adiponectin expression in 3T3-L1 cells, Molecules, 16, 477, 10.3390/molecules16010477 Lee, 2011, Effect of ginsenosides Rg3 and Re on glucose transport in mature 3T3-L1 adipocytes, Phytother Res, 25, 768, 10.1002/ptr.3322 Park, 2012, a novel ginsenoside metabolite, inhibits adipocyte differentiation in 3T3-L1 cells: involvement of angiogenesis and MMPs, Biochem Biophys Res Commun, 422, 263, 10.1016/j.bbrc.2012.04.142 Oh, 2012, Ginseng and its active components ginsenosides inhibit adipogenesis in 3T3-L1 cells by regulating MMP-2 and MMP-9, Evid Based Complement Alternat Med, 2012, 265023, 10.1155/2012/265023 Lim, 2005, Ginsenoside Rb2 upregulates the low density lipoprotein receptor gene expression through the activation of the sterol regulated element binding protein maturation in HepG2 cells, J Ginseng Res, 29, 159, 10.5142/JGR.2005.29.4.159 Lee, 2010, Ginsenoside Rc, an active component of Panax ginseng, stimulates glucose uptake in C2C12 myotubes through an AMPK-dependent mechanism, J Ethnopharmacol, 127, 771, 10.1016/j.jep.2009.11.022 Lee, 2012, Ginsenoside Rg1 promotes glucose uptake through activated AMPK pathway in insulin-resistant muscle cells, Phytother Res, 26, 1017, 10.1002/ptr.3686 Lee, 2009, Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long–Evans Tokushima fatty rats, Metabolism, 58, 1170, 10.1016/j.metabol.2009.03.015 Cha, 2010, Effect of white, taegeuk, and red ginseng root extracts on insulin-stimulated glucose uptake in muscle cells and proliferation of β-cells, J Ginseng Res, 34, 192, 10.5142/jgr.2010.34.3.192 Hwang, 2008, Biological active components found in Panax ginseng improve glucose uptake via AMPK signaling pathway, FASEB J, 22, 683, 10.1096/fasebj.22.2_supplement.683 Yuan, 2010, Ginsenoside 20 (R)-Rg3 stimulates glucose uptake in C2C12 myotubes via CaMKK-AMPK pathways, Food Sci Biotechnol, 19, 1277, 10.1007/s10068-010-0182-z Lee, 2010, Effect of ginsenoside Rg3 and Rh2 on glucose uptake in insulin-resistant muscle cells, J Korean Soc Appl Biological Chem, 53, 106, 10.3839/jksabc.2010.018 Tabandeh, 2015, Ginsenoside Rb1 stimulates adiponectin signaling in C2C12 muscle cells through up-regulation of AdipoR1 and AdipoR2 proteins, Pharm Biol, 53, 125, 10.3109/13880209.2014.912237 Kim, 2016, Rg3 improves mitochondrial function and the expression of key genes involved in mitochondrial biogenesis in C2C12 myotubes, Diabetes Metab J, 40, 10.4093/dmj.2016.40.5.406 Yuan, 2011, Anti-diabetic effect of pectinase-processed ginseng radix (GINST) in high fat diet-fed ICR mice, J Ginseng Res, 35, 308, 10.5142/jgr.2011.35.3.308 Song, 2012, Lipid metabolic effect of Korean red ginseng extract in mice fed on a high-fat diet, J Sci Food Agric, 92, 388, 10.1002/jsfa.4589 Kim, 2013, Red-koji fermented red ginseng ameliorates high fat diet-induced metabolic disorders in mice, Nutrients, 5, 4316, 10.3390/nu5114316 Qureshi, 1983, Suppression of cholesterogenesis and reduction of LDL cholesterol by dietary ginseng and its fractions in chicken liver, Atherosclerosis, 48, 81, 10.1016/0021-9150(83)90019-9 Kim, 2005, Effect of crude saponin of Korean red ginseng on high-fat diet-induced obesity in the rat, J Pharmacol Sci, 97, 124, 10.1254/jphs.FP0040184 Yun, 2004, Wild ginseng prevents the onset of high-fat diet induced hyperglycemia and obesity in ICR mice, Arch Pharm Res, 27, 790, 10.1007/BF02980150 Lee, 2012, Korean red ginseng (Panax ginseng) improves insulin sensitivity in high fat fed Sprague–Dawley rats, Phytother Res, 26, 142, 10.1002/ptr.3610 Gu, 2013, Ginsenoside Rh1 ameliorates high fat diet-induced obesity in mice by inhibiting adipocyte differentiation, Biol Pharm Bull, 36, 102, 10.1248/bpb.b12-00558 Park, 2005, Effects of dietary mulberry, Korean red ginseng, and banaba on glucose homeostasis in relation to PPAR-α, PPAR-γ, and LPL mRNA expressions, Life Sci, 77, 3344, 10.1016/j.lfs.2005.05.043 Xie, 2007, American ginseng berry juice intake reduces blood glucose and body weight in ob/ob mice, J Food Sci, 72, S590, 10.1111/j.1750-3841.2007.00481.x Mollah, 2009, Antiobesity effects of wild ginseng (Panax ginseng CA Meyer) mediated by PPAR-γ, GLUT4 and LPL in ob/ob mice, Phytother Res, 23, 220, 10.1002/ptr.2593 Zheng, 2013, Consumption of Chinese tea-flavor liquor improves circulating insulin levels without affecting hepatic lipid metabolism-related gene expression in Sprague–Dawley rats, Sci World J, 2013, 10.1155/2013/842343 Inoue, 2005, Increased expression of PPARγ in high fat diet-induced liver steatosis in mice, Biochem Biophys Res Commun, 336, 215, 10.1016/j.bbrc.2005.08.070 Sanyal, 2002, AGA technical review on nonalcoholic fatty liver disease, Gastroenterology, 123, 1705, 10.1053/gast.2002.36572 Birkenfeld, 2014, Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes, Hepatology, 59, 713, 10.1002/hep.26672 Jones, 2014, The gut microbiome, probiotics, bile acids axis, and human health, Trends Microbiol, 22, 306, 10.1016/j.tim.2014.04.010 Kawase, 2013, Increased effects of ginsenosides on the expression of cholesterol 7α-hydroxylase but not the bile salt export pump are involved in cholesterol metabolism, J Nat Med, 67, 545 Kawase, 2014, Effects of ginsenosides on the expression of cytochrome P450s and transporters involved in cholesterol metabolism, J Nat Med, 68, 395 Ikehara, 1978, Effect of ginseng saponins on cholesterol metabolism: III. Effect of ginsenoside-Rb1 on cholesterol synthesis in rats fed on high-fat diet, Chem Pharm Bull (Tokyo), 26, 2844, 10.1248/cpb.26.2844 Lim, 2004, The mechanism of LDL receptor up-regulation by ginsenoside-Rb 2 in HepG2 cultured under enriched cholesterol condition, J Ginseng Res, 28, 87, 10.5142/JGR.2004.28.2.087 Muwalla, 1990, Suppression of avian hepatic cholesterogenesis by dietary ginseng, J Nur Biochem, 1, 518, 10.1016/0955-2863(90)90034-I Jones, 2005, Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance, Proc Natl Acad Sci, 102, 6207, 10.1073/pnas.0306743102 Valsamakis, 2004, Modest weight loss and reduction in waist circumference after medical treatment are associated with favorable changes in serum adipocytokines, Metabolism, 53, 430, 10.1016/j.metabol.2003.11.022 Crandall, 1984, Adipocyte blood flow: influence of age, anatomic location, and dietary manipulation, Am J Physiol Regul Integr Comp Physiol, 247, R46, 10.1152/ajpregu.1984.247.1.R46 Cinti, 2005, Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans, J Lipid Res, 46, 2347, 10.1194/jlr.M500294-JLR200 Strissel, 2007, Adipocyte death, adipose tissue remodeling, and obesity complications, Diabetes, 56, 2910, 10.2337/db07-0767 Durante, 2002, Effects of endurance training on activity and expression of AMP-activated protein kinase isoforms in rat muscles, Am J Physiol Endocrinol Metab, 283, E178, 10.1152/ajpendo.00404.2001 Jung, 2013, Effects of Korean red ginseng supplementation on muscle glucose uptake in high-fat fed rats, Chin J Nat Med, 11 Kim, 2003, Effects of Panax ginseng extract on lipid metabolism in humans, Pharmacol Res, 48, 511, 10.1016/S1043-6618(03)00189-0 Reeds, 2011, Ginseng and ginsenoside Re do not improve β-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes, Diabetes Care, 34, 1071, 10.2337/dc10-2299 Kwon, 2012, Efficacy of Korean red ginseng by single nucleotide polymorphism in obese women: randomized, double-blind, placebo-controlled trial, J Ginseng Res, 36, 176, 10.5142/jgr.2012.36.2.176 Cho, 2013, Effect of Korean red ginseng on insulin sensitivity in non-diabetic healthy overweight and obese adults, Asia Pac J Clin Nutr, 22, 365 Park, 2012, Effects of Korean red ginseng on cardiovascular risks in subjects with metabolic syndrome: a double-blind randomized controlled study, Korean J Fam Med, 33, 190, 10.4082/kjfm.2012.33.4.190 Song, 2014, Influence of Panax ginseng on obesity and gut microbiota in obese middle-aged Korean women, J Ginseng Res, 38, 106, 10.1016/j.jgr.2013.12.004 Jung, 2016, Effects of ginseng on peripheral blood mitochondrial DNA copy number and hormones in men with metabolic syndrome: A randomized clinical and pilot study, Complement Ther Med, 24, 40, 10.1016/j.ctim.2015.12.001 Yim, 2004, Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora, Biol Pharm Bull, 27, 1580, 10.1248/bpb.27.1580