Ginger Extract (Zingiber Officinale) has Anti-Cancer and Anti-Inflammatory Effects on Ethionine-Induced Hepatoma Rats

Clinics - Tập 63 Số 6 - Trang 807-813 - 2008
Shafina Hanim Mohd Habib1, Suzana Makpol1, Noor Aini Abdul Hamid1, Srijit Das2, Wan Zurinah Wan Ngah1, Yasmin Anum Mohd Yusof1
1Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan, Malaysia Medical Centre - Kuala Lumpur, Malaysia
2Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan, Malaysia Medical Centre - Kuala Lumpur, Malaysia, Tel.: 603 9289.5297

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Ohshima, 1994, Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis, Mutat Res, 305, 253, 10.1016/0027-5107(94)90245-3

Ohshima, 2003, Chemical basis of inflammation-induced carcinogenesis, Arch Biochem Biophys, 417, 3, 10.1016/S0003-9861(03)00283-2

Philip, 2004, Inflammation as a tumor promoter in cancer induction, Semin Cancer Biol, 14, 433, 10.1016/j.semcancer.2004.06.006

Marx, 2004, Inflammation and cancer: the link grows stronger, Science, 306, 966, 10.1126/science.306.5698.966

Lawrence, 2007, Inflammation and cancer: a failure of resolution?, Trends in Pharmacol Sci, 28, 162, 10.1016/j.tips.2007.02.003

Coussens, 2002, Inflammation and cancer, Nature, 420, 860, 10.1038/nature01322

Aggarwal, 2004, Nuclear factor-κB:The enemy within, Cancer Cell, 6, 203, 10.1016/j.ccr.2004.09.003

Aggarwal, 2003, Signaling pathways of TNF superfamily: a double-edged sword, National Review Immunology, 3, 745, 10.1038/nri1184

Balkwill, 2002, Tumor Necrosis Factor or tumor promoting factor?, Cytokine Growth Factor Rev, 13, 135, 10.1016/S1359-6101(01)00020-X

Lin, 2003, NF-kappaB in cancer: a marked target, Semin Cancer Biol, 13, 107, 10.1016/S1044-579X(02)00128-1

Escárcega, 2007, The transcription factor kappa B and cancer, Clinical Oncology. (R Coll Radiol), 19, 154, 10.1016/j.clon.2006.11.013

Surh, 2003, Cancer chemoprevention with dietary phytochemical, Nat Rev Cancer, 3, 768, 10.1038/nrc1189

Kim, 2004, Inhibitory effects pg 6-gingerol on PMA-induced COX-2 expression and activation of NFκB and p38 MAPK in skin mouse, Biofactors, 21, 27, 10.1002/biof.552210107

Afzal, 2001, Ginger: an ethnomedical, chemical and pharmacological review, Drug Metabol Drug Interact, 18, 159, 10.1515/DMDI.2001.18.3-4.159

Jeyakumar, 1999, Antioxidant activity of ginger (Zingiber officinale) in rats fed a high fat diet, Med Sci Res, 27, 341

Shukla, 2007, Cancer preventive properties of ginger: A brief review, Food Chem Toxicol, 45, 683, 10.1016/j.fct.2006.11.002

Hudson, 2006, Ex vivo cancer chemoprevention research possibilities, Environmental Toxicology and pharmacology, 21, 204, 10.1016/j.etap.2005.07.011

Huang, 2000, Nuclear factor-kappaB activity correlates with growth, angiogenesis, and metastasis of human melanoma cells in nude mice, Clin Cancer Res, 6, 2573

Coppola, 2007, Statins and peripheral arterial disease: effects on claudication, disease progression, and prevention of cardiovascular events, Arch Med Res, 38, 479, 10.1016/j.arcmed.2006.12.012

Nonn, 2007, Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells, Carcinogenesis, 28, 1188, 10.1093/carcin/bgl241

Kim, 2005, Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo, Biochem Biophys Res Commun, 335, 300, 10.1016/j.bbrc.2005.07.076

Rhode, 2007, Ginger inhibits cell growth and modulates angiogenic factors in ovarian cancer cells, BMC Complementary and Alternative Medicine, 20, 7

Akhurst, 2001, A modified Choline-Deficient, Ethionine Supplemented Diet protocol effectively induces oval cells in mouse liver, Hepatology, 34, 519, 10.1053/jhep.2001.26751

Bharti, 2002, Nuclear factor-κB and cancer: Its role in prevention and therapy, Biochem Pharmacol, 64, 883, 10.1016/S0006-2952(02)01154-1

Arsura, 2005, Nuclear factor-κB and liver carcinogenesis, Cancer Lett, 229, 157, 10.1016/j.canlet.2005.07.008

Parkin, 2001, Estimating the world cancer burden: Globocan 2000, Int J Cancer, 94, 153, 10.1002/ijc.1440

Park, 1998, Inhibitory effect of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice, Cancer Lett, 129, 139, 10.1016/S0304-3835(98)00081-0

Aggarwal, 2006, Molecular targets of dietary for prevention and therapy of cancer, Biochem Pharmacol, 71, 1321, 10.1016/j.bcp.2006.02.009

Kundu, 2005, Breaking the relay in deregulated cellular signal transduction as a rationale for chemoprevention with anti-inflammatory phytochemicals, Mutat Research, 591, 123, 10.1016/j.mrfmmm.2005.04.019

Padifico, 2006, NF-kappaB in solid tumors, Biochem Pharmacol, 72, 1142, 10.1016/j.bcp.2006.07.032