Ghrelin administered spinally increases the blood glucose level in mice

Peptides - Tập 54 - Trang 162-165 - 2014
Yun-Beom Sim1, Soo-Hyun Park1, Sung-Su Kim1, Chea-Ha Kim1, Su-Jin Kim1, Su-Min Lim1, Jun-Sub Jung1, Hong-Won Suh1
1Department of Pharmacology, Institute of Natural Medicine, College of Medicine Hallym University, 39 Hallymdaehak-gil, Chuncheon, Gangwon-do 200-702, Republic of Korea

Tài liệu tham khảo

Bewick, 2009, Mice with hyperghrelinemia are hyperphagic and glucose intolerant and have reduced leptin sensitivity, Diabetes, 58, 840, 10.2337/db08-1428 Briggs, 2011, A recent update on the role of ghrelin in glucose homeostasis, Curr Diabetes Rev, 7, 201, 10.2174/157339911795843140 Broglio, 2003, Effects of ghrelin on the insulin and glycemic responses to glucose, arginine, or free fatty acids load in humans, J Clin Endocrinol Metab, 88, 4268, 10.1210/jc.2002-021940 Dezaki, 2004, Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents, Diabetes, 53, 3142, 10.2337/diabetes.53.12.3142 Erşahin, 2010, The anti-inflammatory and neuroprotective effects of ghrelin in subarachnoid hemorrhage-induced oxidative brain damage in rats, J Neurotrauma, 27, 1143, 10.1089/neu.2009.1210 Ferens, 2010, Functional and in situ hybridisation evidence that preganglionic sympathetic vasoconstrictor neurons express ghrelin receptors, Neuroscience, 166, 671, 10.1016/j.neuroscience.2010.01.001 Ferens, 2010, Evidence for functional ghrelin receptors on parasympathetic preganglionic neurons of micturition control pathways in the rat, Clin Exp Pharmacol Physiol, 37, 926, 10.1111/j.1440-1681.2010.05409.x Ferrini, 2009, Ghrelin in central neurons, Curr Neuropharmacol, 7, 37, 10.2174/157015909787602779 Furness, 2011, Investigation of the presence of ghrelin in the central nervous system of the rat and mouse, Neuroscience, 193, 1, 10.1016/j.neuroscience.2011.07.063 Gonzalez, 2006, Interleukin-1 beta-induced anorexia is reversed by ghrelin, Peptides, 27, 3220, 10.1016/j.peptides.2006.09.008 Hirayama, 2010, Contrasting effects of ghrelin and des-acyl ghrelin on the lumbo-sacral defecation center and regulation of colorectal motility in rats, Neurogastroenterol Motil, 22, 1124, 10.1111/j.1365-2982.2010.01553.x Hylden, 1981, Intrathecal substance P elicits a caudally-directed biting and scratching behavior in mice, Brain Res, 217, 212, 10.1016/0006-8993(81)90203-1 Kim, 2004, Chronic central administration of ghrelin reverses the effects of leptin, Int J Obes Relat Metab Disord, 28, 1264, 10.1038/sj.ijo.0802647 Kim, 2003, Changes in ghrelin and ghrelin receptor expression according to feeding status, Neuroreport, 14, 1317 Kroemer, 2013, Fasting levels of ghrelin covary with the brain response to food pictures, Addict Biol, 18, 855, 10.1111/j.1369-1600.2012.00489.x Lattuada, 2013, The expression of GHS-R in primary neurons is dependent upon maturation stage and regional localization, PLoS ONE, 8, e64183, 10.1371/journal.pone.0064183 Laviano, 2012, The growth hormone secretagogue receptor (Ghs-R), Curr Pharm Des, 18, 4749, 10.2174/138161212803216906 Lee, 2012, Ghrelin protects spinal cord motoneurons against chronic glutamate excitotoxicity by inhibiting microglial activation, Korean J Physiol Pharmacol, 16, 43, 10.4196/kjpp.2012.16.1.43 Peeters, 2013, Ghrelin and the gut, Endocr Dev, 25, 41, 10.1159/000346051 Schusdziarra, 2008, Differential inhibition of galanin- and ghrelin-induced food intake by i.c.v. GLP-1(7-36)-amide, Regul Pept, 147, 29, 10.1016/j.regpep.2007.12.004 Scott, 2012, Hindbrain ghrelin receptor signaling is sufficient to maintain fasting glucose, PLoS ONE, 7, e44089, 10.1371/journal.pone.0044089 Shimizu, 2006, Evidence that stimulation of ghrelin receptors in the spinal cord initiates propulsive activity in the colon of the rat, J Physiol, 576, 329, 10.1113/jphysiol.2006.116160 Solomon, 2005, Peripheral ghrelin participates in glucostatic feeding mechanisms and in the anorexigenic signalling mediated by CART and CRF neurons, Nutr Neurosci, 8, 287, 10.1080/10284150500502546 Stevanović, 2008, Consummatory behavior and metabolic indicators after central ghrelin injections in rats, Regul Pept, 147, 52, 10.1016/j.regpep.2008.01.003 Sun, 2006, Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice, Cell Metab, 3, 379, 10.1016/j.cmet.2006.04.004 Tóth, 2008, Effects of intraamygdaloid microinjections of acylated-ghrelin on liquid food intake of rats, Brain Res Bull, 77, 105, 10.1016/j.brainresbull.2008.06.008 Tschöp, 2001, Post-prandial decrease of circulating human ghrelin levels, J Endocrinol Invest, 24, RC19, 10.1007/BF03351037 Ueberberg, 2009, Expression of ghrelin and its receptor in human tissues, Horm Metab Res, 41, 814, 10.1055/s-0029-1233462 Zigman, 2006, Expression of ghrelin receptor mRNA in the rat and the mouse brain, J Comp Neurol, 494, 528, 10.1002/cne.20823