Patrono, 2017, Antiplatelet agents for the treatment and prevention of coronary atherothrombosis, J Am Coll Cardiol, 70, 1760, 10.1016/j.jacc.2017.08.037
Nagelschmitz, 2014, Pharmacokinetics and pharmacodynamics of acetylsalicylic acid after intravenous and oral administration to healthy volunteers, Clin Pharmacol, 6, 51
Floyd, 2012, Comparative pharmacokinetics and pharmacodynamics of platelet adenosine diphosphate receptor antagonists and their clinical implications, Clinical Pharmacokinetics, 51, 429, 10.2165/11630740-000000000-00000
Rossini, 2018, A multidisciplinary approach on the perioperative antithrombotic management of patients with coronary stents undergoing surgery: surgery after stenting 2, JACC Cardiovasc Interv, 11, 417, 10.1016/j.jcin.2017.10.051
Larsen, 2017, Predictive value of whole blood and plasma coagulation tests for intra- and postoperative bleeding risk: a systematic review, Semin Thromb Hemost, 43, 772, 10.1055/s-0037-1602665
Jahn, 2017, Effect of clopidogrel on thrombus formation in an ex vivo parallel plate flow chamber model cannot be reversed by addition of platelet concentrates or vWF concentrate, Anesth Analg, 124, 1091, 10.1213/ANE.0000000000001903
Li, 2017, Microfluidic whole blood testing of platelet response to pharmacological agents, Platelets, 28, 457, 10.1080/09537104.2016.1268254
Prüller, 2017, Implementation of buffy-coat-derived pooled platelet concentrates for internal quality control of light transmission aggregometry: a proof of concept study, J Thromb Haemost, 15, 2443, 10.1111/jth.13870
Le Quellec, 2016, Comparison of current platelet functional tests for the assessment of aspirin and clopidogrel response. A review of the literature, Thromb Haemost, 116, 638, 10.1160/TH15-11-0870
Kozek-Langenecker, 2017, Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology: first update 2016, Eur J Anaesthesiol, 34, 332, 10.1097/EJA.0000000000000630
Price, 2011, Standard- vs. high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial, JAMA, 305, 1097, 10.1001/jama.2011.290
Breet, 2010, Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation, JAMA, 303, 754, 10.1001/jama.2010.181
Collet, 2012, Bedside monitoring to adjust antiplatelet therapy for coronary stenting, N Engl J Med, 367, 2100, 10.1056/NEJMoa1209979
Hansson, 2017, Antiplatelet therapy, platelet function testing, and bleeding complications in cardiac surgery patients, Semin Thromb Hemost, 43, 699, 10.1055/s-0037-1603366
Kwak, 2010, Clopidogrel responsiveness regardless of the discontinuation date predicts increased blood loss and transfusion requirement after off-pump coronary artery bypass graft surgery, J Am Coll Cardiol, 56, 1994, 10.1016/j.jacc.2010.03.108
Preisman, 2010, Modified thromboelastography evaluation of platelet dysfunction in patients undergoing coronary artery surgery, Eur J Cardiothorac Surg, 37, 1367, 10.1016/j.ejcts.2009.12.044
Alström, 2009, Platelet inhibition assessed with VerifyNow, flow cytometry and PlateletMapping in patients undergoing heart surgery, Thrombosis Res, 124, 572, 10.1016/j.thromres.2009.06.024
Malm, 2016, Preoperative platelet function predicts perioperative bleeding complications in ticagrelor-treated cardiac surgery patients: a prospective observational study, Br J Anaesth, 117, 309, 10.1093/bja/aew189
Ranucci, 2011, Multiple electrode whole blood aggregometry and bleeding in cardiac surgery patients receiving thienopyridines, Ann Thorac Surg, 91, 123, 10.1016/j.athoracsur.2010.09.022
Mahla, 2018, Platelet inhibition and bleeding in patients undergoing non-cardiac surgery – The BIANCA Observational Study, Thromb Haemost, 10.1055/s-0038-1641153
Kirmani, 2017, Platelet function testing in cardiac surgery: a comparative study of electrical impedance aggregometry and thromboelastography, Platelets, 28, 550, 10.1080/09537104.2016.1237626
Godier, 2018, Arch Cardiovasc Dis
Authors/Task Force Members, 2014, Eur Heart J, 35, 2541, 10.1093/eurheartj/ehu283
Hansson, 2017, Platelet function recovery after ticagrelor withdrawal in patients awaiting urgent coronary surgery, Eur J Cardiothorac Surg, 51, 633
Alexopoulos, 2014, Ticagrelor vs. prasugrel one-month maintenance therapy: impact on platelet reactivity and bleeding events, Thromb Haemost, 112, 551, 10.1160/TH14-02-0119
Armstrong, 2017, Newly formed reticulated platelets undermine pharmacokinetically short-lived antiplatelet therapies, Arterioscler Thromb Vasc Biol, 37, 949, 10.1161/ATVBAHA.116.308763
Lordkipanidze, 2012, Aspirin twice a day keeps new COX-1 at bay, J Thromb Haemost, 10, 1217, 10.1111/j.1538-7836.2012.04764.x
Mazzeffi, 2017, Perioperative management and monitoring of antiplatelet agents: a focused review on aspirin and P2Y12 inhibitors, Korean J Anesthesiol, 70, 379, 10.4097/kjae.2017.70.4.379
Mahla, 2015, Platelet function testing before cabg is recommended in the guidelines: but do we have enough evidence?, J Interv Cardiol, 28, 233, 10.1111/joic.12194
Grove, 2013, Platelet function testing and prediction of procedural bleeding risk, Thromb Haemost, 109, 817, 10.1160/TH12-11-0806
Tantry, 2013, Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding, J Am Coll Cardiol, 62, 2261, 10.1016/j.jacc.2013.07.101
Berger, 2015, Does preoperative platelet function predict bleeding in patients undergoing off-pump coronary artery bypass surgery?, J Interv Cardiol, 28, 223, 10.1111/joic.12200
Vries, 2017, Determinants of agreement between proposed therapeutic windows of platelet function tests in vulnerable patients, Eur Heart J Cardiovasc Pharmacother, 3, 11, 10.1093/ehjcvp/pvw026
Morici, 2013, Time from adenosine diphosphate receptor antagonist discontinuation to coronary bypass surgery in patients with acute coronary syndrome: meta-analysis and meta-regression, Int J Cardiol, 168, 1955, 10.1016/j.ijcard.2012.12.087
Wiviott, 2007, Prasugrel versus clopidogrel in patients with acute coronary syndromes, N Engl J Med, 357, 2001, 10.1056/NEJMoa0706482
Held, 2011, Ticagrelor versus clopidogrel in patients with acute coronary syndromes undergoing coronary artery bypass surgery: results from the PLATO (Platelet Inhibition and Patient Outcomes) trial, J Am Coll Cardiol, 57, 672, 10.1016/j.jacc.2010.10.029
Mahla, 2012, Circ Cardiovasc Interv, 5, 261, 10.1161/CIRCINTERVENTIONS.111.967208
Bobbitt, 2018, Evaluating the effectiveness of preoperative platelet inhibition testing to reduce costs and preoperative length of stay, Appl Nurs Res, 39, 241, 10.1016/j.apnr.2017.11.029
Ferraris, 2012, 2012 update to the Society of Thoracic Surgeons guideline on use of antiplatelet drugs in patients having cardiac and noncardiac operations, Ann Thorac Surg, 94, 1761, 10.1016/j.athoracsur.2012.07.086
Valgimigli, 2018, Eur Heart J, 39, 213, 10.1093/eurheartj/ehx419
Bonhomme, 2016, [The role of point-of-care platelet function testing in guiding platelet transfusion], Transfus Clin Biol, 23, 202, 10.1016/j.tracli.2016.08.001
Chen, 2004, Clopidogrel and bleeding in patients undergoing elective coronary artery bypass grafting, J Thorac Cardiovasc Surg, 128, 425, 10.1016/j.jtcvs.2004.02.019
Görlinger, 2011, First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study, Anesthesiology, 115, 1179, 10.1097/ALN.0b013e31823497dd
Weber, 2012, Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients, Anesthesiology, 117, 531, 10.1097/ALN.0b013e318264c644
Corredor, 2015, The role of point-of-care platelet function testing in predicting postoperative bleeding following cardiac surgery: a systematic review and meta-analysis, Anaesthesia, 70, 715, 10.1111/anae.13083
Li, 2013, Effect of acetylsalicylic acid usage and platelet transfusion on postoperative hemorrhage and activities of daily living in patients with acute intracerebral hemorrhage, J Neurosurg, 118, 94, 10.3171/2012.9.JNS112286
Bartoszko, 2017, Can predicting transfusion in cardiac surgery help patients?, Br J Anaesth, 119, 350, 10.1093/bja/aex216
Biancari, 2018, External validation of the WILL-BLEED Risk Score, Thromb Haemost, 118, 433, 10.1160/TH17-10-0702
Olechowski, 2017, Changes in platelet function with inflammation in patients undergoing vascular surgery, Platelets, 1
HAS, 2015, 1
ANSM, 2012, 1
Rossaint, 2016, The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition, Crit Care, 20, 100, 10.1186/s13054-016-1265-x
Li, 2012, Reversal of the antiplatelet effects of aspirin and clopidogrel, J Thromb Haemost, 10, 521, 10.1111/j.1538-7836.2012.04641.x
Hansson, 2014, Effects of ex vivo platelet supplementation on platelet aggregability in blood samples from patients treated with acetylsalicylic acid, clopidogrel, or ticagrelor, Br J Anaesth, 112, 570, 10.1093/bja/aet339
Taylor, 2013, Is platelet transfusion efficient to restore platelet reactivity in patients who are responders to aspirin and/or clopidogrel before emergency surgery?, J Trauma Acute Care Surg, 74, 1367, 10.1097/01586154-201305000-00027
Vilahur, 2007, Normalization of platelet reactivity in clopidogrel-treated subjects, J Thromb Haemost, 5, 82, 10.1111/j.1538-7836.2006.02245.x
O’Connor, 2015, Efficacy of ex vivo autologous and in vivo platelet transfusion in the reversal of P2Y12 inhibition by clopidogrel, prasugrel, and ticagrelor: the APTITUDE study, Circ Cardiovasc Interv, 8, e002786, 10.1161/CIRCINTERVENTIONS.115.002786
Schoener, 2017, Reversal of the platelet inhibitory effect of the P2Y12 inhibitors clopidogrel, prasugrel, and ticagrelor in vitro: a new approach to an old issue, Clin Res Cardiol, 106, 868, 10.1007/s00392-017-1128-8
Zafar, 2013, Platelet function normalization after a prasugrel loading-dose: time-dependent effect of platelet supplementation, J Thromb Haemost, 11, 100, 10.1111/jth.12058
Bonhomme, 2015, Impact of non-inhibited platelet supplementation on platelet reactivity in patients treated with prasugrel or ticagrelor for an acute coronary syndrome: an ex vivo study, Platelets, 26, 324, 10.3109/09537104.2015.1035247
Bertling, 2018, Reversibility of platelet P2Y12 inhibition by platelet supplementation: ex vivo and in vitro comparisons of prasugrel, clopidogrel and ticagrelor, J Thromb Haemost, 10.1111/jth.14014
Dobesh, 2014, Ticagrelor: pharmacokinetics, pharmacodynamics, clinical efficacy, and safety, Pharmacotherapy, 34, 1077, 10.1002/phar.1477
Ferri, 2013, Pharmacology of the new P2Y12 receptor inhibitors: insights on pharmacokinetic and pharmacodynamic properties, Drugs, 73, 1681, 10.1007/s40265-013-0126-z
Martin, 2016, The effectiveness of platelet supplementation for the reversal of ticagrelor-induced inhibition of platelet aggregation, Eur J Anaesthesiol, 33, 361, 10.1097/EJA.0000000000000348
Godier, 2015, Inefficacy of platelet transfusion to reverse ticagrelor, N Engl J Med, 372, 196, 10.1056/NEJMc1409373
Zafar, 2017, Impact of timing on the functional recovery achieved with platelet supplementation after treatment with ticagrelor, Circ Cardiovasc Interv, 10, e005120, 10.1161/CIRCINTERVENTIONS.117.005120
Levi, 2011, Bleeding risk and reversal strategies for old and new anticoagulants and antiplatelet agents, J Thromb Haemost, 9, 1705, 10.1111/j.1538-7836.2011.04432.x
Ghadimi, 2016, Perioperative management of the bleeding patient, Br J Anaesth, 117, 10.1093/bja/aew358
Martin, 2017, [Management of the bleeding risk associated with antiplatelet agents], Rev Med Interne, 38, 467, 10.1016/j.revmed.2017.01.013
Colucci, 2014, The effect of desmopressin on platelet function: a selective enhancement of procoagulant COAT platelets in patients with primary platelet function defects, Blood, 123, 1905, 10.1182/blood-2013-04-497123
Orsini, 2017, Bleeding risk of surgery and its prevention in patients with inherited platelet disorders, Haematologica, 102, 1192, 10.3324/haematol.2016.160754
Mannucci, 1997, Desmopressin (DDAVP) in the treatment of bleeding disorders: the first 20 years, Blood, 90, 2515, 10.1182/blood.V90.7.2515
Mannucci, 1988, Desmopressin: a nontransfusional form of treatment for congenital and acquired bleeding disorders, Blood, 72, 1449, 10.1182/blood.V72.5.1449.1449
Reiter, 2003, Desmopressin antagonizes the in vitro platelet dysfunction induced by GPIIb/IIIa inhibitors and aspirin, Blood, 102, 4594, 10.1182/blood-2002-11-3566
Ranucci, 2007, Platelet mapping and desmopressin reversal of platelet inhibition during emergency carotid endarterectomy, J Cardiothorac Vasc Anesth, 21, 851, 10.1053/j.jvca.2007.05.009
Desborough, 2017, Desmopressin for treatment of platelet dysfunction and reversal of antiplatelet agents: a systematic review and meta-analysis of randomized controlled trials, J Thromb Haemost, 15, 263, 10.1111/jth.13576
Altun, 2017, Emergency coronary bypass surgery in patients under the influence of dual antiplatelet therapy: effects of tranexamic acid and desmopressin acetate, Turk J Med Sci, 47
Bonhomme, 2018, Evaluation of recombinant factor VIIa, tranexamic acid and desmopressin to reduce prasugrel-related bleeding: a randomised, placebo-controlled study in a rabbit model, Eur J Anaesth, 35, 208, 10.1097/EJA.0000000000000775
Teng, 2014, The effect of desmopressin on bleeding time and platelet aggregation in healthy volunteers administered ticagrelor, J Clin Pharm Ther, 39, 186, 10.1111/jcpt.12130
Frontera, 2016, Guideline for reversal of antithrombotics in intracranial hemorrhage: a statement for healthcare professionals from the Neurocritical Care Society and Society of Critical Care Medicine, Neurocrit Care, 24, 6, 10.1007/s12028-015-0222-x
Leissinger, 2014, Desmopressin (DDAVP) in the management of patients with congenital bleeding disorders, Haemophilia, 20, 158, 10.1111/hae.12254
Godier, 2018, Use of factor concentrates for the management of perioperative bleeding: guidance from the SSC of the ISTH, J Thromb Haemost, 16, 170, 10.1111/jth.13893
Altman, 2006, Recombinant factor VIIa reverses the inhibitory effect of aspirin or aspirin plus clopidogrel on in vitro thrombin generation, J Thromb Haemost, 4, 2022, 10.1111/j.1538-7836.2006.02088.x
Mazzeffi, 2013, In vitro effects of recombinant activated factor VII on thrombin generation and coagulation following inhibition of platelet procoagulant activity by prasugrel, Thromb Res, 132, 106, 10.1016/j.thromres.2013.04.007
Skolnick, 2011, Reversal of clopidogrel-induced bleeding with rFVIIa in healthy subjects, Anesth Analg, 1
Pehrsson, 2016, Boosting the coagulation restores haemostasis in ticagrelor-treated mice, Blood Coagul Fibrinolysis, 27, 913, 10.1097/MBC.0000000000000511
EMEA. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/001241/WC500100494.pdf [n.d.].
Hindy-François, 2010, Recombinant activated factor VII does not reduce bleeding in rabbits treated with aspirin and clopidogrel, Thromb Haemost, 104, 823, 10.1160/TH10-01-0039
Buchanan, 2015, Structural and functional characterization of a specific antidote for ticagrelor, Blood, 125, 3484, 10.1182/blood-2015-01-622928
Ker, 2012, Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis, BMJ, 344, e3054, 10.1136/bmj.e3054
Duranteau, 2015, Recommandations sur la réanimation du choc hémorragique, Anesth Reanim, 1, 62
http://www.ncepod.org.uk/classification.html [n.d.].
Graham, 2018, Aspirin in patients with previous percutaneous coronary intervention undergoing noncardiac surgery, Ann Intern Med, 168, 237, 10.7326/M17-2341
Oscarsson, 2010, To continue or discontinue aspirin in the perioperative period: a randomized, controlled clinical trial, Br J Anaesth, 104, 305, 10.1093/bja/aeq003
Mantz, 2011, Impact of preoperative maintenance or interruption of aspirin on thrombotic and bleeding events after elective non-cardiac surgery: the multicentre, randomized, blinded, placebo-controlled, STRATAGEM trial, Br J Anaesth, 107, 899, 10.1093/bja/aer274
Rossini, 2014, Perioperative management of antiplatelet therapy in patients with coronary stents undergoing cardiac and non-cardiac surgery: a consensus document from Italian cardiological, surgical and anaesthesiological societies, EuroIntervention, 10, 38, 10.4244/EIJV10I1A8
B. Joseph, 2015, An acute care surgery dilemma: emergent laparoscopic cholecystectomy in patients on aspirin therapy, Am J Surg, 209, 689, 10.1016/j.amjsurg.2014.04.014
CAPRIE Steering Committee, 1996, A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee, Lancet, 348, 1329, 10.1016/S0140-6736(96)09457-3
Chu, 2016, The evaluation of clopidogrel use in perioperative general surgery patients: a prospective randomized controlled trial, Am J Surg, 211, 1019, 10.1016/j.amjsurg.2015.05.036
Columbo, 2018, A meta-analysis of the impact of aspirin, clopidogrel, and dual antiplatelet therapy on bleeding complications in noncardiac surgery, Ann Surg, 267, 1, 10.1097/SLA.0000000000002279
Soo, 2016, Clopidogrel and hip fractures, is it safe? A systematic review and meta-analysis, BMC Musculoskelet Disord, 17, 136, 10.1186/s12891-016-0988-9
Zehir, 2015, Early surgery is feasible in patients with hip fractures who are on clopidogrel therapy, Acta Orthop Traumatol Turc, 49, 249
Benahmed, 2014, Ticlopidine and clopidogrel, sometimes combined with aspirin, only minimally increase the surgical risk in renal transplantation: a case-control study, Nephrol Dial Transplant, 29, 463, 10.1093/ndt/gft385
Pearcy, 2017, Risky business? Investigating outcomes of patients undergoing urgent laparoscopic appendectomy on antithrombotic therapy, Am J Surg, 214, 1012, 10.1016/j.amjsurg.2017.08.035
Chemtob, 2017, Outcome after surgery for acute aortic dissection – influence of preoperative antiplatelet therapy on prognosis, J Cardiothorac Vasc Anesth, 31, 569, 10.1053/j.jvca.2016.10.007
Lee, 2017, Preoperative low-dose aspirin exposure and outcomes after emergency neurosurgery for traumatic intracranial hemorrhage in elderly patients, Anesth Analg, 125, 514, 10.1213/ANE.0000000000002053
Baschin, 2017, Platelet transfusion to reverse antiplatelet therapy before decompressive surgery in patients with intracranial haemorrhage, Vox Sang, 112, 535, 10.1111/vox.12542
Thiele, 2012, Platelet transfusion for reversal of dual antiplatelet therapy in patients requiring urgent surgery: a pilot study, J Thromb Haemost, 10, 968, 10.1111/j.1538-7836.2012.04699.x
Albaladejo, 2011, Non-cardiac surgery in patients with coronary stents: the RECO study, Heart, 97, 1566, 10.1136/hrt.2011.224519
Cornet, 2007, Coronary stent occlusion after platelet transfusion: a case series, J Invasive Cardiol, 19, E297
Myles, 2017, Tranexamic acid in patients undergoing coronary artery surgery, N Engl J Med, 376, 136, 10.1056/NEJMoa1606424
CRASH-2 trial collaborators, 2010, Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial, Lancet, 376, 23, 10.1016/S0140-6736(10)60835-5
Mahmoud, 2016, Perioperative cardiovascular risk of prior coronary stent implantation among patients undergoing noncardiac surgery, J Am Coll Cardiol, 67, 1038, 10.1016/j.jacc.2015.11.063
Mehran, 2013, Cessation of dual antiplatelet treatment and cardiac events after percutaneous coronary intervention (PARIS): 2 year results from a prospective observational study, Lancet, 382, 1714, 10.1016/S0140-6736(13)61720-1
Jaben, 2014, Reversing the effects of antiplatelet agents in the setting of intracranial hemorrhage, J Intensive Care Med, 30, 3, 10.1177/0885066613487298
Inohara, 2018, Association of intracerebral hemorrhage among patients taking non-vitamin K antagonist vs. vitamin K antagonist oral anticoagulants with in-hospital mortality, JAMA, 319, 463, 10.1001/jama.2017.21917
Kobayashi, 2017, Novel oral anticoagulants and trauma: the results of a prospective American Association for the Surgery of Trauma Multi-Institutional Trial, J Trauma Acute Care Surg, 82, 827, 10.1097/TA.0000000000001414
Naidech, 2011, Early platelet transfusion improves platelet activity and may improve outcomes after intracerebral hemorrhage, Neurocrit Care, 16, 82, 10.1007/s12028-011-9619-3
Leong, 2015, Is platelet transfusion effective in patients taking antiplatelet agents who suffer an intracranial hemorrhage?, J Emerg Med, 49, 561, 10.1016/j.jemermed.2015.02.023
Baharoglu, 2016, Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial, Lancet, 387, 2605, 10.1016/S0140-6736(16)30392-0
Arnone, 2018, Impact of platelet transfusion on intracerebral hemorrhage (ICH) in patients on antiplatelet therapy – An analysis based on ICH score, World Neurosurgery, 10.1016/j.wneu.2018.01.006
Oakland, 2017, Re-bleeding and mortality after lower gastrointestinal bleeding in patients taking antiplatelets or anticoagulants, Clin Gastroenterol Hepatol, S1542-3565
Zakko, 2017, No benefit from platelet transfusion for gastrointestinal bleeding in patients taking antiplatelet agents, Clin Gastroenterol Hepatol, 15, 46, 10.1016/j.cgh.2016.07.017
ASGE Standards of Practice Committee, 2016, The management of antithrombotic agents for patients undergoing GI endoscopy, Gastrointest Endosc, 83, 3, 10.1016/j.gie.2015.09.035
Makris, 2013, Guideline on the management of bleeding in patients on antithrombotic agents, Br J Haematol, 160, 35, 10.1111/bjh.12107